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公开(公告)号：KR101826747B1
公开(公告)日：2018-02-08
申请号：KR1020110065010
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: C07D309/40 , A61K8/49 , A61K8/35 , A61Q19/02
Abstract: 본발명은하기화학식 1로표시되는코지산유도체및 그의약학적으로허용가능한염, 이의제조방법및 이를유효성분으로함유하는피부미백용조성물을제공한다. (상기식 중, 상기 R및 R는각각독립적으로탄소수 1 내지 3의알콕시, 히드록시및 수소로이루어진군에서선택되는하나이고, R및 R가모두수소인경우는제외한다.) 본발명에따른코지산유도체및 그의약학적으로허용가능한염을유효성분으로함유하는피부미백용조성물은피부에대한안전성을가지면서멜라닌생성억제효과가우수하여피부의색소침착을억제하므로, 미백을목적으로하는피부외용제에유용하게적용될수 있다.
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公开(公告)号：KR101604053B1
公开(公告)日：2016-03-16
申请号：KR1020110078309
申请日：2011-08-05
Applicant: (주)아모레퍼시픽
IPC: C07C235/46 , C07C235/48 , A61K8/42 , A61Q19/02
CPC classification number: A61K8/42 , A61Q19/00 , A61Q19/02 , C07C235/46 , C07C235/48 , C07C2603/74
Abstract: 본발명은신규벤조산아미드유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을개시한다. 상기신규화합물등은뛰어난피부미백효과를가진다.
Abstract translation: 本发明公开了一种新的苯甲酸酰胺衍生物化合物，其异构体，其药学上可接受的盐，其前药，其水合物或其溶剂化物。 新化合物等具有优异的皮肤美白效果。
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公开(公告)号：KR1020140012274A
公开(公告)日：2014-02-03
申请号：KR1020120078675
申请日：2012-07-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/145 , A23L29/035 , A23L29/045 , A23L29/055 , A23V2200/318 , A61K8/46 , A61K8/63 , A61K31/575 , A61Q19/02 , G01N33/5044
Abstract: Disclosed are: a skin whitening agent containing a liver X receptor agonist as an effective component; and a screening method of a skin whitening material including a step of checking the promotion degree of liver X receptor expression or activation of cells by a candidate substance. [Reference numerals] (AA,BB) Amount of melanin(%)
Abstract translation: 公开了含有肝X受体激动剂作为有效成分的皮肤增白剂; 以及皮肤美白材料的筛选方法，其包括检查候选物质的肝脏X受体表达的促进度或细胞活化的步骤。 [参考号]（AA，BB）黑色素含量（％）
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公开(公告)号：KR1020160105646A
公开(公告)日：2016-09-07
申请号：KR1020150028474
申请日：2015-02-27
Applicant: (주)아모레퍼시픽
IPC: G01N33/50
CPC classification number: G01N33/50 , G01N33/5044 , C12N2502/091
Abstract: 본명세서의일측면에서는미백성분의부작용을예측하는방법으로서, 상기방법은, ⅰ) 미백성분의장시간사용에따른독성증가폭ⅱ) 미백효능농도와세포독성농도의차이ⅲ) 자외선전처리에따른미백성분에대한민감도증가폭중 하나이상을측정하는것을포함하는방법을제공하며, 상기방법은미백성분을장시간사용할경우의부작용발생여부를효과적으로예측하는효과가있다.
Abstract translation: 本发明的一个方面涉及一种预测增白组分的副作用的方法。 该方法包括以下步骤中的至少一个：i）相对于长期使用美白组分的毒性增加量; ii）表现出增白效果的美白组分浓度与表现出细胞毒性的浓度之间的差异; 和iii）增白组分相对于紫外线处理作为预处理的灵敏度的增加量。 该方法有效地预测当美白组分长时间使用时是否发生副作用。
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Patent Agency Ranking
公开(公告)号：KR101338681B1
公开(公告)日：2013-12-09
申请号：KR1020117031657
申请日：2010-06-18
Applicant: (주)아모레퍼시픽
CPC classification number: A23L33/105 , A23V2002/00 , A23V2200/318
Abstract: 본 발명은 밤껍질 추출물을 유효 성분으로 포함하는 가려움증 완화 또는 억제용 건강 식품 또는 약학 조성물에 관한 것이다. 본 발명에 따른 건강 식품 또는 약학 조성물에 포함되는 밤껍질 추출물은 본 발명에 따른 하나의 실시예에서, 가려움의 자극원인 단백분해효소 활성 수용체-2(Proteinase-Activated Receptor-2: PAR-2)의 활성을 억제함으로써, 우수한 가려움증 완화 또는 억제 효과를 발휘할 수 있음이 확인되었는 바, 가려움증 완화 또는 억제용 건강 식품 또는 약학 조성물의 유효 성분으로 적합하게 사용될 수 있다.
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公开(公告)号：KR1020130004616A
公开(公告)日：2013-01-14
申请号：KR1020110065010
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: C07D309/40 , A61K8/49 , A61K8/35 , A61Q19/02
Abstract: PURPOSE: A kojic acid derivative and a cosmetic composition containing the same for skin whitening are provided to suppress melanogenesis and pigmentation with skin safety and to be applied to an external use skin formulation. CONSTITUTION: A kojic acid derivative is denoted by chemical formula 1. A method for preparing the derivative of chemical formula 1 and a pharmaceutically acceptable salt thereof comprises a step of reacting halo kojic acid of chemical formula 2 and inorganic salts of benzoic acid containing an adamantane group of chemical formula 3 to prepare a kojic ester compound. A method for preparing a derivative and pharmaceutically acceptable salt comprises: a step of reacting the kojic acid with halo-thionyl and preparing halo kojic acid; a step of reacting adamantane with benzoic acid containing a substituent of hydrogen, hydroxyl, or alkoxy of 1-3 carbon atoms and preparing benzoic acid containing the adamantane group; a step of reacting an inorganic compound with the benzoic acid and preparing inorganic salts; and a step of reacting prepared kojic acid chloride and inorganic salt of benzoic acid and preparing a kojic acid ester compound. A composition for whitening contains 0.01-20 wt% of the derivative and pharmaceutically acceptable salts thereof as active ingredients.
Abstract translation: 目的：提供曲酸衍生物和含有其的用于皮肤美白的化妆品组合物以抑制黑色素生成和皮肤安全性的色素沉积并施用于外用皮肤制剂。 组合物：曲酸衍生物由化学式1表示。制备化学式1的衍生物的方法及其药学上可接受的盐包括使化学式2的卤代曲酸与含有金刚烷的苯甲酸的无机盐反应的步骤 化学式3组，以制备曲酸酯化合物。 制备衍生物和药学上可接受的盐的方法包括：使曲酸与卤代亚硫酰基反应并制备卤代曲酸的步骤; 使金刚烷与含有1-3个碳原子的氢，羟基或烷氧基的取代基的苯甲酸反应并制备含有金刚烷基的苯甲酸的步骤; 使无机化合物与苯甲酸反应并制备无机盐的步骤; 和使制备的曲酸酰氯和苯甲酸的无机盐反应并制备曲酸酯化合物的步骤。 用于增白的组合物含有0.01-20重量％的衍生物和其药学上可接受的盐作为活性成分。
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公开(公告)号：KR1020160116861A
公开(公告)日：2016-10-10
申请号：KR1020150045201
申请日：2015-03-31
Applicant: (주)아모레퍼시픽
IPC: C07C233/70 , A61K8/42 , A61K31/166 , A23L1/30 , A61Q19/00
CPC classification number: C07C233/70 , A61K8/42 , A61K31/166 , A61Q19/00 , A61Q19/02
Abstract: 본발명은신규벤조산아마이드유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을개시한다. 상기신규화합물등은멜라닌생성을억제하고, 타이로시나제활성을저해하며, 뛰어난피부미백효과를가진다.
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公开(公告)号：KR1020130003171A
公开(公告)日：2013-01-09
申请号：KR1020110064294
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition containing a fermentation of a Fraxinus rhynchophylla Hance extract is provided to suppress tyrosinase activation and melanogenesis and to ensure excellent skin whitening effect. CONSTITUTION: A composition for skin whitening contains 0.001-20 wt% of a fermentation of a Fraxinus rhynchophylla Hance as an active ingredient. The extract is prepared using water, an organic solvent, or a mixture thereof. The fermentation is preparing by fermenting the extract with yeast such as Saccaromyces sp., Schizosaccharomyces sp., Torulopsis sp., Rhodotorula sp., or Candida ap. The composition is a cosmetic or pharmaceutical composition.
Abstract translation: 目的：提供含有Fraxinus rhynchophylla Hance提取物发酵的组合物，以抑制酪氨酸酶活化和黑素生成，并确保优异的皮肤美白效果。 构成：用于皮肤美白的组合物含有作为活性成分的Fraxinus rhynchophylla Hance的发酵量的0.001-20重量％。 提取物是用水，有机溶剂或其混合物制备的。 发酵是通过用酵母如Saccaromyces sp。，粟酒裂殖酵母属（Saccharomyces sp。），Torulopsis sp。，红酵母属（Rhodotorula sp。）或假丝酵母（Candida ap）发酵提取物制备的。 组合物是化妆品或药物组合物。
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公开(公告)号：KR1020120027432A
公开(公告)日：2012-03-21
申请号：KR1020117031657
申请日：2010-06-18
Applicant: (주)아모레퍼시픽
CPC classification number: A23L33/105 , A23V2002/00 , A23V2200/318
Abstract: PURPOSE: Health food or pharmaceutical composition including containing a chestnut skin extract is provided to reduce the pruritus of a user. CONSTITUTION: Health food or pharmaceutical composition contains 0.005-80wt% of chestnut skin extract for reducing or controlling the pruritus of a user. The chestnut skin is selected from the inner skin, the outer skin, or their mixture. The chestnut skin extract is obtained by extracting the chestnut skin using water, low class alcohol having 1-4 carbons, 1,3-butyl glycol, or their mixed solution.
Abstract translation: 目的：提供包含栗子皮肤提取物的保健食品或药物组合物，以减少使用者的瘙痒。 规定：保健食品或药物组合物含有0.005-80wt％的栗子皮肤提取物，用于减少或控制使用者的瘙痒。 板栗皮肤选自内皮，外皮或其混合物。 栗子皮提取物是通过使用水，含1-4碳的低级醇，1,3-丁二醇或它们的混合溶液提取栗子皮来获得的。
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