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1.发明授权히알루론산―도파민 컨쥬게이트로 표면이 개질된 하이드록시아파타이트 나노입자를 포함하는 실크피브로인 나노섬유 및 이를 이용한 지지체 有权包含用羟丙酸/多巴胺结合物修饰的羟基磷酸酯的纳米纤维素和使用其的SCAFFOLD
公开(公告)号：KR101313898B1
公开(公告)日：2013-09-30
申请号：KR1020120044954
申请日：2012-04-27
Applicant: 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: D01F4/02 , A61F2/2846 , A61L24/00 , A61L27/3604 , D01D5/0015 , D01D10/06 , D01F1/10
Abstract: PURPOSE: The complex nanofiber of hydroxyapatite and silk fibroin, a two dimensional structure and a three dimensional structure supporter using the same is provided to easily facilitate the uniformity and guarantee of reappearance, is able to electrospinning for a long time, and useful for cell formation, bond tissue regeneration and supporter as its mechanical property is satisfied. CONSTITUTION: The complex nanofiber uniformly disperses the hydroxyapatite nano particle which surface is reformed with the hyaluronic acid-dopamine conjugate inside the silk fibroin nanofiber. Conjugate of the hyaluronic acid-dopamine is the formation of amide bond by combining the carboxyl group of hyaluronic acid and amine group of dopamine. The hydroxyapatite which surface is reformed with the hyaluronic acid-dopamine conjugate is the combination of two hydroxyl radicals of dopamine to the surface of the hydroxyapatite. The diameter of the complex nanofiber is 100-1000 nm.
Abstract translation: 目的：提供复合纳米纤维的羟基磷灰石和丝素蛋白，二维结构和三维结构支持体，使其易于均匀，保证再现，能长时间静电纺丝，可用于细胞形成 ，粘合组织再生和支持体作为其机械性能得到满足。 构成：复合纳米纤维将丝氨蛋白纳米纤维内透明质酸 - 多巴胺缀合物表面的羟基磷灰石纳米粒子均匀分散。 透明质酸 - 多巴胺的结合物是通过将透明质酸的羧基和多巴胺的胺基组合而形成酰胺键。 表面用透明质酸 - 多巴胺缀合物重整的羟基磷灰石是多巴胺的两个羟基自由基与羟基磷灰石表面的组合。 复合纳米纤维的直径为100-1000nm。
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公开(公告)号：KR1020130051602A
公开(公告)日：2013-05-21
申请号：KR1020110116838
申请日：2011-11-10
Applicant: 한림대학교 산학협력단 , 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: A61L27/60 , A61L27/22 , A61L2430/34 , D01D5/0007
Abstract: PURPOSE: A 3 dimensional silk nano fiber film and a manufacturing method thereof are provided to control biodegradation speed by having similar structure with human skin in size and thickness. CONSTITUTION: A manufacturing method of 3 dimensional silk nano filber film for skin substitute comprises a process for preparing nano fiber undiluted solution, salt adding process and applying voltage and diffusing prepared nano fiber undiluted solution at the same time, and salt removing process from the diffused nano fiber film. On the salt adding process with the electro-spinning, the supply quantity and particle size controlled salt is sprayed on the nano fiber film to form an air gap. The size of the air gap is 10-100 micrometer and the thickness is 1-5 millimeters.
Abstract translation: 目的：提供一种三维丝纳米纤维膜及其制造方法，以通过与人体皮肤的尺寸和厚度相似的结构来控制生物降解速度。 构成：用于皮肤代用品的三维丝纳米薄膜的制造方法包括同时制备纳米纤维未稀释溶液，加盐过程和施加电压并扩散制备的纳米纤维未稀释溶液的方法，以及从扩散的脱盐过程 纳米纤维膜。 在电纺丝的加盐过程中，将供给量和粒度控制盐喷洒在纳米纤维膜上形成气隙。 气隙的大小为10-100微米，厚度为1-5毫米。
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公开(公告)号：KR101582172B1
公开(公告)日：2016-01-06
申请号：KR1020120112845
申请日：2012-10-11
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은 PCR 방법을이용하여밀리타리스동충하초를동정하는방법, 상기방법에사용되는프라이머및 상기프라이머를포함하는밀리타리스동충하초동정용키트에관한것이다. 본발명의방법을이용하면, 외관상으로용이하게구별되지않는밀리타리스동충하초를정확하고신속하게동정할수 있으므로, 밀리타리스동충하초를포함하는다양한제품의개발에널리활용될수 있을것이다.
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公开(公告)号：KR101501554B1
公开(公告)日：2015-03-13
申请号：KR1020130070167
申请日：2013-06-19
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
Abstract: 본 발명은 누에 혈림프 유래 70kDa 단백질을 포함하는 화장료 조성물에 관한 것이다.
본 발명의 화장료 조성물은 누에 혈림프 유래 70kDa 단백질을 포함하는 것을 특징으로, 보다 상세하게는 누에로부터 실샘을 제거하고 남은 혈림프를 분쇄한 다음 물에 넣고 열처리한 후 이를 원심분리하여 얻은 상등액을 컬럼을 통해 분리하여 얻은 누에 혈림프 유래 70kDa 단백질을 포함하는 것이 특징이다.
본 발명에 의해, 인체 무해하면서 항산화능, 항균활성능, 미백효과 등이 우수한 누에 혈림프 유래 70kDa 단백질을 포함하는 화장료 조성물이 제공된다.-
公开(公告)号：KR1020140147913A
公开(公告)日：2014-12-31
申请号：KR1020130070167
申请日：2013-06-19
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
CPC classification number: A61K8/64 , A61K8/987 , A61K2800/84 , A61Q17/005 , A61Q19/02 , B01D15/34
Abstract: The present invention relates to a cosmetic composition containing a 70-kDa protein derived from silkworm hemolymph. The cosmetic composition of the present invention contains 70-kDa protein derived from silkworm hemolymph, and more specifically, 70-kDa protein derived from silkworm hemolymph, which is obtained by removing silk glands from silkworms, pulverizing the remaining hemolymph, putting the pulverized hemolymph in water, performing heat treatment, and obtaining a supernatant through centrifugation, and subjecting the supernatant to column separation. According to the present invention, provided is a cosmetic composition containing a 70-kDa protein derived from silkworm hemolymph, wherein the cosmetic composition is harmless to the human body and has excellent anti-oxidative capability, antibacterial activity, and whitening effect.
Abstract translation: 本发明涉及含有来源于蚕血淋巴的70-kDa蛋白质的化妆品组合物。 本发明的化妆品组合物含有来源于蚕血淋巴的70-kDa蛋白质，更具体地说，来源于蚕血淋巴的70-kDa蛋白质，其通过从蚕中除去丝腺获得，粉碎剩余的血淋巴，将粉碎的血淋巴 水，进行热处理，通过离心获得上清液，并对上清液进行柱分离。 根据本发明，提供了含有来源于蚕血淋巴的70-kDa蛋白质的化妆品组合物，其中所述化妆品组合物对人体无害，并且具有优异的抗氧化能力，抗菌活性和增白效果。
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Patent Agency Ranking
公开(公告)号：KR101444303B1
公开(公告)日：2014-11-04
申请号：KR1020120104477
申请日：2012-09-20
Applicant: 대한민국(농촌진흥청장) , (주)차바이오텍
Abstract: 본 발명은 누에 실샘 유래 가수분해물을 포함하는 화장료 조성물에 관한 것이다.
본 발명의 화장료 조성물은 누에 실샘 유래 가수분해물을 포함하는 것을 특징으로, 보다 상세하게는 누에로부터 실샘을 분리해 낸 다음, 그 분리된 실샘을 물로 용해한 후 원심분리하여 얻은 상등액에, 알칼리를 첨가한 후 가수분해한 다음 중화 및 탈염과정을 거쳐 얻은 가수분해물을 포함하는 것이 특징이다.
본 발명에 의해, 인체 무해하면서 항산화능, 피부세포증식능, 피부 친화력 등이 우수한 누에 실샘 유래 가수분해물을 포함하는 화장료 조성물이 제공된다.-
公开(公告)号：KR101413101B1
公开(公告)日：2014-07-04
申请号：KR1020130023537
申请日：2013-03-05
Applicant: 대한민국(농촌진흥청장)
Abstract: The present invention relates to a fermented alcoholic beverage using mulberries and Cordyceps and a manufacturing method thereof. The manufacturing method of the fermented alcoholic beverage using mulberries and Cordyceps, given in the present invention, includes a first step of manufacturing a mulberry-fermented liquor by fermenting mulberries; a second step of immersing Cordyceps into an alcohol solution and extracting Cordyceps extract; a third step of adding water to the Cordyceps extract to get a diluted Cordyceps extract solution; a fourth step of mixing the mulberry-fermented liquor and the diluted Cordyceps extract solution to get a crude solution for producing a mulberry-Cordyceps alcoholic beverage; and a fifth step of fermenting the crude solution for producing a mulberry-Cordyceps alcoholic beverage and producing a mulberry-Cordyceps alcoholic beverage. The present invention is able to provide a fermented alcoholic beverage using mulberries and Cordyceps capable of preventing decomposition of Cordyceps while having low alcohol concentration, having effects from both mulberries and Cordyceps, improving organoleptic properties, and accordingly increasing consumer preference.
Abstract translation: 本发明涉及使用桑berry和冬虫夏草的发酵酒精饮料及其制造方法。 在本发明中给出的使用桑berry和冬虫夏草的发酵酒精饮料的制造方法包括通过发酵桑蚕制造桑berry发酵液的第一步骤; 将冬虫夏草浸入酒精溶液中并提取冬虫夏草提取物的第二步; 向冬虫夏萃取液中加入水以获得稀释的冬虫夏草提取物溶液的第三步; 将桑叶发酵液和稀释的冬虫夏草提取物溶液混合以获得用于生产桑蛹虫草酒精饮料的粗溶液的第四步骤; 以及第五步骤，用于生产桑Cord虫酒精饮料的粗溶液并生产桑蛹虫草酒精饮料。 本发明能够提供一种发酵酒精饮料，其使用能够防止冬虫夏草分解，同时具有低酒精浓度，具有桑果和冬虫夏草的作用，改善感官特性，从而增加消费者偏好的桑蛹和冬虫夏草。
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公开(公告)号：KR101211583B1
公开(公告)日：2012-12-12
申请号：KR1020100046142
申请日：2010-05-17
Applicant: 대한민국(농촌진흥청장)
CPC classification number: Y02P60/877
Abstract: 본발명은잠상부산물의 50 내지 70% 에탄올추출물을함유하는사료용조성물, 상기잠상부산물의에탄올추출물을산란계에급이하여얻어진파고민을함유하는기능성계란, 또상기잠상부산물의에탄올추출물을산란계에게급이하고, 당해산란계로부터파고민을함유하는기능성계란을생산하는방법을제공한다. 상기본 발명의구성에의하면, 인체내인슐린의분비를촉진하는파고민을계란내에이행시켜농축할수 있어고부가가치의기능성계란과같은식품용소재로서제공할수 있음은물론, 나아가계란으로부터파고민을순수분리하여약제학적조성물의활성성분으로서공급하는것이가능하다.
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公开(公告)号：KR1020110126460A
公开(公告)日：2011-11-23
申请号：KR1020100046142
申请日：2010-05-17
Applicant: 대한민국(농촌진흥청장)
CPC classification number: Y02P60/877 , A23K10/26 , A23K10/37 , A23K50/75
Abstract: PURPOSE: A feed composition containing silkworm mulberry by-products, and functional eggs produced by using thereof, and a producing method of the functional egg are provided to improve the productivity of egg laying hens. CONSTITUTION: A feed composition contains 1-2wt% of extract of silkworm mulberry by-products obtained by using 50-70% ethanol. Functional eggs containing fagomine are obtained by feeding the 50-70% ethanol extract of the silkworm mulberry by-products to egg laying hens for 6 weeks. The fagomine promotes the secretion of insulin in the human body.
Abstract translation: 目的：提供含有桑蚕桑副产物的饲料组合物，以及通过使用它们产生的功能性鸡蛋和功能蛋的生产方法，以提高产蛋鸡的生产力。 构成：饲料组合物含有1-2重量％的通过使用50-70％乙醇获得的桑蚕桑叶副产物提取物。 通过将蚕桑桑副产物的50-70％乙醇提取物喂给产蛋鸡6周，得到含有fagomine的功能性蛋白。 fagomine促进胰岛素在人体内的分泌。
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公开(公告)号：KR1020110044085A
公开(公告)日：2011-04-28
申请号：KR1020090100905
申请日：2009-10-22
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: A producing method of silk gland powder of matured silkworms is provided to easily obtain the silk gland powder by collecting silkworms right before a pupae stage. CONSTITUTION: A producing method of silk gland powder of matured silkworms comprises the following steps: breeding silkworms until the fifth instar, to obtain the matured silkworms; rapidly freezing the matured silkworms with liquid nitrogen, and storing; freeze-drying the matured silkworms; separating silk glands from the freeze-dried silkworms; and crushing the obtained silk glands.
Abstract translation: 目的：提供成熟蚕丝腺粉的生产方法，通过在蛹期前收集蚕丝，轻松获得丝腺粉末。 构成：成熟蚕丝腺粉的制备方法，包括以下步骤：将蚕培养至五龄，获得成熟蚕; 用液氮快速冷冻成熟的蚕，储存; 冷冻成熟的蚕; 从冷冻干蚕分离丝腺; 并粉碎获得的丝腺。
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