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公开(公告)号：EP3186355A4
公开(公告)日：2018-03-21
申请号：EP15827147
申请日：2015-07-31
Applicant: RAO GOVIND , KOSTOV YORDAN , TOLOSA LEAH , TRAN KEVIN , PILLI MANOHAR , TOLOSA MICHAEL , GURRAMKONDA CHANDRASHEKAR
Inventor： RAO GOVIND , KOSTOV YORDAN , TOLOSA LEAH , TRAN KEVIN , PILLI MANOHAR , TOLOSA MICHAEL , GURRAMKONDA CHANDRASHEKAR
CPC classification number: C07K1/36 , A61K35/14 , A61M1/3621 , B01D15/08
Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
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2.发明公开MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING FROM HUMAN BLOOD 审中-公开微血管生物加工系统和由人血液制造蛋白质的方法
公开(公告)号：EP3186355A2
公开(公告)日：2017-07-05
申请号：EP15827147.8
申请日：2015-07-31
Applicant: Rao, Govind , Kostov, Yordan , Tolosa, Leah , Tran, Kevin , Pilli, Manohar , Tolosa, Michael , Gurramkonda, Chandrashekar
Inventor： Rao, Govind , Kostov, Yordan , Tolosa, Leah , Tran, Kevin , Pilli, Manohar , Tolosa, Michael , Gurramkonda, Chandrashekar
CPC classification number: C07K1/36 , A61K35/14 , A61M1/3621 , B01D15/08
Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
Abstract translation: 提供了一种用于从人类血液制造蛋白质的生物处理系统，该系统紧凑，集成并适合按需生产和向患者递送治疗性蛋白质。 患者自己的血液可以用作生产治疗性蛋白质的细胞提取物的来源。
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3.发明申请
公开(公告)号：WO2004101769A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/006276
申请日：2004-03-01
Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY , TOLOSA, Leah , RAO, Govind , GE, Xudong
Inventor： TOLOSA, Leah , RAO, Govind , GE, Xudong
IPC: C12N
CPC classification number: G01N33/542 , Y10T436/143333 , Y10T436/144444 , Y10T436/17
Abstract: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors.
Abstract translation: 蛋白质感测分子能够结合样品中的分析物。 当蛋白质感测分子与分析物结合时，蛋白质感测分子包括以浓度依赖性方式变化的第一可检测质量。 蛋白质感测分子还包括当蛋白质感测分子与分析物结合时不会发生实质变化的第二可检测质量。 蛋白质感测分子可用于表征样品的方法中，也可用于传感器。
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4.发明申请
公开(公告)号：WO2004101769A3
公开(公告)日：2005-04-21
申请号：PCT/US2004006276
申请日：2004-03-01
Applicant: UNIV MARYLAND , TOLOSA LEAH , RAO GOVIND , GE XUDONG
Inventor： TOLOSA LEAH , RAO GOVIND , GE XUDONG
IPC: C12N20060101 , G01N33/558
CPC classification number: G01N33/542 , Y10T436/143333 , Y10T436/144444 , Y10T436/17
Abstract: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors.
Abstract translation: 蛋白质感测分子能够结合样品中的分析物。 当蛋白质感测分子与分析物结合时，蛋白质感测分子包括以浓度依赖性方式变化的第一可检测质量。 蛋白质感测分子还包括当蛋白质感测分子与分析物结合时不经历实质性变化的第二可检测质量。 蛋白质感测分子可用于表征样品的方法中，也可用于传感器。
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5.发明申请MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING 审中-公开MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR蛋白质制造
公开(公告)号：WO2012122413A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028358
申请日：2012-03-08
Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY , RAO, Govind , KOSTOV, Yordan , TOLOSA, Leah , LAM, Hung , GE, Xudong , FREY, Douglas , SINGH, Virendra
Inventor： RAO, Govind , KOSTOV, Yordan , TOLOSA, Leah , LAM, Hung , GE, Xudong , FREY, Douglas , SINGH, Virendra
IPC: C12M1/12
CPC classification number: C12M21/14 , B01D15/327 , B01D15/361 , B01D15/3847 , C07K1/34 , C07K1/36 , C12M21/18 , C12M29/04 , C12M41/34 , C12M41/48 , C12M43/00 , C12M47/12
Abstract: A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
Abstract translation: 提供了一种用于蛋白质制造的生物处理系统，其紧凑，集成并适合于按需生产和递送治疗性蛋白质给患者。 该系统还可用于任何类型蛋白质的按需生产。
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Patent Agency Ranking6.发明申请ANALYTE SENSING SYSTEM AND METHOD UTILIZING SEPARATE EQUILIBRIUM AND MEASUREMENT CHAMBERS 审中-公开分析感测系统和使用分离式均衡器和测量座的方法
公开(公告)号：WO2012045046A2
公开(公告)日：2012-04-05
申请号：PCT/US2011/054434
申请日：2011-09-30
Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY , RAO, Govind , KOSTOV, Yordan , GE, Xudong , TOLOSA, Leah , LAM, Hung , HENDERSON, Robert
Inventor： RAO, Govind , KOSTOV, Yordan , GE, Xudong , TOLOSA, Leah , LAM, Hung , HENDERSON, Robert
IPC: G01N21/64 , A61B5/1455
CPC classification number: G01N21/643 , G01N21/77 , G01N21/78 , G01N31/223 , G01N33/1886 , G01N2021/7733 , G01N2021/7786 , G01N2201/0612 , G01N2201/062
Abstract: An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly suited for monitoring of CO 2 levels in oceans or other bodies of water.
Abstract translation: 提供了分析物传感系统，其利用分离的和去耦的平衡和测量室来提高灵敏度和稳定性。 该系统和方法特别适用于监测海洋或其他水体中的二氧化碳水平。
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公开(公告)号：WO2010085736A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021960
申请日：2010-01-25
Applicant: University of Maryland Baltimore County , RAO, Govind , LAM, Hung , KOSTOV, Yordan , TOLOSA, Leah , GE, Xudong
Inventor： RAO, Govind , LAM, Hung , KOSTOV, Yordan , TOLOSA, Leah , GE, Xudong
IPC: C12Q1/02
CPC classification number: G01N33/5308 , G01N21/05 , G01N21/15 , G01N21/532 , G01N21/645 , G01N21/6486 , G01N21/82 , G01N21/8507 , G01N2021/635 , G01N2021/6432 , G01N2201/0218 , G01N2201/0627
Abstract: A low cost sensing system that can measure both chlorophyll concentration and turbidity is provided. The system is an optical system that utilizes at least three light sensors for measuring side-scattered and forward scattered light, as well as fluorescence. The system is able to take optical density measurements, steady state fluorescence measurements and maximum fluorescence measurements, and can be configured for wireless control and data transmission. The system may also be housed in one or more fluidtight housings so as to make it submersible.
Abstract translation: 提供了可以测量叶绿素浓度和浊度的低成本感测系统。 该系统是利用至少三个光传感器来测量侧向散射和向前散射光以及荧光的光学系统。 该系统能够进行光密度测量，稳态荧光测量和最大荧光测量，并可配置为无线控制和数据传输。 该系统还可以容纳在一个或多个流体密封的壳体中，以使其潜水。
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8.发明申请MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING FROM HUMAN BLOOD 审中-公开微生物生物处理系统及人血清蛋白质制备方法
公开(公告)号：WO2016019350A3
公开(公告)日：2016-08-18
申请号：PCT/US2015043314
申请日：2015-07-31
Applicant: RAO GOVIND , KOSTOV YORDAN , TOLOSA LEAH , TRAN KEVIN , PILLI MANOHAR , TOLOSA MICHAEL , GURRAMKONDA CHANDRASHEKAR
Inventor： RAO GOVIND , KOSTOV YORDAN , TOLOSA LEAH , TRAN KEVIN , PILLI MANOHAR , TOLOSA MICHAEL , GURRAMKONDA CHANDRASHEKAR
Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
Abstract translation: 提供了一种用于从人血液制备蛋白质的生物处理系统，其是紧凑的，整合的并且适合按需生产和递送治疗性蛋白质给患者。 患者自己的血液可以用作细胞提取物的来源，用于生产治疗性蛋白质。
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9.发明申请MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING FROM HUMAN BLOOD 审中-公开微血管生物加工系统和由人血液制造蛋白质的方法
公开(公告)号：WO2016019350A2
公开(公告)日：2016-02-04
申请号：PCT/US2015/043314
申请日：2015-07-31
Applicant: RAO, Govind , KOSTOV, Yordan , TOLOSA, Leah , TRAN, Kevin , PILLI, Manohar , TOLOSA, Michael , GURRAMKONDA, Chandrashekar
Inventor： RAO, Govind , KOSTOV, Yordan , TOLOSA, Leah , TRAN, Kevin , PILLI, Manohar , TOLOSA, Michael , GURRAMKONDA, Chandrashekar
IPC: C07K1/16
CPC classification number: C07K1/36 , A61K35/14 , A61M1/3621 , B01D15/08
Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
Abstract translation: 提供了一种用于从人血液制造蛋白质的生物处理系统，该系统紧凑，集成且适合按需生产和向患者递送治疗性蛋白质。 患者自己的血液可以用作生产治疗性蛋白质的细胞提取物的来源。
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10.发明申请ANALYTE SENSING SYSTEM AND METHOD UTILIZING SEPARATE EQUILIBRIUM AND MEASUREMENT CHAMBERS 审中-公开利用分离平衡和测量室的分析物传感系统和方法
公开(公告)号：WO2012045046A3
公开(公告)日：2012-05-24
申请号：PCT/US2011054434
申请日：2011-09-30
Applicant: UNIV MARYLAND , RAO GOVIND , KOSTOV YORDAN , GE XUDONG , TOLOSA LEAH , LAM HUNG , HENDERSON ROBERT
Inventor： RAO GOVIND , KOSTOV YORDAN , GE XUDONG , TOLOSA LEAH , LAM HUNG , HENDERSON ROBERT
CPC classification number: G01N21/643 , G01N21/77 , G01N21/78 , G01N31/223 , G01N33/1886 , G01N2021/7733 , G01N2021/7786 , G01N2201/0612 , G01N2201/062
Abstract: An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly suited for monitoring of CO2 levels in oceans or other bodies of water.
Abstract translation: 提供分析物传感系统，利用分离和解耦的平衡和测量室提高灵敏度和稳定性。 该系统和方法特别适用于监测海洋或其他水体中的二氧化碳含量。
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