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    폐암 진단용 조성물 및 폐암 진단키트
    1.
    发明授权
    폐암 진단용 조성물 및 폐암 진단키트 有权
    用于肺癌诊断和肺癌诊断试剂盒的组成

    公开(公告)号：KR101297309B1

    公开(公告)日：2013-08-16

    申请号：KR1020110104949

    申请日：2011-10-14

    Applicant: 서울대학교산학협력단

    Inventor： 조제열 ,  성혜진

    IPC: G01N33/574 ,  C12Q1/68

    CPC classification number: G01N33/573 ,  G01N33/57423

    Abstract: 본 발명은 폐암의 조기 진단에 유용한 바이오마커로서 퀴에신-설프히드릴 옥시다제 1(Quescin-sulfhydryl oxidase 1), 피브릴린-1(Fibrillin-1), 라민-A/C(Isoform A of Lamin-A/C), 잠재 형질전환증식인자 베타-결합단백질 2(Latent-transforming growth factor beta-binding protein 2), 갈렉틴-1(Galectin-1), 딕오프관련단백질 3(highly similar to Dickkopf-related protein 3), 이질성 핵 리보핵단백질 A1(Isoform A1-B of Heterogeneous nuclear ribonucleoprotein A1), 14-3-3 엡실론 단백질(14-3-3 protein epsilon), 시스타틴-C(Cystatin-C), 결합 조직 성장인자 1(Isoform 1 of Connective tissue growth factor), 프로필린-1(Profilin-1), 세포외 간질단백질 1(Isoform 1 of Extracellular matrix protein 1), 히스톤 H2B 타입 2-E(Histone H2B type 2-E), 키네신 유사 단백질 KIF26A(Kinesin-like protein KIF26A), 징크 핑거 단백질 516(Zinc finger protein 516) 및 A-키나제 앵커 단백질 9(Isoform 1 of A-kinase anchor protein 9)로 이루어진 군에서 선택된 하나 이상의 단백질을 제공한다.

    폐암 진단용 조성물 및 폐암 진단키트
    4.
    发明公开
    폐암 진단용 조성물 및 폐암 진단키트 有权
    肺癌诊断组和肺癌诊断组

    公开(公告)号：KR1020130040293A

    公开(公告)日：2013-04-24

    申请号：KR1020110104949

    申请日：2011-10-14

    Applicant: 서울대학교산학협력단

    Inventor： 조제열 ,  성혜진

    IPC: G01N33/574 ,  C12Q1/68

    CPC classification number: G01N33/573 ,  G01N33/57423 ,  C12Q1/6886 ,  G01N33/5302 ,  G01N33/6857 ,  G01N33/6893 ,  G01N2033/57453

    Abstract: PURPOSE: A composition for diagnosing lung cancer is provided to early diagnose lung cancer and to ensure sensitivity and specificity. CONSTITUTION: A composition for diagnosing lung cancer contains an antibody which specifically binds to one or more proteins selected from the group consisting of quescin-sulfhydryl oxidase 1, fibrillin-1, isoform A of lamin-A/C, latent-transforming growth factor beta-binding protein 2, galectin-1, Dickkopf-related protein 3, isoform A1-B of heterogeneous nuclear ribonucleoprotein A1, 14-3-3 protein epsilon, stanniocalcin-2, cystatin-C, isoform 1 of connective tissue growth factor, profilin-1, isoform 1 of extracellular matrix protein 1, histone H2B type 2-E, kinesin-like protein KIF26A, zinc finger protein 516, and isoform 1 of A-kinase anchor protein 9. The lung cancer is selected from the group consisting of adenocarcinoma of the lung, squamous cell carcinoma, large cell carcinoma, and small cell cancer. A kit for diagnosing lung cancer contains the composition as an active ingredient. A microarray for diagnosing lung cancer contains the composition as an active ingredient. [Reference numerals] (AA,GG) Patient number; (B1,H1) Gender; (B2,B3,B4,B5,H2,H3,H4) Male; (B6) Female; (CC,II) Age; (D1,J1) Histological classification; (D2,D4,D6,J2,J3,J4) Adenocarcinoma; (D3,D5) Squamous cell carcinoma; (E1,K1) Step; (E2,E5,K4) Step IIA; (E3,E4,E6,K3) Step IB; (F1,L1) Smoking history; (F2,F3) 30 boxes/year; (F4) 15 boxes/year; (F5) 70 boxes/year; (K2) Step IA; (L2) 80 boxes/year; (L3) 40 boxes/year; (MM,NN) Information X;

    Abstract translation: 目的：提供诊断肺癌的组合物，以早期诊断肺癌并确保敏感性和特异性。 构成：用于诊断肺癌的组合物含有特异性结合一种或多种选自以下的蛋白质的抗体：蛋白质 - 巯基氧化酶1，原纤维蛋白-1，层状A / C的同种型A，潜伏转化生长因子β 结合蛋白2，半乳凝素-1，Dickkopf相关蛋白3，异源核核糖核蛋白A1异构体A1-B，14-3-3蛋白质ε，猕猴桃素-2，半胱氨酸蛋白酶C，结缔组织生长因子异构体1 -1，细胞外基质蛋白1的同种型1，组蛋白H2B型2-E，驱动蛋白样蛋白KIF26A，锌指蛋白516和A激酶锚蛋白9的同种型1。肺癌选自 肺腺癌，鳞状细胞癌，大细胞癌和小细胞癌。 用于诊断肺癌的试剂盒含有作为活性成分的组合物。 用于诊断肺癌的微阵列包含该组合物作为活性成分。 （附图标记）（AA，GG）患者编号; （B1，H1）性别; （B2，B3，B4，B5，H2，H3，H4）男; （B6）女; （CC，II）年龄; （D1，J1）组织学分类; （D2，D4，D6，J2，J3，J4）腺癌; （D3，D5）鳞状细胞癌; （E1，K1）步骤; （E2，E5，K4）步骤IIA; （E3，E4，E6，K3）步骤1B; （F1，L1）吸烟史; （F2，F3）30箱/年; （F4）15箱/年; （F5）70箱/年; （K2）步骤1A; （L2）80箱/年; （L3）40箱/年; （MM，NN）信息X;

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