公开(公告)号：US20050220994A1

公开(公告)日：2005-10-06

申请号：US10815010

申请日：2004-03-31

Applicant: Rajesh Mehta ,  Ramesh Jagannathan ,  Seshadri Jagannathan ,  David Nelson

Inventor： Rajesh Mehta ,  Ramesh Jagannathan ,  Seshadri Jagannathan ,  David Nelson

IPC: B05D1/02 ,  B05D1/12

CPC classification number: B05D1/025 ,  B05D1/12 ,  B05D2401/90

Abstract: A process for the patterning of a desired substance on a surface includes: (i) charging a particle formation vessel with a compressed fluid; (ii) introducing into the particle formation vessel a first feed stream comprising a solvent and the desired substance dissolved therein and a second feed stream comprising the compressed fluid, wherein the desired substance is less soluble in the compressed fluid relative to its solubility in the solvent and the solvent is soluble in the compressed fluid, and wherein the first feed stream is dispersed in the compressed fluid, allowing extraction of the solvent into the compressed fluid and precipitation of particles of the desired substance; (iii) exhausting compressed fluid, solvent and the desired substance from the particle formation vessel at a rate substantially equal to a rate of addition of such components to the vessel in step (ii) through a restrictive passage to a lower pressure whereby the compressed fluid is transformed to a gaseous state, and wherein the restrictive passage includes a discharge device that produces a shaped beam of particles of the desired substance at a point beyond an outlet of the discharge device, where the fluid is in a gaseous state at a location before or beyond the outlet of the discharge device; and (iv) exposing a receiver surface to the shaped beam of particles of the desired substance and selectively depositing a pattern of particles on the receiver surface.

Abstract translation: 用于在表面上图案化所需物质的方法包括：（i）用压缩流体填充颗粒形成容器; （ii）向颗粒形成容器中引入包含溶剂和所需物质溶解在其中的第一进料流和包含压缩流体的第二进料流，其中所需物质相对于其在溶剂中的溶解度较不溶于压缩流体 并且溶剂可溶于压缩流体中，并且其中第一进料流分散在压缩流体中，允许将溶剂萃取到压缩流体中并沉淀所需物质的颗粒; （iii）通过限制性通道将压缩流体，溶剂和所需物质从所述颗粒形成容器排出，其速率基本上等于在步骤（ii）中将这些组分加入到容器中的速率，由此压缩流体 转化为气态，并且其中限制通道包括排出装置，其在超出排放装置的出口的点处产生所需物质的成形颗粒束，其中流体在气体状态处于位于之前的位置处 或超出排出装置的出口; 和（iv）将接收器表面暴露于所需物质的成形的颗粒束并选择性地在接收器表面上沉积颗粒图案。

公开(公告)号：US20050218076A1

公开(公告)日：2005-10-06

申请号：US10814354

申请日：2004-03-31

Applicant: Rajesh Mehta ,  Ramesh Jagannathan ,  Seshadri Jagannathan ,  Robert Zabelny ,  Ross Sprout ,  Carl Burns

Inventor： Rajesh Mehta ,  Ramesh Jagannathan ,  Seshadri Jagannathan ,  Robert Zabelny ,  Ross Sprout ,  Carl Burns

IPC: A61K9/14 ,  B01D11/02 ,  B01F3/04 ,  B01F3/12 ,  B01F7/22 ,  B01J2/04

CPC classification number: B01F3/1207 ,  A61K9/145 ,  B01F7/22 ,  B01F2003/0064 ,  B01F2003/04092 ,  B01J2/04

Abstract: A process for the formation of particulate material of a desired substance including: (i) charging a particle formation vessel with a supercritical fluid; (ii) agitating the contents of the particle formation vessel with a rotary agitator, creating a relatively highly agitated zone and a bulk mixing zone; (iii) introducing into the agitated particle formation vessel at least a first feed stream comprising at least a solvent and the desired substance dissolved therein and a second feed stream comprising the supercritical fluid through a second feed stream introduction port, wherein the desired substance is less soluble in the supercritical fluid relative to its solubility in the solvent, and wherein the first and second feed streams are introduced into the highly agitated zone of the particle formation vessel and the first feed stream is dispersed in the supercritical fluid by action of the rotary agitator, allowing extraction of the solvent into the supercritical fluid, and (iv) precipitating particles of the desired substance in the particle formation vessel with a volume-weighted average diameter of less than 100 nanometers.

Abstract translation: 用于形成所需物质的颗粒材料的方法，包括：（i）用超临界流体填充颗粒形成容器; （ii）用旋转搅拌器搅拌颗粒形成容器的内容物，产生相对高度搅拌的区域和本体混合区域; （iii）将搅拌的颗粒形成容器至少包含至少包含溶剂和溶解在其中的所需物质的第一进料流和通过第二进料流引入口包含超临界流体的第二进料流，其中所需物质较少 相对于其在溶剂中的溶解度可溶于超临界流体，并且其中将第一和第二进料流引入到颗粒形成容器的高度搅拌的区域中，并且通过旋转搅拌器的作用将第一进料流分散在超临界流体中 允许将溶剂萃取到超临界流体中，和（iv）以小于100纳米的体积加权平均直径在颗粒形成容器中沉淀所需物质的颗粒。