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公开(公告)号：KR1020100028608A
公开(公告)日：2010-03-12
申请号：KR1020100007230
申请日：2010-01-27
Applicant: (주)다림티센
Abstract: PURPOSE: A collagen base matrix as a texture restoration material and a method for manufacturing the same are provided, which can enhance the mechanical strength and prevent the porous film from being partly destroyed in the manufacturing process. CONSTITUTION: A method for manufacturing a collagen base matrix as a texture restoration material comprises: a step of forming a collagen porous layer by freeze-drying after forming the uniform film of the constant thickness by dispersing the collagen in the fixed thickness; and a step of forming a collagen hard layer with a dense tissue by compacting collagen particles and discharging water.
Abstract translation: 目的：提供作为纹理恢复材料的胶原基质基质及其制造方法，其可以在制造过程中增强机械强度并防止多孔膜部分破坏。 构成：作为纹理恢复材料的胶原基质基质的制造方法包括：通过将固定厚度的胶原分散而形成固定厚度的均匀膜后，通过冷冻干燥形成胶原多孔层的工序; 以及通过压实胶原颗粒并排出水来形成具有致密组织的胶原蛋白硬质层的步骤。
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Patent Agency Ranking
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公开(公告)号：KR101068967B1
公开(公告)日：2011-09-29
申请号：KR1020100007230
申请日：2010-01-27
Applicant: (주)다림티센
Abstract: 본 발명은 조직수복재료로서의 콜라겐 기반 매트릭스 제조방법 및 이 방법에 의해 제조된 콜라겐 기반 매트릭스에 관한 것으로서, 콜라겐 분산액으로 평판 위에 일정두께로 확산시킨 상태에서 동결건조시켜 콜라겐 다공성막을 얻고 별도의 콜라겐 분산액을 평판 위에 일정두께로 확산시켜 가압하여 콜라겐 경질막을 얻은 다음 경질막 위에 상기 콜라겐 다공성막을 가볍게 적층시켜 풍건하여 2중막을 얻고 이를 에탄올용액에 EDC를 용해시킨 혼합용액에 침지하여 다공성막과 경질막을 가교시켜 일체화시키고 가교화된 2중막을 세척하여 잔류 EDC를 제거시킨 다음 다시 동결건조하여 일정크기로 재단한 방법에 의해 제조된 콜라겐 기반 매트릭스에 관한 것이다.
Abstract translation: 本发明是一种基于胶原的基质制造方法以及涉及由该方法制备的基于胶原的基质中，冷冻干燥，其中分散在具有恒定的厚度在板与胶原分散体以得到胶原多孔膜分离胶原分散体组织修复材料的状态下 压在上平坦胶原恒定的厚度进行传播交联的刚性，则硬质被膜上获得2内侧，并在空气中干燥，轻轻层状膜，其中所述胶原多孔浸渍在由EDC它溶解到多孔膜的乙醇溶液和硬质覆膜得到的膜而得到的混合溶液 通过整合和交联双膜以除去残留的EDC制备基于胶原的基质，然后冻干并切割成预定尺寸。
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公开(公告)号：KR100947765B1
公开(公告)日：2010-03-18
申请号：KR1020080080360
申请日：2008-08-18
Applicant: (주)다림티센
Abstract: 본 발명은 조직수복재료로서의 콜라겐 기반 매트릭스 제조방법 및 이 방법에 의해 제조된 콜라겐 기반 매트릭스에 관한 것으로 콜라겐분산액으로 평판위에 일정두께로 확산시킨 상태에서 동결건조시켜 콜라겐 다공성막을 얻고 별도의 콜라겐 분산액을 평판위에 일정두께로 확산시켜 가압하여 콜라겐 경질막을 얻은 다음 경질막 위에 상기 콜라겐 다공성막을 가볍게 적층시켜 2중막을 얻고 이를 에탄올용액에 EDC를 용해시킨 혼합용액에 침지하여 다공성막과 경질막을 가교시켜 일체화시키고 가교화된 2중막을 세척하여 잔류 EDC를 제거시킨 다음 다시 동결건조하여 일정크기로 재단한 이 방법에 의해 제조된 콜라겐 기반 매트릭스에 관한 것이다.
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公开(公告)号：KR1020100021763A
公开(公告)日：2010-02-26
申请号：KR1020080080360
申请日：2008-08-18
Applicant: (주)다림티센
CPC classification number: A61L27/60 , A61L27/24 , A61F2310/00371 , A61L27/20 , A61L27/50 , A61L27/54
Abstract: PURPOSE: A collagen base matrix as the texture restoration material and a method of manufacture thereof are provided, in which the collagen base matrix is not easily separated in the water solution condition. CONSTITUTION: A manufacturing method of collagen base matrix as the texture restoration material includes a first step for processing a porous film; a second step for processing a hard film; a third step for obtaining the duplex film in which the porous film is laminated in the hard film; a fourth step for obtaining mixture by stirring ethanol solution and EDC; a fifth step for cross-linking the porous film and hard film; a sixth step for washing the cross-linked duplex film by the distilled water; a seventh step for manufacturing the duplex film of the fixed type; an eighth step for cutting the duplex film.
Abstract translation: 目的：提供作为纹理恢复材料的胶原基质基质及其制造方法，其中胶原基质基质在水溶液状态下不容易分离。 构成：作为纹理修复材料的胶原基质基质的制造方法包括加工多孔膜的第一工序; 加工硬膜的第二步; 获得其中多孔膜层压在硬膜中的双相膜的第三步骤; 通过搅拌乙醇溶液和EDC获得混合物的第四步; 交联多孔膜和硬膜的第五步骤; 用蒸馏水洗涤交联的双相膜的第六步骤; 制造固定型双相膜的第七步骤; 用于切割双相膜的第八步骤。
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公开(公告)号：KR100828494B1
公开(公告)日：2008-05-13
申请号：KR1020070125904
申请日：2007-12-06
Applicant: (주)다림티센
CPC classification number: A61K8/65 , A61K8/14 , A61K8/44 , A61K8/606 , A61K8/735 , A61K2800/80 , A61Q19/08
Abstract: A cosmetic composition comprising atelocollagen is provided to inhibit immune response in skin permeation, improve skin permeability by treating atelocollagen with succinate anhydride, increase antibacterial effects and skin absorption by weak acidification of collagen, and promote growth of fibers and cells and cell mobility, so that the composition is useful for improving skin wrinkles. A cosmetic composition for improving skin wrinkles comprises 0.4-4 wt.% of atelocollagen, 0.4-4 wt.% of hyaluronic acid, 0.04-0.4 wt.% of adenosine, 0.0002-0.002 wt.% of lysine, and 91.6-99.15 wt.% of purified water. A method for preparing the anti-wrinkle cosmetic composition comprises the steps of: adding atelocollagen treated with succinate anhydride, adenosine and purified water into 0.5% of hyaluronic acid solution and stirring the mixture at 5 deg. C; regulating pH of the solution to 6.1 by using caustic soda to dissolve completely the collagen; adding 0.07g of lysine into the collagen solution and stirring the mixture; and compensating evaporated water by adding purified water and regulating pH of the solution to 6.1.
Abstract translation: 提供包含阿胶原的化妆品组合物以抑制皮肤渗透中的免疫应答，通过用琥珀酸酐处理阿胶原并提高皮肤渗透性，通过弱酸化胶原增加抗菌作用和皮肤吸收，并促进纤维和细胞的生长以及细胞迁移率，使得 该组合物可用于改善皮肤皱纹。 用于改善皮肤皱纹的化妆品组合物包含0.4-4重量％的胶原，0.4-4重量％的透明质酸，0.04-0.4重量％的腺苷，0.0002-0.002重量％的赖氨酸和91.6-99.15重量％ 。净化水的百分比。 制备抗皱化妆品组合物的方法包括以下步骤：将用琥珀酸酐，腺苷和纯化水处理的胶原蛋白加入到0.5％透明质酸溶液中，并在5℃下搅拌该混合物。 C; 通过使用苛性钠将溶液的pH调节至6.1，完全溶解胶原蛋白; 向胶原溶液中加入0.07g赖氨酸并搅拌混合物; 并通过加入纯水补偿蒸发水，并将溶液的pH值调节至6.1。
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