Abstract:
PURPOSE: A pharmaceutical composition and a health food for preventing or treating inflammatory diseases are provided to suppress lipopolysaccharide-induced NO generation in RAW 264.7 macrophage and beef feet inflammation in a carrageenan-induced mouse, thereby strongly preventing inflammatory diseases and having stability as a natural medicinal material. CONSTITUTION: A pharmaceutical composition for preventing or treating inflammatory diseases contains a luteolin-5-O-beta-D-glucopyranoside compound as an active ingredient. The compound is derived from Cirsium maackii MAX. The pharmaceutical composition contains a crude extract or a non-solvent soluble extract of Cirsium maackii MAX as an active ingredient. The extract contains the luteolin-5-O-beta-D-glucopyranoside compound of chemical formula 1. A health food for preventing or treating inflammatory diseases contains the composition.
Abstract:
본 발명은 탁월한 항산화활성을 갖는 연수( Nelumbo nucifera stamen)의 추출물 및 그로부터 분리된 플라보노이드(flavonoid)계 화합물에 관한 것으로서, 유리 라디칼(Free radical), 지질과산화에 의해 생성되는 활성 산소종(reactive oxygen species, ROS)의 활성을 유의적으로 억제하여, 산화적 스트레스에 기인한 각종 질환의 예방 및 치료에 효과적이고 안전한 의약품 및 건강기능식품을 제공한다.
Abstract:
The present invention relates to a pharmaceutical composition and a health functional food containing raw extract and non polar solvent-soluble extract of Cirsium maackii, or a compound of luteolin 5-O-β-D-glucopyranoside for preventing or treating inflammatory diseases. An active ingredient has an anti-inflammatory activity in lipopolysaccharides-induced nitrogen oxide generation of RAW 264.7 macrophage and right leg edema in carrageenan-induced mice. Thus, the Cirsium maackii extract has a strong preventive activity against the inflammatory diseases and secures the safety as a natural medicinal herb, thereby being able to be useful as the pharmaceutical composition and health functional food for preventing or treating the inflammatory diseases.