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    METHOD AND DEVICE FOR HIGH THROUGHPUT IMAGING
    11.
    发明申请
    METHOD AND DEVICE FOR HIGH THROUGHPUT IMAGING 审中-公开
    用于高吞吐量成像的方法和设备

    公开(公告)号：WO2017144619A1

    公开(公告)日：2017-08-31

    申请号：PCT/EP2017/054244

    申请日：2017-02-23

    Applicant: SINGLE TECHNOLOGIES AB

    Inventor： STUBBE, Raoul ,  SAHLGREN, Bengt ,  STRÖMQUIST, Johan

    IPC: G01N21/64 ,  G01N21/47 ,  G02B21/00 ,  G02B21/33 ,  G02B21/26

    CPC classification number: G01N21/6458 ,  G01N21/474 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/103 ,  G02B19/0019 ,  G02B19/0057 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/33 ,  G02B27/1006 ,  G02B27/141

    Abstract: Apparatus for imaging a sample (109), said apparatus comprising: illumination means (101, 102, 103, 104, 105, 106, 107, 108) for illuminating said sample (109) simultaneously in a line focus or an array of foci; and detection means (108, 107, 106b, 111, 112, 113) for detecting photons emitted or scattered from a sample (109) simultaneously in an array of fields of view; wherein an array of sub-observation volumes in a sample (109), from which photons are emitted or scattered during imaging, is defined by the volumes in space where the line focus or array of foci from the illumination means (101, 102, 103, 104, 105, 106, 107, 108) overlap with the corresponding array of field of views of the detection means (108, 107, 106b, 111, 112, 113); a sample holder (110, 110a), preferably a cylindrical sample holder (110, 110a), configured to hold the sample (109) at a surface thereof, said sample holder (110, 110a) being rotatably arranged such that at least a portion of said sample (109) can be transported through at least one of said sub-observation volumes by rotating the sample holder (110, 110a).

    Abstract translation: （109）成像的设备，所述设备包括：照明装置（101,102,103,104,105,106,107,108），用于同时照亮所述样品（109）和所述样品 线焦点或焦点阵列; 和检测装置（108,107,106b，111,112,113），用于同时在一个视场阵列中检测从样本（109）发射或散射的光子; 其中在成像过程中从其发射或散射光子的样本（109）中的子观察体积的阵列由空间体积限定，其中来自照明装置（101,102,103）的线焦点或焦点阵列 ，104,105,106,107,108）与所述检测装置（108,107,106b，111,112,113）的所述视场的对应阵列重叠。 样品保持器（110,110a），优选圆柱形样品保持器（110,110a），被配置为将样品（109）保持在其表面处，所述样品保持器（110,110a）可旋转地布置成使得至少一部分 可以通过旋转样本保持器（110,110a）将所述样本（109）的至少一个传送通过所述子观察容积中的至少一个。

    HIGH THROUGHPUT BIOCHEMICAL SCREENING
    12.
    发明申请
    HIGH THROUGHPUT BIOCHEMICAL SCREENING 审中-公开
    高通量生物化学筛选

    公开(公告)号：WO2016030464A1

    公开(公告)日：2016-03-03

    申请号：PCT/EP2015/069656

    申请日：2015-08-27

    Applicant: SINGLE TECHNOLOGIES AB

    Inventor： SAHLGREN, Bengt ,  STUBBE, Raoul ,  STRÖMQVIST, Johan

    IPC: G01N21/25 ,  G01N21/64 ,  G02B21/36 ,  G01N35/02

    CPC classification number: G01N21/253 ,  G01N21/6452 ,  G01N35/02 ,  G02B21/00 ,  G02B21/36 ,  G02B21/367

    Abstract: A method and apparatus are provided, in which an observation volume is defined by a volume where light from illumination means (16) and a field of view of detection means (18) overlap. The central axes of said light from the illumination means (16) and said field of view of the detection means (18) are non-parallel, and the sample is transported through the observation volume during imaging, preferably by rotation of a sample container holding the sample (12).

    Abstract translation: 提供了一种方法和装置，其中观察体积由其中来自照明装置（16）的光和检测装置（18）的视场重叠的体积限定。 来自照明装置（16）的所述光的中心轴和检测装置（18）的所述视野是不平行的，并且样品在成像期间优选通过样品容器的旋转保持 样品（12）。

    SAMPLE HOLDER WITH MATRIX LAYER
    13.
    发明申请
    SAMPLE HOLDER WITH MATRIX LAYER 审中-公开

    公开(公告)号：WO2022238355A1

    公开(公告)日：2022-11-17

    申请号：PCT/EP2022/062537

    申请日：2022-05-10

    Applicant: SINGLE TECHNOLOGIES AB

    Inventor： SAHLGREN, Bengt ,  STRÖMQVIST, Johan

    IPC: G01N21/64 ,  G01N2021/0325 ,  G01N2021/6482 ,  G01N21/6458

    Abstract: A sample holder (100) for an apparatus (300) configured to perform an assay at a plurality of sample sites (130) is disclosed, wherein each sample site comprises a concatemer. The sample holder comprises a rotatable body (110), a matrix layer (120) and a liquid layer arranged on the matrix layer. The plurality of samples sites are distributed in the matrix layer in both a lateral direction and a thickness direction of the matrix layer, and the rotatable body is configured to be arranged in the apparatus to be rotatable around an axis (A) while the assay is performed at the plurality of sample sites. A corresponding method (200) and apparatus (300) are also disclosed.

    HIGH THROUGHPUT BIOCHEMICAL SCREENING
    16.
    发明公开
    HIGH THROUGHPUT BIOCHEMICAL SCREENING 审中-公开
    高通量生化筛选

    公开(公告)号：EP3186615A1

    公开(公告)日：2017-07-05

    申请号：EP15754250.7

    申请日：2015-08-27

    Applicant: Single Technologies AB

    Inventor： SAHLGREN, Bengt ,  STUBBE, Raoul ,  STRÖMQVIST, Johan

    IPC: G01N21/25 ,  G01N21/64 ,  G02B21/36 ,  G01N35/02

    CPC classification number: G01N21/253 ,  G01N21/6452 ,  G01N35/02 ,  G02B21/00 ,  G02B21/36 ,  G02B21/367

    Abstract: A method and apparatus are provided, in which an observation volume is defined by a volume where light from illumination means and a field of view of detection means overlap. The central axes of said light from the illumination means and said field of view of the detection means are non-parallel, and the sample is transported through the observation volume during imaging, preferably by rotation of a sample container holding the sample.

    Abstract translation: 提供了一种方法和设备，其中观察体积由来自照明装置（16）的光线和检测装置（18）的视场重叠的体积限定。 来自照明装置（16）的所述光的中心轴线和检测装置（18）的所述视野是不平行的，并且样品在成像期间被传送通过观察体积，优选地通过旋转样品容器保持件 样品（12）。

    LIQUID HANDLING MEANS FOR PERFORMING ASSAYS
    20.
    发明公开
    LIQUID HANDLING MEANS FOR PERFORMING ASSAYS 审中-公开

    公开(公告)号：EP4053538A1

    公开(公告)日：2022-09-07

    申请号：EP21159928.7

    申请日：2021-03-01

    Applicant: Single Technologies AB

    Inventor： STRÖMQVIST, Johan ,  SAHLGREN, Bengt ,  TINGSTAM, Nils

    IPC: G01N21/03 ,  G01N21/11 ,  G01N21/64 ,  G01N21/51

    Abstract: The present invention relates to an apparatus for conducting assays on samples and/or processing of samples. The apparatus comprises a rotatably arranged cylindrical sample holder for holding a sample at a lateral surface of the cylindrical sample holder. The cylindrical sample holder is configured to be at least partly covered by a liquid layer. The apparatus further comprises a liquid dispensing means configured to add liquid to the liquid layer, a reagent dispensing means configured to add a reagent to the liquid layer and a liquid contacting means configured to distribute liquid within said liquid layer. The liquid contacting means comprises a plate-like element flexibly assembled in relation to the cylindrical sample holder. The present invention also relates to a method for conducting assays on samples and/or processing of samples

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