公开(公告)号：WO2009125375A3

公开(公告)日：2009-12-17

申请号：PCT/IB2009051528

申请日：2009-04-10

Applicant: UNIV ROMA ,  GASPARI ACHILLE LUCIO ,  DI LORENZO NICOLA ,  IEZZI LUCA

Inventor： GASPARI ACHILLE LUCIO ,  DI LORENZO NICOLA ,  IEZZI LUCA

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00065 ,  A61B2018/00113 ,  A61B2018/00136

Abstract: A surgical instrument (3), in particular for use in laparoscopy, comprises means for inducing the surface adsorption of ions in correspondence of said sheath (10) allowing to reducing burns due to electrical dispersions.

Abstract translation: 特别是用于腹腔镜检查的手术器械（3）包括用于诱导对应于所述护套（10）的离子的表面吸附的装置，其允许减少由于电分散引起的灼伤。

公开(公告)号：WO2009040755A2

公开(公告)日：2009-04-02

申请号：PCT/IB2008053905

申请日：2008-09-25

Applicant: UNIV ROMA ,  UNIV SIENA ,  BIAVA MARIANGELA ,  PORRETTA GIULIO CESARE ,  POMPEI RAFFAELLO ,  BOTTA MAURIZIO ,  MANETTI FABRIZIO ,  DE LOGU ALESSANDRO

Inventor： BIAVA MARIANGELA ,  PORRETTA GIULIO CESARE ,  POMPEI RAFFAELLO ,  BOTTA MAURIZIO ,  MANETTI FABRIZIO ,  DE LOGU ALESSANDRO

IPC: C07D207/33 ,  A61K31/402 ,  A61P31/06 ,  C07D417/06

CPC classification number: C07D207/335

Abstract: The present invention relates to a compound having the general formula (3): synthesis, intermediates and uses thereof.

Abstract translation: 本发明涉及具有通式（3）的化合物：其合成，中间体和用途。

公开(公告)号：WO2009011007A3

公开(公告)日：2009-03-19

申请号：PCT/IT2008000474

申请日：2008-07-15

Applicant: UNIV ROMA ,  UNIV CATTOLICA SACRO CUORE ,  SPIRITO MARCO DE ,  FRAZIANO MAURIZIO ,  QUINTILIANI GIANLUCA ,  GRECO EMANUELA

Inventor： FRAZIANO MAURIZIO ,  QUINTILIANI GIANLUCA ,  GRECO EMANUELA

IPC: A61K9/127 ,  A61P31/04 ,  A61P31/06 ,  A61P31/08

CPC classification number: A61K9/127 ,  A61K9/0073 ,  A61K47/6911

Abstract: The invention concerns new asymmetric liposomes and uses thereof in medical field transport lipids involved in antimicrobial or antiviral response, particularly at level of pulmonary target cells.

Abstract translation: 本发明涉及新的不对称脂质体及其在医学领域中的运用，所述运输脂质涉及抗微生物或抗病毒应答，特别是在肺靶细胞水平。

公开(公告)号：WO2008090585A3

公开(公告)日：2009-02-26

申请号：PCT/IT2008000040

申请日：2008-01-25

Applicant: UNIV ROMA ,  DI RIENZO BARBARA ,  MAI ANTONELLO

Inventor： DI RIENZO BARBARA ,  MAI ANTONELLO

IPC: A61K47/48 ,  A61K31/167 ,  A61K31/19 ,  A61P3/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P33/02 ,  A61P35/00

CPC classification number: A61K31/167 ,  A61K31/19 ,  A61K47/6951 ,  B82Y5/00 ,  C07C233/83 ,  C07D213/75 ,  C07D213/82

Abstract: The invention relates to the preparation of soluble forms of complexes of histone deacetylase inhibitors and cyclodextrins. The preparation process involves the formation of inclusion complexes with cyclodextrins with the aid of microwaves. Their use is in the pharmaceutical field.

Abstract translation: 本发明涉及组蛋白脱乙酰酶抑制剂和环糊精复合物的可溶形式的制备。 制备过程涉及在微波辅助下与环糊精形成包合物。 他们的使用是在制药领域。

公开(公告)号：WO2009004664A3

公开(公告)日：2009-02-19

申请号：PCT/IT2008000439

申请日：2008-06-27

Applicant: UNIV ROMA ,  DI NARDO PAOLO ,  FORTE GIANCARLO ,  FRANZESE ORNELLA ,  BONMASSAR ENZO ,  PRAT MARIA

Inventor： DI NARDO PAOLO ,  FORTE GIANCARLO ,  FRANZESE ORNELLA ,  BONMASSAR ENZO ,  PRAT MARIA

IPC: C12N5/0775

CPC classification number: C12N5/0663 ,  C12N2510/04

Abstract: The present invention concerns a new immortalized cell line of mesenchymal murine stem cells, method for preparation and uses thereof, particularly as an experimental model.

公开(公告)号：WO2008104900A2

公开(公告)日：2008-09-04

申请号：PCT/IB2008050594

申请日：2008-02-19

Applicant: UNIV ROMA ,  LAVAGNA SILVIO

Inventor： LAVAGNA SILVIO

IPC: B01D1/00 ,  B01D1/30 ,  C02F1/04

CPC classification number: B01D1/0017 ,  B01D1/0082 ,  B01D1/305 ,  C02F1/043 ,  C02F1/045 ,  C02F1/048 ,  C02F1/302 ,  C02F2209/42 ,  C02F2301/024

Abstract: A distillation system (1 ) and method, for the distillation by evaporation of a liquid solution and subsequent condensation thereof. The system (1) comprises a control unit, suitable for managing production processes and controlling process parameters; a tank (10) for storage of said liquid solution; means (11 ) for collecting a given flow rate of said liquid solution from said tank (10) and inletting it into a fluid-dynamic circuit of said system (1 ); a phase separation chamber (100), apt to induct said given flow rate of liquid solution until attaining a corresponding hydrostatic column H in said separation chamber (100); a heat exchanger (30), in double fluid connection (a,b), respectively liquid and gaseous, with said phase separation chamber (100), apt to carry out a preliminary evaporation of a given fluid stream of said liquid solution, returned into said exchanger (30) from said phase separation chamber (100); power-generating means, apt to cooperate with said heat exchanger (30) so as to output thereto the power required to carry out said evaporation; an unit (50) for condensing said vapour (50) and extracting the distillate deriving therefrom by distillation ducts (6); wherein said power-generating means comprises a modular electromagnetic microwave generator (200), cooperating with said control unit in the sense of adjusting the power developed proportionally to the hydrostatic head that is established in said heat exchanger (30) at the transit of said fluid stream of said liquid solution.

Abstract translation: 蒸馏系统（1）和方法，用于通过蒸发液体溶液进行蒸馏并随后冷凝。 系统（1）包括一个控制单元，适用于管理生产过程和控制过程参数; 用于储存所述液体溶液的罐（10）; 用于从所述罐（10）收集所述液体溶液的给定流速并将其引入所述系统（1）的流体动力学电路的装置（11）; 相分离室（100），其易于引导所述给定的液体流速，直到在所述分离室（100）中达到相应的静液压柱H; 与所述相分离室（100）一起，双重流体连接（a，b）（液体和气体）的热交换器（30）易于对所述液体溶液的给定流体流进行初步蒸发，返回到 所述交换器（30）来自所述相分离室（100）; 发电装置，适于与所述热交换器（30）协作以便向其输出执行所述蒸发所需的功率; 用于冷凝所述蒸气（50）并通过蒸馏管（6）提取从其衍生的馏出物的单元（50）; 其中所述发电装置包括模块化电磁微波发生器（200），其与所述控制单元配合，以便在所述流体的过渡处调节与所述热交换器（30）中建立的静水压头成比例地发展的功率 所述液体溶液流。

公开(公告)号：WO2008075397A2

公开(公告)日：2008-06-26

申请号：PCT/IT2007000878

申请日：2007-12-17

Applicant: UNIV CALABRIA ,  UNIV ROMA ,  CNR CT NAZ DELLE RICERCHE ,  D ALESSANDRO ANTONIO ,  BECCHERELLI ROMEO ,  UMETON CESARE ,  ASQUINI RITA ,  DONISI DOMENICO ,  DE SIO LUCIANO ,  CAPUTO ROBERTO

Inventor： D ALESSANDRO ANTONIO ,  BECCHERELLI ROMEO ,  UMETON CESARE ,  ASQUINI RITA ,  DONISI DOMENICO ,  DE SIO LUCIANO ,  CAPUTO ROBERTO

IPC: C14B1/58

CPC classification number: G02F1/225 ,  G02F1/13 ,  G02F1/1326 ,  G02F2201/066 ,  G02F2201/307 ,  G02F2202/022 ,  G02F2203/055

Abstract: An electro-optical filter made of a support in which an optical guide with a diffused channel waveguide and of a cover, that are created in borosilicate glass, and which includes a gap obtained by the use of suitable spacers, filled with a grating constituted of alternating strips of polymer and liquid crystal called POLICRYPS (Polymer Liquid CRYstal Polymer Slices), and with first electrodes that are coplanar to the support and next to the optical guide with a channel, that electrically control the grating making the filter tunable, and a manufacturing process.

Abstract translation: 一种由支撑体制成的电光滤波器，其中具有扩散通道波导和盖的光导，其在硼硅玻璃中产生，并且包括通过使用合适的间隔件获得的间隙，该间隙填充有由 称为POLICRYPS（聚合物液体CRYstal聚合物切片）的聚合物和液晶的交替条带以及与支撑体共面的第一电极和具有通道的光导体旁边的第一电极，其电控制使滤光片可调谐的光栅，以及制造 处理。

公开(公告)号：WO2007015280A8

公开(公告)日：2008-04-10

申请号：PCT/IT2006000401

申请日：2006-05-26

Applicant: UNIV ROMA ,  SILVESTRI ROMANO ,  MARFE GABRIELLA ,  ABRUZZESE ELISABETTA ,  CATALANO GIANFRANCO ,  DI STEFANO CARLA ,  NOVELLINO ETTORE ,  SINIBALDI SALIMEI PAOLA ,  DE MARTINO MARIA GABRIELLA ,  LA REGINA GIUSEPPE ,  LAVECCHIA ANTONIO

Inventor： SILVESTRI ROMANO ,  MARFE GABRIELLA ,  ABRUZZESE ELISABETTA ,  CATALANO GIANFRANCO ,  DI STEFANO CARLA ,  NOVELLINO ETTORE ,  SINIBALDI SALIMEI PAOLA ,  DE MARTINO MARIA GABRIELLA ,  LA REGINA GIUSEPPE ,  LAVECCHIA ANTONIO

IPC: C07D513/04 ,  A61K31/55 ,  A61P35/02 ,  C07D487/04

CPC classification number: C07D513/04

Abstract: The invention concerns benzodiazepine derivatives of formula (I) wherein Y it is SO 2 or NR, wherein R is H or C 1 -C 6 alkyl; X is H, C 1 -C 12 alkyl, -CO, -SO, -SO 2 , or - CO-R 2 , SO-R 2 , SO 2 - R 2 , wherein R 2 is selected from H, C 1 -C 12 alkyl, (C 3 -C 8 cycloalkyl) C 0 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C2-C 6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with 0 to 3 substituents selected from halogen, -CN, -NH 2 , -OH, -NO 2 , COOR 3 , wherein R 3 is selected from H, C 1 -C 12 alkyl, (C 3 -C 8 cycloalkyl) C 0 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 2 -C 6 alkoxy carbonyl; phenyl, benzyl, naphtyl, biphenyl, or heterocycle, n is 0-6; R 4 is selected from H, OH, COOH, CN, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkoxycarbonyl, -CO, -SO, - SO 2 , or -CO-R 5 , SO-R 5 , SO 2 -R 2 , -OCO-R 5 , OSO-R 5 , OSO 2 -R 5 , COOR 5 , SOOR 5 , SO 2 OR 5 , NHR 5 , NHCOR 5 , NHSO 2 R 5 , SR 5 , SCOR 5 , wherein R 5 is selected from H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 2 -C 6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with O to 3 substituents selected from halogen, -CN, -NH 2 , -OH, -NO 2 , COOR 5' , wherein R 5 is selected from H, C 1 -C 12 alkyl, (C 3 -C 8 cycloalkyl) C 0 -C 6 alkyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 2 -C 6 alkoxy carbonyl; R 6 and R 7 independently of each other are selected from the group consisting of H, OH, halogen, CN, NH 2 , NO 2 , COOR 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and C 2 -C 6 alkoxy carbonyl; R 3 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or physiologically acceptable salts and uses thereof in medical field, particularly as anti-tumoral agents.

Abstract translation: 本发明涉及式（I）的苯并二氮杂衍生物，其中Y为SO 2或NR，其中R为H或C 1 -C 6 - 烷基; X是H，C 1 -C 12烷基，-CO，-SO，-SO 2 - 或 - CO- 2，SO-R 2，SO 2，R 2，其中R 2选自 C 1 -C 12烷基，（C 3 -C 8 - 环烷基）C 1 -C 12烷基， C 1 -C 6烷基，C 2 -C 6亚烷基，C 2 -C 6烷基，C 2 -C 6亚烷基，C 2 -C 6亚烷基， C 6 -C 6炔基，C 2 -C 6烷氧基羰基，苯基，苄基，萘基，联苯基或杂环，每个对位，间位或邻位取代彼此独立地为0〜 3个选自卤素，-CN，-NH 2，-OH，-NO 2，COOR 3的取代基，其中R 3 （C 3 -C 12）烷基，（C 3 -C 12）烷基，C 1 -C 12烷基， 环烷基）C 0 -C 6烷基，C 1 -C 6烷氧基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， C 1 -C 6亚烷基，C 2 -C 6炔基或C 2 -C 6亚烷基 > 6烷氧基羰基; 苯基，苄基，萘基，联苯基或杂环，n为0-6; R 4选自H，OH，COOH，CN，C 1 -C 6烷基，C 1〜 -C 6烷氧基，C 2 -C 6亚烯基，C 2 -C 6烷基，C 2 -C 6亚烷基， C 1 -C 6烷基，C 1 -C 6烷基羰基，-CO 2，-SO 3 SO 2 SO 2，或-CO- 5，SO-R 5，SO 2 -R 2，-OCO-R 5， ，OSO-R 5，OSO 2，R 5，COOR 5，SOOR 5， SO 2，SO 2，或5，NHR 5，NHCOR 5，NH 2 SO 2， R 5，SR 5，SOR 5，其中R 5选自H，C 1 -C 5烷基， C 1 -C 6烷基，C 1 -C 6烷氧基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， C 1 -C 6亚烷基，C 2 -C 6炔基或C 2 -C 6炔基。 烷氧基羰基，苯基，苄基，萘基，联苯基或杂环，每个对位，间位或邻位取代彼此独立地为O至3个选自卤素，-CN，-NH 2， -OH， - NO 2，COOR 5'，其中R 5选自H，C 1 -C 3烷基， C 1 -C 12烷基，（C 3 -C 8环烷基）C 0 -C 6烷基， 苯基，苄基，萘基，联苯基或杂环，C 1 -C 6烷基，C 1 -C 6亚烷基，C 1 -C 6 - 烷氧基，C 2 -C 6亚烯基，C 2 -C 6炔基或C 1 -C 6烷基， C 2 -C 6烷氧基羰基; R 6和R 7彼此独立地选自H，OH，卤素，CN，NH 2，NO 3， CO 2 3，C 1 -C 6烷基，C 1 -C 3烷基，C 1 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， C 6 -C 6烷氧基，C 2 -C 6亚烯基，C 2 -C 6亚烷基，C 2 -C 6亚烷基，C 2 -C 6亚烷基， 炔基和C 2 -C 6烷氧基羰基; R 3是H，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， 亚烷基，C 2 -C 6 -C 6炔基或其医学领域中的生理上可接受的盐及其用途，特别是抗肿瘤剂。

公开(公告)号：WO2006137101B1

公开(公告)日：2007-07-05

申请号：PCT/IT2006000470

申请日：2006-06-20

Applicant: UNIV ROMA ,  NOVELLI GIUSEPPE ,  MANGO RUGGERO ,  ROMEO FRANCESCO ,  LAURO RENATO ,  CLEMENTI FABRIZIO

Inventor： NOVELLI GIUSEPPE ,  MANGO RUGGERO ,  ROMEO FRANCESCO ,  LAURO RENATO ,  CLEMENTI FABRIZIO

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C07K14/7056 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: The invention relates to a new alternative splicing isoform of OLR1 gene encoding for the LOX-1 protein, uses and methods related to the treatment and to the prediction of the risk of cardiovascular diseases.

Abstract translation: 本发明涉及编码LOX-1蛋白的OLR1基因的新的选择性剪接同种型，与治疗相关的用途和方法，以及预测心血管疾病的风险。

公开(公告)号：WO2005005634A3

公开(公告)日：2005-02-24

申请号：PCT/IT2004000381

申请日：2004-07-09

Applicant: UNIV ROMA ,  BOZZONI IRENE ,  DENTI MICHELA ALESSANDRA ,  ROSA ALESSANDRO

Inventor： BOZZONI IRENE ,  DENTI MICHELA ALESSANDRA ,  ROSA ALESSANDRO

IPC: C12N15/113 ,  C12N15/11 ,  A61K31/713 ,  C12N15/85

CPC classification number: C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2330/30

Abstract: The authors describe an expression system for the correct, stable and effective expression in mammalian cells of a siRNA comprising: a) a polymerase II RNA-dependent promoter derived from the U1 RNA gene; downstream from the sequence b) suitable restriction sites for the cloning of the sequence transcribing the pre-siRNA; downstream from these sites c) sequences derived from the sequences at 3' of the gene for U1 snRNA that are necessary and sufficient for the correct formation of 3' of the presiRNA.

Abstract translation: 作者描述了用于siRNA在哺乳动物细胞中正确，稳定和有效表达的表达系统，其包含：a）源自U1RNA基因的聚合酶IIRNA依赖性启动子; 在序列的下游b）合适的用于克隆转录pre-siRNA的序列的限制性位点; 在这些位点的下游c）来自U1 snRNA基因3'的序列的序列，其对于正确形成3'preIRNA是必需的和足够的。