公开(公告)号：KR1020140074118A

公开(公告)日：2014-06-17

申请号：KR1020120142342

申请日：2012-12-07

Applicant: 서울대학교산학협력단

Inventor： 노동영 ,  한원식 ,  문형곤 ,  이경민

IPC: A61K48/00 ,  A61K31/7105 ,  A61K31/7088 ,  A61P35/00

CPC classification number: A61K48/00 ,  A23L29/00 ,  A23V2200/308 ,  A61K39/395 ,  G01N33/50

Abstract: The present invention relates to a composition containing a CD49d inhibitor as an active ingredient to prevent or treat cancer and, more specifically, to a pharmaceutical composition containing a CD49d inhibitor as an active ingredient to prevent or treat cancer, health functional foods for preventing or treating cancer, a method for treating cancer comprising a step of injecting the pharmaceutical composition into individuals, and a composition and a method for diagnosing cancer by measuring the expression level of CD49d. Since the CD49d of the present invention is an appropriate therapeutic target for cancers like breast cancer, the present invention can be applied to develop drugs preventing or treating the cancer by inhibiting the CD49d. The CD49d is also valuable as a marker diagnosis of the cancer, thereby being useful for research and development of the cancer.

Abstract translation: 本发明涉及含有CD49d抑制剂作为预防或治疗癌症的活性成分的组合物，更具体地说，涉及含有CD49d抑制剂作为预防或治疗癌症的活性成分的药物组合物，用于预防或治疗的健康功能性食品 癌症，治疗癌症的方法，包括将药物组合物注入个体的步骤，以及通过测量CD49d的表达水平来诊断癌症的组合物和方法。 由于本发明的CD49d是乳腺癌等癌症的适当的治疗靶，因此本发明可以通过抑制CD49d来开发预防或治疗癌症的药物。 CD49d也作为癌症的标志物诊断是有价值的，因此可用于研究和开发癌症。

公开(公告)号：KR1020130102693A

公开(公告)日：2013-09-23

申请号：KR1020120023708

申请日：2012-03-08

Applicant: (주)바이오메디앙 ,  서울대학교산학협력단

Inventor： 이헌수 ,  신혜승 ,  강운범 ,  노동영 ,  문형곤

IPC: G01N33/68 ,  C12N9/38 ,  G01N33/53 ,  G01N33/532

Abstract: PURPOSE: Apolipoprotein (a) which is a protein marker for diagnosing breast cancer, a method for detecting the same, and a kit containing an antibody for the same for diagnosing breast cancer are provided to enhance diagnostic sensitivity and accuracy and to simply diagnose breast cancer using blood from a patient, thereby early diagnosing breast cancer. CONSTITUTION: A method for selectively detecting apolipoprotein (a) with a sequence of sequence number 1 from a blood sample comprises the step of detecting the protein through multiple reaction monitoring using a triple quadrupole mass spectrometer. A kit for diagnosing breast cancer contains information on a target peptide of the protein and a pair of parent and daughter ions of the target peptide for detecting the protein from a blood sample by multiple reaction monitoring.

Abstract translation: 目的：提供作为诊断乳腺癌的蛋白质标记物的载脂蛋白（a），检测乳腺癌的方法，以及含有用于诊断乳腺癌的抗体的试剂盒，以提高诊断灵敏度和准确性，并简单地诊断乳腺癌 使用患者的血液，从而早期诊断乳腺癌。 构成：从血液样品中选择性检测序列号为1的载脂蛋白（a）的方法包括通过使用三重四极杆质谱仪进行多重反应监测来检测蛋白质的步骤。 用于诊断乳腺癌的试剂盒包含关于蛋白质的目标肽的信息和用于通过多重反应监测从血液样品检测蛋白质的目标肽的一对母体和子代离子。

公开(公告)号：KR1020130102689A

公开(公告)日：2013-09-23

申请号：KR1020120023704

申请日：2012-03-08

Applicant: (주)바이오메디앙 ,  서울대학교산학협력단

Inventor： 이헌수 ,  신혜승 ,  강운범 ,  노동영 ,  문형곤

IPC: G01N33/68 ,  G01N33/574 ,  C12Q1/34 ,  G01N33/532

Abstract: PURPOSE: A protein marker for diagnosing breast cancer, apolipoprotein C-1, a method for detecting the same, and a kit containing an antibody for the same for diagnosing breast cancer are provided to have superior diagnostic sensitivity and accuracy and to simply diagnose breast cancer using blood from a patient, thereby diagnosing breast cancer early. CONSTITUTION: A method for selectively detecting apolipoprotein C-1 with a sequence of sequence number 1 from a blood sample comprises the steps of detecting apolipoprotein C-1 through multiple reaction monitoring using a triple quadrupole mass spectrometer. A kit for diagnosing breast cancer contains information on a target peptide of apolipoprotein C-1 and on a pair of parent and daughter ions of the target peptide for detecting apolipoprotein C-1 from a blood sample through multiple reaction monitoring.

Abstract translation: 目的：提供诊断乳腺癌的蛋白质标记物，载脂蛋白C-1，检测乳腺癌的方法，以及含有其诊断乳腺癌的抗体的试剂盒，具有优越的诊断灵敏度和准确性，简单地诊断乳腺癌 使用患者的血液，从而早日诊断乳腺癌。 构成：从血液样品中选择性检测序列号为1的载脂蛋白C-1的方法包括通过使用三重四极杆质谱仪进行多重反应监测来检测载脂蛋白C-1的步骤。 用于诊断乳腺癌的试剂盒包含关于载脂蛋白C-1的目标肽和目标肽的一对母体和子代离子的信息，用于通过多重反应监测从血液样品检测载脂蛋白C-1。