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公开(公告)号：KR1020110056820A
公开(公告)日：2011-05-31
申请号：KR1020090113295
申请日：2009-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q17/04 , A61K8/37 , A61K8/4946
Abstract: PURPOSE: A composition containing octyl salicylate or phenylbenaimidazole sulfonic acid is provided to effectively block UVC and UVB. CONSTITUTION: A composition for blocking UVC contains one or more selected from the group consisting of octyl salicylate or phenylbenzimidazole sulfonic acid as an active ingredient. The composition is used in the form of solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, foundation, oil-in-water, or water-in-oil. The maximum absorbance is in the wavelength of 200-290 nm.
Abstract translation: 目的：提供含有辛基水杨酸酯或苯乙咪唑磺酸的组合物，以有效阻断UVC和UVB。 构成：用于封闭UVC的组合物含有选自水杨酸辛酯或苯基苯并咪唑磺酸作为活性成分的一种或多种。 该组合物以溶液，悬浮液，乳液，糊剂，凝胶，霜剂，洗剂，粉末，肥皂，含表面活性剂的清洁剂，油，粉底液，水包油或油包水的形式使用。 最大吸光度为200-290nm波长。
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公开(公告)号：KR101663971B1
公开(公告)日：2016-10-12
申请号：KR1020100037969
申请日：2010-04-23
Applicant: (주)아모레퍼시픽
IPC: A61K36/185 , A61K8/97 , A61K9/00 , C12N5/0775
Abstract: 본발명은인간중간엽줄기세포의지방세포로의분화를촉진하는조성물에관한것으로, 보다상세하게는미후도및 미후등추출물중 적어도 1종이상을유효성분으로함유하여인간중간엽줄기세포를지방세포로분화하는것을촉진시킴으로써지방체(Lipid droplet)를생성하여피부의볼륨과탄력을증진시키고주름을개선시키는조성물에관한것이다.
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公开(公告)号：KR101637973B1
公开(公告)日：2016-07-11
申请号：KR1020137016899
申请日：2011-01-03
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/00 , A61K8/97 , A61K36/58 , A61K36/62 , A61K2300/00
Abstract: 본발명은새로운피부자극완화제로서고련피및 연꽃잎추출물을함유하는항산화용및 황사에의한피부유해영향완화용조성물에관한것이다. 구체적으로, 본발명은고련피및 연꽃잎추출물을함유하여, 독소를해독하는효소인 NQO1, 독소를배출하는효소인 GSTT1의발현을증가시켜독소를해독및 배출하고, 자연면역인자인피부항균펩타이드 hBD3의발현을증가시켜피부를보호하며, GPX1, 카탈라아제(catalase), Trx1, Prdx1의항산화단백질의발현을증가시켜활성산소의생성을억제함으로써피부보호및 노화억제의효과를갖는다.
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15.发明授权황사에 의한 피부 자극 인자, 피부 자극 유도 방법, 상기 피부 자극 인자를 억제시키고 피부 자극을 완화시키는 물질을 스크리닝하는 방법 및 상기 방법으로 스크리닝된 물질을 함유하는 피부 외용제 조성물 有权黄沙的皮肤刺激因素以及诱导皮肤刺激和筛选抑制皮肤刺激因子的材料的方法，减轻角质形成细胞中的皮肤刺激和包含通过该方法筛选的材料的外用皮肤组合物
公开(公告)号：KR101566818B1
公开(公告)日：2015-11-09
申请号：KR1020080117680
申请日：2008-11-25
Applicant: (주)아모레퍼시픽 , 고려대학교 산학협력단
IPC: A61K31/195 , C12Q1/68 , A61K31/352
Abstract: 본발명은각질형성세포에황사를처리하여발현량이유의적으로증가한물질을스크리닝함으로써황사에의한피부자극을유도하는데관여하는물질을스크리닝하는방법, 각질형성세포내에서 AhR 또는 CYP 단백질의발현량을증가시켜황사에의한피부자극을유도하는방법, 포유류에서 AhR 또는 CYP의발현을억제시킴으로써황사로인한피부자극을완화시키는방법, 상기황사에의한피부자극인자의발현정도를측정함으로써황사에의한피부자극을완화시키는물질을스크리닝하는방법, 및상기방법으로스크리닝된물질, 즉황사에의한피부자극을완화시키는물질을유효성분으로함유하는피부외용제조성물을제공한다.
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Patent Agency Ranking
公开(公告)号：KR1020120002482A
公开(公告)日：2012-01-05
申请号：KR1020110064247
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K38/16 , A61K31/7105 , A61P17/00
CPC classification number: A61K31/7105 , A61K8/64 , A61K31/7115 , A61K38/005 , A61K48/005 , A61Q19/08
Abstract: PURPOSE: A composition containing an oligonucleotide or mimic acting as an inhibitor of miRNA-526b is provided to control collagen generation and to prevent or treat aging. CONSTITUTION: A composition for controlling collagen contains 15-23 serial nucleotides of sequence number 1. The collagen is controlled by regulating the expression of matrix metalloproteinase 1(MMP1). The oligonucleotide reduces or suppresses the expression of MMP1 by hybridization with MMP1 mRNA. The composition is used for anti-aging.
Abstract translation: 目的：提供含有作为miRNA-526b抑制剂的寡核苷酸或模拟物的组合物，以控制胶原蛋白的产生和预防或治疗老化。 构成：用于控制胶原的组合物含有序列1的15-23个连续核苷酸。通过调节基质金属蛋白酶1（MMP1）的表达来控制胶原蛋白。 寡核苷酸通过与MMP1 mRNA杂交降低或抑制MMP1的表达。 该组合物用于抗衰老。
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17.发明公开꽃가루, 집먼지 진드기 또는 황사에 의한 피부 유해반응을 스크리닝하는 방법 및 이를 조절하는 피부 외용제 조성물 有权用于通过花粉，房尘螨或黄锈砂筛选皮肤有害反应的方法，以及用于控制反应的皮肤外部应用的组合物
公开(公告)号：KR1020100060752A
公开(公告)日：2010-06-07
申请号：KR1020080119483
申请日：2008-11-28
Applicant: (주)아모레퍼시픽
CPC classification number: G01N33/5023 , A61K36/58 , C12Q1/6844 , C12Q2600/136 , G01N33/15
Abstract: PURPOSE: A method for screening a material which relieves skin irritation by environmental harmful factor is provided to manufacture an external use formulation and to detoxify. CONSTITUTION: A method for screening a material which relieves skin irritation by environmental harmful factor comprises: a step of treating candidates which regulates intracellular factor in vitro; a step of treating the environmental harmful factor to test cells to induce overexpression of the factor; and a step of measuring expression level. The test cells are keratinocytes. The environmental harmful factor is pollen or yellow sand. The overexpressed factor is interleukin 6 or 8, GSTT1, NQ01, or hBD3. The screened material is Melia azedarach L. var. japonica Makino or Tussilago farfara L. extract.
Abstract translation: 目的：提供一种用于筛选由环境有害因素减轻皮肤刺激的物质的方法，以制造外用制剂和解毒。 构成：通过环境有害因子筛选缓解皮肤刺激的材料的方法包括：处理体外调节细胞因子的候选物的步骤; 治疗环境有害因素以测试细胞以诱导因子过表达的步骤; 以及测量表达水平的步骤。 测试细胞是角质形成细胞。 环境有害因素是花粉或黄沙。 过表达因子是白细胞介素6或8，GSTT1，NQ01或hBD3。 筛选的材料是Melia azedarach L. var。 粳稻或东方龙草L.提取物。
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18.发明公开황사에 의한 피부 자극 인자, 피부 자극 유도 방법, 상기 피부 자극 인자를 억제시키고 피부 자극을 완화시키는 물질을 스크리닝하는 방법 및 상기 방법으로 스크리닝된 물질을 함유하는 피부 외용제 조성물 有权皮肤刺激因子，含有黄皮质，以及诱导皮肤刺激和筛选抑制皮肤刺激因子的材料的方法，评估杀菌剂中的皮肤刺激，以及包含通过该方法筛选的材料的皮肤外部应用的组合物
公开(公告)号：KR1020100059042A
公开(公告)日：2010-06-04
申请号：KR1020080117680
申请日：2008-11-25
Applicant: (주)아모레퍼시픽 , 고려대학교 산학협력단
IPC: A61K31/195 , C12Q1/68 , A61K31/352
CPC classification number: A61K31/195 , A61K31/352 , C12Q1/6844 , C12Q2600/136 , C12Q2600/158 , G01N33/15 , G01N33/5023
Abstract: PURPOSE: A method for screening a material which induces skin irritation by yellow dust is provided to reduce skin irritative factor expression and to reduce skin irritation by yellow dust. CONSTITUTION: A method for screening a material which induces skin irritation by yellow dust comprises: a step of treating yellow dust to keratinocytes; and a step of screening a gene of which expression level is significantly changed comparing with the expression of normal keratinocytes through RT-PCR. The material which induces skin irritation by yellow dust is AhR or CYP. A method for screening a material which relieves skin irritation by yellow dust comprises: a step of treating yellow dust to test cells to induce overexpression of an irritative factor; a step of treating a candidate material to the overexpressed cells; a step of measuring expression level of the irritative factor by RT-PCR. The material which relieves skin irritation by yellow dust is Trichosanthis semen. An external use skin composition for relieving skin irritation contains 0.001-1 weight% of Trichosanthis semen.
Abstract translation: 目的：提供一种筛选黄色粉尘引起皮肤刺激的材料的方法，以减少皮肤刺激因子的表达，并减少黄色粉尘的皮肤刺激。 构成：用于筛选黄色粉尘引起皮肤刺激的材料的方法包括：将黄色粉末处理成角质形成细胞的步骤; 与通过RT-PCR的正常角质化细胞的表达相比，筛选其表达水平显着变化的基因的步骤。 黄色粉尘引起皮肤刺激的物质是AhR或CYP。 用于筛选减轻黄色粉尘对皮肤刺激的材料的方法包括：处理黄色粉尘以测试细胞以诱导刺激性因子的过度表达的步骤; 将候选材料处理到过表达细胞的步骤; 通过RT-PCR测定刺激因子的表达水平的步骤。 减轻黄色粉尘的皮肤刺激性的物质是Trichosanthis精液。 用于缓解皮肤刺激的外用皮肤组合物含有0.001-1重量％的Trichosanthis精液。
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公开(公告)号：KR1020100056239A
公开(公告)日：2010-05-27
申请号：KR1020080115315
申请日：2008-11-19
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition containing polysaccharides for adsorbing heavy metal and micro dust is provided to reduce skin inflammation caused by heavy metal and micro dust, and to prevent skin trouble. CONSTITUTION: A cosmetic composition for adsorbing heavy metal and micro dust contains 0.01-20.0 weight% of Schizopyllum commune, seaweed, and ginseng polysaccharides as active ingredient. The Schizopyllum commune polysaccharide is beta-1,3-glucan. The seaweed polysaccharide is Laminaria digitata polysaccharide. A method for producing the polysaccharides comprises: a step of culturing mycelium of Schizopyllum commune, seaweed, or ginseng; a step of extracting with water to obtain water soluble fraction; a step of freeze-drying and extracting with methanol to obtain methanol insoluble fraction; a step of extracting with ethanol to obtain ethanol insoluble fraction; and a step of eluting by column chromatography.
Abstract translation: 目的：提供含有重金属和微粉尘多糖的化妆品组合物，以减少重金属和微尘引起的皮肤炎症，防止皮肤发生麻烦。 构成：用于吸附重金属和微尘的化妆品组合物含有0.01-20.0重量％的裂殖酵母，海藻和人参多糖作为活性成分。 裂殖酵母多糖是β-1,3-葡聚糖。 海藻多糖是层状多糖。 制备多糖的方法包括：培养裂殖酵母菌丝，海藻或人参的菌丝体的步骤; 用水萃取得到水溶性成分的步骤; 用甲醇进行冷冻干燥萃取，得到不溶于甲醇的级分; 用乙醇萃取得到乙醇不溶级分的步骤; 和通过柱色谱法洗脱的步骤。
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公开(公告)号：KR101904918B1
公开(公告)日：2018-10-08
申请号：KR1020110116647
申请日：2011-11-09
Applicant: (주)아모레퍼시픽
Abstract: 본발명은피부색소침착조절물질을스크리닝하는방법에관한것이다. 본명세서에기재된기술을이용하면, 피부에유용한피부색소침착조절용물질을스크리닝할수 있다. 또한, 본발명의세포간, 세포내 신호전달인자및 전사인자를조절함으로써, 피부멜라닌양의감소또는증가에의하여발생하는저색소증또는과색소침착증등의질환을효과적으로개선할수 있다. 즉, 자외선에의한피부흑화뿐만아니라, 아토피나건선에의한 2차적인피부저색소증및 색소이상증, 피부염증이관여한다고알려져있는기미, 점(nevi), 흑자, 검버섯과같은피부과색소침착증, 백반증또는백모와같은색소결여증에유용한물질을스크리닝할수 있고그 스크리닝된 물질을사용하여상기증상들을개선, 치료할수 있다.
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