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    Parenteral formulation for epothilone analogs
    13.
    发明授权
    Parenteral formulation for epothilone analogs 有权
    埃坡霉素类似物的肠胃外制剂

    公开(公告)号：US08632788B2

    公开(公告)日：2014-01-21

    申请号：US12264375

    申请日：2008-11-04

    Applicant: Rebanta Bandyopadhyay ,  Timothy M. Malloy ,  Andrea Panaggio ,  Krishnaswamy Srinivas Raghavan ,  Sailesh Amilal Varia

    Inventor： Rebanta Bandyopadhyay ,  Timothy M. Malloy ,  Andrea Panaggio ,  Krishnaswamy Srinivas Raghavan ,  Sailesh Amilal Varia

    IPC: A61K9/00 ,  A61K31/425

    CPC classification number: C07D491/044 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/19 ,  A61K31/395 ,  A61K31/425 ,  A61K31/427 ,  A61K47/10 ,  A61K47/44 ,  A61K2300/00

    Abstract: A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog and the resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil and a preferred diluent is Lactated Ringer's Injection.

    Abstract translation: 公开了一种用于肠胃外给药的某些埃坡霉素类似物的制备方法，其中将类似物溶解在至少50体积％的叔丁醇在水中的混合物中，将该混合物冻干，将得到的冻干产品以足够的量包装在一个小瓶中 在第二小瓶中含有无水乙醇和合适的非离子表面活性剂的溶剂量。 所有步骤均采用防光保护。 在使用中，将第二或稀释剂小瓶的内容物加入到冻干产品中并混合以构成埃坡霉素类似物，并将所得溶液用合适的稀释剂稀释，以产生静脉内注射溶液，其中含有埃托霉素类似物的浓度为 约0.1mg / mL至约0.9mg / mL。 优选的表面活性剂是聚乙氧基化蓖麻油，优选的稀释剂是乳酸林格氏注射液。

    Method and apparatus for monitoring message status in an asynchronous mediated communication system
    14.
    发明授权
    Method and apparatus for monitoring message status in an asynchronous mediated communication system 有权
    用于在异步介质通信系统中监视消息状态的方法和装置

    公开(公告)号：US08595302B2

    公开(公告)日：2013-11-26

    申请号：US12551520

    申请日：2009-08-31

    Applicant: Govindarajan Krishnamurthi ,  Stewart A. Skomra ,  Srinivas Raghavan ,  Allan Schougaard ,  Deepa Suri

    Inventor： Govindarajan Krishnamurthi ,  Stewart A. Skomra ,  Srinivas Raghavan ,  Allan Schougaard ,  Deepa Suri

    IPC: G06F15/16

    CPC classification number: H04L51/14 ,  G06F19/00 ,  H04L51/34

    Abstract: A system and method for mediating the routing of asynchronous messages includes routing the asynchronous message to a first recipient, determining whether the first recipient opened the asynchronous message, and re-routing the asynchronous message to a second recipient who is qualified to receive and respond to the message if the first recipient fails to open the message (i.e., read, listen, display, act upon the message). In an embodiment, the message is re-routed to the second recipient if the first recipient fails to open the message within a deadline automatically imposed by the system when the message is of a certain type. In an embodiment, a mediator monitors if any recipient accepts responsibility for the asynchronous message and informs the other recipients that the asynchronous message may be deleted from their message queues.

    Abstract translation: 用于中介异步消息的路由的系统和方法包括将异步消息路由到第一接收者，确定第一接收者是否打开异步消息，以及将异步消息重新路由到有资格接收和响应的第二接收者 如果第一个收件人无法打开消息（即，读取，收听，显示，对消息执行操作）的消息。 在一个实施例中，如果第一接收方在消息是某种类型时在系统自动强加的期限内无法打开该消息，则该消息被重新路由到第二接收方。 在一个实施例中，调解器监视任何接收者是否接受异步消息的责任，并通知其他收件人异步消息可能从其消息队列中删除。

    Method and apparatus for asynchronous mediated communicaton
    15.
    发明授权
    Method and apparatus for asynchronous mediated communicaton 有权
    用于异步介质通信的方法和装置

    公开(公告)号：US08149850B2

    公开(公告)日：2012-04-03

    申请号：US12389358

    申请日：2009-02-19

    Applicant: Govindarajan Krishnamurthi ,  Stewart A. Skomra ,  Srinivas Raghavan ,  Deepa Suri ,  Donald J. Jones

    Inventor： Govindarajan Krishnamurthi ,  Stewart A. Skomra ,  Srinivas Raghavan ,  Deepa Suri ,  Donald J. Jones

    IPC: H04L12/56

    CPC classification number: H04L51/14 ,  H04L51/34

    Abstract: A system and method for mediating the routing of asynchronous messages includes routing the asynchronous message to a first recipient, determining whether the first recipient opened the asynchronous message, and re-routing the asynchronous message to a second recipient who is qualified to receive and respond to the message if the first recipient fails to open the message. In an aspect, the second recipient is selected based upon the role that the second recipient performs within the system. In another aspect, the message is re-routed to the second recipient if the first recipient fails to open the message within a deadline imposed by the message sender. In another aspect, the message is re-routed to the second recipient if the first recipient fails to open the message within a deadline automatically imposed by the system when the message is of a certain type.

    Abstract translation: 用于中介异步消息的路由的系统和方法包括将异步消息路由到第一接收者，确定第一接收者是否打开异步消息，以及将异步消息重新路由到有资格接收和响应的第二接收者 该消息如果第一个收件人无法打开该消息。 在一方面，基于第二接收者在系统内执行的角色来选择第二接收者。 在另一方面，如果第一接收方在消息发送者施加的最后期限内未能打开消息，则该消息被重新路由到第二接收者。 在另一方面，如果第一接收方在消息是某种类型时在系统自动强加的期限内无法打开消息，则该消息被重新路由到第二接收方。

    PARENTERAL FORMULATION FOR EPOTHILONE ANALOGS
    18.
    发明申请
    PARENTERAL FORMULATION FOR EPOTHILONE ANALOGS 有权
    EPOTHILONE ANALOGS的配方配方

    公开(公告)号：US20090069393A1

    公开(公告)日：2009-03-12

    申请号：US12264375

    申请日：2008-11-04

    Applicant: Rebanta Bandyopadhyay ,  Timothy M. Malloy ,  Andrea Panaggio ,  Krishnaswamy Srinivas Raghavan ,  Sailesh Amilal Varia

    Inventor： Rebanta Bandyopadhyay ,  Timothy M. Malloy ,  Andrea Panaggio ,  Krishnaswamy Srinivas Raghavan ,  Sailesh Amilal Varia

    IPC: A61K31/427 ,  C07D491/044

    CPC classification number: C07D491/044 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/19 ,  A61K31/395 ,  A61K31/425 ,  A61K31/427 ,  A61K47/10 ,  A61K47/44 ,  A61K2300/00

    Abstract: A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog and the resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil and a preferred diluent is Lactated Ringer's Injection.

    Abstract translation: 公开了一种用于肠胃外给药的某些埃坡霉素类似物的制备方法，其中将类似物溶解在至少50体积％的叔丁醇在水中的混合物中，将混合物冻干，将所得的冻干产品包装在一个小瓶中， 在第二小瓶中含有无水乙醇和合适的非离子表面活性剂的溶剂量。 所有步骤均采用防光保护。 在使用中，将第二或稀释剂小瓶的内容物加入到冻干产品中并混合以构成埃坡霉素类似物，并将所得溶液用合适的稀释剂稀释，以产生静脉内注射溶液，其中含有埃托霉素类似物的浓度为 约0.1mg / mL至约0.9mg / mL。 优选的表面活性剂是聚乙氧基化蓖麻油，优选的稀释剂是乳酸林格氏注射液。

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