公开(公告)号：US20070272389A1

公开(公告)日：2007-11-29

申请号：US11396107

申请日：2006-03-31

Applicant: Peter Gruber ,  John Knickerbocker

Inventor： Peter Gruber ,  John Knickerbocker

IPC: B22D11/124 ,  B05D5/12

CPC classification number: H05K3/3457 ,  H01L21/288 ,  H01L24/11 ,  H01L24/12 ,  H01L2224/11009 ,  H01L2224/1147 ,  H01L2224/13099 ,  H01L2224/13111 ,  H01L2224/1319 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/181 ,  H05K2203/0113 ,  H05K2203/0557 ,  H01L2924/00

Abstract: A method and apparatus for the formation of coplanar electrical interconnectors. Solder material is deposited onto a wafer, substrate, or other component of an electrical package using a complaint mold such that the terminal ends of the solder material being deposited, i.e., the ends opposite to those forming an attachment to the wafer, substrate, or other component of an electrical package are coplanar with one another. A complaint mold is used having one or more conduits for receiving solder material and having a compliant side and a planar side. The compliant side of the mold is positioned adjacent to the wafer, substrate, or other component of an electrical package allowing solder material to be deposited onto the surface thereof such that the planar side of the compliant mold provides coplanar interconnectors. An Injection Molded Solder (IMS) head can be used as the means for filling the conduits of the compliant mold of the present invention.

Abstract translation: 用于形成共面电连接器的方法和装置。 使用投诉模具将焊料沉积到电气封装的晶片，基板或其他部件上，使得焊料材料的末端被沉积，即与形成与晶片，基板或附件形成连接的端部相对的端部 电气封装的其他部件彼此共面。 使用投诉模具具有一个或多个用于接收焊料材料并具有柔性侧面和平面侧的导管。 模具的柔性侧被定位成与电气封装的晶片，衬底或其它部件相邻，允许将焊料材料沉积到其表面上，使得柔性模具的平面侧提供共面的互连器件。 可以使用注射成型焊料（IMS）头作为填充本​​发明的柔性模具的导管的装置。

公开(公告)号：US06962717B1

公开(公告)日：2005-11-08

申请号：US09890104

申请日：1999-01-29

Applicant: Gerald Huber ,  Peter Gruber

Inventor： Gerald Huber ,  Peter Gruber

IPC: A61K9/32 ,  A61K9/00 ,  A61K9/02 ,  A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K31/135 ,  A61K31/485 ,  A61K31/606 ,  A61K47/32 ,  A61K47/38 ,  A61P25/04 ,  A61P29/00 ,  A61K9/14 ,  A61K9/22 ,  A61K9/46

CPC classification number: A61K9/2081 ,  A61K9/1635 ,  A61K9/5026 ,  A61K9/5073

Abstract: A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 μm, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.

Abstract translation: 一种用于在胃肠道中缓慢释放活性成分的药物组合物，其包含多种含有不溶于胃和肠液的材料的活性成分颗粒，其中颗粒具有包含活性药物成分和 不溶于胃肠液的聚合物，平均内孔径不超过35μm，即使使用相对少量的聚合物也能有效且不依赖于pH的延迟释放。 另外由于保质期长，特别适用于非球形颗粒。

公开(公告)号：US06675444B2

公开(公告)日：2004-01-13

申请号：US10204210

申请日：2002-08-19

Applicant: Peter Gruber

Inventor： Peter Gruber

IPC: D01G1900

CPC classification number: D01G19/10

Abstract: In a top comb for a combing machine, having at least one row of stamped needles that are arranged in a parallel side-by-side relation and enclosed between two cover plates with a free needle projection (8) being left free, wherein compressed air channels are formed between the cover plates and adjacent pairs of needles are provided, in order to increase the efficiency of the cleaning effect, that the needles (1,1′,1″) incorporate embossings such that the congruent embossings of adjacent needles form an air channel (9,9′,9″), wherein the embossings taper in their widths towards the outlet area (outlet opening 11,11′,11″).

Abstract translation: 在用于精梳机的顶梳中，具有至少一排平行的并列关系排列的冲压针，并封闭在两个盖板之间，其中游离针突起（8）保持自由，其中压缩空气 在盖板和相邻的针之间形成通道，为了提高清洁效果，针（1,1'，1“）包括压纹，使得相邻针的一致的压花形成 空气通道（9,9'，9“），其中所述压花的宽度朝向出口区域（出口开口11,11'，11”）逐渐变细。

公开(公告)号：US06171617B2

公开(公告)日：2001-01-09

申请号：US09125210

申请日：1999-01-06

Applicant: Peter Gruber

Inventor： Peter Gruber

IPC: A61K914

CPC classification number: A61K31/192 ,  A61K9/0007 ,  Y10S514/951

Abstract: In particular, the invention relates to a new, clearly dissolving ibuprofen effervescent formulation and a process for the preparation of this formulation. Ibuprofen or (±)2-(4-isobutylphenyl)-propionic acid has the following structural formula and has been for years a proven, non-steroidal antiphlogistic from the group of phenylpropionic acid derivatives, which shows effectiveness in veterinary experimental inflammation models by inhibiting prostaglandin synthesis.

Abstract translation: 特别地，本发明涉及一种新的，明确溶解的布洛芬泡腾制剂及其制备方法。布洛芬或（±）2-（4-异丁基苯基） - 丙酸具有以下结构式， 经苯基丙酸衍生物组证实非甾体类消炎药，其通过抑制前列腺素合成显示了兽医实验炎症模型的有效性。

公开(公告)号：US6015577A

公开(公告)日：2000-01-18

申请号：US421351

申请日：1995-04-12

Applicant: Wolfgang Eisert ,  Peter Gruber

Inventor： Wolfgang Eisert ,  Peter Gruber

IPC: A61K31/60 ,  A61K9/22 ,  A61K9/24 ,  A61K9/48 ,  A61K9/50 ,  A61K9/58 ,  A61P7/02 ,  A61K9/36 ,  A61K9/62 ,  A61K31/62

CPC classification number: A61K9/5084 ,  A61K31/60 ,  A61K9/209 ,  A61K9/4808 ,  Y10S514/822 ,  Y10S514/824

Abstract: The specification describes a pharmaceutical combination consisting of dipyridamole or mopidamol and acetylsalicylic acid or the physiologically acceptable salts thereof, processes for preparing this pharmaceutical combination and the use thereof for the controlled prevention of clot formation.

Abstract translation: 本说明书描述了由双嘧达莫或莫比达莫和乙酰水杨酸或其生理学上可接受的盐组成的药物组合，制备该药物组合的方法及其用于控制​​预防凝块形成的用途。

公开(公告)号：US5932249A

公开(公告)日：1999-08-03

申请号：US619556

申请日：1996-07-15

Applicant: Peter Gruber ,  Hans Joachim Lach ,  Norbert Otterbeck

Inventor： Peter Gruber ,  Hans Joachim Lach ,  Norbert Otterbeck

IPC: A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K31/58 ,  A61K47/32 ,  A61K9/14

CPC classification number: C12Y304/24 ,  A61K31/58 ,  A61K9/5078

Abstract: Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacquer insoluble in gastric fluids but soluble in intestinal fluids and 3 to 20% of at least one lacquer insoluble in both gastric and intestinal fluids; and d) a second lacquer coating consisting of at least one lacquer insoluble in gastric and intestinal fluids. The invention also relates to a process for producing budesonide pellets with a controlled release pattern.

Abstract translation: PCT No.PCT / EP94 / 02531 Sec。 371日期：1996年7月15日 102（e）日期1996年7月15日PCT提交1994年7月29日PCT公布。 公开号WO95 / 08323 日期1995年3月30日公开是具有控制释放模式的布地奈德颗粒，其包含从内到外的：a）中性颗粒; b）微粉化布地奈德和一种或多种水溶性助剂的活性主层; c）第一漆包衣，其由80-97％的至少一种不溶于胃液但可溶于肠液的漆和3至20％至少一种不溶于胃液和肠液的漆组成; 和d）由至少一种不溶于胃液和肠液的漆组成的第二漆层。 本发明还涉及一种具有控制释放模式的布地奈德颗粒的制备方法。

公开(公告)号：US4707309A

公开(公告)日：1987-11-17

申请号：US593978

申请日：1984-03-27

Applicant: Gunther M. Voss ,  Volker I. Glasel ,  Peter Gruber ,  Walter Bubeck

Inventor： Gunther M. Voss ,  Volker I. Glasel ,  Peter Gruber ,  Walter Bubeck

IPC: B05B1/14 ,  A23P1/02 ,  A23P1/10 ,  A61J3/10 ,  A61K9/28 ,  B05B7/04 ,  B30B11/00 ,  B30B15/00 ,  B29C33/58 ,  B29C43/58

CPC classification number: B30B15/0011 ,  Y10S425/115

Abstract: The invention is directed to a process for dotting molding tools with droplets of liquid or suspended lubricant in the production of shaped articles in the pharmaceutical, food, or catalyst fields. Pressurized lubricant solutions or suspensions and pressurized gas are alternately passed through capillaries, in conjunction with alternating single-substance nozzles, in such a way that drops are formed on the nozzle surface, in between the jets of gas, and are then detached form this surface and directed to specific zones of pressing tools. The apparatus comprises fast-acting valves for the brief release of pressurized gases and lubricant liquids or suspensions. The delivery lines of a gas valve and a liquid valve combine upstream of a capillary, and single-substance nozzles are mounted at the end of the capillaries.

Abstract translation: 本发明涉及一种用于在制药，食品或催化剂领域中成形制品的生产中点滴具有液体液滴或悬浮润滑剂的模制工具的方法。 加压的润滑剂溶液或悬浮液和加压气体与交替的单一物质喷嘴交替地通过毛细管，使得在喷嘴表面之间，在气体喷射之间形成液滴，然后从该表面上分离 并针对特定的按压工具区域。 该装置包括用于短暂释放加压气体和润滑剂液体或悬浮液的快速作用阀。 气体阀和液体阀的输送管线组合在毛细管的上游，单个物质的喷嘴安装在毛细管的末端。

公开(公告)号：US4650664A

公开(公告)日：1987-03-17

申请号：US772166

申请日：1985-09-03

Applicant: Gottfried Schepky ,  Rolf Brickl ,  Peter Gruber ,  Jochen Schmid ,  Ursula Springmeier

Inventor： Gottfried Schepky ,  Rolf Brickl ,  Peter Gruber ,  Jochen Schmid ,  Ursula Springmeier

IPC: C07D487/04 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K31/505 ,  A61K47/12 ,  A61P7/02 ,  A61K9/54

CPC classification number: A61K9/2013 ,  A61K31/505 ,  A61K9/4841 ,  A61K9/5078

Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol or its acid addition salt.

Abstract translation: 本发明涉及给予莫匹达莫的载体。 更具体地说，本发明涉及在需要这种治疗的宿主中治疗心血管疾病，恶性肿瘤或血栓形成的方法，该方法包括向所述宿主施用心血管，抗重复或抗血栓形成的有效量的组合物，所述组合物包含（i）莫比达莫 或其酸加成盐和（ii）至少一种药理学上可接受的酸或酸物质，存在酸加成盐的酸的总量和酸或酸性物质的比例为至少约1当量酸1摩尔 莫比达莫或其酸加成盐。

公开(公告)号：US4548825A

公开(公告)日：1985-10-22

申请号：US538200

申请日：1983-10-03

Applicant: Gunther Voss ,  Peter Gruber

Inventor： Gunther Voss ,  Peter Gruber

IPC: A61J3/00 ,  A61K9/20 ,  B41J3/407 ,  A61K9/00 ,  A23L1/00

CPC classification number: A61K9/2095 ,  A61J3/00 ,  B41J3/4073 ,  A61J2205/20

Abstract: This invention is directed to a method for the non-contact application of letters or symbols to the exterior surfaces of uncoated tablets or uncoated tablet cores, which comprises dotting color solution or suspension by means of an ink-jet printer in specific quantity in the form of discrete droplets of specific volume onto the exterior surfaces of the uncoated tablets or uncoated tablet cores.

Abstract translation: 本发明涉及一种用于在未涂覆片剂或未包衣片芯的外表面上非接触施加字母或符号的方法，其包括通过喷墨打印机以特定数量的形式点滴颜色溶液或悬浮液 具有特定体积的离散液滴到未包衣片剂或未包衣片芯的外表面上。

公开(公告)号：US4524281A

公开(公告)日：1985-06-18

申请号：US439060

申请日：1982-11-03

Applicant: Jurg Muggli ,  Peter Gruber

Inventor： Jurg Muggli ,  Peter Gruber

IPC: G01N21/53 ,  G08B17/10 ,  G08B17/107

CPC classification number: G08B17/107 ,  G08B17/113

Abstract: A smoke detector is disclosed containing a radiation source and a radiation receiver arranged externally of a direct radiation region of the radiation source. In the presence of smoke or other combustion particles in the radiation region the radiation receiver is impinged by scattered radiation. The smoke detector contains optical elements which can be altered by external mechanical actuation, by means of which it is possible to alter in a predetermined manner an output signal of the radiation receiver. In this regard it is possible to either mechanically alter the solid angle which is so-to-speak viewed by the radiation receiver or the solid angle irradiated by the radiation source. The constriction of the active solid angle is preferably accomplished by a diaphragm or membrane displaceable along the radiation direction. Displacement of the diagram is preferably achieved in that, this diaphragm engages by means of dogs or detents in a cam groove, such as a helical-shaped groove of a cam disk, and by rotating the cam disk there can be achieved a defined displacement of the diaphragm.

Abstract translation: 公开了一种烟雾探测器，其包含布置在辐射源的直接辐射区域的外部的辐射源和辐射接收器。 在辐射区域内存在烟雾或其他燃烧颗粒的情况下，辐射接收器被散射辐射撞击。 烟雾探测器包含可以通过外部机械致动而改变的光学元件，借助于此，可以以预定方式改变辐射接收器的输出信号。 在这方面，可以机械地改变辐射接收器所观察到的立体角或由辐射源照射的立体角。 活性立体角的收缩优选通过沿辐射方向可移位的隔膜或膜来实现。 优选地实现该图的位移，其中该隔膜通过诸如凸轮盘的螺旋形凹槽的凸轮槽中的卡爪或棘爪啮合，并且通过旋转凸轮盘可以实现定义的位移 隔膜。