公开(公告)号：IL136494D0

公开(公告)日：2001-06-14

申请号：IL13649498

申请日：1998-12-11

Applicant: MAGNETIC IMAGING TECHNOLOGIES

IPC: A61K49/00 ,  A61B5/055 ,  A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  G02F1/1337 ,  F25J

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

公开(公告)号：CA2313480A1

公开(公告)日：1999-07-08

申请号：CA2313480

申请日：1998-12-11

Applicant: MAGNETIC IMAGING TECHNOLOGIES

Inventor： DEATON DANIEL ,  HASSON KENTON CHRISTOPHER ,  LANGHORN ALAN ,  DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID

IPC: A61K49/00 ,  A61B5/055 ,  A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  G02F1/1337

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

公开(公告)号：NO20002930L

公开(公告)日：2000-07-28

申请号：NO20002930

申请日：2000-06-08

Applicant: MAGNETIC IMAGING TECHNOLOGIES

Inventor： DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON K C ,  LANGHORN ALAN

IPC: A61B5/055 ,  A61K49/00 ,  A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  G02F1/1337

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

公开(公告)号：NO20002930A

公开(公告)日：2000-07-28

申请号：NO20002930

申请日：2000-06-08

Applicant: MAGNETIC IMAGING TECHNOLOGIES

Inventor： DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON K C ,  LANGHORN ALAN

IPC: A61K49/00 ,  A61B5/055 ,  A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  G02F1/1337

CPC classification number: G02F1/133723 ,  A61K49/1815 ,  B01J19/26 ,  B01J2219/00099 ,  F17C2221/07 ,  F25J3/0685 ,  F25J2205/20 ,  F25J2210/42 ,  F25J2215/36 ,  F25J2270/904 ,  G01R33/282 ,  Y10S62/919 ,  Y10S62/925

公开(公告)号：CA2602360A1

公开(公告)日：1999-07-08

申请号：CA2602360

申请日：1998-12-11

Applicant: MAGNETIC IMAGING TECHNOLOGIES

Inventor： DEATON DANIEL ,  ZOLLINGER DAVID ,  DRIEHUYS BASTIAAN ,  HASSON KENTON CHRISTOPHER ,  LANGHORN ALAN

IPC: F17C13/00 ,  F25J1/00 ,  F25J3/06

公开(公告)号：BR9813492A

公开(公告)日：2000-11-21

申请号：BR9813492

申请日：1998-12-11

Applicant: MAGNETIC IMAGING TECHNOLOGIES

Inventor： DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON K C ,  LANGHORN ALAN

IPC: A61K49/00 ,  A61B5/055 ,  A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  G02F1/1337 ,  G01N24/08

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

公开(公告)号：CA2324269A1

公开(公告)日：1999-09-23

申请号：CA2324269

申请日：1999-03-17

Applicant: MAGNETIC IMAGING TECHNOLOGIES

Inventor： DRIEHUYS BASTIAAN ,  BOGORAD PAUL LEV ,  HASSON KENTON CHRISTOPHER

IPC: A61B5/026 ,  A61B5/0275 ,  A61B5/055 ,  A61K49/18 ,  G01R33/28 ,  G01R33/563

Abstract: MR spectroscopy and imaging methods for imaging pulmonary and cardiac vasculature and the cardiac region and evaluating blood flow or circulatory deficits use dissolved phase polarized 129Xe gas and large flip angle excitation pulses. Pulmonary and cardiac vasculature MRI images are obtained by delivering gas to a patient via inhalation such as with a breath-hold delivery-procedure, exciting the dissolved phase gas with a large flip angle pulse, and generating a corresponding image. Preferably, the image is obtained using multi-echo imaging techniques. Blood flow is quantified using low field MR spectroscopy and an RF excitation pulse with a frequency which corresponds to the resonance of the dissolved phase 129Xe.

公开(公告)号：EP1051602A2

公开(公告)日：2000-11-15

申请号：EP98967030.2

申请日：1998-12-11

Applicant: Magnetic Imaging Technologies Inc.

Inventor： DRIEHUYS, Bastiaan ,  ZOLLINGER, David ,  DEATON, Daniel ,  HASSON, K. C. ,  LANGHORN, Alan

IPC: G01N1/00

CPC classification number: G02F1/133723 ,  A61K49/1815 ,  B01J19/26 ,  B01J2219/00099 ,  F17C2221/07 ,  F25J3/0685 ,  F25J2205/20 ,  F25J2210/42 ,  F25J2215/36 ,  F25J2270/904 ,  G01R33/282 ,  Y10S62/919 ,  Y10S62/925

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

公开(公告)号：EP1066537A1

公开(公告)日：2001-01-10

申请号：EP99918429.4

申请日：1999-03-17

Applicant: Magnetic Imaging Technologies Inc.

Inventor： DRIEHUYS, Bastiaan ,  HASSON, Kenton Christopher ,  BOGORAD, Paul, Lev

IPC: G01R33/28

CPC classification number: G01R33/5601 ,  A61B5/0263 ,  A61B5/02755 ,  A61B5/055 ,  A61K49/1815 ,  G01R33/563

Abstract: MR spectroscopy and imaging methods for imaging pulmonary and cardiac vasculature and the cardiac region and evaluating blood flow or circulatory deficits use dissolved phase polarized 129Xe gas and large flip angle excitation pulses. Pulmonary and cardiac vasculature MRI images are obtained by delivering gas to a patient via inhalation such as with a breath-hold delivery-procedure, exciting the dissolved phase gas with a large flip angle pulse, and generating a corresponding image. Preferably, the image is obtained using multi-echo imaging techniques. Blood flow is quantified using low field MR spectroscopy and an RF excitation pulse with a frequency which corresponds to the resonance of the dissolved phase 129Xe.

公开(公告)号：EP1126883A1

公开(公告)日：2001-08-29

申请号：EP99956775.3

申请日：1999-10-29

Applicant: Magnetic Imaging Technologies Inc.

Inventor： DRIEHUYS, Bastiaan

IPC: A61K49/00

CPC classification number: A61K49/1815 ,  Y10T436/24

Abstract: Methods for increasing the T1 of injectable microbubble formulations of hyperpolarized 3He include the step of introducing the hyperpolarized 3He to a quantity of microbubbles held in a chamber and increasing the pressure therein to facilitate the movement or loading of the 3He into the microbubbles. Subsequently, a limited quantity of carrier liquid or a carrier liquid solution alone, or pre-mixed with 3He, can be introduced to the microbubble/3He in the chamber to inhibit the tendency of the 3He to leach out of the bubble. Related pharmaceutical products and associated containers as well as an evacuation based method for rapid mixing and delivery of the bubbles and the 3He is also disclosed. An additional method for dissolving 129Xe gas by using bubbles as an accelerant is also described.