Abstract:
PURPOSE: A composition for diagnosing lung cancer is provided to early diagnose lung cancer and to ensure sensitivity and specificity. CONSTITUTION: A composition for diagnosing lung cancer contains an antibody which specifically binds to one or more proteins selected from the group consisting of quescin-sulfhydryl oxidase 1, fibrillin-1, isoform A of lamin-A/C, latent-transforming growth factor beta-binding protein 2, galectin-1, Dickkopf-related protein 3, isoform A1-B of heterogeneous nuclear ribonucleoprotein A1, 14-3-3 protein epsilon, stanniocalcin-2, cystatin-C, isoform 1 of connective tissue growth factor, profilin-1, isoform 1 of extracellular matrix protein 1, histone H2B type 2-E, kinesin-like protein KIF26A, zinc finger protein 516, and isoform 1 of A-kinase anchor protein 9. The lung cancer is selected from the group consisting of adenocarcinoma of the lung, squamous cell carcinoma, large cell carcinoma, and small cell cancer. A kit for diagnosing lung cancer contains the composition as an active ingredient. A microarray for diagnosing lung cancer contains the composition as an active ingredient. [Reference numerals] (AA,GG) Patient number; (B1,H1) Gender; (B2,B3,B4,B5,H2,H3,H4) Male; (B6) Female; (CC,II) Age; (D1,J1) Histological classification; (D2,D4,D6,J2,J3,J4) Adenocarcinoma; (D3,D5) Squamous cell carcinoma; (E1,K1) Step; (E2,E5,K4) Step IIA; (E3,E4,E6,K3) Step IB; (F1,L1) Smoking history; (F2,F3) 30 boxes/year; (F4) 15 boxes/year; (F5) 70 boxes/year; (K2) Step IA; (L2) 80 boxes/year; (L3) 40 boxes/year; (MM,NN) Information X;
Abstract:
The present invention relates to a method for screening formulations used for preventing or treating diseases related to FGF2, which comprises a step of measuring the level of CXCL5 in cells for making bones and vascular endothelial cells processed with FGF2 and candidate materials to prevent or treat diseases related to FGF2 including clone myeloblastic cellular diseases, a screening kit used in the screening method and a formulation obtained by the screening method for treating or preventing diseases related to FGF2. In the present invention, using the screening method is allowed to easily screen the formulation with a high reliability wherein the formulation is used for treating or preventing diseases related to bones caused by excesses FGF2 and other diseases related to hematopoietic stem cells like an effect on movement of hematopoietic stem cell series in bone marrow by the change of bone, thereby being used for manufacturing drugs to treat or prevent diseases related to FGF2 or to hematopoietic stem cell series.
Abstract:
본 발명은 소세포폐암의 조기 진단에 유용한 바이오마커로서 퀴혈청 파라옥소나제 1(Serum paraoxonase 1), 피브릴린-1(Fibrillin-1), 리포폴리사카라이드-반응 및 베이지-유사 앵커 단백질(Isoform 1 of Lipopolysaccharide-responsive and beige-like anchor protein), 아포리포단백질 D(Apolipoprotein D), 세로트랜스페린(Serotransferrin), 칼리스타틴(Kallistatin), 혈장 칼리클레인(Plasma kallikrein), 루미칸(Lumican), 히스티딘-리치 당단백질(Histidine-rich glycoprotein), 알파-2-HS-당단백질(Alpha-2-HS-glycoprotein), 알파-1B-당단백질(Alpha-1B-glycoprotein) 및 아포리포단백질A-IV(Apolipoprotein A-IV)로 이루어진 군에서 선택된 하나 이상의 단백질 또는 합토글로빈(Haptoglobin), 헤모펙신(Hemopexin), C4b-결합 단백질 알파 체인(C4b-binding protein alpha chain), 보체성분 C9(Complement component C9), CD5 유사 항원(CD5 antigen-like), 인터-알파-트립신 억� ��제 중쇄 H2(Inter-alpha-trypsin inhibitor heavy chain H2), 혈청 아밀로이드 P 성분(Serum amyloid P component), 인터-알파-트립신 억제제 중쇄 H4(Isoform 2 of Inter-alpha-trypsin inhibitor heavy chain H4), 합토글로빈 관련 단백질(Isoform 1 of Haptoglobin-related protein), 알파-1-안티키모트립신(ALPHA-1-antichymotrypsin) 및 알파-1-안티트립신(Isoform 1 of Alpha-1-antitrypsin)으로 이루어진 군에서 선택된 하나 이상의 단백질을 제공한다.
Abstract:
본 발명은 후기내피전구세포를 RGD-알지네이트 용액에 혼합하여 현탁액을 제조하는 단계; 혈관내피성장인자(VEGF)와 간세포성장인자(HGF)를 상기 현탁액에 추가하는 단계; 상기 현탁액을 전기분무시키는 단계를 포함하는 것을 특징으로 하는 허혈성 질환 치료용 주입식 마이크로젤의 제조방법이다.상기 주입식 마이크로젤은 후기내포전구세포등 혈관치료세포의 생존률을 높이고 마이크로젤 안에 함유된 혈관내피성장인자(VEGF)및 간세포성장인자(HGF)등의 혈관성장인자들을 지속적으로 방출하여 더욱 향상된 신혈관 생성효과를 발휘할 수 있다.
Abstract:
The present invention relates to a biomarker which is useful for the early diagnosis of lung cancer. The biomarker is a lung cancer-diagnosing composition including an antibody which is specific to a GPI specific phospholipase D1 (GPLD1) protein and a lung cancer-diagnosing composition including a primer or a probe which is specific to nucleic acid encoding the protein. The biomarker of the present invention can be usefully used for early lung cancer diagnosis and also to evaluate the progress of diseases and give a prognosis before and after treatment.
Abstract:
본 발명은 폐암의 조기 진단에 유용한 바이오마커로서 퀴에신-설프히드릴 옥시다제 1(Quescin-sulfhydryl oxidase 1), 피브릴린-1(Fibrillin-1), 라민-A/C(Isoform A of Lamin-A/C), 잠재 형질전환증식인자 베타-결합단백질 2(Latent-transforming growth factor beta-binding protein 2), 갈렉틴-1(Galectin-1), 딕오프관련단백질 3(highly similar to Dickkopf-related protein 3), 이질성 핵 리보핵단백질 A1(Isoform A1-B of Heterogeneous nuclear ribonucleoprotein A1), 14-3-3 엡실론 단백질(14-3-3 protein epsilon), 시스타틴-C(Cystatin-C), 결합 조직 성장인자 1(Isoform 1 of Connective tissue growth factor), 프로필린-1(Profilin-1), 세포외 간질단백질 1(Isoform 1 of Extracellular matrix protein 1), 히스톤 H2B 타입 2-E(Histone H2B type 2-E), 키네신 유사 단백질 KIF26A(Kinesin-like protein KIF26A), 징크 핑거 단백질 516(Zinc finger protein 516) 및 A-키나제 앵커 단백질 9(Isoform 1 of A-kinase anchor protein 9)로 이루어진 군에서 선택된 하나 이상의 단백질을 제공한다.