公开(公告)号：WO2010109343A1

公开(公告)日：2010-09-30

申请号：PCT/IB2010/050582

申请日：2010-02-09

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  WIECZOREK, Herfried, K. ,  BIPPUS, Rolf, Dieter

Inventor： WIECZOREK, Herfried, K. ,  BIPPUS, Rolf, Dieter

IPC: A61B5/0275 ,  G01T1/29

CPC classification number: G06T7/0081 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/037 ,  A61B6/507 ,  A61B6/541 ,  G06T7/11 ,  G06T2207/10108 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: A patient (14), at rest, is injected with a first isotope tracer. After a first uptake period, the patient is stressed and injected with a second isotope tracer. After a second isotope tracer uptake period, first and second isotope imaging data are concurrently detected by data acquiring devices (16). The first and second isotope imaging data are reconstructed into a first or rest state image, a second or stressed state image, and optionally a combined first and second isotope image. The image with the better image statistics is segmented to generate segmentation parameters, which segmentation parameters are applied to both the first or rest and second or stressed state images. In this manner, an image whose image statistics may be too weak for accurate segmentation is accurately segmented by generating two inherently aligned images and applying the same segmentation parameters to both.

Abstract translation: 静止的患者（14）注射第一同位素示踪剂。 在第一次摄取期后，患者受压并注射第二同位素示踪剂。 在第二同位素示踪剂摄取期之后，第一和第二同位素成像数据由数据获取装置（16）同时检测。 第一和第二同位素成像数据被重建成第一或静止状态图像，第二或应力状态图像，以及可选地组合的第一和第二同位素图像。 具有更好的图像统计的图像被分割以生成分割参数，这些分割参数被应用于第一或第二或应力状态图像。 以这种方式，通过产生两个固有排列的图像并且将相同的分割参数应用于两者，精确地对图像统计可能太弱以进行精确分割的图像进行分割。

公开(公告)号：WO2010041196A1

公开(公告)日：2010-04-15

申请号：PCT/IB2009/054366

申请日：2009-10-06

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  WIECZOREK, Herfried, Karl

Inventor： WIECZOREK, Herfried, Karl

IPC: G06T5/00 ,  G06T11/00

CPC classification number: G06T5/008 ,  G06T5/10 ,  G06T11/006 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20056 ,  G06T2211/416 ,  G06T2211/424

Abstract: When reconstructing low-collimation nuclear scan data (18) (e.g., SPECT) into a nuclear image volume (19), a spatial frequency-dependent (SFD) filter function is applied in Fourier space to the reconstructed image (19) to improve image resolution given a predefined number of reconstruction iterations and/or to reduce the number of reconstruction iterations required to achieve a predetermined level of image resolution. Size of an object to be imaged is determined, and the SFD filter function is determined or generated based on signal power spectrum (and/or modulated transfer function) data, object size, and desired image quality (or number of reconstruction iterations). The SFD filter function amplifies higher-energy components (e.g., corresponding to a lesion or tumor, or the like) of the spatial frequency spectrum to improve viability in a low collimated nuclear image (19) using fewer reconstruction iterations.

Abstract translation: 当将低准直核扫描数据（18）（例如，SPECT）重建成核图像体积（19）时，在傅立叶空间中将空间频率依赖（SFD）滤波函数应用于重建图像（19）以改善图像 给定预定数量的重建迭代和/或减少实现预定水平的图像分辨率所需的重建迭代次数。 确定要成像的对象的尺寸，并且基于信号功率谱（和/或调制传递函数）数据，对象大小和期望的图像质量（或重建迭代次数）来确定或生成SFD滤波器功能。 SFD滤波器功能放大空间频谱的较高能量分量（例如，对应于病变或肿瘤等），以使用更少的重建迭代来改善低准直核图像（19）中的存活力。

公开(公告)号：WO2007023401A1

公开(公告)日：2007-03-01

申请号：PCT/IB2006/052584

申请日：2006-07-27

Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V. ,  U.S. PHILIPS CORPORATION ,  WIECZOREK, Herfried ,  GOEDICKE, Andreas ,  FRACH, Thomas

Inventor： WIECZOREK, Herfried ,  GOEDICKE, Andreas ,  FRACH, Thomas

IPC: G01T1/164

CPC classification number: G01T1/1642

Abstract: A detector arrangement providing imaging information at the edge of the scintillator is provided. The detector arrangement provides complete information and improved spatial resolution. SiPMs can be used in place of PMTs in order to provide the geometrical coverage of the scintillator and improved spatial resolution. With such detector arrangements, the spatial resolution can be under 2 mm. Furthermore, the overall thickness of the detector can be substantially reduced and depth of interaction resolution is also improved.

Abstract translation: 提供了一种在闪烁体边缘处提供成像信息的检测器装置。 检测器布置提供完整的信息和改进的空间分辨率。 可以使用SiPM代替PMT，以提供闪烁体的几何覆盖和改善的空间分辨率。 利用这种检测器布置，空间分辨率可以在2mm以下。 此外，可以显着地减少检测器的总体厚度，并且还提高了相互作用分辨率的深度。

公开(公告)号：WO2006111900A3

公开(公告)日：2006-10-26

申请号：PCT/IB2006/051157

申请日：2006-04-13

Applicant: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  RONDA, Cornelis Reinder ,  ZEITLER, Günter ,  WÄDOW, Dieter ,  WIECZOREK, Herfried ,  SCHREINEMACHER, Herbert

Inventor： RONDA, Cornelis Reinder ,  ZEITLER, Günter ,  WÄDOW, Dieter ,  WIECZOREK, Herfried ,  SCHREINEMACHER, Herbert

IPC: C09K11/77 ,  G21K4/00

Abstract: The present invention is directed to a Gd 2 O 2 S: M fluorescent ceramic material with a very short afterglow, wherein M represents at least one element selected from the group Pr, Tb, Yb, Dy, Sm and/or Ho and the Gd 2 O 2 S: M fluorescent ceramic material comprises further: europium of ≤ 1 wt. ppm based on Gd 2 O 2 S, and cerium of ≥ 0.1 wt. ppm to ≤ 100 wt. ppm based on Gd 2 O 2 S, wherein the content of cerium is in excess of the content of europium with a ratio of europium to cerium of 1 : l0 to l : 150.

公开(公告)号：WO2006040707A1

公开(公告)日：2006-04-20

申请号：PCT/IB2005/053231

申请日：2005-09-30

Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V. ,  U.S. PHILIPS CORPORATION ,  WIECZOREK, Herfried, K.

Inventor： WIECZOREK, Herfried, K.

IPC: G01T1/164 ,  G21K1/02

CPC classification number: G01T1/1648 ,  A61B6/037 ,  G01T1/1615 ,  G01T1/1644 ,  G21K1/025

Abstract: A radiation imaging device suitable for SPECT or other nuclear imaging includes a detector (22) which receives radiation. A fan beam-slit collimator (20) is positioned adjacent a radiation receiving face (32) of the detector, intermediate the detector and a radiation source (12, 18). The collimator includes a plurality of slats (30) having a common focus. A body (44) adjacent the slats defines one or more elongate slits (46). The slit is arranged such that radiation passes through the slit and between the slats to the detector face. The body is at least substantially impermeable to the radiation. The fan beam-slit collimator (20) enables higher resolution or efficiency to be achieved from the detector.

Abstract translation: 适用于SPECT或其他核成像的辐射成像装置包括接收辐射的检测器（22）。 扇形光束狭缝准直器（20）位于检测器的辐射接收面（32）附近，位于检测器和辐射源（12,18）之间。 准直器包括具有共同焦点的多个板条（30）。 邻近板条的主体（44）限定一个或多个细长狭缝（46）。 狭缝被布置成使得辐射通过狭缝并且在板条之间穿过检测器面。 身体至少对辐射是不可渗透的。 扇形光束狭缝准直器（20）能够从检测器获得更高的分辨率或效率。

公开(公告)号：WO2005057235A1

公开(公告)日：2005-06-23

申请号：PCT/IB2004/052640

申请日：2004-12-02

Applicant: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  VOGTMEIER, Gereon ,  STEADMAN, Roger ,  ENGEL, Klaus Jürgen ,  WIECZOREK, Herfried ,  ECKENBACH, Wolfgang

Inventor： VOGTMEIER, Gereon ,  STEADMAN, Roger ,  ENGEL, Klaus Jürgen ,  WIECZOREK, Herfried ,  ECKENBACH, Wolfgang

IPC: G01T1/20

CPC classification number: G01T1/2018

Abstract: The invention relates to an X-ray detector with detector elements (1) arranged in a layer. The detector elements (1) contain a scintillator element (2) for the conversion of X-rays (X) into photons (v), a photodiode (5) for detection of the photons (v), and a processing circuit (4) for the processing of electric signals generated by the photodiode (5). In order to protect the electronics (4) from X-rays a shielding (3) of variable effective thickness (dl, d2) is disposed in front of the electronics (4). This shielding (3) can in particular be L-shaped. By reduction of the effective thickness of the shielding (3) to a necessary minimum the volume of the scintillator unit (2) can be maximized.

Abstract translation: 本发明涉及一种具有布置在一层中的检测器元件（1）的X射线检测器。 检测器元件（1）包括用于将X射线（X）转换成光子（v）的闪烁体元件（2），用于检测光子（v）的光电二极管（5）和处理电路（4） 用于处理由光电二极管（5）产生的电信号。 为了保护电子器件（4）免受X射线影响，可变有效厚度（d1，d2）的屏蔽（3）设置在电子器件（4）的前面。 这种屏蔽（3）可以特别是L形。 通过将屏蔽（3）的有效厚度减小到所需的最小值，可以使闪烁体单元（2）的体积最大化。

公开(公告)号：WO2011004273A2

公开(公告)日：2011-01-13

申请号：PCT/IB2010/052671

申请日：2010-06-15

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  WIECZOREK, Herfried ,  THIELE, Frank, O. ,  NARAYANAN, Manoj, V.

Inventor： WIECZOREK, Herfried ,  THIELE, Frank, O. ,  NARAYANAN, Manoj, V.

IPC: G01T1/29

CPC classification number: G01T1/2985 ,  A61B6/037

Abstract: A nuclear imaging system includes a scanner (8), such as a PET scanner. A patient is injected with a [ 13 N]ammonia radioisotope tracer which is contaminated with a small percent of 18 F contamination. The scanner receives radiation from the injected tracer and a reconstruction processor (28) reconstructs the detected radiation into image representations. A warning generator (12) generates warnings to the clinician concerning the effects of the 18 F contamination. A calibration processor (16) generates an estimated decay curve based on a time since the end of the proton bombardment which created the tracer and a priori information about the tracer. An activity meter (42) measures radiation emitted from a sample of the tracer and a dose calibrator (44) determines a decay curve from the measured radiation. Either the detected radiation is corrected in accordance with one of the decay curves during reconstruction or a correction processor (50) corrects reconstructed images in accordance with one or both of the decay curves. A display (14) displays uncorrected reconstructed images and the decay curve and/or the corrected images.

Abstract translation: 核成像系统包括诸如PET扫描仪的扫描器（8）。 注射一个[13 N]氨放射性同位素示踪剂，其被少量的18 F污染污染。 扫描仪接收来自被注入示踪剂的辐射，并且重建处理器（28）将检测到的辐射重建成图像表示。 警告发生器（12）向临床医生发出关于18 F污染的影响的警告。 校准处理器（16）基于自产生示踪剂的质子轰击结束以及关于示踪剂的先验信息之后的时间产生估计衰减曲线。 活性计量器（42）测量从示踪剂的样品发射的辐射，剂量校准器（44）从测量的辐射确定衰减曲线。 根据重建期间的衰减曲线之一校正检测到的辐射，或者校正处理器（50）根据衰减曲线中的一个或两个校正重建图像。 显示器（14）显示未校正的重建图像和衰减曲线和/或校正图像。

公开(公告)号：WO2009022270A3

公开(公告)日：2009-06-25

申请号：PCT/IB2008053165

申请日：2008-08-06

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  WIECZOREK HERFRIED K

Inventor： WIECZOREK HERFRIED K

IPC: A61B5/11 ,  G01T1/164

CPC classification number: A61B5/1127 ,  A61B5/055 ,  A61B5/706 ,  A61B6/037 ,  A61B6/4258 ,  A61B90/39 ,  A61B2090/3937 ,  A61B2090/3945

Abstract: In a medical system, at least one medically operative member (10, 12, 100) is configured to interact with or acquire data from a subject (74) disposed in an examination region. An array of photosensors (70, 170) is disposed on the at least one medically operative member. The array of photosensors is arranged to view the examination region. A position-determining member (82, 82a, 82b) is configured to determine a position of at least one optically detectable marker (72, 172) disposed with the subject in the examination region based on light from the at least one optically detectable marker sensed by the array of photosensors.

Abstract translation: 在医疗系统中，至少一个医疗操作的构件（10,12,100）配置成与设置在检查区域中的被检体（74）相互作用或从其获取数据。 一组光传感器（70,170）设置在至少一个医疗操作部件上。 安排了一系列光传感器来查看检查区域。 位置确定构件（82,82a，82b）被配置为基于所检测到的至少一个光学可检测标记的光来确定在检查区域中与受检者一起设置的至少一个光学可检测标记（72,172）的位置 通过光电传感器阵列。

公开(公告)号：WO2008036517A3

公开(公告)日：2008-03-27

申请号：PCT/US2007/077978

申请日：2007-09-10

Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V. ,  U. S. PHILIPS CORPORATION ,  GOEDICKE, Andreas, G. ,  WIECZOREK, Herfried, K. ,  DORSCHEID, Ralf ,  SCHAAF, Michael

Inventor： GOEDICKE, Andreas, G. ,  WIECZOREK, Herfried, K. ,  DORSCHEID, Ralf ,  SCHAAF, Michael

IPC: G01T1/00

Abstract: In a disclosed imaging method, the instantaneous speed or data acquisition dwell times of a detector head (14, 16) is optimized as a function of position along a path (P) of the detector head around a subject (S, SS, SXL). The optimization is respective to an expected radioactive emission profile (EPROI) of a region of interest (H, HS, HXL) that is less than the entire subject. The detector head is traversed along the path using the optimized instantaneous speed or data acquisition dwell times (40). During the traversing, imaging data are acquired using the detector head. The acquired imaging data are reconstructed to generate a reconstructed image of at least the region of interest. A gamma camera (10) configured to perform the foregoing imaging method is also disclosed.

公开(公告)号：WO2006111900A2

公开(公告)日：2006-10-26

申请号：PCT/IB2006051157

申请日：2006-04-13

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  RONDA CORNELIS REINDER ,  ZEITLER GUENTER ,  WAEDOW DIETER ,  WIECZOREK HERFRIED ,  SCHREINEMACHER HERBERT

Inventor： RONDA CORNELIS REINDER ,  ZEITLER GUENTER ,  WAEDOW DIETER ,  WIECZOREK HERFRIED ,  SCHREINEMACHER HERBERT

CPC classification number: C04B35/547 ,  C04B35/64 ,  C04B35/645 ,  C04B2235/3224 ,  C04B2235/3229 ,  C04B2235/6581 ,  C04B2235/662 ,  C04B2235/786 ,  C09K11/7771 ,  G21K4/00

Abstract: The present invention is directed to a Gd 2 O 2 S: M fluorescent ceramic material with a very short afterglow, wherein M represents at least one element selected from the group Pr, Tb, Yb, Dy, Sm and/or Ho and the Gd 2 O 2 S: M fluorescent ceramic material comprises further: europium of = 1 wt. ppm based on Gd 2 O 2 S, and cerium of = 0.1 wt. ppm to = 100 wt. ppm based on Gd 2 O 2 S, wherein the content of cerium is in excess of the content of europium with a ratio of europium to cerium of 1 : l0 to l : 150.

Abstract translation: 本发明涉及具有非常短的余辉的Gd 2 O 2 S 2 M荧光陶瓷材料，其中M表示选自Pr， Tb，Yb，Dy，Sm和/或Ho和Gd 2 O 2 S 2 M荧光陶瓷材料进一步包括：铕= 1wt。 基于Gd 2 O 2 S的ppm和= 0.1重量％的铈。 ppm至= 100重量％ ppm，基于Gd 2 O 2 S，其中铈的含量超过铕的含量，铕与铈的比例为1:10至1： 150。