公开(公告)号：WO2013169989A1

公开(公告)日：2013-11-14

申请号：PCT/US2013/040287

申请日：2013-05-09

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  HONG KONG BAPTIST UNIVERSITY ,  MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  LIANG, Chun ,  JIANG, Zhihong ,  WANG, Ziyi ,  YU, Zhiling ,  WANG, Jingrong ,  BAI, Liping

Inventor： LIANG, Chun ,  JIANG, Zhihong ,  WANG, Ziyi ,  YU, Zhiling ,  WANG, Jingrong ,  BAI, Liping

IPC: A61K31/56 ,  A61K47/48 ,  A61K47/30 ,  A61P35/00

CPC classification number: A61K31/7048 ,  A61K31/585 ,  G01N33/5011 ,  G01N33/5044 ,  G01N33/574 ,  G01N2458/00 ,  G01N2500/10

Abstract: A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.

Abstract translation: 一种通过使用能够抑制MCM复合物的功能的试剂，由六个亚基形成的异六氢环在DNA复制过程中治疗癌症的方法以及通过检测这些试剂的位置和功能来筛选这些试剂的方法 MCM亚基，如hMcm2和hMcm6，在用候选化合物处理的细胞中。

公开(公告)号：WO2013118033A1

公开(公告)日：2013-08-15

申请号：PCT/IB2013/050812

申请日：2013-01-31

Applicant: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： LIU, Liang ,  LI, Ting ,  WONG, Kam Wai ,  JIANG, Zhihong ,  ZHOU, Hua

IPC: C12Q1/68 ,  A61K38/00 ,  A61K39/00 ,  A61P19/02 ,  A61P35/00 ,  A61P37/02

CPC classification number: G01N33/573 ,  A61K31/352 ,  A61K31/4188 ,  G01N33/574 ,  G01N2333/91205 ,  G01N2333/91215 ,  G01N2500/04 ,  G01N2800/102 ,  G01N2800/44

Abstract: Uses and applications derived from the discovery of a novel binding site of ΙΚΚ-β, such as method of screening a therapeutic agent as drug candidate for treating cancer, inflammation, or other diseases/disorders, are provided.

Abstract translation: 提供了从发现IotaKappaKappa-β的新结合位点得到的用途和应用，例如筛选治疗剂作为治疗癌症，炎症或其它疾病/障碍的候选药物的方法。

公开(公告)号：US20240169691A1

公开(公告)日：2024-05-23

申请号：US18515832

申请日：2023-11-21

Applicant: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Zhiyao LIANG ,  Jixiang YANG ,  Jianqing LI

IPC: G06V10/75 ,  G06V10/46 ,  G06V10/762 ,  G06V10/86 ,  G06V20/00

CPC classification number: G06V10/758 ,  G06V10/46 ,  G06V10/751 ,  G06V10/763 ,  G06V10/86 ,  G06V20/95

Abstract: A method for a copy-paste tampered image detection, including: extracting, using a scale-invariant feature transformation algorithm, key points of an image and features corresponding to the key points; constructing, using a gradient hash matching algorithm, a hash table based on the features, and putting the key points into rows corresponding to serial numbers of the hash table; performing a matching operation, using a k-nearest neighbor algorithm, on the key points in each row of the hash table to obtain key point pairs; and clustering and grouping, using a distance clustering filtering algorithm, the key point pairs, and retaining the key point pairs in a cluster group whose number of the key point pairs is greater than a quantity threshold; and marking circles in the image with each key point, in the key point pairs that are retained, as a center and according to a specified radius.

公开(公告)号：US20240087310A1

公开(公告)日：2024-03-14

申请号：US18063781

申请日：2022-12-09

Applicant: Macau University of Science and Technology

Inventor： Jianqing LI ,  Anran Yuan ,  Binbin WANG ,  Hailin ZOU ,  Jierui WANG

IPC: G06V20/10 ,  G06F16/51 ,  G06V10/764 ,  G06V10/774 ,  G06V10/82

CPC classification number: G06V20/188 ,  G06F16/51 ,  G06V10/764 ,  G06V10/774 ,  G06V10/82 ,  G06V2201/07

Abstract: The present disclosure relates to a method and system for multi-source algae image target detection, and relates to the field of monitoring of algal bloom events in fresh water. The method includes first crawling images of algae of a selected species by using a built automated algae crawling tool, where the images include all formats; classifying and labeling algae in the algae images, and forming a source domain dataset by using all the classified and labeled algae images; performing transfer learning by using a faster recurrent revolutional neural network (Faster RCNN) with reference to a target domain dataset, to obtain a multi-source algae image target detection model; and finally performing identification and classification by using the multi-source algae image target detection model.

公开(公告)号：US20230293564A1

公开(公告)日：2023-09-21

申请号：US18135229

申请日：2023-04-17

Applicant: The Hong Kong University Of Science And Technology ,  Hong Kong Baptist University ,  Macau University Of Science And Technology

Inventor： Chun LIANG ,  Zhihong JIANG ,  Ziyi Wang ,  Zhiling Yu ,  Jingrong Wang ,  Liping Bai

IPC: A61K31/7048 ,  G01N33/50 ,  G01N33/58 ,  A61P35/00

CPC classification number: A61K31/7048 ,  G01N33/5011 ,  G01N33/582 ,  A61P35/00

Abstract: A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.

公开(公告)号：US20220088055A1

公开(公告)日：2022-03-24

申请号：US17094903

申请日：2020-11-11

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Lee-Fong Yau ,  Tian-Tian Tong ,  Hao Huang ,  Kua Hu ,  Elaine Lai-Han Leung

IPC: A61K31/7105 ,  A61P35/00 ,  A61K31/713 ,  C07K16/28

Abstract: This invention discloses a medicinal composition includes a non-coding RNA molecule and an antibody targeting a tumor antigen for preventing and/or treating cancer. This invention uses the synergistic combination of a non-coding RNA molecule or its functional variant or homologue, and an antibody targeting a tumor antigen to prevent and/or treat cancer, thereby providing a novel and effective method in preventing and/or treating various cancers.

公开(公告)号：US11263708B2

公开(公告)日：2022-03-01

申请号：US15396992

申请日：2017-01-03

Applicant: Macau University of Science and Technology

Inventor： Si Wei Zhang ,  Nai Qi Wu ,  Zhi Wu Li

IPC: G06Q50/04 ,  G06Q10/06

Abstract: A system and method for scheduling at least one event includes a component module arranged to receive component data regarding a plurality of possible operation decisions, a modelling module arranged to utilise the plurality of operation decisions to construct a Petri net model to simulate a real world system, a scheduling module arranged to utilise the Petri net and variable data regarding the plurality of operation decisions to determine a schedule of events that is feasible subject to a set of predetermined constraints, and an operation module arranged to provide the schedule of events to at least one external device.

公开(公告)号：US20210254066A1

公开(公告)日：2021-08-19

申请号：US17247265

申请日：2020-12-06

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Kai-Yue CAO ,  Yu PAN ,  Tong-Meng YAN

IPC: C12N15/113

Abstract: A method of treating a subject suffering from cancer comprising a step of administering an effective amount of a group of double-stranded RNA molecules to the subject, wherein the RNA molecule is isolated or derived from a bacteria of the genus Escherichia. A method of inhibiting growth or proliferation of cancer cells comprising a step of contacting said cells with said RNA molecule; and a pharmaceutical composition for treating cancer comprising said RNA molecule and a pharmaceutically tolerable excipient. Also a double-stranded RNA molecule and a recombinant vector comprising the double-stranded RNA molecule.

公开(公告)号：US10985906B2

公开(公告)日：2021-04-20

申请号：US15880566

申请日：2018-01-26

Applicant: Macau University of Science and Technology

Inventor： Zhanchuan Cai ,  Ting Lan

IPC: H04L9/06 ,  H04L29/06 ,  G06F21/60 ,  G06F7/49

Abstract: A method executed by a computer system that transmits a multimedia content through a negative-base number. The method includes generating a binary sequence for the multimedia content, converting the binary sequence into a negative-base number, receiving the negative-base number, retrieving a negative base of the negative base number, calculating the binary sequence based on the negative-base number and the negative base, and obtaining the multimedia content based on the binary sequence.

公开(公告)号：US20210052630A1

公开(公告)日：2021-02-25

申请号：US16999051

申请日：2020-08-20

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Kua HU ,  Tong-Meng YAN

IPC: A61K31/7105 ,  A61K47/54 ,  A61P9/00

Abstract: Application of transfer RNA Molecules and their derived fragments for prevention or treatment of heart disease. The present invention provides a method of preventing or treating a subject suffering from heart diseases comprising administration of transfer RNA molecules and fragments derived from transfer RNA molecules or its functional variants or homologous to the subject, wherein the RNA molecules isolated from or derived from a plant of the genus Panax. The present invention also provides a pharmaceutical composition for the prevention or treatment of heart diseases comprising said effective amount of RNA molecule and a pharmaceutically tolerable vector, virus or excipient. The present invention provides a method for the prevention or treatment of a subject suffering from a heart disease. It is found that transfer RNA molecules from ginseng are particularly effective in the treatment of heart diseases, and also have a restorative effect on the myocardial cytoskeleton after ischemia-reperfusion injury.