公开(公告)号：US10900966B2

公开(公告)日：2021-01-26

申请号：US16281122

申请日：2019-02-21

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Jing-Rong Wang ,  Weina Gao ,  Leefong Yau ,  Hao Huang ,  Qiong Meng ,  Tiantian Tong ,  Zhi-Hong Jiang

IPC: G01N33/564 ,  G01N33/48 ,  G01N1/40 ,  G01N30/08 ,  G01N30/60 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

Abstract: The present invention discloses a method of determining the presence of autoimmune disease with the use of glycan biomarkers. A method of improving the detection sensitivity of trace glycans from a mixture of glycans and a microfluidic chip therefor are also disclosed.

公开(公告)号：US10688105B2

公开(公告)日：2020-06-23

申请号：US15644945

申请日：2017-07-10

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Kam Wai Wong ,  Yuen Kwan Law ,  Cong Ling Qiu

IPC: A61K31/185 ,  A61K31/495 ,  A61K31/56 ,  A61K31/519 ,  A61K31/573 ,  A61K31/165 ,  A61K31/42 ,  A61K45/06 ,  A61K31/635 ,  A61K31/19 ,  A61K39/00 ,  A61K31/365

Abstract: A method for treating a subject suffering from refractory rheumatoid arthritis includes the step of administering an effective amount of a quinonemethide triterpenoid or a pharmaceutically tolerable salt, solvate or anhydrate thereof to the subject. Also is a method for inducing autophagy in a synovial fibroblast, and a method of inducing calcium mobilization in a synovial fibroblast. Further a pharmaceutical composition includes an effective dose of a quinonemethide triterpenoid and an anti-arthritis compound. The quinonemethide triterpenoid is suitable to treat refractory rheumatoid arthritis (RA) in particular ABC-protein-dependent RA and apoptosis-deficient RA. The quinonemethide triterpenoid also possesses significant inhibitory effects on the growth of synovial fibroblasts, in particular modulating the calcium homeostasis in multidrug-resistant rheumatoid arthritis synovial fibroblasts.

公开(公告)号：US10515724B2

公开(公告)日：2019-12-24

申请号：US15150732

申请日：2016-05-10

Applicant: Macau University of Science and Technology

Inventor： Yong Liang ,  Hai-Hui Huang ,  Xiao-Ying Liu

IPC: G06N7/02 ,  G16H50/20

Abstract: A method and a system for determining an association of at least one biological feature with a medical condition utilizes the novel L1/2 penalized network-constraint regression model to achieve an improved biological analysis, in particular by solving high-dimensional problems. The method and the system of the present invention attain high accuracy and preciseness.

公开(公告)号：US10322097B2

公开(公告)日：2019-06-18

申请号：US14971153

申请日：2015-12-16

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Thomas Efferth ,  Su-Wei Xu ,  Sami Hamdoun ,  Liang Liu

IPC: A61K31/19 ,  A61K31/337 ,  A61K31/553 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24

Abstract: A quinonemethide triterpenoid is administered to subjects with multidrug-resistant cancer, in particular a cancer with enhanced expression and/or functional activity of ABC transporter proteins such as P-glycoprotein and/or an apoptosis-deficient, in particular p53-, Bax- or Bak-deficient, cancer, i.e. specific subgroups of subjects with cancer. The quinonemethide triterpenoid is suitable to treat cancer allowing for an accumulation of cytotoxic or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity towards the multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds. Methods for specifically targeting cancer cells with multidrug-resistance and methods for potentiating the activity of a chemotherapeutic compound in those cancer cells are also disclosed. A kit including a quinonemethide triterpenoid and a chemotherapeutic compound is also provided.

公开(公告)号：US10220064B2

公开(公告)日：2019-03-05

申请号：US15345842

申请日：2016-11-08

Applicant: Macau University of Science and Technology

Inventor： Hua Zhou ,  Quanbing Han ,  Yihan Zuo ,  Liang Liu ,  Ruiqi Yue

IPC: A61K36/258 ,  A61K31/715

Abstract: Methods of treating a subject suffering from an ischemic condition and of preventing an ischemia-reperfusion injury in a subject suffering from an ischemic condition, particularly, but not exclusively ischemic heart disease and the subject is in particular a human, includes administering an effective amount of a carbohydrate composition extracted from Panax ginseng to the subject. The carbohydrate composition of the present invention extracted from Panax ginseng shows exceptional cardio-protective effect and, thus, provides a highly advantageous and highly promising treatment option for treatment of ischemic conditions and prevention of ischemia-reperfusion injury. The present invention further provides a method of protecting cells against hypoxia and reoxygenation induced cell death. Still further, the present invention provides a carbohydrate composition extracted from Panax ginseng and a pharmaceutical formulation comprising it.

公开(公告)号：US10101721B2

公开(公告)日：2018-10-16

申请号：US14920026

申请日：2015-10-22

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Fajun Yang ,  Yan Qiao ,  Mengchu Zhou

IPC: G05B19/04 ,  G05B19/41 ,  G05B19/042 ,  G05B19/418

Abstract: A method determines an optimized production schedule of a production line including a hybrid multi-cluster tool formed by a plurality of single-arm tools and dual-arm tools interconnected with each other. The method includes determining time for individual operations of a robotic arm and a processing module in the plurality of single-arm tools and dual-arm tools; determining robot waiting time of the single-arm tools and dual-arm tools based on the time for individual operations and different connection relationships of the plurality of single-arm tools and dual-arm tools; determining whether the optimized production schedule exists using the determined waiting time, wherein the optimized production schedule only exists if the hybrid multi-cluster tool is process-dominant where the robot activity time of the plurality of single-arm tools and dual-arm tools is substantially shorter than processing time at the processing module; and determining the optimized production schedule if the optimized production schedule exists.

公开(公告)号：US10084661B2

公开(公告)日：2018-09-25

申请号：US15416035

申请日：2017-01-26

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Rongchang Duan ,  Hanwen Zhang ,  Yujun Zhang ,  Zhongcheng Li

IPC: H04W24/00 ,  H04W84/18 ,  H04L12/24 ,  H04W4/00 ,  H04L12/26 ,  H04W4/70

CPC classification number: H04L41/142 ,  H04L43/08 ,  H04L43/0888 ,  H04L67/12 ,  H04W4/70

Abstract: A method for evaluating performance of a data communication network with a receiver node arranged to initiate data transmission thereto from a plurality of transmitter nodes directly connected therewith includes applying to the data communication network a stochastic operation model arranged to model operation characteristics of the receiver node, and determining throughput or power consumption of the network based on the stochastic operation model. The operation characteristics include: a duration of a work cycle of the receiver node (Tcycle), the work cycle including an active data communication period (Thold) and an inactive period (Tdwell); a duration of the active data communication period (Thold), the active data communication period including a number of data communication events; the number of data communication events in the work cycle n; a duration of the respective data communication events (Ttx); and amount of data successfully received at the receiver node in the work cycle (Bi).

公开(公告)号：US20180212836A1

公开(公告)日：2018-07-26

申请号：US15416035

申请日：2017-01-26

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Rongchang Duan ,  Hanwen Zhang ,  Yujun Zhang ,  Zhongcheng Li

IPC: H04L12/24 ,  H04W4/00 ,  H04L12/26

CPC classification number: H04L41/142 ,  H04L43/08 ,  H04L43/0888 ,  H04W4/70

Abstract: A method for evaluating performance of a data communication network with a receiver node arranged to initiate data transmission thereto from a plurality of transmitter nodes directly connected therewith includes applying to the data communication network a stochastic operation model arranged to model operation characteristics of the receiver node, and determining throughput or power consumption of the network based on the stochastic operation model. The operation characteristics include: a duration of a work cycle of the receiver node (Tcycle), the work cycle including an active data communication period (Thold) and an inactive period (Tdwell); a duration of the active data communication period (Thold), the active data communication period including a number of data communication events; the number of data communication events in the work cycle n; a duration of the respective data communication events (Ttx); and amount of data successfully received at the receiver node in the work cycle (Bi).

公开(公告)号：US10004037B2

公开(公告)日：2018-06-19

申请号：US15219293

申请日：2016-07-26

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Caihong Kai ,  Hanxu Zheng

IPC: G08C17/00 ,  H04W52/02 ,  H04B17/391

CPC classification number: H04W52/0219 ,  H04B17/3912 ,  H04W4/70 ,  Y02D70/00 ,  Y02D70/22

Abstract: The throughput of a wireless network can be boosted by network coding (NC). The present invention combines NC-aware routing and TDMA-based MAC protocol for energy-efficient design in the wireless network, and provides a method thereof. An optimization model, which is a minimum energy consumption model (MECM), is formulated for minimizing the energy consumption for accomplishing a set of flow transmissions. In particular, based on a set of user traffic-flow demands, a NC-aware traffic-flow assignment that minimizes a total energy consumption of packets delivering to meet the user traffic-flow demands is determined. Thereafter, given the optimal flow assignment, a minimum timeslots model (MTM) which leads to a TDMA-based scheduling strategy at the MAC layer is developed. The MTM is to minimize the total number of timeslots required for transmission under a condition that the NC-aware traffic-flow assignment as already determined is accomplishable.

公开(公告)号：US09961702B2

公开(公告)日：2018-05-01

申请号：US14828159

申请日：2015-08-17

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Fangxin Xu ,  Yu Zeng ,  Jie Yang

IPC: H04W74/08 ,  H04W74/00 ,  H04W74/02

CPC classification number: H04W74/0866 ,  H04W74/008 ,  H04W74/02 ,  H04W74/08 ,  H04W74/0816

Abstract: A MAC protocol, useful for wireless local area networks (WLANs), is provided for improving throughput efficiency. The protocol includes three concurrent processes, and the channel is divided into a contention subchannel and a transmission subchannel. In the contention process, all nodes use the standard RTS/CTS mechanism operated on the contention channel to contend for a right of transmission. When one node gains the right, all the nodes store the contention result into their respective contention queue (CQ) buffers. In the transmission process, the nodes sequentially transmit their data over the transmission channel according to the order of the nodes stored in the CQ buffers. When one node finishes data transmission, the CQ buffers are updated. The contention process and the transmission process are connected by the queuing process, where each node dynamically updates its own CQ buffer according to the contention result and each instance of data transmission.