公开(公告)号：EP1474689B1

公开(公告)日：2012-09-12

申请号：EP03708103.1

申请日：2003-02-17

Applicant: Sorg, Clemens ,  Roth, Johannes

Inventor： Sorg, Clemens ,  Roth, Johannes

IPC: G01N33/564 ,  G01N33/68

CPC classification number: G01N33/53 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/4727 ,  G01N2333/52 ,  G01N2800/065

Abstract: Method for diagnosing inflammatory diseases, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, based on the marker Calgranulin C. The method comprises the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or connection of Calgranulin C polypeptide(s) and/or nucleic acids encoding the polypeptide(s) present in the biological sample; and (c) comparing the amount and/or concentration of Calgranulin C and/or nucleic acids encoding the polypeptide(s) determine to be in the biological sample with that of a corresponding control sample, wherein the difference in the amount of Calgranulin C and/or nucleic acids encoding the polypeptide(s) is indicative for the stages of the disease to be diagnosed.

Abstract translation: 用于诊断炎性疾病的方法，特别是用于诊断炎性疾病的特定阶段和/或用于确定复发的风险和/或用于鉴别具有相似症状的疾病之间的疾病，基于标记物钙粒蛋白C.该方法包括以下步骤：（a） 获得要诊断的哺乳动物体液或组织的生物样品; （b）测定生物样品中存在的钙粒蛋白C多肽和/或编码多肽的核酸的量和/或连接; 将（c）将生物样品中所确定的Calgranulin C和/或编码多肽的核酸的量和/或浓度与相应对照样品的量和/或浓度进行比较，其中Calgranulin C和 /或编码多肽的核酸指示要诊断的疾病的阶段。

公开(公告)号：EP1474689A2

公开(公告)日：2004-11-10

申请号：EP03708103.1

申请日：2003-02-17

Applicant: Sorg, Clemens ,  Roth, Johannes

Inventor： Sorg, Clemens ,  Roth, Johannes

IPC: G01N33/564 ,  G01N33/68

CPC classification number: G01N33/53 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/4727 ,  G01N2333/52 ,  G01N2800/065

Abstract: Method for diagnosing inflammatory diseases, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, based on the marker Calgranulin C. The method comprises the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or connection of Calgranulin C polypeptide(s) and/or nucleic acids encoding the polypeptide(s) present in the biological sample; and (c) comparing the amount and/or concentration of Calgranulin C and/or nucleic acids encoding the polypeptide(s) determine to be in the biological sample with that of a corresponding control sample, wherein the difference in the amount of Calgranulin C and/or nucleic acids encoding the polypeptide(s) is indicative for the stages of the disease to be diagnosed.

公开(公告)号：DE102016012235B3

公开(公告)日：2018-02-15

申请号：DE102016012235

申请日：2016-10-10

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: A61B90/16 ,  A61B1/273 ,  A61M25/01

Abstract: Zur Durchführung endoskopischer Untersuchungen des oberen Gastrointestinaltraktes wird ein Beißring benötigt, der in den Mund des Patienten eingeführt wird. Die Seiten des Mittelstückes des Beißringes sind bisher starr und verhindern unter gewissen Umständen das Einführen des Beißringes, wodurch die Untersuchung nicht durchgeführt werden kann, oder es kommt zu Verletzungen des Mund-/Zahnapparates des Patienten mit z. T. erheblichen Folgen. Die Seiten (b) des Mundstückes (a) des Beißringes werden flexibel (ähnlich einer Ziehharmonika) verändert, so dass eine vertikale Höhenverstellung/-verminderung möglich wird. Konsekutiv erfolgt eine entsprechende ziehharmonika ähnliche Veränderung in den Haltebögen (c) des Beißringes. Dies ermöglicht bisher nicht durchführbare Untersuchungen und führt zur Reduktion substantieller Verletzungen im Mund-/Zahnapparat des Patienten mit weiteren möglichen Folgen (z. B. Aspiration abgebrochener Zahnanteile in das Bronchialsystem). Durchführung endoskopischer Untersuchungen des oberen Gastrointestinaltraktes

公开(公告)号：AU2003212245A8

公开(公告)日：2003-09-04

申请号：AU2003212245

申请日：2003-02-17

Applicant: ROTH JOHANNES ,  SWITCH BIOTECH AG ,  SORG CLEMENS

Inventor： SORG CLEMENS ,  ROTH JOHANNES

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68

Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

公开(公告)号：GB191010471A

公开(公告)日：1911-04-27

申请号：GB191010471D

申请日：1910-04-28

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: B28B11/16

Abstract: 10,471. Roth, J. April 28. Stream-cutting machines; punching and perforating machines.-Relates to automatic tile-cutting machines of the type in which the cutting &c. devices are driven from an independently-driven shaft controlled by a shaft operated by the moving clay stream, and consists in the combination with the controlling-shaft of means for actuating the carriage carrying the cutting-devices, means for periodically releasing the cutter-actuating shaft, and means for controlling a stub cutter. The stream of clay 2, Fig. 1, passes over rollers 7 mounted upon shafts 3 fitted with pulleys 4, Fig. 5, around which passes a band 6 adapted to drive an interchangeable pulley 5 mounted upon the controlling shaft 17. A disk 59, Fig. 1, mounted upon the shaft 17 is fitted with a pin 60 which engages with a rod 61 connected to the carriage 9 and moves it forward, and with a cam 62 which engages with a lever 63, also connected to the carriage 9, and returns it. The pin 60 m a y be adjustably arranged on the disk 59. On the end of the shaft 17 is mounted a cam 18, Fig. 11, which deflects a lever 19 against the action of a spring 24 out of the path of a cam 14 and releases a shaft 11 connected to an independently-driven shaft through a friction coupling 12, Fig. 1. A crank 34, Fig. 3, on the shaft 11 rocks a lever by means of a pin 36 and slot 37, and this lever reciprocates a frame 45 which, by gearing 44, 30, oscillates a frame 33 carrying the cutting- wire 58, for the shaped end of the tile. The wire 58 is attached to pieces 33 , 33 , sliding radially on arms 33, 33 and fitted with rollers 57 engaging with a pattern guide 56, Fig. 1. The straight ends of the tiles are cut by a wire 52 , Fig. 4, carried by a frame 52, which is reciprocated by a lever 49 connected to a crank by a rod 46. A roller 66 on the frame 52 raises a lever 67 carrying the stub cutter 67 , which is then retained by a lever 68 mounted on a shaft 71. A cam 69, Fig. 3, on the shaft 17 engages a lever 70 carried by the shaft 71 and rocks the latter to deflect the lever 68 when a sufficient length of the rib 2 has been cut away. The tiles are also stamped and perforated during the movement of the frame 52 by means of devices carried by a frame 74, which is depressed by a roller 72 against the action of a spring 75. Fig. 6 shows a modification in which the stamping and perforating devices and also the stub cutter are actuated by the sliding frame 45 ; the reciprocation of the frame 45 rocks a shaft 82 which, by means of a pin 84 carried by a lever 83 engaging which a slotted member 86, depresses the stamping and perforating devices 90, and through levers 89, 93 and a link 94 elevates the stub cutter 98, which is retained by a member 99 engaging a catch 100 until, on the return of the carriage 9, the catch is deflected by an adjustable stop 101. In a further modification shown in Fig. 9, the whole of the cutting-devices are actuated by the frame 45, the straight end of the tile being cut by a wire 103 carried by a frame 102 mounted on the shaft 82.

公开(公告)号：WO2003069349A3

公开(公告)日：2003-08-21

申请号：PCT/EP2003/001576

申请日：2003-02-17

Applicant: SORG, Clemens ,  ROTH, Johannes

Inventor： SORG, Clemens ,  ROTH, Johannes

IPC: G01N33/68

Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker MRP8/MRP14, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of: (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex and/or nucleic acids encoding the polypeptide(s) present in said biological sample; and (c) comparing the amount and/or concentration of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex determined in said biological sample with the amount and/or concentration of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding MRP8 and/or MRP14 polypeptide(s) determined in said biological sample with the amount and/or concentration of nucleic acids encoding MRP8 and/or MRP14 polypeptide(s) measured in a control sample, wherein the difference in the amount of MRP8 and/or MRP14 polypeptide(s) and/or MRP8/MRP14 protein complex and/or nucleic acids encoding the polypeptide(s) is indicative for the stages of the disease to be diagnosed.

公开(公告)号：WO2003069341A2

公开(公告)日：2003-08-21

申请号：PCT/EP2003/001575

申请日：2003-02-17

Applicant: SWITCH BIOTECH AG ,  SORG, Clemens ,  ROTH, Johannes

Inventor： SORG, Clemens ,  ROTH, Johannes

IPC: G01N33/564

CPC classification number: G01N33/53 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/4727 ,  G01N2333/52 ,  G01N2800/065

Abstract: The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or con­centration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

Abstract translation: 本发明涉及一种用于诊断基于标记物CALGRANULIN C的炎性疾病的方法，特别是用于诊断炎性疾病的特定阶段和/或用于确定复发的风险和/或用于区分具有相似症状的疾病的所述方法，所述方法包括 获得待诊断的哺乳动物体液或组织的生物样品的步骤b确定存在于所述生物样品中的CALGRANULIN C多肽和/或编码多肽的核酸的量和/或浓度，c将所述量和/或 CALGRANULIN C多肽的浓度在对照样品中测定的CALGRANULIN C多肽的量和/或浓度确定在所述生物样品中，和/或比较在所述生物样品中测定的编码CALGRANULIN C多肽的核酸的量和/或浓度与 编码CALGRANULIN C p。的核酸的量和/或浓度 在对照样品中测量的双糖，其中CALGRANULIN C多肽和/或编码多肽的核酸的量的差异指示待诊断的疾病的阶段。

公开(公告)号：DE102021000985A1

公开(公告)日：2022-08-25

申请号：DE102021000985

申请日：2021-02-24

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: A61B1/24 ,  A61B1/273 ,  A61B90/16 ,  A61C7/08 ,  A61M16/04 ,  A61M25/01

Abstract: Die vorliegende Erfindung betrifft einen Beißring zur Durchführung aller Arten endoskopischer Untersuchungen des oberen Gastrointestinaltraktes mit einem für ein endoskopisches Instrument eine Durchgangsöffnung bietenden Mundstück und den dazugehörigen Haltebögen, dadurch gekennzeichnet, dass die vertikalen Seiten (b) des Mundstückes (a) bei vertikalem Druck komprimierbar sind. Dabei bestehen die Seitenteile (b) aus einer glatten Oberfläche aus thermoplastischem elastomeren Material, so dass keine Reibungsdefekte am Endoskop entstehen. Sind die Seitenteile (b) ziehharmonikaähnlich angeordnet wird medial dieser Seitenteile (b) eine Membran (d), ebenfalls aus einem thermoplastischen elastomeren Material eingefügt, die das Endoskop vor möglichen Reibungsdefekten schützt.

公开(公告)号：DE102016012235B8

公开(公告)日：2018-04-19

申请号：DE102016012235

申请日：2016-10-10

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: A61B90/16 ,  A61B1/273 ,  A61M25/01

公开(公告)号：DE20019235U1

公开(公告)日：2001-04-05

申请号：DE20019235

申请日：2000-11-08

Applicant: ROTH JOHANNES

IPC: G11B33/04 ,  G11B23/03