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    METHOD FOR DIAGNOSIS OF INFLAMMATORY DISEASES USING MRP8/MRP14
    11.
    发明申请
    METHOD FOR DIAGNOSIS OF INFLAMMATORY DISEASES USING MRP8/MRP14 审中-公开
    使用MRP8 / MRP14诊断炎性疾病的方法

    公开(公告)号：WO2003069349A2

    公开(公告)日：2003-08-21

    申请号：PCT/EP2003/001576

    申请日：2003-02-17

    Applicant: SORG, Clemens ,  ROTH, Johannes

    Inventor： SORG, Clemens ,  ROTH, Johannes

    IPC: G01N33/68

    CPC classification number: G01N33/6872 ,  G01N2333/4727

    Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker MRP8/MRP14, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of: (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex and/or nucleic acids encoding the polypeptide(s) present in said biological sample; and (c) comparing the amount and/or concentration of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex determined in said biological sample with the amount and/or concentration of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding MRP8 and/or MRP14 polypeptide(s) determined in said biological sample with the amount and/or concentration of nucleic acids encoding MRP8 and/or MRP14 polypeptide(s) measured in a control sample, wherein the difference in the amount of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex and/or nucleic acids encoding the polypeptide(s) is indicative for the stages of the disease to be diagnosed.

    Abstract translation: 本发明涉及一种用于诊断基于标志物MRP8 / MRP14的炎性疾病的方法，特别是用于诊断炎性疾病的特定阶段和/或用于确定复发的风险和/或用于鉴别具有相似症状的疾病之间的所述方法 包括以下步骤：（a）获得要诊断的哺乳动物体液或组织的生物样品; （b）确定存在于所述生物样品中的MRP8和/或MRP14多肽和/或MRP8 / MRP14蛋白复合物和/或编码多肽的核酸的量和/或浓度; 和（c）将在所述生物样品中测定的MRP8和/或MRP14多肽和/或MRP8 / MRP14蛋白质复合物的量和/或浓度与MRP8和/或MRP14多肽的量和/或浓度进行比较 ）和/或MRP8 / MRP14蛋白复合物，和/或将编码所述生物样品中测定的MRP8和/或MRP14多肽的核酸的量和/或浓度与量和/或浓度 编码在对照样品中测量的MRP8和/或MRP14多肽的核酸，其中MRP8和/或MRP14多肽和/或MRP8 / MRP14多肽和/或编码 多肽指示要诊断的疾病的阶段。

    METHOD OF DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C
    12.
    发明申请
    METHOD OF DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C 审中-公开

    公开(公告)号：WO2003069341A3

    公开(公告)日：2003-08-21

    申请号：PCT/EP2003/001575

    申请日：2003-02-17

    Applicant: SORG, Clemens ,  ROTH, Johannes

    Inventor： SORG, Clemens ,  ROTH, Johannes

    IPC: G01N33/564

    Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or con­centration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

    METHOD OF DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C
    15.
    发明专利
    METHOD OF DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C 未知

    公开(公告)号：AU2003212245A1

    公开(公告)日：2003-09-04

    申请号：AU2003212245

    申请日：2003-02-17

    Applicant: ROTH JOHANNES ,  SWITCH BIOTECH AG ,  SORG CLEMENS

    Inventor： ROTH JOHANNES ,  SORG CLEMENS

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68

    Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

    17.
    发明专利
    未知

    公开(公告)号：AT47612B

    公开(公告)日：1911-04-25

    申请号：AT47612D

    申请日：1910-01-10

    Applicant: ROTH JOHANNES

    Inventor： ROTH JOHANNES

    METHOD OF DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C
    19.
    发明专利
    METHOD OF DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C 未知

    公开(公告)号：CA2474890A1

    公开(公告)日：2003-08-21

    申请号：CA2474890

    申请日：2003-02-17

    Applicant: SORG CLEMENS ,  ROTH JOHANNES

    Inventor： SORG CLEMENS ,  ROTH JOHANNES

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68

    Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, sa id method comprising the steps of (a) obtaining a biological sample of mammalia n body fluid or tissue to be diagnosed; (b) determining the amount and/or con~centration of CALGRANULIN C polypeptide and/or nucleic acids encoding th e polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biologic al sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

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