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1.发明专利Mammalian type glycosylation reaction in plant by expression of glycosyltransferase of non-mammalian animal 有权通过表达非哺乳动物的谷氨酰胺酶的植物中的MAMMALIAN型糖蛋白反应
公开(公告)号：JP2014036669A
公开(公告)日：2014-02-27
申请号：JP2013222359
申请日：2013-10-25
CPC classification number: C12N15/8257 , C07K2319/00 , C12N9/1051 , C12N15/8245 , C12N15/8246 , C12P21/005
Abstract: PROBLEM TO BE SOLVED: To provide β-1,4-galactosyltransferase of non-mammalian animal usable in a wild type or modified form.SOLUTION: There are provided a transformed plant and a plant cell expressing β-1,4-galactosyltransferase of non-mammalian animal, further provided is a method for producing modified glycoprotein, preferably mammalian glycosylated glycoprotein. In addition, there are provided a nucleic acid molecule of β-1,4-galactosyltransferase of a non-mammalian animal and an expression vector for it.
Abstract translation: 要解决的问题：提供可用于野生型或修饰形式的非哺乳动物的β-1,4-半乳糖基转移酶。解决方案：提供转化的植物和表达α-1,4-半乳糖基转移酶的植物细胞 的非哺乳动物，进一步提供了制备修饰的糖蛋白，优选哺乳动物糖基化糖蛋白的方法。 此外，还提供了非哺乳动物的β-谷氨酸-1,4-半乳糖基转移酶的核酸分子及其表达载体。
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公开(公告)号：JP2012070761A
公开(公告)日：2012-04-12
申请号：JP2012006293
申请日：2012-01-16
Inventor： BAKKER HENDRIKUS ANTONIUS CORNELIUS , FLORACK DIONISIUS ELISABETH ANTONIUS , BOSCH HENDRIK JAN , ROUWENDAL GERARD JOHAN ADOLPH
IPC: A01H1/00 , C12N15/09 , A01H1/02 , A01H5/00 , C07K14/00 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/12 , C12N15/29 , C12N15/54 , C12N15/82 , C12P21/02 , C12P21/08
CPC classification number: C12N9/1051 , C07K2317/13 , C07K2317/41 , C07K2319/02 , C12N15/8257 , C12N15/8258
Abstract: PROBLEM TO BE SOLVED: To provide a means for optimizing glycan processing in plants.SOLUTION: The invention is directed to methods for optimizing glycan processing of a cell or a living tissue, in particular a plant, containing glycoproteins with N-glycans, so that a glycoprotein, having a complex type double-stranded N-glycan containing a galactose residue on at least one arm and being devoid of (or reduced in) xylose and fucose residues, can be obtained. The invention is further directed to the glycoprotein obtained and in particular a plant host system comprising the protein.
Abstract translation: 要解决的问题：提供一种优化植物中聚糖加工的方法。 解决方案：本发明涉及用于优化含有N-聚糖的糖蛋白的细胞或活组织，特别是植物的聚糖加工的方法，从而具有复合型双链N-聚糖的糖蛋白 在至少一个臂上含有半乳糖残基并且没有（或还原）木糖和岩藻糖残基）。 本发明还涉及获得的糖蛋白，特别是包含该蛋白质的植物宿主系统。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2014221077A
公开(公告)日：2014-11-27
申请号：JP2014168344
申请日：2014-08-21
Applicant: スティヒティング ディーンスト ランドバウクンディフ オンデルズーク , Stichting Dienst Landbouwkundig Onderzoek , スティヒティング ディーンスト ランドバウクンディフ オンデルズーク
Inventor： BAKKER HENDRIKUS ANTONIUS CORNELIUS , FLORACK DIONISIUS ELISABETH ANTONIUS , BOSCH HENDRIK JAN , ROUWENDAL GERARD JOHAN ADOLPH
IPC: A01H1/00 , C12N15/09 , A01H1/02 , A01H5/00 , C07K14/00 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/12 , C12N15/29 , C12N15/54 , C12N15/82 , C12P21/02
CPC classification number: C12N9/1051 , C07K2317/13 , C07K2317/41 , C07K2319/02 , C12N15/8257 , C12N15/8258
Abstract: 【課題】植物体内のグリカンプロセシングの最適化手段の提供。【解決手段】本発明は、N-グリカンをもつ糖タンパク質を含む細胞または生体組織特に植物のグリカンプロセシングを最適化し、もって複合型の2本鎖N-グリカンをもち、また少なくとも1本のアーム上にガラクトース残基を含み、かつキシロースおよびフコース残基を欠く(または少なくした)糖タンパク質が得られるようにする方法に関する。本発明はさらに、得られる糖タンパク質、および特に該タンパク質を含む植物宿主系に関する。【選択図】なし
Abstract translation: 要解决的问题：提供用于优化植物中的聚糖加工的方法。解决方案：本发明涉及用于优化含有N-聚糖的糖蛋白的细胞或活组织，特别是植物的聚糖加工的方法， 糖蛋白，其具有在至少一个臂上含有半乳糖残基并且没有（或还原）的木糖和岩藻糖残基）的复合型双链N-聚糖。 本发明还涉及获得的糖蛋白，特别是包含该蛋白质的植物宿主系统。
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公开(公告)号：JP2010279383A
公开(公告)日：2010-12-16
申请号：JP2010177955
申请日：2010-08-06
Inventor： BAKKER HENDRIKUS ANTONIUS CORNELIUS , FLORACK DIONISIUS ELISABETH ANTONIUS , BOSCH HENDRIK JAN
IPC: A01H1/00 , C12N15/09 , A01H1/02 , A01H5/00 , A61K38/00 , A61K38/43 , A61K38/45 , A61P1/16 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/415 , C07K14/705 , C07K19/00 , C08B37/00 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/24 , C12N15/82 , C12P21/02
CPC classification number: C12N15/8243 , C12N9/1051 , C12N15/8257 , C12P21/02
Abstract: PROBLEM TO BE SOLVED: To provide GnTIII expression in a plant. SOLUTION: A field of glycoprotein processing in transgenic plants used as cost-efficient and contamination possibility-free factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising glycoproteins, is provided. In the field, a plant contains a functional mammalian enzyme providing mammalian GnTII (EC 2.4.1.144)I that is normally not present in plants, wherein the plant additionally contains at least a second mammalian protein or functional fragment thereof that is normally not present in plants. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：在植物中提供GnTIII表达。 提供了用于转基因植物中用于生产重组生物药物蛋白质或包含糖蛋白的药物组合物的成本效益和不可污染污染的工厂的糖蛋白加工领域。 在该领域中，植物含有提供哺乳动物GnTII（EC 2.4.1.144）I的功能性哺乳动物酶，其通常不存在于植物中，其中该植物另外含有至少一种通常不存在于其中的哺乳动物蛋白或其功能片段 植物。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：US09464024B2
公开(公告)日：2016-10-11
申请号：US14913833
申请日：2014-08-26
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Jerome Emile Lucien Le Notre , Elinor Lindsey Scott , Roeland Leo Croes , Jacobus Van Haveren
IPC: C07C51/38
Abstract: Disclosed is a method of making methacrylic acid, or a carboxylic derivative thereof, from itaconic acid, isomers, or precursors thereof. A starting material comprising an acid selected from the group consisting of itaconic acid, citraconic acid, mesaconic acid, citric acid, aconitic acid, isocitric acid and mixtures thereof, is subjected to contact with 0.1 eq. to 3.0 eq. of a base, at a temperature of 150° C. to 350° C., under the influence of a transition metal-containing heterogeneous catalyst. A better yield at lower temperatures is achieved.
Abstract translation: 公开了从衣康酸，异构体或其前体制备甲基丙烯酸或其羧酸衍生物的方法。 包含选自衣康酸，柠康酸，中康酸，柠檬酸，乌头酸，异柠檬酸及其混合物的酸的原料与0.1eq接触。 至3.0当量 的碱，在150℃至350℃的温度下，在含过渡金属的非均相催化剂的影响下。 在较低温度下获得更好的产率。
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Patent Agency Ranking
6.发明授权Process and intermediates for the production of furan-2,5-dicarboxylic acid or derivatives thereof 有权用于生产呋喃-2,5-二羧酸或其衍生物的方法和中间体公开(公告)号：US09376414B2
公开(公告)日：2016-06-28
申请号：US14786723
申请日：2014-05-08
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Jacobus van Haveren , Daniël Stephan van Es , Frits van der Klis , Henricus Wilhelmus Carolina Raaijmakers
IPC: C07D307/68 , C07D307/46 , C07D307/56
CPC classification number: C07D307/68 , C07D307/56
Abstract: Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp.
Abstract translation: 公开了制备5-甲酰基-2-糠酸和呋喃-2,5-二羧酸的方法。 该方法包括使用5-酮基醛糖酸作为中间体，因为它们可以在温和条件下通过环化脱水反应进行环形成。 使5-甲酰基-2-糠酸或其羧酸衍生物进行氧化，形成呋喃-2,5-二羧酸。 5-酮基醛糖酸中间体可以通过糖糖酸异构化得到，该糖醛酸可由甜菜浆，菊苣浆，果皮，包括橙皮或非陆地来源如海藻得到。 优选的来源是甜菜浆。
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公开(公告)号：US09255277B2
公开(公告)日：2016-02-09
申请号：US13921737
申请日：2013-06-19
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Hendrikus Antonius Cornelis Bakker , Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
CPC classification number: C12N15/8243 , C12N9/1051 , C12N15/8257 , C12P21/02
Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
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公开(公告)号：US20150306560A1
公开(公告)日：2015-10-29
申请号：US14431524
申请日：2013-09-24
Inventor： Erhan BAT , Pascal JONKHEIJM , Jurriaan HÜSKENS
CPC classification number: B01J19/0046 , B01J2219/00382 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00619 , B01J2219/00659 , B05D1/18 , C40B60/14
Abstract: A stamp for making a microarray of biomolecules, wherein the stamp has a stamp body having a stamping surface for stamping the biomolecules onto a substrate, a plurality of reservoirs for liquids having the biomolecules, wherein each of the reservoirs has a bottom wall and a plurality of channels extending between each of the bottom wall and the stamping surface, wherein each of the reservoirs and the channels has a macroporous hydrogel and wherein the stamping surface is provided with a hydrophobic coating.
Abstract translation: 一种用于制造生物分子微阵列的印模，其中所述印模具有印模体，所述印模体具有用于将所述生物分子冲压到基底上的冲压表面，用于具有所述生物分子的液体的多个储存器，其中每个所述储存器具有底壁和多个 在每个底壁和冲压表面之间延伸的通道，其中每个储存器和通道具有大孔水凝胶，并且其中冲压表面设置有疏水涂层。
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9.发明申请STATISTICAL APPROACH FOR OPTIMAL USE OF GENETIC INFORMATION COLLECTED ON HISTORICAL PEDIGREES 审中-公开用于最佳使用历史遗传资源的遗传信息的统计方法公开(公告)号：US20130117878A1
公开(公告)日：2013-05-09
申请号：US13670623
申请日：2012-11-07
Applicant: Pioneer Hi-Bred International, Inc. , Wageningen University , Stichting Dienst Landbouwkundig Onderzoek
Inventor： MARINUS C.A.M. BINK , CARL J.F. ter BRAAK , OSCAR S. SMITH , L. RADU TOTIR
Abstract: This invention provides a novel means of predicting plant phenotypes that incorporates previously unusable dense marker data derived from historical pedigrees. The method operates by collecting information from a population pertaining to one or more loci, which is used to build one or more matrices by calculating, for the alleles present at the measured loci, the probability that the alleles are identical by descent. These matrices are then used to develop a second set of one or more matrices in which each value represents the probability that a certain individual in the population descended from a certain ancestral (founder) genotype. This set of second matrices can then be used as part of a breeding program for selecting and breeding individuals from the population or can be used to better classify the individuals in the population, leading to improved plant phenotypes.
Abstract translation: 本发明提供了一种预测植物表型的新手段，其中包含从历史谱系中得到的先前不可用的密集标记数据。 该方法通过从属于一个或多个基因座的群体收集信息来操作，该基因座用于通过计算在测量的基因座处存在的等位基因来构建一个或多个基因，等位基因通过下降相等的概率来构建一个或多个基因。 然后，这些矩阵用于开发第二组一个或多个矩阵，其中每个值表示群体中的某个人从某个祖先（创始人）基因型下降的概率。 然后，该组第二个矩阵可用作育种计划的一部分，用于从群体中选择和繁殖个体，或者可以用于更好地对群体中的个体进行分类，导致改良的植物表型。
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公开(公告)号：US09745594B2
公开(公告)日：2017-08-29
申请号：US14341296
申请日：2014-07-25
Applicant: Stichting Dienst Landbouwkundig Onderzoek
CPC classification number: C12N15/8257 , C07K2319/00 , C12N9/1051 , C12N15/8245 , C12N15/8246 , C12P21/005
Abstract: The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases.
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