公开(公告)号：WO1997036994A1

公开(公告)日：1997-10-09

申请号：PCT/DK1997000111

申请日：1997-03-14

Applicant: RADIOMETER MEDICAL A/S ,  CLAUSEN, Lydia, Dahl ,  BYRNARD, Allan, Milton ,  KRISTENSEN, Jesper, Svenning

Inventor： RADIOMETER MEDICAL A/S

IPC: C12M01/40

CPC classification number: B01D67/0093 ,  C12Q1/002

Abstract: In a sensor for measuring an analyte in a biological sample whose measuring surface is covered by or comprises a membrane, the membrane has free groups on the surface facing the sample. The surface is modified such that a hydrophilic component is immobilised on the surface in such a manner that chains of the hydrophilic component are chemically bonded to free groups on the surface. Thus, the surface is provided with a more hydrophilic character relative to its unmodified state.

Abstract translation: 在用于测量其测量表面被膜覆盖或包含膜的生物样品中的分析物的传感器中，膜在面向样品的表面上具有游离基团。 修饰表面使得亲水组分固定在表面上，使得亲水组分的链与表面上的自由基化学键合。 因此，相对于其未修饰状态，表面被赋予更亲水的特性。

公开(公告)号：WO1997019350A1

公开(公告)日：1997-05-29

申请号：PCT/DK1996000468

申请日：1996-11-14

Applicant: RADIOMETER MEDICAL A/S ,  CLAUSEN, Lydia, Dahl ,  LARSEN, Eiler

Inventor： RADIOMETER MEDICAL A/S

IPC: G01N33/487

CPC classification number: G01N35/00 ,  C11D3/384 ,  C11D11/0041 ,  G01N35/1004

Abstract: In instruments analyzing protein-containing biological liquids, the instrument-driven rinse procedure is performed by a rinse solution containing heparin. Preferably the rinse solution also contains a blood dissolving organic substance, such as diethylene glycol. In a second aspect, the instrument-driven rinse procedure is performed by a rinse solution containing or consisting of a blood dissolving organic substance. In a third aspect, a substance containing or consisting of a blood dissolving organic substance is used in a manual rinse procedure for rinsing an instrument analyzing protein-containing biological liquids.

Abstract translation: 在分析含蛋白质的生物液体的仪器中，仪器驱动的清洗程序由含有肝素的冲洗溶液进行。 优选地，冲洗溶液还含有血液溶解有机物质，例如二甘醇。 在第二方面，仪器驱动的冲洗程序由含有血液溶解有机物质的或由其组成的冲洗溶液进行。 在第三方面，含有或由血液溶解有机物组成的物质用于手动漂洗程序，用于冲洗分析含蛋白质的生物液体的仪器。

公开(公告)号：WO1996029107A1

公开(公告)日：1996-09-26

申请号：PCT/DK1996000100

申请日：1996-03-14

Applicant: RADIOMETER MEDICAL A/S ,  LUND, Per, William ,  PETERSEN, Knud, Robert

Inventor： RADIOMETER MEDICAL A/S

IPC: A61M05/32

CPC classification number: A61M5/3271 ,  A61M2005/3228 ,  A61M2005/3252

Abstract: The shielding means is for a needle of a container-needle assembly comprising a container (21) having an elongate body, a needle (13) and connecting parts (22, 14) for connecting the container (21) releasably with the needle (13). The shielding means comprises two coaxial tubular bodies, an inner (5) and an outer (1) body, which are made to telescope in relation to each other. The outer tubular body (1) is adapted to at least partially receive the body of the container (21), and the inner tubular body (5) is adapted to be displaced from a retracted position, in which the needle (13) is exposed, to an advanced position, in which the needle (13) is surrounded by the inner tubular body (5). The shielding means further comprises connection means (3) for connecting said outer tubular body (1) with the needle (13) without connecting to the container.

Abstract translation: 屏蔽装置用于容器 - 针组件的针，其包括具有细长主体的容器（21），针（13）和用于将容器（21）可释放地与针头（13）连接的连接部件（22,14） ）。 屏蔽装置包括两个同轴的管状体，内部（5）和外部（1）主体，它们相对于彼此制成望远镜。 外管状体（1）适于至少部分地容纳容器（21）的主体，并且内管状体（5）适于从针（13）暴露在其中的缩回位置移位 到针头（13）被内管状体（5）包围的高级位置。 屏蔽装置还包括用于将所述外管状体（1）与针（13）连接而不连接到容器的连接装置（3）。

公开(公告)号：WO1994026333A1

公开(公告)日：1994-11-24

申请号：PCT/DK1994000184

申请日：1994-05-09

Applicant: RADIOMETER MEDICAL A/S ,  SPORK, Allan ,  McGUGAN, Steve

Inventor： RADIOMETER MEDICAL A/S

IPC: A61M05/31

CPC classification number: A61M5/3205 ,  A61M2005/3206

Abstract: The ejection means (100) comprises an elongate jacket (10) configured to, at least partially, surround the container (2), and an ejection member (12) located substantially inside the jacket (10). The ejection member (12) extends in the longitudinal direction of the jacket (10) from a first end of the jacket (10) to an opposite second end, the ejection member (12) being partially exposed at said second end prior to ejecting the needle (8). Through pressure on the member at the second end of the jacket (10) in the direction of the first end of the jacket (10), the ejection member (12) is displaceable in the longitudinal direction of the jacket (10) for abutting against and ejecting the needle (8). The ejection means (100) is applicable for generally all types of sampling devices, such as devices with containers (2) of the type with built-in measuring chambers (5a, 5b, 5c, 5d) or containers of the piston syringe type.

Abstract translation: 喷射装置（100）包括被配置为至少部分地围绕容器（2）的细长护套（10）和基本上位于护套（10）内部的弹出构件（12）。 喷射构件（12）在护套（10）的纵向方向上从护套（10）的第一端延伸到相对的第二端，弹出构件（12）在弹出构件（12）之前部分地暴露在所述第二端 针（8）。 通过在护套（10）的第二端的构件上的构件上的压力，护套（10）的第一端的方向上的排出构件（12）能够在护套（10）的纵向方向上移位，以抵抗 并排出针（8）。 喷射装置（100）通常适用于所有类型的采样装置，例如具有内置测量室（5a，5b，5c，5d）的类型的容器（2）或活塞式注射器类型的容器的装置。

公开(公告)号：EP1292823A1

公开(公告)日：2003-03-19

申请号：EP01933650.2

申请日：2001-05-23

Applicant: RADIOMETER MEDICAL A/S

Inventor： CLAUSEN, Lydia, Dahl

IPC: G01N27/26 ,  G01N27/40

CPC classification number: C12Q1/66 ,  C12Q1/26 ,  C12Q1/58

Abstract: A membrane for a sensor, a method for the preparation thereof, a layered membrane structure and a sensor for analytical measurements which require controlled analyte permeability. The membrane, layered structure and sensor may be used for biological, physiological and chemical measurements, however, are especially applicable for electrochemical measurements of glucose, lactate, urea and creatinine. The membrane comprises at least one polymer material, at least one surfactant, and at least one hydrophilic compound in admixture to provide a membrane structure in which micelles of hydrophilic compound lined with thin layers of surfactant are randomly distributed in the bulk polymer of the membrane. Upon conditioning of the membrane a structure of a perculating network of pores lined with surfactant is formed which has excellent permeability properties. The membrane has the additional advantage of a proper adhesion to polymer encapsulant structures. The membrane is prepared from a mixture of at least one polymer material, at least one surfactant, at least one hydrophilic compound and at least one solvent.

公开(公告)号：EP1273920A2

公开(公告)日：2003-01-08

申请号：EP02022484.6

申请日：1996-08-29

Applicant: RADIOMETER MEDICAL A/S

Inventor： Spork, Allan ,  Pedersen, Bent ,  Fremming, Niels ,  Hvidtfeldt, Kristian Jacob

IPC: G01N35/10 ,  B01L3/00 ,  G01N33/49 ,  G01N33/487

CPC classification number: G01N33/4925 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The apparatus for analysis has means for automatic introduction of reference fluid for the apparatus. The apparatus comprises an inlet member with a displaceable inlet tube, programmable control means for control of the introduction of fluid into the apparatus, a holder for simultaneously holding several sealed containers with reference fluid, and opening means for opening a sealed container. The apparatus further comprises first movement means for bringing a container selected by the programmable control means and the opening means into position in relation to each other, second movement means for bringing the opened container and the inlet member into position in relation to each other, displacement means for displacing the inlet tube into the reference fluid, and third movement means for removing the container and the inlet member from each other. The containers comprise a container body and a cap having a penetration part provided with a through hole and being arranged for breaking open the sealed container when the cap is moved relative to the container body. The opening means comprises a press element for moving the cap of a container relative to the container body in order to break open the sealed container by pressing the penetration part of the cap into the container.

Abstract translation: 用于分析的装置具有用于自动引入装置的参考流体的装置。 该装置包括具有可移动入口管的入口构件，用于控制将流体引入装置的可编程控制装置，用于同时容纳具有参考流体的多个密封容器的保持器和用于打开密封容器的打开装置。 该装置还包括第一移动装置，用于使由可编程控制装置选择的容器和打开装置相互关联的位置;第二移动装置，用于使打开的容器和入口构件相对于彼此位置，位移 用于将入口管移动到参考流体中的装置，以及用于将容器和入口构件彼此移除的第三移动装置。 容器包括容器主体和盖，其具有设置有通孔的穿透部，并且布置成当盖相对于容器主体移动时，用于打开密封容器。 打开装置包括用于使容器的帽相对于容器主体移动的按压元件，以便通过将盖的穿透部分压入容器来打开密封容器。

公开(公告)号：EP1269172A1

公开(公告)日：2003-01-02

申请号：EP01909570.2

申请日：2001-03-01

Applicant: RADIOMETER MEDICAL A/S

Inventor： S RENSEN, Poul, Ravn ,  ZACHAU-CHRISTIANSEN, Birgit

IPC: G01N27/327

CPC classification number: G01N27/301 ,  G01N27/333 ,  G01N27/4035

Abstract: The invention concerns an electrode device comprising an ion selective material, a solid state, inner reference system of sodium vanadium bronze and a contact material, where sodium may be reversibly intercalated in the bronze. Such an electrode device may for instance be sensitive to ions, such as H?+, Na+, K+ and Ca2+¿. It may also include a reactive material in which a particular analyte is reacted to form an ion product, to which the ion selective material is sensitive, such as in electrode devices of the Severinghaus-type or in biosensors. The electrode device according to the invention can be prepared by thick film printing.

公开(公告)号：EP1232382A1

公开(公告)日：2002-08-21

申请号：EP00972639.9

申请日：2000-10-30

Applicant: RADIOMETER MEDICAL A/S

Inventor： TAAGAARD, Michael ,  LARSEN, Allan

IPC: G01N7/00 ,  A61B5/145 ,  A61M5/36

CPC classification number: G01N7/00 ,  A61M2230/20

Abstract: In the method claimed, the liquid is placed in a measuring chamber and is in contact with a sensor for measuring the content of a particular gas in the liquid. A first measurement of the content of said gas in the liquid is performed at a first pressure in the measuring chamber, after which the pressure in the measuring chamber is changed to a second pressure. Then a second measurement of the content of said gas in the liquid is performed at the second pressure in the measuring chamber. An expected result of the second measurement is provided based on the first measurement and assuming that no bubbles are present in the measuring chamber during any of the measurements. The actual result of the second measurement is compared with the expected result.

公开(公告)号：EP0705241B1

公开(公告)日：1999-01-13

申请号：EP94919563.0

申请日：1994-06-22

Applicant: RADIOMETER MEDICAL A/S

Inventor： BYRNARD, Allan, Milton ,  UNGARO, Rocco ,  POCHINI, Andrea

IPC: C07C245/08 ,  C07C255/40 ,  G01N33/84

CPC classification number: C07C245/10 ,  G01N33/84

Abstract: A novel calix[4]arene compound, application of the compounds as an active component in a calcium sensitive sensor, and a calcium sensitive sensor containing the compound. The calix[4]arene compound has general formula (I). The sensor is not very sensitive to sodium and potassium ions.

公开(公告)号：EP0478683B1

公开(公告)日：1995-12-27

申请号：EP90910605.6

申请日：1990-06-13

Applicant: RADIOMETER MEDICAL A/S

Inventor： ANDERSEN, Joergen ,  HVIDTFELDT, Kristian Jacob ,  SINNERUP, Ib Olaf

IPC: G01N35/00 ,  G01N35/08 ,  B01L3/00

CPC classification number: G01N35/1002 ,  G01N35/1079 ,  G01N2035/1006

Abstract: New apparatus for measuring parameters such as pH, pCO2, pO2, and Hb content of physiological fluids, especially blood, is described. The apparatus comprises novel means for suspending reagent vessels (34, 35, 40, 45, 50) having shoulders (51, 52) and containing calibrating solutions, rinsing solutions etc., as well as for suspending a liquid waste vessel (26) by suspending the vessels between rods (53, 54) fed to the analyser. The reagent vessels are provided with caps (55, 58) at the top and include liquid reagent conduit extending from the outlet aperture of the cap down into the liquid. When the vessel is mounted on the anaylser a fixed inlet tube extending horizontally outwardly from the analyser penetrates a seal across the outlet aperture and connects with the liquid reagent conduit.