公开(公告)号：KR101099895B1

公开(公告)日：2011-12-28

申请号：KR1020110035908

申请日：2011-04-18

Applicant: 강원대학교산학협력단

Inventor： 김태웅 ,  박해일 ,  성재모 ,  조재열

IPC: C07C43/23 ,  C07C43/205 ,  A61K31/085 ,  A61P35/00

Abstract: PURPOSE: An isooctylphenol derivative inducing the apoptosis of cancer cells by improving the activity of AMPK, and a use thereof as an anti-cancer drug are provided to generate the cell cycle arrest and MAPK of the cancer cells. CONSTITUTION: An isooctylphenol-4 compound marked with chemical formula (I) is an active component of an anti-cancer drug composition. The anti-cancer effect of the isooctylphenol-4 compound can be tested by the following steps: synthesizing a biosynthesis compound of isooctylphenol-4; and examining a transmitting process of the cancer cell death signal of the isooctylphenol-4.

Abstract translation: 目的：通过改善AMPK活性诱导癌细胞凋亡的异辛基酚衍生物，提供其作为抗癌药物的用途，以产生癌细胞的细胞周期停滞和MAPK。 构成：用化学式（I）标记的异辛基酚-4化合物是抗癌药物组合物的活性成分。 异辛基酚-4化合物的抗癌作用可以通过以下步骤来测试：合成异辛基酚-4的生物合成化合物; 并检查异辛基酚-4的癌细胞死亡信号的传递过程。

公开(公告)号：KR1020110048216A

公开(公告)日：2011-05-11

申请号：KR1020090104913

申请日：2009-11-02

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  박해일

IPC: C07D311/30 ,  C07D311/36 ,  A61K31/352 ,  A61P35/00

Abstract: PURPOSE: A novel flavonoid derivative and a pharmaceutical composition containing the same are provided to suppress COX-2 and iNOS expression or activation and to prevent inflammatory disease or cancer. CONSTITUTION: A flavonoid compound having an activity of suppressing COX-2 and iNOS inflammation mediates synthesis has a structure of general formula I. In general formula I, X is O; and R1-R9 are independently hydrogen atom, hydroxy group, methoxy group, or phenyl group, butyl group, oxyacetyl group or dimethylamino methyl group-substituted furan group, thiopene group, pyridine group, or triazole group. A pharmaceutical composition for preventing and treating inflammatory diseases, immune system disorder, or cancer contains the flavonoid compouds as an active ingredient and pharmaceutically acceptable excipient or carrier.

Abstract translation: 目的：提供一种新的类黄酮衍生物和含有这些组合物的药物组合物，以抑制COX-2和iNOS表达或活化，并防止炎性疾病或癌症。 构成：具有抑制COX-2和iNOS炎症介导合成活性的类黄酮化合物具有通式I的结构。通式I中，X为O; 并且R 1 -R 9独立地为氢原子，羟基，甲氧基或苯基，丁基，氧基乙酰基或二甲基氨基甲基取代的呋喃基，噻吩基，吡啶基或三唑基。 用于预防和治疗炎性疾病，免疫系统疾病或癌症的药物组合物含有作为活性成分的类黄酮和药学上可接受的赋形剂或载体。

公开(公告)号：KR100868702B1

公开(公告)日：2008-11-13

申请号：KR1020060055964

申请日：2006-06-21

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  박해일 ,  장현욱

IPC: C07D407/04 ,  C07D407/12 ,  C07D407/06

Abstract: 본 발명은 염증, 알러지성 질환의 치료용 조성물에 관한것으로서, 상세하게는 바이플라보노이드 유도체를 유효성분으로 함유하는 염증, 알러지 질환에 효과적인 조성물에 관한 것이다.
본 발명의 바이플라보노이드는 포스포리파아제 A2 저해능을 나타냄으로써, 염증, 알러지 질환의 예방 및 치료를 위한 약학 조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
바이플라보노이드, 염증, 알러지, 포스포리파아제

公开(公告)号：KR1020070121203A

公开(公告)日：2007-12-27

申请号：KR1020060055964

申请日：2006-06-21

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  박해일 ,  장현욱

IPC: C07D407/04 ,  C07D407/12 ,  C07D407/06

Abstract: A composition comprising biflavonoid derivatives is provided to inhibit activity of phospholipase A2, so that it is useful for prevention and treatment of inflammation and allergy diseases. A composition for prevention and treatment of inflammation and allergy diseases comprises biflavonoid derivatives represented by the formula(I) or pharmaceutically acceptable salts thereof, wherein any two substituents of R1, R2 and R3 are each independently hydrogen, OH, O-R', SH, S-R", CO-R"' or COO-R"" in which R', R", R"' and R"" are each independently C1-C18 alkyl group, alkylene group or alkynyl group; another substituent of R1, R2 and R3 is represented by -X-A in which X is a hetero atom selected from O, S and N or -(CH2)m- (m is an integer from 0 to 5) and A is represented by the formula(II), wherein the formula(II) is compound that each substituent of R1, R2 and R3 of the compound represented by the formula(I) is substituted by at least group selected from hydrogen, OH, O-R', SH, S-R", CO-R"' or COO-R"".

Abstract translation: 提供包含双黄酮衍生物的组合物以抑制磷脂酶A2的活性，因此其可用于预防和治疗炎症和变态反应疾病。 用于预防和治疗炎症和过敏疾病的组合物包括由式（I）表示的双黄酮衍生物或其药学上可接受的盐，其中R 1，R 2和R 3的任何两个取代基各自独立地为氢，OH，O-R'，SH ，其中R'，R“，R”'和R“”各自独立地为C 1 -C 18烷基，亚烷基或炔基的SR“，CO-R”'或COO-R“ R1，R2和R3的另一个取代基由-XA表示，其中X是选自O，S和N的杂原子或 - （CH 2）m - （m是0至5的整数），A由 式（II）其中式（II）是由式（I）表示的化合物的R1，R2和R3的每个取代基被至少选自氢，OH，O-R'，SH ，SR“，CO-R”'或COO-R“”。