公开(公告)号：US20160207867A1

公开(公告)日：2016-07-21

申请号：US14913833

申请日：2014-08-26

Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Inventor： Jerome Emile Lucien Le Notre ,  Elinor Lindsey Scott ,  Roeland Leo Croes ,  Jacobus Van Haveren

IPC: C07C51/38

CPC classification number: C07C51/38 ,  C07C57/04

Abstract: Disclosed is a method of making methacrylic acid, or a carboxylic derivative thereof, from itaconic acid, isomers, or precursors thereof. A starting material comprising an acid selected from the group consisting of itaconic acid, citraconic acid, mesaconic acid, citric acid, aconitic acid, isocitric acid and mixtures thereof, is subjected to contact with 0.1 eq. to 3.0 eq. of a base, at a temperature of 150° C. to 350° C., under the influence of a transition metal-containing heterogeneous catalyst. A better yield at lower temperatures is achieved.

Abstract translation: 公开了从衣康酸，异构体或其前体制备甲基丙烯酸或其羧酸衍生物的方法。 包含选自衣康酸，柠康酸，中康酸，柠檬酸，乌头酸，异柠檬酸及其混合物的酸的原料与0.1eq接触。 至3.0当量 的碱，在150℃至350℃的温度下，在含过渡金属的非均相催化剂的影响下。 在较低温度下获得更好的产率。

公开(公告)号：US20160107967A1

公开(公告)日：2016-04-21

申请号：US14782947

申请日：2014-04-07

Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Inventor： Daniël Stephan VAN ES ,  Frits VAN DER KLIS ,  Jacobus VAN HAVEREN ,  Richard Johannes Antonius GOSSELINK

IPC: C07C37/50 ,  C07C41/18

CPC classification number: C07C37/50 ,  C07C1/20 ,  C07C37/54 ,  C07C41/18 ,  C07C45/512 ,  C07C45/59 ,  C07C2521/18 ,  C07C2523/42 ,  C07C2523/44 ,  C07C2523/46 ,  C07C2601/14 ,  C10G3/42 ,  C10G3/44 ,  C10G3/52 ,  C10G2400/30 ,  Y02P30/20 ,  C07C39/04 ,  C07C43/23 ,  C07C43/2055 ,  C07C43/205 ,  C07C49/84 ,  C07C49/403 ,  C07C15/04 ,  C07C13/18

Abstract: A catalytic method is disclosed for the valorization of lignin. The method comprises subjecting lignin to a catalyzed hydrothermal conversion reaction, said reaction being conducted in the presence of water at an alkaline pH>8 and a temperature of 200° C.-300° C., under the influence of a noble metal catalyst comprising a carbon support. The same reaction can also be applied to subsequently defunctionalize one or more phenolic compounds, notably guaiacol, so as to produce six-membered cyclic hydrocarbons, such as phenol.

Abstract translation: 公开了一种用于木质素增值的催化方法。 该方法包括使木质素进行催化水热转化反应，所述反应在碱性pH> 8和温度为200℃-300℃的水存在下，在贵金属催化剂的影响下进行，所述贵金属催化剂包括 碳支持。 同样的反应也可以应用于随后使一种或多种酚类化合物，特别是愈创木酚的官能化，以产生六元环烃，如苯酚。

公开(公告)号：US20150192575A1

公开(公告)日：2015-07-09

申请号：US14420325

申请日：2013-07-23

Applicant: Stichting Dienst Landbouwkundig Onderzoek

Inventor： Aart Van Amerongen ,  Jan Herman Wichers

IPC: G01N33/53

CPC classification number: G01N33/5304 ,  G01N33/54386 ,  G01N33/54393 ,  G01N33/558

Abstract: The invention relates to an elongate membrane assembly having a length, a width and a height, the assembly comprising a microporous membrane layer supported on a liquid-impermeable support layer and the assembly being suitable for lateral flow of a liquid through the membrane layer under the action of capillary forces, wherein the assembly has a constant height and at least part of the membrane layer has a first thickness in the range of from 20 to 80 μm over the entire width of the assembly. The invention further relates to a lateral flow immunoassay device comprising such membrane assembly.

Abstract translation: 本发明涉及具有长度，宽度和高度的细长膜组件，所述组件包括支撑在液体不可渗透的支撑层上的微孔膜层，并且所述组件适于液体通过膜层的横向流动 毛细力的作用，其中组件具有恒定的高度，并且至少部分膜层在组件的整个宽度上具有在20至80μm范围内的第一厚度。 本发明还涉及包括这种膜组件的侧流免疫测定装置。

公开(公告)号：US20130347146A1

公开(公告)日：2013-12-26

申请号：US13921737

申请日：2013-06-19

Applicant: Stichting Dienst Landbouwkundig Onderzoek

Inventor： Hendrikus Antonius Cornelis Bakker ,  Dionisius Elisabeth Antonius Florack ,  Hendrik Jan Bosch

IPC: C12N15/82 ,  C12N9/10

CPC classification number: C12N15/8243 ,  C12N9/1051 ,  C12N15/8257 ,  C12P21/02

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract translation: 本发明涉及转基因植物中用于生产重组生物药物蛋白质的成本效益和污染安全的工厂的糖蛋白加工领域或包含这些糖蛋白的药物组合物。 本发明提供了一种植物，其包含提供通常不存在于植物中的哺乳动物GnTIII的功能哺乳动物酶，所述植物另外包含至少一种通常不存在于植物中的哺乳动物蛋白质或其功能片段。

公开(公告)号：US20170231136P1

公开(公告)日：2017-08-10

申请号：US14998739

申请日：2016-02-09

Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK-PPO/PRI

Inventor： Rene SMULDERS

IPC: A01H5/08

Abstract: A new and distinct cultivar of Apple tree named ‘WUR37’, characterized by its upright plant habit; vigorous growth habit; numerous fruit produced per plant; fruits with red-colored skin spotted with lenticels; resistance to Apple Scab; and suitability for organic farming practices.

公开(公告)号：US09512297B2

公开(公告)日：2016-12-06

申请号：US14400814

申请日：2013-06-04

Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK ,  ARCHER DANIELS MIDLAND COMANPY

Inventor： Daniel Stephen VanEs ,  Jacobus VanHaveren ,  Augustinus Emmanuel Frissen ,  Johannes Cornelis VandeKolk

IPC: C08K5/1535 ,  C08J5/18 ,  C08K5/00

CPC classification number: C08K5/1535 ,  C08J5/18 ,  C08J2327/06 ,  C08K5/0016 ,  C08L27/06

Abstract: Plasticized, unpigmented and pigmented PVC films are described which utilize a biobased, phthalate ester alternative primary plasticizer. The films show comparable color performance to the phthalate ester-plasticized unpigmented or pigmented PVC films, even where the neat biobased plasticizer has a much higher Pt—Co color as measured according to DIN-6271 (ASTM D 1209) compared to the neat phthalate ester plasticizer. Biobased primary plasticizers in the form of diesters of furan-2,5-dicarboxylic acid are especially contemplated, and provide increased thermal stability to the PVC films as an added benefit.

Abstract translation: 描述了增塑的，未着色的和着色的PVC膜，其利用生物基邻​​苯二甲酸酯替代的主要增塑剂。 与邻苯二甲酸酯类相比，即使在纯生物基增塑剂具有比DIN-6271（ASTM D 1209）测量的Pt-Co颜色高得多的情况下，该胶片显示出与邻苯二甲酸酯增塑的未着色或着色的PVC膜相当的颜色性能。 增塑剂 特别考虑了呋喃-2,5-二羧酸二酯形式的基于生物的初级增塑剂，并为PVC膜提供了增加的热稳定性，作为额外的益处。

公开(公告)号：US20160271241A1

公开(公告)日：2016-09-22

申请号：US14892746

申请日：2014-05-21

Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Inventor： Jeroen Alexander Kortekaas ,  Paulus-Jozef Wichgers Schreur ,  Nadia Dimitrova Oreshkova ,  Robertus Jacobus Maria Moormann

IPC: A61K39/12 ,  C12N7/00

CPC classification number: A61K39/12 ,  A61K2039/525 ,  C12N7/00 ,  C12N2760/12034 ,  C12N2760/12221 ,  C12N2760/12234 ,  C12N2760/12243 ,  C12N2760/12262

Abstract: The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.

Abstract translation: 本发明涉及布尼亚病毒，其中分离的（NSm）Gn和Gc编码区功能上存在于两个不同的基因组片段上，优选包含总共至少4个基因组片段的布尼亚病毒。 本发明还涉及用于生产所述布尼亚病毒的方法，以及包含所述布尼亚病毒和合适赋形剂的组合物。

公开(公告)号：US09340552B2

公开(公告)日：2016-05-17

申请号：US14375230

申请日：2013-02-19

Applicant: Stichting Dienst Landbouwkundig Onderzoek

Inventor： Erik Hagberg ,  Kevin Martin ,  Jerome Le Notre ,  Daniel Stephan van Es ,  Jacobus van Haveren ,  Jan van Ee

IPC: C07D493/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/46 ,  B01J23/52 ,  B01J23/755

CPC classification number: C07D493/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/462 ,  B01J23/464 ,  B01J23/52 ,  B01J23/755

Abstract: Disclosed is a process for the preparation of isoidide from isosorbide. An aqueous solution of isosorbide is subjected to epimerization in the presence of hydrogen under the influence of a catalyst comprising ruthenium on a support, preferably a carbon support. The process of the invention can be conducted using a relatively low hydrogen pressure, and leads to a desired distribution of epimers, favoring isoidide over isomannide and isosorbide.

Abstract translation: 公开了从异山梨醇制备异氰酸酯的方法。 在氢气存在下，在包含钌的催化剂在载体，优选碳载体上的影响下，使异山梨醇的水溶液进行差向异构化。 本发明的方法可以使用相对较低的氢气压力进行，并导致差向异构体的期望分布，有利于异麦芽酮糖苷和异山梨醇上的异氰酸酯。

公开(公告)号：US20150111056A1

公开(公告)日：2015-04-23

申请号：US14404434

申请日：2013-05-28

Applicant: Stichting Dienst Landbouwkundig Onderzoek

Inventor： Richard Johannes Antonius Gosselink ,  Jan Evert Gerard Van Dam ,  Wouter Teunissen

IPC: B27K3/50 ,  B27K5/00

CPC classification number: B27K3/50 ,  A01N61/00 ,  B27K3/15 ,  B27K3/48 ,  B27K5/001 ,  B27K2240/70 ,  Y10T428/662 ,  A01N25/00 ,  A01N25/10 ,  A01N2300/00

Abstract: The invention relates to a lignocellulose preservative composition comprising in the range of from 50 to 98 wt % of a pyrolysis oil obtainable by pyrolysis of lignocellulosic material, a polymerisable furan compound and a catalyst for polymerising the furan compound in a catalytically effective amount. The invention further relates to a process for producing preserved lignocellulosic material comprising impregnating lignocellulosic material by immersion in such composition and subsequently curing the impregnated material and to preserved lignocellulosic material obtainable by such process and to an engineered wood or non-wood product comprising such lignocellulosic material.

Abstract translation: 本发明涉及一种木质纤维素防腐组合物，其包含50至98重量％的通过木质纤维素材料的热解可获得的热解油的范围，可聚合的呋喃化合物和用于使呋喃化合物以催化有效量聚合的催化剂。 本发明还涉及一种生产保藏的木质纤维素材料的方法，包括通过浸入该组合物中浸渍木质纤维素材料，随后固化浸渍的材料和通过这种方法获得的保存的木质纤维素材料和包含这种木质纤维素材料的工程木材或非木制品 。

公开(公告)号：US20140322778A1

公开(公告)日：2014-10-30

申请号：US14350923

申请日：2012-10-03

Applicant: IFP ENERGIES NOUVELLES ,  STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Inventor： Florent Collas ,  Remy Marchal ,  Benjamin Clement ,  Ana Maria Lopez Contreras ,  Pieternel A.M Claassen

IPC: C12P7/04 ,  C12P7/18 ,  C12N15/52

CPC classification number: C12P7/04 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/13 ,  C12N9/88 ,  C12N15/52 ,  C12P7/065 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  C12P7/54 ,  Y02E50/10 ,  Y02E50/17 ,  Y02P20/52

Abstract: The expression vector includes: the nucleic acids coding for the polypeptides forming a polypeptide complex having an enzyme activity allowing acetoacetyl-CoA to be converted to acetoacetate; optionally, at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetoacetate to be converted to acetone; and at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetone to be converted to isopropanol; the expression of the nucleic acids being controlled by a single constitutive promoter located upstream of the abovementioned nucleic acids.

Abstract translation: 表达载体包括：编码形成具有允许乙酰乙酰辅酶A转化为乙酰乙酸酯的酶活性的多肽复合物的多肽的核酸; 任选地，编码具有允许乙酰乙酸酯转化为丙酮的酶活性的多肽的至少一种核酸; 和编码具有允许丙酮转化为异丙醇的酶活性的多肽的至少一种核酸; 核酸的表达由位于上述核酸上游的单个组成型启动子控制。