公开(公告)号：US20150157610A1

公开(公告)日：2015-06-11

申请号：US14402430

申请日：2013-05-23

Applicant: OSAKA UNIVERSITY ,  SHIZUOKA PREFECTURE PUBLIC UNIVERSITY CORPORATION

Inventor： Tetsuo Minamino ,  Issei Komuro ,  Takashi Matsuzaki ,  Naoto Oku ,  Tomohiro Asai ,  Haiying Fu

IPC: A61K31/436 ,  A61K9/127 ,  A61K38/13

CPC classification number: A61K31/436 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/137 ,  A61K38/13

Abstract: A pharmaceutical composition which comprises, as an active ingredient, a liposome encapsulating an immunosuppressant such as FK506, FTY720 and cyclosporin A is effective in the treatment of cardiovascular inflammatory diseases such as my ocardial infarction, myocarditis and vasculitis syndrome, allows the immunosuppressant at a low dose to produce stronger effects than those of the same dose of the immunosuppressant used alone, and causes fewer side effects.

Abstract translation: 包含作为活性成分的包封免疫抑制剂如FK506，FTY720和环孢菌素A的脂质体的药物组合物在治疗心血管炎性疾病如我的心脏梗塞，心肌炎和血管炎综合征方面是有效的，允许免疫抑制剂低 剂量以产生比单独使用的相同剂量的免疫抑制剂更强的作用，并且引起较少的副作用。

公开(公告)号：US20140220624A1

公开(公告)日：2014-08-07

申请号：US14119639

申请日：2012-04-25

Applicant: SHIZUOKA PREFECTURE ,  SHIMADZU CORPORATION

Inventor： Yutaka Aoki ,  Yukari Umino ,  Taka-Aki Sato ,  Isamu Hayashi ,  Keiichi Hatakeyama ,  Shun-ichiro Ogura

IPC: G01N1/30 ,  G01N33/68

CPC classification number: G01N1/30 ,  G01N33/68 ,  G01N33/6848

Abstract: A protein retrieval treatment system used for activating proteins contained in a deparaffinized tissue section obtained by removing paraffin from a formalin-fixed paraffin-embedded tissue section. The protein retrieval treatment system includes: a dispensing unit for dispensing a retrieval treatment solution over a dispensing area including a measurement area on the deparaffinized tissue section; and a moist-heat treatment unit for heating, in a saturated water vapor, the deparaffinized tissue section with the dispensing area covered with the retrieval treatment solution.

Abstract translation: 一种蛋白质回收处理系统，用于激活通过从福尔马林固定的石蜡包埋的组织切片中除去石蜡获得的脱蜡组织切片中所含的蛋白质。 蛋白质回收处理系统包括：分配单元，用于在包括脱蜡组织部分上的测量区域的分配区域上分配回收处理溶液; 以及湿热处理单元，用于在饱和水蒸汽中加热脱蜡组织部分，其中所述分配区域被所述回收处理溶液覆盖。

公开(公告)号：US20140030296A1

公开(公告)日：2014-01-30

申请号：US13948273

申请日：2013-07-23

Applicant: SHIZUOKA PREFECTURE ,  OLYMPUS CORPORATION

Inventor： Kouji MARUYAMA ,  Mitsuru TAKAHASHI ,  Masahiro NAKAGAWA ,  Yasuto AKIYAMA ,  Hidee ISHII ,  Jinyan CHENG

IPC: A61K33/42 ,  A61K39/00

CPC classification number: A61K33/42 ,  A61K9/0024 ,  A61K9/2072 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/6012

Abstract: A method for enhancing a vaccine therapy effect by a vaccine composition. The method including a step of implanting β-tricalcium phosphate in an inside of a body of a subject, and a step of administering the vaccine composition to the subject at the same time with or before or after the implanting step.

Abstract translation: 一种通过疫苗组合物增强疫苗治疗效果的方法。 该方法包括将磷酸β-磷酸钙植入受试者体内的步骤，以及在植入步骤之前或之后同时向受试者施用疫苗组合物的步骤。

公开(公告)号：US11433141B2

公开(公告)日：2022-09-06

申请号：US16320587

申请日：2017-07-25

Applicant: SHIZUOKA PREFECTURE

Inventor： Yasuto Akiyama ,  Akira Iizuka

IPC: A61K47/69 ,  A61K47/68 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  A61K39/00

Abstract: An object is to produce a new anti-B7-H4 antibody having high specificity and affinity and provide a composition for treating cancer making use thereof. A monoclonal antibody that specifically binds to an extracellular domain protein of a human B7-H4 protein is newly produced and an “anti-B7-H4 antibody-effector cell complex” in which the monoclonal antibody and an effector cell are bound in order to enhance the antibody-dependent cellular cytotoxicity of the monoclonal antibody or a bispecific antibody comprising an antigen recognition region of the monoclonal antibody and an effector cell antigen recognition region is further produced and used as a composition for treating cancer.

公开(公告)号：US11280792B2

公开(公告)日：2022-03-22

申请号：US16123444

申请日：2018-09-06

Applicant: ON-CHIP BIOTECHNOLOGIES CO., LTD. ,  SHIZUOKA PREFECTURE

Inventor： Kazuo Takeda ,  Namiko Yamashita ,  Yuu Fujimura ,  Kaori Nishio ,  Yasuhiro Koh ,  Masaru Watanabe ,  Fumiaki Koizumi ,  Yuri Uehara

IPC: G01N33/574 ,  C12N5/09 ,  G01N33/58

Abstract: The object of the present invention is to provide an evaluation method capable of accurately determining a metastasis of cancer, the stage of cancer progression, or the malignancy of cancer.
The object can be solved by a method for detecting the degree of malignancy of each of the circulating tumor cells, characterized by the following steps: (a) bringing an epithelial cell-binding component, which specifically binds to a marker molecule expressed on epithelial cells and is fluorescently-labeled or luminescent enzyme-labeled, and a mesenchymal cell-binding component, which specifically binds to a marker molecule expressed on mesenchymal cells and is fluorescently-labeled or luminescent enzyme-labeled, into contact with a sample that possibly contains circulating tumor cells, (b) detecting a fluorescence signal or a luminescence signal of the epithelial cell-binding component and a fluorescence signal or a luminescence signal of the mesenchymal cell-binding component of each of the cells, and (c) determining the degree of epithelial-mesenchymal transition of circulating tumor cells based on the signal amount of the epithelial cell-binding component (E) and the signal amount of the mesenchymal cell-binding component (M).

公开(公告)号：US20190011450A1

公开(公告)日：2019-01-10

申请号：US16123444

申请日：2018-09-06

Applicant: ON-CHIP BIOTECHNOLOGIES CO., LTD. ,  SHIZUOKA PREFECTURE

Inventor： Kazuo TAKEDA ,  Namiko YAMASHITA ,  Yuu FUJIMURA ,  Kaori NISHIO ,  Yasuhiro KOH ,  Masaru WATANABE ,  Fumiaki KOIZUMI ,  Yuri UEHARA

IPC: G01N33/574 ,  G01N33/58 ,  C12N5/09

Abstract: The object of the present invention is to provide an evaluation method capable of accurately determining a metastasis of cancer, the stage of cancer progression, or the malignancy of cancer.The object can be solved by a method for detecting the degree of malignancy of each of the circulating tumor cells, characterized by the following steps: (a) bringing an epithelial cell-binding component, which specifically binds to a marker molecule expressed on epithelial cells and is fluorescently-labeled or luminescent enzyme-labeled, and a mesenchymal cell-binding component, which specifically binds to a marker molecule expressed on mesenchymal cells and is fluorescently-labeled or luminescent enzyme-labeled, into contact with a sample that possibly contains circulating tumor cells, (b) detecting a fluorescence signal or a luminescence signal of the epithelial cell-binding component and a fluorescence signal or a luminescence signal of the mesenchymal cell-binding component of each of the cells, and (c) determining the degree of epithelial-mesenchymal transition of circulating tumor cells based on the signal amount of the epithelial cell-binding component (E) and the signal amount of the mesenchymal cell-binding component (M).

公开(公告)号：US10018539B2

公开(公告)日：2018-07-10

申请号：US14978115

申请日：2015-12-22

Applicant: SHIMADZU CORPORATION ,  SHIZUOKA PREFECTURE

Inventor： Yutaka Aoki ,  Yukari Umino ,  Taka-Aki Sato ,  Isamu Hayashi ,  Keiichi Hatakeyama ,  Shun-ichiro Ogura

IPC: G01N1/30 ,  G01N33/68

CPC classification number: G01N1/30 ,  G01N33/68 ,  G01N33/6848

Abstract: A protein retrieval treatment system used for activating proteins contained in a deparaffinized tissue section obtained by removing paraffin from a formalin-fixed paraffin embedded tissue section. The protein retrieval treatment system includes: a dispensing unit for dispensing a retrieval treatment solution over a dispensing area including a measurement area on the deparaffinized tissue section; and a moist-heat treatment unit for heating, in a saturated water vapor, the deparaffinized tissue section with the dispensing area covered with the retrieval treatment solution.

公开(公告)号：US20180098767A1

公开(公告)日：2018-04-12

申请号：US15566894

申请日：2016-02-24

Applicant: Jichi Medical University ,  Shizuoka Prefecture ,  Tamachi Industries Co., Ltd.

Inventor： Shunji SARUKAWA ,  Hideaki KAMOCHI ,  Keita INOUE ,  Noriko SAEGUSA ,  Masahiro NAKAGAWA ,  Kunihiro OHTA

IPC: A61B17/11 ,  A61B17/064

CPC classification number: A61B17/11 ,  A61B17/0469 ,  A61B17/0644 ,  A61B2017/00358 ,  A61B2017/1107 ,  A61B2017/1132 ,  A61F2/06 ,  A61F2/064 ,  A61F2/90

Abstract: An anastomosis device 3 includes a corrugated circumference section (20;120;120′), a top-side slender member (10A-1;110A-1), and a bottom-side slender member (10B-1;110B-12). The top-side slender member (10A-1;110A-1) is connected to one top section (20A-1;30A-1;120A-1) of the corrugated circumference section (20; 120;120′). The bottom-side slender member (10B-1;110B-12) is connected to one (20B-1;30B-1;120B-12) at the corrugated circumference section (20;120;120′).

公开(公告)号：US20150126368A1

公开(公告)日：2015-05-07

申请号：US14415285

申请日：2013-07-19

Applicant: Nippon Soda Co., Ltd. ,  Shizuoka Prefecture

Inventor： Chizuko Kageyama ,  Hiroyuki Iyozumi ,  Hideki Nukui ,  Kimihiko Kato ,  Junya Mannen ,  Kazuyuki Tomida ,  Shinsuke Sano ,  Hideki Kato ,  Satoru Makita ,  Toshio Mizuno

IPC: A01N57/16 ,  C07H15/26 ,  C07D307/62 ,  C07F9/655 ,  A01N43/08 ,  A01N43/16

CPC classification number: A01N57/16 ,  A01N43/08 ,  A01N43/16 ,  C07D307/62 ,  C07F9/65515 ,  C07F9/65586 ,  C07H15/26 ,  A01N25/32 ,  A01N43/40 ,  A01N43/54 ,  A01N47/24 ,  A01N2300/00 ,  A01N25/22

Abstract: A method of providing a plant with stress resistance, comprising applying at least one substance (A) to the plant, said at least one substance (A) being selected from the group consisting of a compound represented by Formula (I) and the like and salts thereof. Phytotoxicity of a plant due to agricultural chemicals is reduced by providing the plant with stress resistance. [In Formula (I), R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group or —COR11. R11 represents an unsubstituted or substituted C1 to C30 alkyl group or an unsubstituted or substituted C2 to C30 alkenyl group.].

Abstract translation: 一种提供植物抗胁迫性的方法，包括将至少一种物质（A）施用于植物，所述至少一种物质（A）选自由式（I）等表示的化合物和 的盐。 通过为植物提供抗压力，减少了农药对植物的植物毒性。 [式（I）中，R 1〜R 4各自独立地表示氢原子，-SO 3 H，-PO 3 H 2，糖基或-COR 11。 R11表示未取代或取代的C1至C30烷基或未取代或取代的C2至C30烯基。

公开(公告)号：US20130253953A1

公开(公告)日：2013-09-26

申请号：US13848656

申请日：2013-03-21

Applicant: FUJIFILM CORPORATION ,  SHIZUOKA PREFECTURE

Inventor： Ryuji HISANAGA ,  Masahiro Endo

IPC: G06F19/00 ,  G06Q50/24

CPC classification number: G06Q50/24 ,  G06F19/321 ,  G16H50/70

Abstract: Image search conditions that are past search conditions are displayed in an image search history area, and text search conditions are displayed in a text search history area. When a user selects a desired image search condition out of the search conditions displayed in the image search history area, and selects a desired text search condition out of the search conditions displayed in the text search history area, case data that matches the selected image search condition and the text search condition is extracted from a database and displayed in a search result display area.

Abstract translation: 过去搜索条件的图像搜索条件显示在图像搜索历史区域中，并且文本搜索条件显示在文本搜索历史区域中。 当用户从图像搜索历史区域中显示的搜索条件中选择期望的图像搜索条件，并且从文本搜索历史区域中显示的搜索条件中选择所需的文本搜索条件时，匹配所选图像搜索的大小写数据 条件，并且从数据库中提取文本搜索条件并显示在搜索结果显示区域中。