公开(公告)号：KR101721357B1

公开(公告)日：2017-03-29

申请号：KR1020160012740

申请日：2016-02-02

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  이종국

IPC: A61K31/343

Abstract: 하기식 1로표시되는모라신 M 유도체또는상기모라신 M 유도체의약제학적으로허용가능한염을유효성분으로포함하는호흡기염증질환의예방및 치료용약학조성물이제공된다. [식 1](상기식에서 R, R, R는 H,formyl, acetyl, propanoyl, isopropanoyl, butanoyl, pivaloyl, dimethylcarbamoyl, diethylcarbamoyl, dipropylcarbamoyl, dibutylcarbamoyl methylcarbamoyl 및 ethylcarbamoyl기로이루어진군으로부터선택된어느하나이고, R, R및 R가동시에 H가아님)

公开(公告)号：KR1020150090529A

公开(公告)日：2015-08-06

申请号：KR1020140011276

申请日：2014-01-29

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  이종국

IPC: A61K31/343 ,  A61P31/16 ,  A61P11/00

CPC classification number: A61K31/343 ,  A61K31/34

Abstract: 본발명은모라신 (Moracin) M 화합물또는이의약학적으로허용가능한염을유효성분으로함유하는호흡기염증질환의예방및 치료용조성물에관한것으로, 상세하게는본 발명의모라신(Moracin) M 화합물이시험관내상피세포 (In vitro lung epithelial cell)에서의저해능확인실험에서염증성시토킨(cytokine)인 IL-6의생산을강력하세저해하여폐세포의염증을강력하게억제함을확인하였을뿐만아니라, 리포폴리사카리드(lipopolysaccharide; LPS)-유도기관지염실험모델을이용한기관지염억제능을확인한결과, 상기실험에서본 발명의시료들이탁월한호흡기질환에대하여강력한억제효과를나타냄을확인함으로써, 상기조성물을호흡기염증질환의예방및 치료용약학조성물또는건강기능식품으로유용함을확인하였다.

Abstract translation: 本发明涉及一种用于预防和治疗呼吸道炎症疾病的组合物，其中含有Moracin M化合物或其药学上可接受的盐作为活性成分。 特别地，已经证实本发明的Moracin M化合物通过在体外肺上皮细胞的抑制活性确认实验中强烈地抑制作为炎性细胞因子的IL-6的产生而强烈地控制肺细胞中的炎症。 此外，作为使用脂多糖（LPS）诱导的支气管炎实验模型确认支气管炎控制功能的结果，已经证实本实验的样品在控制呼吸系统疾病中表现出很强的效果。 已证实该组合物可用作预防和治疗呼吸道炎症疾病的药物组合物或健康功能食品。

公开(公告)号：KR1020130081478A

公开(公告)日：2013-07-17

申请号：KR1020120002478

申请日：2012-01-09

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  고현정 ,  권용수 ,  서상욱

IPC: A61K36/25 ,  A61P31/12 ,  A61P31/16

Abstract: PURPOSE: A hedera helix leaf extract or a compound separated from the same are provided to utilize as a medicinal composition for prevention and treatment of an infectious diseas by an influenza virus or a health functional food by checking a high survival rate when taken together with an antivirus agent. CONSTITUTION: A medicinal composition for prevention and treatment of an infectious disease caused by an influenza virus contains a Hedera helix leaf extract or hederacoside C separated from the same as an active ingredient. The Hedera helix leaft extract is a crude extract, a polar solvent soluble extract, and a non-polar solvent soluble extract. The medicinal moposition for prevention and treatment of an infectious disease contains the combination of the Hedera helix leaf extract or hederacoside C and an anti-influenza agent. The anti-influenza agent is selected from Oseltamivir (Tamiflu), Zanamivir (Relenza), Peramivir, Amantadine (Symmetrel), Rimantadine, Rivaririn, or Taribavirin. [Reference numerals] (AA) Survival rate; (BB) Medicine injection; (CC) Time (day) after infection; (DD) Extract of Ivy leaf

Abstract translation: 目的：提供野草螺旋叶提取物或与其分离的化合物，以利用流感病毒或健康功能性食物的预防和治疗感染性疾病的药物组合物，通过与 防毒剂。 构成：用于预防和治疗由流感病毒引起的感染性疾病的药物组合物含有与活性成分相同的间叶螺旋叶提取物或鲱鱼苷C。 Hedera螺旋提取物是粗提取物，极性溶剂可溶性提取物和非极性溶剂可溶性提取物。 用于预防和治疗感染性疾病的药物组合包含常春藤螺旋叶提取物或鲱鱼苷C与抗流感药剂的组合。 抗流感剂选自奥司他韦（Tamiflu），扎那米韦（Relenza），帕拉米韦，安他胺（Symmetrel），Rimantadine，Rivaririn或Taribavirin。 （附图标记）（AA）存活率; （BB）药物注射; （CC）感染后的时间（天） （DD）常春藤叶提取物

公开(公告)号：KR1020120039610A

公开(公告)日：2012-04-25

申请号：KR1020120036914

申请日：2012-04-09

Applicant: 주식회사파마킹 ,  강원대학교산학협력단

Inventor： 김순배 ,  김광순 ,  김완배 ,  곽의종 ,  방성혜 ,  김현표 ,  손건호

IPC: A61K36/605 ,  A61K36/35 ,  A61P29/00 ,  A61P25/00

Abstract: PURPOSE: A pharmaceutical composition containing Broussonetia papyrifera (L.) Vent. (Moraceae) extract and Lonicera japonica extract is provided to relieve pain and/or inflammation. CONSTITUTION: A pharmaceutical composition for preventing, relieving, or treating inflammation and/or pain contains: a first material selected from Broussonetia papyrifera (L.) Vent. (Moraceae) extract, fraction, and pharmaceutically acceptable salt thereof; and a second material selected from Lonicera japonica extract and pharmaceutically acceptable salt thereof.

Abstract translation: 目的：含有Broussonetia papyrifera（L.）Vent的药物组合物。 （Moraceae）提取物和金银花提取物以减轻疼痛和/或炎症。 构成：用于预防，缓解或治疗炎症和/或疼痛的药物组合物包含：选自布鲁氏菌（Broussonetia papyrifera（L.）Vent。 （Moraceae）提取物，级分及其药学上可接受的盐; 和选自金银花提取物及其药学上可接受的盐的第二种物质。

公开(公告)号：KR101084926B1

公开(公告)日：2011-11-17

申请号：KR1020110026265

申请日：2011-03-24

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  정재훈

IPC: A61K36/03 ,  A61P19/02 ,  A61P19/00

Abstract: PURPOSE: A composition containing Dictyota coriaceae extract or fraction is provided to suppress the expression of MMP-1 and to treat and preventing degenerative arthritis. CONSTITUTION: A pharmaceutical composition for preventing and treating degenerative arthritis or rheumatoid arthritis contains Dictyota coriaceae extract as an active ingredient. A method for preparing the extract comprises: a step of adding 5-50 time(v/w) of water or mixture solvent of water and ethanol to Dictyota coriaceae by enfleurage; a step of filtering and drying the extract; a step of suspending the extract in 1-50 times voluyme(v/w) of water; and a step of fractioning with hexane, chloroform, methylene chloride, or ethyl acetate. A neutraceutical food for preventing and treating degenerative arthritis or rheumatoid arthritis contains the extract as an active ingredient.

Abstract translation: 目的：提供含有Dictyota coriaceae提取物或级分的组合物以抑制MMP-1的表达并治疗和预防退行性关节炎。 构成：用于预防和治疗退行性关节炎或类风湿性关节炎的药物组合物含有茜草科提取物作为活性成分。 制备提取物的方法包括：通过灌肠向茜草科加入5-50次（v / w）水或水和乙醇的混合溶剂的步骤; 过滤和干燥提取物的步骤; 将提取物悬浮在1-50倍体积（v / w）的水中的步骤; 和用己烷，氯仿，二氯甲烷或乙酸乙酯分馏的步骤。 用于预防和治疗退行性关节炎或类风湿性关节炎的营养食品含有提取物作为活性成分。

公开(公告)号：KR1020110064212A

公开(公告)日：2011-06-15

申请号：KR1020090120711

申请日：2009-12-07

Applicant: 주식회사파마킹 ,  강원대학교산학협력단

Inventor： 김순배 ,  김광순 ,  김완배 ,  곽의종 ,  방성혜 ,  김현표 ,  손건호

IPC: A61K36/60 ,  A61K36/355 ,  A61P29/00 ,  A61P11/06

CPC classification number: A61K36/355 ,  A61K36/60 ,  A61K2300/00

Abstract: PURPOSE: A medicinal composition containing Broussonetia papyrifera and Lonicera japonica extract is provided to ensure anti-inflammation and analgesic effects. CONSTITUTION: A medicinal composition for preventing, relieving, treating inflammation and/or pain contains a first substance selected from Broussonetia papyrifera extract, fraction of the extract, and pharmaceutically acceptable salt thereof; a second substance of Lonicera japonica extract of pharmaceutically acceptable salt thereof as an active ingredient. The medicinal composition further contains pharmaceutically acceptable carrier.

Abstract translation: 目的：提供含有Broussonetia papyrifera和Lonicera japonica提取物的药物组合物，以确保抗炎和止痛作用。 构成：用于预防，缓解，治疗炎症和/或疼痛的药物组合物含有选自布鲁泊氏菌提取物，提取物组分及其药学上可接受的盐的第一物质; 作为其药学上可接受的盐的金银花提取物的第二物质作为活性成分。 药物组合物还含有药学上可接受的载体。

公开(公告)号：KR1020090087782A

公开(公告)日：2009-08-18

申请号：KR1020080013234

申请日：2008-02-13

Applicant: 주식회사 메디트론바이오 ,  강원대학교산학협력단

Inventor： 김현표 ,  임학태 ,  김윤수

IPC: A61K36/81 ,  A61P1/04

Abstract: A pharmaceutical composition for preventing and treating gastritis, stomach ulcer and duodenal ulcer, which contains juice or starch of Solanum tuberosum L., cv. Redking valley is provided to suppress the amount of PGE 2 (prostaglandin 2) without toxicity. A pharmaceutical composition for preventing and treating gastritis, stomach ulcer, or duodenal ulcer comprises juice or starch of prostaglandin 2 as an active ingredient. A method for producing the starch comprises: a step of placing the juice at room temperature for ten minutes; a step of separating starch layer and remaining liquid; and a step of decompressing to dry the starch layer or drying at 65‹C. The daily dose of the juice and starch is respectively 0.1-5 ml/kg and 1 mg-500 mg/kg.

Abstract translation: 一种用于预防和治疗胃炎，胃溃疡和十二指肠溃疡的药物组合物，其含有马铃薯（Solanum tuberosum L.）的汁液或淀粉， 提供补救谷以抑制PGE 2（前列腺素2）的量无毒性。 用于预防和治疗胃炎，胃溃疡或十二指肠溃疡的药物组合物包含作为活性成分的前列腺素2的果汁或淀粉。 制备淀粉的方法包括：将果汁放置在室温下10分钟的步骤; 分离淀粉层和剩余液体的步骤; 和减压干燥淀粉层或在65℃干燥的步骤。 果汁和淀粉的日剂量分别为0.1-5ml / kg和1mg-500mg / kg。

公开(公告)号：KR101749016B1

公开(公告)日：2017-06-20

申请号：KR1020170062030

申请日：2017-05-19

Applicant: 강원대학교산학협력단

Inventor： 김현표

IPC: A61K36/38 ,  A61K31/352

CPC classification number: A61K36/38 ,  A61K31/352

Abstract: 본발명은산비장이(var.Kitamura) 추출물을유효성분으로포함하는항바이러스활성을갖는조성물을개시한다. 또한, 산비장이에서추출한퀘르세틴-3-메틸에테르(quercetin-3-methyl ether) 및아이소켐페라이드(isokaempferide)의화합물을유효성분으로포함하는바이러스감염에의한질환을치료또는예방하는조성물을제공한다.

公开(公告)号：KR101646009B1

公开(公告)日：2016-08-08

申请号：KR1020150165528

申请日：2015-11-25

Applicant: 강원대학교산학협력단 ,  한국생명공학연구원

Inventor： 고현정 ,  허문영 ,  김현표 ,  송재형 ,  조성찬 ,  송혁환

IPC: A61K31/352 ,  A61K31/35 ,  A61K36/539 ,  A23L1/30

CPC classification number: Y02A50/465

Abstract: 본발명은항엔테로바이러스를갖는조성물에관한것으로, 상세하게는황금의추출물또는이로부터분리된화합물을유효성분으로함유하는본 발명의조성물은(1) 베로(vero) 세포에서의세포독성및 EV71, CVB3, CVA16의항바이러스활성실험, 세포병변억제실험; (2) EV71에대한항바이러스활성을확인하기위한 enterovirus 71의 VP단백질에대한 Western blot 분석법; (3) replicon system(pRibFluc-EV71)을이용한 Replicon 분석법을통한항바이러스활성메카니즘분석실험; (4) BALB/c 마우스를이용한 CVB3 바이러스에대한항바이러스활성측정을위한 in vivo 동물실험등의광범위한시험관내실험(in vitro test) 및생체내동물실험(in vivo test)를통하여, 본발명의상기시료들이강력한항 엔테로바이러스활성을나타냄을확인함으로, 상기조성물을엔테로바이러스에기인한질환의예방및 치료용약학조성물또는건강기능식품으로유용하게이용될수 있다.

公开(公告)号：KR1020160015691A

公开(公告)日：2016-02-15

申请号：KR1020140098280

申请日：2014-07-31

Applicant: 안국약품 주식회사 ,  강원대학교산학협력단

Inventor： 정현근 ,  김종걸 ,  이정화 ,  김현표 ,  권용수

IPC: A61K36/8988 ,  A61P25/00

CPC classification number: A61K36/8988 ,  A61K36/00

Abstract: 본발명은천마추출물또는이로부터분리된화합물을유효성분으로함유하는만성통증완화, 억제또는치료용조성물, 및이의제조방법에관한것으로, 본발명에따른천마추출물은다양한만성통증의완화, 억제및 치료에유용한약학적조성물또는기능성식품조성물로이용될수 있다.

Abstract translation: 本发明涉及包含天竺葵根茎提取物或其分离的化合物作为缓和，抑制或治疗慢性疼痛的活性成分的组合物及其制造方法。 根据本发明，天竺葵根提取物可以用作药物组合物或功能性食品组合物，其可用于缓解，抑制和治疗各种慢性疼痛。