中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

131 records (took 0.024 seconds)

    INHIBITION OF MYCOBACTERIAL TYPE VII SECRETION
    16.
    发明申请
    INHIBITION OF MYCOBACTERIAL TYPE VII SECRETION 有权

    公开(公告)号：US20220280487A1

    公开(公告)日：2022-09-08

    申请号：US17638086

    申请日：2020-08-26

    Applicant: Stichting VUmc ,  Stichting VU

    Inventor： Eelco RUIJTER ,  Mark Karsten RONG ,  Alexander SPEER ,  Wilhelmus BITTER ,  Stewart Thomas COLE

    IPC: A61K31/433 ,  A61P31/06

    Abstract: The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and/or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion.
    The compounds have the following formula wherein Q and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C; R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms; R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, and R3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl, or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

    MEANS AND METHODS FOR TREATING DIASTOLIC DYSFUNCTION IN A SUBJECT
    17.
    发明申请
    MEANS AND METHODS FOR TREATING DIASTOLIC DYSFUNCTION IN A SUBJECT 审中-公开

    公开(公告)号：US20190160147A1

    公开(公告)日：2019-05-30

    申请号：US16095273

    申请日：2017-04-21

    Applicant: Stichting VUmc

    Inventor： Walter Joseph Paulus

    IPC: A61K38/17 ,  A61K31/121

    Abstract: The treatment of diastolic dysfunction in a subject and, in particular, compositions for use and methods in treating diastolic dysfunction are disclosed. In one aspect, the disclosure provides a composition for use comprising a therapeutically effective amount of a substance that increases the level and/or activity of a crystalline protein in cardiomyocytes of the subject. In particular, the composition for use according to the disclosure comprises a therapeutically effective amount of the alpha B crystalline protein. It was found that the composition for use is capable of treating diastolic dysfunction and diastolic heart disease in subjects with failing hearts that have a higher cardiomyocyte stiffness than controls. Particularly, addition of alpha B crystalline reduced the higher stiffness of failing cardiomyocytes to the level observed in control cardiomyocytes.

    METHOD OF EVALUATING A RECONSTRUCTED SURFACE, CORNEAL TOPOGRAPHER AND CALIBRATION METHOD FOR A CORNEAL TOPOGRAPHER
    18.
    发明申请
    METHOD OF EVALUATING A RECONSTRUCTED SURFACE, CORNEAL TOPOGRAPHER AND CALIBRATION METHOD FOR A CORNEAL TOPOGRAPHER 审中-公开

    公开(公告)号：US20190082953A1

    公开(公告)日：2019-03-21

    申请号：US16127377

    申请日：2018-09-11

    Applicant: Stichting VUmc

    Inventor： Victor Arni de Paz Sicam ,  Joris-Joost Snellenburg ,  Gerrit Ludolph van der Heijde

    IPC: A61B3/107 ,  G01B11/25

    Abstract: A Method of evaluating a correspondence between a target surface and a reconstructed surface representing the target surface is includes constructing the reconstructed surface by processing information obtained by illuminating the target surface with a pattern of light of a stimulator source, and capturing a reflected image of the pattern of light on an image target. The method further includes the steps of: determining a reference image point on the image target corresponding to a reference stimulator point on the stimulator source; calculating for the reference image point, using the reconstructed surface; a residual representing the correspondence between the target surface and the reconstructed surface; and displaying the residual together with the reflected image.

    METHOD, SYSTEM AND COMPUTER READABLE MEDIUM TO DETERMINE A STRABISMUS ANGLE BETWEEN THE EYES OF AN INDIVIDUAL
    19.
    发明申请
    METHOD, SYSTEM AND COMPUTER READABLE MEDIUM TO DETERMINE A STRABISMUS ANGLE BETWEEN THE EYES OF AN INDIVIDUAL 审中-公开

    公开(公告)号：US20190029511A1

    公开(公告)日：2019-01-31

    申请号：US16070042

    申请日：2017-01-11

    Applicant: Stichting VUmc

    Inventor： Bob Wilhelm van Dijk

    IPC: A61B3/08 ,  A61B3/113 ,  A61B3/11 ,  A61B3/00

    Abstract: A method, system and computer readable medium for determining a strabismus angle of the eyes of an individual by: positioning the individual with his or her eyes in front of an eye tracker device and in front of a screen at a viewing distance; displaying a small image element on the screen; measuring a position and line of sight of the eyes of the individual with the eye tracker device while the individual is focussing on the small image element; forwarding the measured position and line of sight of the eyes from the eye tracker device to a computer system; and, calculating the strabismus angle between the eyes by calculating the difference in line of sight of the left and right eyes of the individual.

Patent Agency Ranking