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公开(公告)号：KR1020100028608A
公开(公告)日：2010-03-12
申请号：KR1020100007230
申请日：2010-01-27
Applicant: (주)다림티센
Abstract: PURPOSE: A collagen base matrix as a texture restoration material and a method for manufacturing the same are provided, which can enhance the mechanical strength and prevent the porous film from being partly destroyed in the manufacturing process. CONSTITUTION: A method for manufacturing a collagen base matrix as a texture restoration material comprises: a step of forming a collagen porous layer by freeze-drying after forming the uniform film of the constant thickness by dispersing the collagen in the fixed thickness; and a step of forming a collagen hard layer with a dense tissue by compacting collagen particles and discharging water.
Abstract translation: 目的：提供作为纹理恢复材料的胶原基质基质及其制造方法，其可以在制造过程中增强机械强度并防止多孔膜部分破坏。 构成：作为纹理恢复材料的胶原基质基质的制造方法包括：通过将固定厚度的胶原分散而形成固定厚度的均匀膜后，通过冷冻干燥形成胶原多孔层的工序; 以及通过压实胶原颗粒并排出水来形成具有致密组织的胶原蛋白硬质层的步骤。
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公开(公告)号：KR101811391B1
公开(公告)日：2017-12-21
申请号：KR1020170133105
申请日：2017-10-13
Applicant: (주)다림티센 , 서울대학교산학협력단
Abstract: 본발명은콜라겐기반의 BMP 전달체에비스포스포네이트를함유시키고선택적으로헤파린을고정하여콜라겐기반의 BMP 전달체에서콜라겐과 BMP의친화성을높임으로써, 적정농도의 BMP를지속적으로방출할수 있고 BMP의방출속도및 방출정도를조절할수 있는콜라겐기반의서방형 BMP 전달체및 이의제조방법을제공한다. 본발명에따르면적정농도의 BMP를지속적으로방출함으로써골수유래중간엽줄기세포의골분화를유도및 촉진할수 있고, 또한골결손부에서는골형성내지골재생을촉진할수 있다.
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公开(公告)号：KR101790782B1
公开(公告)日：2017-10-26
申请号：KR1020150086395
申请日：2015-06-18
Applicant: (주)다림티센 , 서울대학교산학협력단
Abstract: 본발명은콜라겐기반의 BMP 전달체에비스포스포네이트를함유시키고선택적으로헤파린을고정하여콜라겐기반의 BMP 전달체에서콜라겐과 BMP의친화성을높임으로써, 적정농도의 BMP를지속적으로방출할수 있고 BMP의방출속도및 방출정도를조절할수 있는콜라겐기반의서방형 BMP 전달체및 이의제조방법을제공한다. 본발명에따르면적정농도의 BMP를지속적으로방출함으로써골수유래중간엽줄기세포의골분화를유도및 촉진할수 있고, 또한골결손부에서는골형성내지골재생을촉진할수 있다.
Abstract translation: 含有双膦酸BMP的和可选地通过增加胶原蛋白和BMP uichin的火星BMP递送系统固定肝素胶原为基础的，可以继续发射足够浓度的BMP和释放速率，和基于胶原的释放的BMP递送系统的本发明 胶原基缓释BMP载体及其制造方法。 在根据本发明通过BMP的持续释放至合适的浓度并能诱导和促进的骨髓来源的间充质干细胞的分化骨，也能促进骨形成骨再生骨缺损。
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公开(公告)号：KR101735560B1
公开(公告)日：2017-05-16
申请号：KR1020150045477
申请日：2015-03-31
Applicant: 재단법인 아산사회복지재단 , (주)다림티센
Abstract: 본발명은양이온화아텔로콜라겐, 헤파린, 췌도세포및 중간엽줄기세포의복합체를포함하는당뇨병치료용약학조성물, 상기복합체를포함하는췌도세포이식용조성물및 상기복합체를포함하는인공췌장에관한것이다. 본발명에서제공하는양이온화아텔로콜라겐, 헤파린, 췌도세포및 중간엽줄기세포의복합체를포함하는조성물은, 그자체로서인슐린을효과적으로분비생산할수 있을뿐만아니라췌도세포를안정화시킬수 있으므로, 보다효과적인당뇨병의치료에널리활용될수 있을것이다.
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公开(公告)号：KR1020130101488A
公开(公告)日：2013-09-13
申请号：KR1020130099743
申请日：2013-08-22
Applicant: (주)다림티센 , 울산대학교 산학협력단
CPC classification number: A61L27/24 , A61K35/39 , A61L27/3804 , C12N5/0676 , C12N11/02 , C12N2533/54 , C12N2533/74
Abstract: PURPOSE: A method for culturing islet cells using atelocollagen is provided to effectively culture islet cells using a cationized atelocollagen or crosslinked atelocollagen support which is acquired by ionizing high purity atelocollagen. CONSTITUTION: A method for culturing islet cells using atelocollagen comprises the steps of preparing a cationized atelocollagen solution; applying the cationized atelocollagen solution on a culture container and drying to form a cationized atelocollagen support; inoculating islet cells to the cationized atelocollagen solution; and culturing the inoculated islet cells in the cationized atelocollagen solution or on the cationized atelocollagen support. [Reference numerals] (AA) Number of islet cells; (BB) 1 day; (CC) 3 weeks; (DD) 8 weeks
Abstract translation: 目的：提供使用小胶原蛋白培养胰岛细胞的方法，以有效培养胰岛细胞，使用通过离子化高纯度胶原蛋白获得的阳离子化的阿胶原或交联的阿胶原载体。 构成：使用阿胶囊培养胰岛细胞的方法包括制备阳离子化的胶原蛋白溶液的步骤; 将阳离子化的胶原凝胶溶液施加到培养容器上并干燥以形成阳离子化的胶原蛋白载体; 将胰岛细胞接种到阳离子化的胶原蛋白溶液中; 并在阳离子化的胶原蛋白溶液或阳离子化的胶原蛋白载体上培养接种的胰岛细胞。 （附图标记）（AA）胰岛细胞数; （BB）1天; （CC）3周; （DD）8周
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Patent Agency Ranking
公开(公告)号：KR1020120001704A
公开(公告)日：2012-01-04
申请号：KR1020110120742
申请日：2011-11-18
Applicant: (주)다림티센
Abstract: PURPOSE: A method for preparing esterified atellocollagen is provided to ensure excellent biocompatibility and to be applied in various types. CONSTITUTION: A method for preparing esterified atellocollagen comprises: a step of preparing atellocollagen dispersion solution and adding acid; a step of neutralizing atellocollagen dispersion solution; a step of centrifuging the atellocollagen dispersion solution to collect esterified atellocollagen precipitate; a step of performing dialysis of the precipitate in purified water; and a step of freeze-drying the precipitate.
Abstract translation: 目的：提供一种制备酯化的atolacollagen的方法，以确保优异的生物相容性并应用于各种类型。 构成：制备酯化的atolacollagen的方法包括：制备atellocollagen分散液并加入酸的步骤; 中和阿托洛胶分散液的步骤; 离心该胶原分散液以收集酯化的胶原沉淀物的步骤; 在纯净水中进行沉淀物透析的步骤; 和冷冻干燥沉淀物的步骤。
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公开(公告)号：KR1020110125772A
公开(公告)日：2011-11-22
申请号：KR1020100045322
申请日：2010-05-14
Applicant: (주)다림티센
CPC classification number: C07K14/78 , A61L27/24 , Y10T428/249988
Abstract: PURPOSE: A method for isolating atelocollagen is provided to efficiently and simply remove impurity through a single process. CONSTITUTION: A method for isolating atelocollagen comprises: a step of preparing a sample containing telopeptide-removed atelocollagen in a container; a step of passing the sample containing atelocollagen through a filter; a step of collecting atelocollagen solution and measuring flow of the atelocollagen solution to determine ultrafiltration speed; a step of stopping ultrafiltration; a step of adding water to unfiltered materials and performing diafiltration process; and a step of collecting filtered atelocollagen solution.
Abstract translation: 目的：提供一种隔离无胶原蛋白的方法，以通过单一过程有效和简单地去除杂质。 构成：分离无胶原蛋白的方法包括：在容器中制备含有去离子肽胶原的样品的步骤; 使含有胶原蛋白的样品通过过滤器的步骤; 收集胶原蛋白溶液并测量阿胶囊溶液的流量以确定超滤速度的步骤; 停止超滤的一个步骤; 向未过滤材料加水并进行渗滤的步骤; 和收集过滤的胶原蛋白溶液的步骤。
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19.发明公开
公开(公告)号：KR1020130101204A
公开(公告)日：2013-09-13
申请号：KR1020120022152
申请日：2012-03-05
Applicant: (주)다림티센 , 울산대학교 산학협력단
CPC classification number: A61K35/39 , A61L27/26 , A61L27/3804 , C12N5/0676 , C12N11/02 , C12N2533/54 , C12N2533/74 , C08L89/06 , C08L5/04
Abstract: PURPOSE: A manufacturing method of a carrier for the islet cell transplantation using atelocollagen, and an artificial pancreas manufactured using the same are provided to be able to efficiently incubate islet cells and provide a carrier for the islet cell transplantation with an excellent stability and an artificial pancreas by using cationized atelocollagen. CONSTITUTION: A manufacturing method of a carrier for the islet cell transplantation comprises the following steps: a cationized atelocollagen solution and an alginate solution are mixed; islet cells are mixed in the mixed solution of the cationized atelocollagen solution and the alginate solution; an islet cell complex, which is surrounded by the mixed solution of the cationized atelocollagen solution and the alginate solution and mixed with islet cells, is formed; an islet cell complex, which is surrounded by the mixed solution of the cationized atelocollagen solution and the alginate solution and mixed with islet cells, is deposited in a chelating agent to produce a cationized atelocollagen/alginate bead in which an islet cell is accommodated inside. [Reference numerals] (AA) Number of langerhans islet cells; (BB) 1 day; (CC) 3 week; (DD) 8 week
Abstract translation: 目的：提供使用小胶质细胞的胰岛细胞移植的载体的制造方法和使用其制造的人造胰腺，以能够有效孵育胰岛细胞并提供具有优异的稳定性和人造的胰岛细胞移植的载体 胰腺通过使用阳离子化的atelocollagen。 构成：用于胰岛细胞移植的载体的制造方法包括以下步骤：将阳离子化的胶原凝胶溶液和藻酸盐溶液混合; 胰岛细胞在阳离子化的胶原蛋白溶液和藻酸盐溶液的混合溶液中混合; 形成由阳离子化的胶原凝胶溶液和藻酸盐溶液的混合溶液包围并与胰岛细胞混合的胰岛细胞复合体; 由阳离子化的胶原蛋白溶液和藻酸盐溶液的混合溶液包围并与胰岛细胞混合的胰岛细胞复合物沉积在螯合剂中以产生其中容纳胰岛细胞的阳离子化的胶原/藻酸盐珠粒。 （附图标记）（AA）朗格汉斯胰岛细胞数; （BB）1天; （CC）3周; （DD）8周
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公开(公告)号：KR101188167B1
公开(公告)日：2012-10-08
申请号：KR1020110120742
申请日：2011-11-18
Applicant: (주)다림티센
Abstract: 본 발명의 에스테르화 아텔로 콜라겐 제조방법은, (a) 에탄올 또는 메탄올에 아텔로 콜라겐을 넣은 아텔로 콜라겐 분산액을 준비하고 산을 첨가하여 상기 아텔로 콜라겐 분산액을 산성 상태로 만든 후 교반하는 단계와, (b) 상기 (a) 단계에서 교반된 상기 아텔로 콜라겐 분산액을 대략 중성 상태로 만드는 단계와, (c) 상기 (b) 단계에서 대략 중성 상태로 된 상기 아텔로 콜라겐 분산액을 원심분리하여 에스테르화 아텔로 콜라겐 침사를 수득하는 단계와, (d) 상기 (c) 단계에서 수득된 에스테르화 아텔로 콜라겐 침사를 투석 멤브레인에 넣어 정제수 내에서 투석을 실시하는 단계를 포함한다.
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