公开(公告)号：KR1020130118131A

公开(公告)日：2013-10-29

申请号：KR1020120041087

申请日：2012-04-19

Applicant: 대한민국(농촌진흥청장)

Inventor： 노형준 ,  김금숙 ,  이승은 ,  김영옥 ,  김승유 ,  홍윤표 ,  조재한 ,  엄선영 ,  이강노

IPC: A61K31/4045 ,  A61K31/404 ,  A61K31/4035 ,  A61K36/07

CPC classification number: A61K31/4035 ,  A61K36/07

Abstract: PURPOSE: A pharmaceutical composition for preventing or treating dementia is provided to suppress the activity of acetylcholine esterase, to effectively prevent and treat dementia, and to produce a pharmaceutical composition and a health food. CONSTITUTION: An inhibitor of acetylcholine esterase activation contains a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The compounds are derived from Hericium erinacium. A method for manufacturing the inhibitor comprises the steps of: pulverizing Hericium erinacium; adding alcohols to the pulverized Hericium erinacium and concentrating the extract by reduced pressure; preparing a primary fraction from the concentrated extract using an organic solvent; preparing a secondary fraction from the primary fraction through chromatography; and isolating and purifying the compound of chemical formula 1.

Abstract translation: 目的：提供用于预防或治疗痴呆的药物组合物，以抑制乙酰胆碱酯酶的活性，有效预防和治疗痴呆，以及制备药物组合物和保健食品。 构成：乙酰胆碱酯酶活化抑制剂含有化学式1的化合物或其药学上可接受的盐作为活性成分。 该化合物衍生自赫氏酵母（Hericium erinacium）。 制备抑制剂的方法包括以下步骤：粉碎赫氏酵母; 向粉碎的Hericium erinacium中加入醇，并通过减压浓缩提取物; 使用有机溶剂从浓缩提取物中制备一级馏分; 通过色谱从一级馏分制备二级馏分; 并分离和纯化化学式1的化合物。