인지장애 질환 진단용 다중 마커 및 그 용도
    14.
    发明公开
    인지장애 질환 진단용 다중 마커 및 그 용도 无效
    用于诊断认知障碍及其使用的多重标记

    公开(公告)号:KR1020140042331A

    公开(公告)日:2014-04-07

    申请号:KR1020120108964

    申请日:2012-09-28

    Inventor: 묵인희 한선호

    Abstract: Disclosed in the present invention are a protein differently expressed from a cognitive disorder and a use thereof. A marker according to the present invention, which is selected from the group composed of a transthyretin, an ApoE, an alpha-synuclein, a vitamin D binding protein, a neurogranin, a vimentin, a stathmin, a contactin, and a HDL-cholesterol, especially is used as a mix, to be used as a target content of a cognitive disorder diagnosis or a medicine development.

    Abstract translation: 在本发明中公开的是从认知障碍及其用途不同地表达的蛋白质。 根据本发明的标记,其选自由转甲状腺素蛋白,ApoE,α-突触核蛋白,维生素D结合蛋白,神经粒蛋白,波形蛋白,stathmin,接合蛋白和HDL-胆固醇组成的组 特别用作混合物,用作认知障碍诊断或药物开发的目标含量。

    금 나노입자를 이용한 알츠하이머병 또는 치매 관련 신경계 질환의 진단 방법
    16.
    发明授权
    금 나노입자를 이용한 알츠하이머병 또는 치매 관련 신경계 질환의 진단 방법 有权
    使用金纳米颗粒诊断阿尔茨海默病或与发病相关的神经病变的方法

    公开(公告)号:KR101003124B1

    公开(公告)日:2010-12-21

    申请号:KR1020100005124

    申请日:2010-01-20

    Abstract: PURPOSE: A method for diagnosing Alzheimer disease or dementia-associated nerve system using gold nanopaticles is provided to confirm the presence of beta-amyloid aggregation and to simply diagnose the disease. CONSTITUTION: A method for confirming the presence of beta-amyloid aggregation inhibitor in a test sample comprises: a step of chemically binding gold nanoparticles and beta-amyloid; a step of mixing the gold nanoparticle-beta-amyloid to the test sample; and a step of comparing the precipitation of the gold nanoparticles with that of a control group or comparing by absorbance of supernatant.

    Abstract translation: 目的:提供一种使用金纳米颗粒诊断阿尔茨海默病或痴呆相关神经系统的方法,以证实β-淀粉样蛋白聚集的存在并简单地诊断该疾病。 构成:用于确认测试样品中β-淀粉样蛋白聚集抑制剂的存在的方法包括:化学结合金纳米颗粒和β-淀粉样蛋白的步骤; 将金纳米颗粒-β-淀粉样蛋白混合到测试样品的步骤; 以及比较金纳米颗粒与对照组的沉淀或通过上清液的吸光度进行比较的步骤。

    아밀로이드 베타 플라크에 특이적인 이광자 형광 프로브, 이의 제조방법, 및 이를 이용한 생체 내 아밀로이드 베타 플라크의 영상화 방법
    20.
    发明公开
    아밀로이드 베타 플라크에 특이적인 이광자 형광 프로브, 이의 제조방법, 및 이를 이용한 생체 내 아밀로이드 베타 플라크의 영상화 방법 有权
    AMYLOID-B特异性双光子荧光探针,以及使用它们在体内成像AMYLOID-B PLAQUE的方法

    公开(公告)号:KR1020140049370A

    公开(公告)日:2014-04-25

    申请号:KR1020120115538

    申请日:2012-10-17

    Inventor: 김환명 묵인희

    CPC classification number: G01N33/582 A61K31/428 A61K49/0021 G01N33/5091

    Abstract: The present invention relates to an amyloid-beta-plaque-specific two-photon fluorescent probe and a method for imaging an amyloid-beta-plaque in vivo using the same. The two-photon fluorescent probe according to the present invention can pass through blood brain barrier, has excellent specificity of staining and strength of light emission compared to a conventional amyloid-beta-specific two-photon fluorescent probe (PIB, MeO-X04), and can be used as an useful amyloid-beta-specific two-photon fluorescent probe for diagnosing Alzheimer′s disease since ex vivo/in vivo imaging capability is excellent.

    Abstract translation: 本发明涉及淀粉样蛋白-β-斑块特异性双光子荧光探针和使用其淀粉样蛋白-β-斑块体内成像的方法。 根据本发明的双光子荧光探针可以通过血脑屏障,与传统的淀粉样蛋白-β特异性双光子荧光探针(PIB,MeO-X04)相比具有优异的染色特异性和光发射强度, 并且可以用作用于诊断阿尔茨海默氏病的有用的淀粉样蛋白-β特异性双光子荧光探针,因为离体/体内成像能力优异。

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