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公开(公告)号:WO2016138498A2
公开(公告)日:2016-09-01
申请号:PCT/US2016/019966
申请日:2016-02-26
Applicant: INVISTA NORTH AMERICA S.À.R.L.
Inventor: BOTES, Adriana, L. , KADI, Nadia
IPC: C07K14/435
CPC classification number: C12N9/88 , A61K31/01 , C07C11/167 , C07C11/18 , C07C11/21 , C07K16/40 , C08F136/06 , C08F136/08 , C08F136/22 , C11B9/0007 , C12P5/026 , C12Y402/01 , C12Y402/01127
Abstract: The present disclosure provides novel polypeptides with improved 3-buten-2- ol dehydratase activity, polypeptides with improved linalool dehydratase activity, and polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene. Methods of making and using the polypeptides are also provided.
Abstract translation: 本公开提供了具有改善的3-丁烯-2-醇脱水酶活性的新型多肽,具有改进的芳樟醇脱水酶活性的多肽,以及在将3-甲基-3-丁烯-2-醇转化为异戊二烯时具有催化活性的多肽。 还提供了制备和使用多肽的方法。