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公开(公告)号：KR101531231B1
公开(公告)日：2015-06-24
申请号：KR1020130073277
申请日：2013-06-25
Applicant: 서울대학교산학협력단
Abstract: 스피루리나비드, 상기스피루리나비드의제조방법, 상기스피루리나비드를포함하는중금속흡착제, 상기스피루리나비드를포함하는희토류금속흡착제; 및, 클로렐라비드, 상기클로렐라비드의제조방법, 상기클로렐라비드를포함하는중금속흡착제, 및상기클로렐라비드를포함하는희토류금속흡착제에관한것이다.
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Patent Agency Ranking
公开(公告)号：KR1020150000757A
公开(公告)日：2015-01-05
申请号：KR1020130073277
申请日：2013-06-25
Applicant: 서울대학교산학협력단
Abstract: 스피루리나비드, 상기스피루리나비드의제조방법, 상기스피루리나비드를포함하는중금속흡착제, 상기스피루리나비드를포함하는희토류금속흡착제; 및, 클로렐라비드, 상기클로렐라비드의제조방법, 상기클로렐라비드를포함하는중금속흡착제, 및상기클로렐라비드를포함하는희토류금속흡착제에관한것이다.
Abstract translation: 本发明涉及螺旋藻珠，螺旋藻珠的制造方法，包含螺旋藻珠的重金属吸附剂和包含螺旋藻珠的稀土金属吸附剂; 和小球藻珠，小球藻珠的制造方法，包含小球藻珠的重金属吸附剂和包含小球藻珠的稀土金属吸附剂。
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公开(公告)号：KR101454360B1
公开(公告)日：2014-10-24
申请号：KR1020120096313
申请日：2012-08-31
Applicant: 서울대학교산학협력단
Abstract: 본 발명에서는 미세조류의 기능성 물질을 나노섬유에 혼입하여 창상피복재로 사용하기 위하여, 기존에 파에도닥틸룸 트리코르누툼으로부터 에이코사펜타에노산(eicosapentaenoic acid, EPA)를 추출하는 과정 없이, 젤라틴을 방사 용매인 트리플루오르에틸 알콜(trifluoroethyl alcohol, TFE)에 용해하고, 상기 젤라틴이 용해된 방사 용매에 파에도닥틸룸 트리코르누툼을 첨가함으로써, 젤라틴과 파에도닥틸룸 트리코르누툼 추출물이 혼합된 용액을 제조하였고, 상기 방사 용매를 전기 방사하여 EPA가 적재된 젤라틴 나노 섬유를 제조하였다. 제조된 젤라틴 나노 섬유에 EPA가 적재된 것을 확인하였고, 상기 제조된 EPA-젤라틴 나노 섬유가 항균 기능을 가지고, 세포 독성이 낮으며, 세포의 부착능 및 세포의 증식력이 우수한 것을 확인하였으므로, 상기 제조된 EPA-젤라틴 나노 섬유를 창상피복재로 유용하게 사용할 수 있다.
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14.发明授权히알루론산―도파민 컨쥬게이트로 표면이 개질된 하이드록시아파타이트 나노입자를 포함하는 실크피브로인 나노섬유 및 이를 이용한 지지체 有权包含用羟丙酸/多巴胺结合物修饰的羟基磷酸酯的纳米纤维素和使用其的SCAFFOLD
公开(公告)号：KR101313898B1
公开(公告)日：2013-09-30
申请号：KR1020120044954
申请日：2012-04-27
Applicant: 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: D01F4/02 , A61F2/2846 , A61L24/00 , A61L27/3604 , D01D5/0015 , D01D10/06 , D01F1/10
Abstract: PURPOSE: The complex nanofiber of hydroxyapatite and silk fibroin, a two dimensional structure and a three dimensional structure supporter using the same is provided to easily facilitate the uniformity and guarantee of reappearance, is able to electrospinning for a long time, and useful for cell formation, bond tissue regeneration and supporter as its mechanical property is satisfied. CONSTITUTION: The complex nanofiber uniformly disperses the hydroxyapatite nano particle which surface is reformed with the hyaluronic acid-dopamine conjugate inside the silk fibroin nanofiber. Conjugate of the hyaluronic acid-dopamine is the formation of amide bond by combining the carboxyl group of hyaluronic acid and amine group of dopamine. The hydroxyapatite which surface is reformed with the hyaluronic acid-dopamine conjugate is the combination of two hydroxyl radicals of dopamine to the surface of the hydroxyapatite. The diameter of the complex nanofiber is 100-1000 nm.
Abstract translation: 目的：提供复合纳米纤维的羟基磷灰石和丝素蛋白，二维结构和三维结构支持体，使其易于均匀，保证再现，能长时间静电纺丝，可用于细胞形成 ，粘合组织再生和支持体作为其机械性能得到满足。 构成：复合纳米纤维将丝氨蛋白纳米纤维内透明质酸 - 多巴胺缀合物表面的羟基磷灰石纳米粒子均匀分散。 透明质酸 - 多巴胺的结合物是通过将透明质酸的羧基和多巴胺的胺基组合而形成酰胺键。 表面用透明质酸 - 多巴胺缀合物重整的羟基磷灰石是多巴胺的两个羟基自由基与羟基磷灰石表面的组合。 复合纳米纤维的直径为100-1000nm。
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公开(公告)号：KR1020130051602A
公开(公告)日：2013-05-21
申请号：KR1020110116838
申请日：2011-11-10
Applicant: 한림대학교 산학협력단 , 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: A61L27/60 , A61L27/22 , A61L2430/34 , D01D5/0007
Abstract: PURPOSE: A 3 dimensional silk nano fiber film and a manufacturing method thereof are provided to control biodegradation speed by having similar structure with human skin in size and thickness. CONSTITUTION: A manufacturing method of 3 dimensional silk nano filber film for skin substitute comprises a process for preparing nano fiber undiluted solution, salt adding process and applying voltage and diffusing prepared nano fiber undiluted solution at the same time, and salt removing process from the diffused nano fiber film. On the salt adding process with the electro-spinning, the supply quantity and particle size controlled salt is sprayed on the nano fiber film to form an air gap. The size of the air gap is 10-100 micrometer and the thickness is 1-5 millimeters.
Abstract translation: 目的：提供一种三维丝纳米纤维膜及其制造方法，以通过与人体皮肤的尺寸和厚度相似的结构来控制生物降解速度。 构成：用于皮肤代用品的三维丝纳米薄膜的制造方法包括同时制备纳米纤维未稀释溶液，加盐过程和施加电压并扩散制备的纳米纤维未稀释溶液的方法，以及从扩散的脱盐过程 纳米纤维膜。 在电纺丝的加盐过程中，将供给量和粒度控制盐喷洒在纳米纤维膜上形成气隙。 气隙的大小为10-100微米，厚度为1-5毫米。
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公开(公告)号：KR1020110040389A
公开(公告)日：2011-04-20
申请号：KR1020090097627
申请日：2009-10-14
Applicant: 서울대학교산학협력단 , 대한민국(농촌진흥청장)
CPC classification number: A61L27/3604 , A61F2310/00796 , A61L27/32 , A61L27/56
Abstract: PURPOSE: A manufacturing method of a silk/hydroxyapatite complex nanofiber supporter for osteanagenesis is provided to efficiently coat the silk nanofiber supporter with hydroxyapatite in a short time. CONSTITUTION: A manufacturing method of a silk/hydroxyapatite complex nanofiber supporter for osteanagenesis comprises: a step of preparing silk spinning undiluted solution; a step of electrospinning the silk spinning undiluted solution; a step of dispersing the spun silk nanofiber; a step of manufacturing silk nanofiber having a sponge shape by freeze-drying the dispersed silk nanofiber; a step of coating the silk nanofiber with hydroxyapatite by dipping the silk nanofiber in simulated body fluid; and a step of forming pores on the silk nanofiber coated with hydroxyapatite.
Abstract translation: 目的：提供一种用于骨形成的丝/羟基磷灰石复合纳米纤维支持体的制造方法，以在短时间内有效地涂覆含有羟基磷灰石的丝绸纳米纤维支持体。 构成：用于骨形成的丝/羟基磷灰石复合纳米纤维支持体的制造方法包括：制备未纺丝的溶液的步骤; 静电纺丝未稀释溶液的步骤; 分散纺丝蚕丝纳米纤维的步骤; 通过将分散的蚕丝纳米纤维进行冷冻干燥来制造具有海绵形状的丝绸纳米纤维的步骤; 通过将丝素纳米纤维浸入模拟体液中，用羟基磷灰石涂覆蚕丝纳米纤维; 以及在涂有羟基磷灰石的丝素纳米纤维上形成孔的步骤。
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