Abstract:
본 발명은 원숭이 CD43 항원에 특이적으로 결합하는 고 친화성 단일 클론 항 원숭이 CD43 항체 (anti-monkey CD43 antibody), 이를 생산하는 융합 세포주 (hybridoma)에 관한 것이다. 본 발명은 면역증강 작용이 있는 항 원숭이 CD43 항체 및 항체 변형물에 관한 것으로 이를 이용하여 암 치료 및 바이러스 감염치료에 응용할 수 있다.
Abstract:
PURPOSE: A cytotoxic T lymphocyte antigen 4-immunoglobulin G (CTLA-4IgG) fusion protein is provided to be effectively conjugated to a lipid vehicle and to suppress T cells, thereby being used as a pharmaceutical composition for suppressing immunity, such as an agent for treating autoimmune diseases. CONSTITUTION: A CTLA-4IgG fusion protein has the C-terminal of immunoglobulin CH3 domain, wherein the amino acid, lysine is substituted with cysteine. The IgG is selected among IgG1, IgG2, IgG3, and IgG4. The CTLA-4IgG fusion protein is conjugated with a lipid vehicle.
Abstract:
PURPOSE: A high affinity monoclonal antibody anti-monkey CD43 antibody and a hybridoma producing the same are provided to recognize monkey-specific CD43 antigen with high affinity and to enhance T cell activation. CONSTITUTION: An anti-monkey CD43 monoclonal antibody is specific to CD43 antigen isolated from a monkey. The CD43 antibody contains a variable region of heavy chain having an amino acid of sequence number 1 and a variable region of light chain having an amino acid of sequence number 2. The monoclonal antibody is produced by a hydridoma(deposit number KCLRF-BP-00231). A composition for treating CD43+T cell-mediated or related diseases contains the CD43 antibody or a variant thereof.
Abstract:
본발명은대체경로억제제를함유하는대체경로억제용조성물및 이를이용한대체경로억제방법에관한것으로, 보다구체적으로는보체인자 H 또는인자 B 길항제와같은대체경로억제제및 면역억제물질을함유하는대체경로억제용조성물및 이를이용한대체경로억제방법에관한것으로, 이는 IMBIR을저해하고이식물의존속기간을연장하는효과가있어성체돼지로부터분리한췌도의내문이식등 이식수술에활용될수 있다.