Abstract:
Disclosed is a new use of estrogen which inhibits the infection by nontuberculous mycobacteria forming rough colonies. The present invention provides a pharmaceutical composition including estrogen which inhibits the infection by mycobacteria or prevents or treats diseases caused by mycobacetria. According the present invention, the estrogen or the pharmaceutical composition including the same inhibits the infection by nontuberculous mycobacteria forming rough colonies and thus can be used as a treating agent.
Abstract:
PURPOSE: A mycobacteria-derived DNA mismatch repair DNA nucleic acid molecule is provided to enhance resistance to UV and macrophage. CONSTITUTION: A mycobacteria-derived DNA mismatch repair DNA nucleic acid molecule has a nucleotide sequence of sequence number 1 or 2. The gene expression regulatory sequence with UV resistance contains the promoter containing a nucleotide sequence of sequence number 3. A recombinant vector contains an expression target-coding nucleotide sequence and a promoter operatively linked to the nucleotide sequence. The expression target-coding nucleotide sequence is a DNA mismatch repair protein-encoding nucleotide sequence of sequence number 1 or 2. The recombinant vector additionally contains a selection marker. A method for detecting mycobacteria other than tuberculosis(MOTT) comprises: a step of preparing a sample containing the nucleic acid molecule; and a step of detecting MutS4A or MutS4B from a sample.