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Patent Agency Ranking
公开(公告)号：KR1020140039370A
公开(公告)日：2014-04-02
申请号：KR1020120104477
申请日：2012-09-20
Applicant: 대한민국(농촌진흥청장) , (주)차바이오텍
CPC classification number: A61K8/987 , A61K8/64 , A61K2800/80 , A61Q19/00
Abstract: The present invention relates to a cosmetic composition including a hydrolysate from a silkworm silk gland. A cosmetic composition of the present invention is characterized in including a hydrolysate from a silkworm silk gland, and more specifically, the hydrolysate is prepared by separating a gland from a silkworm, dissolving the separated gland into water, centrifuging and obtaining a supernatant, adding an alkaline compound to conduct hydrolysis, neutralizing and desalting. According to the present invention, provided is a cosmetic composition comprising a hydrolysate from a silkworm silk gland which is harmless to humans and having good antioxidant activity, dermal fibroblast proliferating properties, skin affinity, etc.
Abstract translation: 本发明涉及包含来自蚕丝腺的水解产物的化妆品组合物。 本发明的化妆品组合物的特征在于包括来自蚕丝腺的水解产物，更具体地说，通过从蚕分离腺体，将分离的腺液溶解在水中，离心并得到上清液，加入 碱性化合物进行水解，中和脱盐。 根据本发明，提供了一种化妆品组合物，其包含来自对人类无害且具有良好抗氧化活性，真皮成纤维细胞增殖性质，皮肤亲和性等的蚕丝腺的水解产物。
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公开(公告)号：KR101346057B1
公开(公告)日：2013-12-31
申请号：KR1020120068585
申请日：2012-06-26
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
IPC: C07K1/14 , C07K14/435 , C12N1/04
Abstract: The present invention relates to a mass purification method of a silkworm hemolymph-derived protein and a protein purified thereby. The mass purification method according to the present invention comprises a first step of freeze-drying silkworm to prepare a silkworm dried material; a second step of removing silk gland and obtaining the remainder hemolymph; a third step of crushing the hemolymph and adding water thereto to prepare a hemolymph lysate; a fourth step of subjecting the hemolymph lysate to centrifugation to obtain a supernatant; and a fifth step of subjecting the supernatant to column chromatography to isolate a protein of 70kDa. According to the present invention, the silkworm hemolymph is applicable for several uses, such as a cell cryopreservative, a medium supplement for cell culture, and the like. Especially, the ingredients remaining after the isolation of silkworm hemolymph are also reusable, so that the present invention contributes to an increase in the income of sericulture farmers. [Reference numerals] (AA) Silk gland removal;(BB) Grown-up silkworm;(CC) live body weight 3.13g;(DD) Centrifugation;(EE) Quick freezing;(FF) Grown-up silkworm freeze-drying 590 mg;(GG) pulverization/selection;(HH) hemolymph 380 mg;(II) Dissolution (distilled water);(JJ) 63 mg after heat treatment;(KK) 30k 70k separation;(LL) Final retrieval amount
Abstract translation: 本发明涉及一种蚕血淋巴衍生蛋白的质量纯化方法和由此纯化的蛋白质。 根据本发明的质量净化方法包括：冷冻干燥蚕的第一步骤，制备蚕干物质; 去除丝腺并获得剩余血淋巴的第二步; 破碎血淋巴并向其中加入水以制备血淋巴溶胞产物的第三步骤; 第四步，使血淋巴溶胞产物离心得到上清液; 和将上清液进行柱色谱分离70kDa的蛋白质的第五步骤。 根据本发明，蚕血淋巴可应用于细胞冷冻保存剂，细胞培养用培养基等的多种用途。 特别是在分离蚕血淋淋后残留的成分也是可重复利用的，因此本发明有助于增加蚕食农民的收入。 （参考号）（AA）丝腺去除;（BB）成熟蚕;（CC）活体重3.13g;（DD）离心;（EE）快速冷冻;（FF）成熟蚕冷冻590 （GG）粉碎/选择;（HH）血淋巴380mg;（II）溶解（蒸馏水）;（JJ）热处理后63mg;（KK）30k 70k分离;（LL）最终检索量
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公开(公告)号：KR101501554B1
公开(公告)日：2015-03-13
申请号：KR1020130070167
申请日：2013-06-19
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
Abstract: 본 발명은 누에 혈림프 유래 70kDa 단백질을 포함하는 화장료 조성물에 관한 것이다.
본 발명의 화장료 조성물은 누에 혈림프 유래 70kDa 단백질을 포함하는 것을 특징으로, 보다 상세하게는 누에로부터 실샘을 제거하고 남은 혈림프를 분쇄한 다음 물에 넣고 열처리한 후 이를 원심분리하여 얻은 상등액을 컬럼을 통해 분리하여 얻은 누에 혈림프 유래 70kDa 단백질을 포함하는 것이 특징이다.
본 발명에 의해, 인체 무해하면서 항산화능, 항균활성능, 미백효과 등이 우수한 누에 혈림프 유래 70kDa 단백질을 포함하는 화장료 조성물이 제공된다.-
公开(公告)号：KR1020140147913A
公开(公告)日：2014-12-31
申请号：KR1020130070167
申请日：2013-06-19
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
CPC classification number: A61K8/64 , A61K8/987 , A61K2800/84 , A61Q17/005 , A61Q19/02 , B01D15/34
Abstract: The present invention relates to a cosmetic composition containing a 70-kDa protein derived from silkworm hemolymph. The cosmetic composition of the present invention contains 70-kDa protein derived from silkworm hemolymph, and more specifically, 70-kDa protein derived from silkworm hemolymph, which is obtained by removing silk glands from silkworms, pulverizing the remaining hemolymph, putting the pulverized hemolymph in water, performing heat treatment, and obtaining a supernatant through centrifugation, and subjecting the supernatant to column separation. According to the present invention, provided is a cosmetic composition containing a 70-kDa protein derived from silkworm hemolymph, wherein the cosmetic composition is harmless to the human body and has excellent anti-oxidative capability, antibacterial activity, and whitening effect.
Abstract translation: 本发明涉及含有来源于蚕血淋巴的70-kDa蛋白质的化妆品组合物。 本发明的化妆品组合物含有来源于蚕血淋巴的70-kDa蛋白质，更具体地说，来源于蚕血淋巴的70-kDa蛋白质，其通过从蚕中除去丝腺获得，粉碎剩余的血淋巴，将粉碎的血淋巴 水，进行热处理，通过离心获得上清液，并对上清液进行柱分离。 根据本发明，提供了含有来源于蚕血淋巴的70-kDa蛋白质的化妆品组合物，其中所述化妆品组合物对人体无害，并且具有优异的抗氧化能力，抗菌活性和增白效果。
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公开(公告)号：KR101444303B1
公开(公告)日：2014-11-04
申请号：KR1020120104477
申请日：2012-09-20
Applicant: 대한민국(농촌진흥청장) , (주)차바이오텍
Abstract: 본 발명은 누에 실샘 유래 가수분해물을 포함하는 화장료 조성물에 관한 것이다.
본 발명의 화장료 조성물은 누에 실샘 유래 가수분해물을 포함하는 것을 특징으로, 보다 상세하게는 누에로부터 실샘을 분리해 낸 다음, 그 분리된 실샘을 물로 용해한 후 원심분리하여 얻은 상등액에, 알칼리를 첨가한 후 가수분해한 다음 중화 및 탈염과정을 거쳐 얻은 가수분해물을 포함하는 것이 특징이다.
본 발명에 의해, 인체 무해하면서 항산화능, 피부세포증식능, 피부 친화력 등이 우수한 누에 실샘 유래 가수분해물을 포함하는 화장료 조성물이 제공된다.
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