公开(公告)号：WO2012045047A3

公开(公告)日：2012-04-05

申请号：PCT/US2011/054437

申请日：2011-09-30

Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY ,  RAO, Govind ,  KOSTOV, Yordan ,  GE, Xudong ,  TOLOSA, Leah ,  WOO, Hyung ,  VISCARDI, Rose

Inventor： RAO, Govind ,  KOSTOV, Yordan ,  GE, Xudong ,  TOLOSA, Leah ,  WOO, Hyung ,  VISCARDI, Rose

IPC: A61B5/145

Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.

公开(公告)号：WO2012045047A2

公开(公告)日：2012-04-05

申请号：PCT/US2011054437

申请日：2011-09-30

Applicant: UNIV MARYLAND ,  RAO GOVIND ,  KOSTOV YORDAN ,  GE XUDONG ,  TOLOSA LEAH ,  WOO HYUNG ,  VISCARDI ROSE

Inventor： RAO GOVIND ,  KOSTOV YORDAN ,  GE XUDONG ,  TOLOSA LEAH ,  WOO HYUNG ,  VISCARDI ROSE

IPC: A61B5/1455

CPC classification number: A61B5/14552 ,  A61B5/6807 ,  A61B5/6829

Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.

Abstract translation: 提供一种非侵入性气体分析物感测和监测系统和方法，其特别适用于哺乳动物的动脉血气的经皮监测。 该系统和方法依赖于待测量分析物扩散到扩散室中，并使用光学化学传感器和相关联的光电子学来远程检测扩散室中的分析物。

公开(公告)号：WO2011044573A1

公开(公告)日：2011-04-14

申请号：PCT/US2010/052286

申请日：2010-10-12

Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY ,  RAO, Govind ,  KOSTOV, Yordan ,  TOLOSA, Leah ,  LAM, Hung

Inventor： RAO, Govind ,  KOSTOV, Yordan ,  TOLOSA, Leah ,  LAM, Hung

IPC: A61B5/00

CPC classification number: A61B5/015

Abstract: A remote parameter sensing system is provide that includes a gel sensor, a light source, a detector and a controller 140. The gel sensor is in contact with a surface where the parameter is to be measured, and is preferably a gel that is embedded with a chemical that emits light 160 (via, for example, fluorescence) when it is excited by excitation light from the light source at an appropriate excitation frequency. The chemical properties of the gel sensor are such that at least one characteristic of the emission light (such as, for example, emission intensity) varies as a function of variations in the parameter being measured. The system is particularly suited for use as remote body temperature sensing system in incubators and radiant warmers for infant and neonatal care.

Abstract translation: 提供了一种远程参数感测系统，其包括凝胶传感器，光源，检测器和控制器140.凝胶传感器与要测量参数的表面接触，并且优选地是嵌入 当通过来自光源的激发光以适当的激发频率激发时，发出光160（通过例如荧光）的化学品。 凝胶传感器的化学性质使得发射光（例如发光强度）的至少一个特性随着被测参数的变化而变化。 该系统特别适用于孵化器中的远程体温感测系统和用于婴儿和新生儿护理的辐射加热器。

公开(公告)号：WO2010148392A1

公开(公告)日：2010-12-23

申请号：PCT/US2010/039337

申请日：2010-06-21

Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY ,  RAO, Govind ,  KOSTOV, Yordan ,  TOLOSA, Leah

Inventor： RAO, Govind ,  KOSTOV, Yordan ,  TOLOSA, Leah

IPC: C12M1/12

CPC classification number: C12M23/00 ,  C12M23/20 ,  C12M41/00 ,  C12M41/26 ,  C12M41/34

Abstract: A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.

Abstract translation: 用于测量至少一个生物过程参数的系统和方法利用将外部传感器与培养基分离的屏障。 屏障允许分析物扩散进出培养容器，从而允许外部传感器非侵入性地测量生物过程参数。

公开(公告)号：CA2956924A1

公开(公告)日：2016-02-04

申请号：CA2956924

申请日：2015-07-31

Applicant: RAO GOVIND ,  KOSTOV YORDAN ,  TOLOSA LEAH ,  TRAN KEVIN ,  PILLI MANOHAR ,  TOLOSA MICHAEL ,  GURRAMKONDA CHANDRASHEKAR

Inventor： RAO GOVIND ,  KOSTOV YORDAN ,  TOLOSA LEAH ,  TRAN KEVIN ,  PILLI MANOHAR ,  TOLOSA MICHAEL ,  GURRAMKONDA CHANDRASHEKAR

IPC: C07K1/16 ,  C12M3/06

Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.