公开(公告)号：KR1020120017203A

公开(公告)日：2012-02-28

申请号：KR1020100079753

申请日：2010-08-18

Applicant: 이화여자대학교 산학협력단 ,  연세대학교 산학협력단

Inventor： 오세관 ,  정만길 ,  정재철

IPC: C07C49/84 ,  C07C45/72 ,  A61K31/12 ,  A61P39/06

Abstract: PURPOSE: A manufacturing method of 4-hydroxy-3-methoxyphenyl-2-propenone derivatives is provided to obtain 4-hydroxy-3-methoxyphenyl-2-propenone derivatives with high purity and high yield under mild reaction condition. CONSTITUTION: A compound or pharmaceutically acceptable salts thereof are in chemical formula 1, 2, or 3. A manufacturing method of the compound comprises a step of reacting a compound in chemical formula 4, and 1,3-diacetylbenzene, or 1,3,5-triacetylbenzene under the presence of acid. In chemical formulas R1 and R2 is respectively and independently selected from a group consisting of hydrogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, trimethylsilyl, and C1-6 alkylcarbonyl.

Abstract translation: 目的：提供4-羟基-3-甲氧基苯基-2-丙烯酮衍生物的制备方法，以在温和的反应条件下获得高纯度和高收率的4-羟基-3-甲氧基苯基-2-丙烯酮衍生物。 化合物的化合物或其药学上可接受的盐为化学式1,2或3.化合物的制备方法包括使化学式4中的化合物与1,3-二乙酰基苯或1,3-二乙酰基苯反应的步骤， 5-三乙酰苯。 在化学式中，R 1和R 2分别独立地选自氢，羟基，C 1-6烷基，C 1-6烷氧基，三甲基甲硅烷基和C 1-6烷基羰基。

公开(公告)号：KR1020100077639A

公开(公告)日：2010-07-08

申请号：KR1020080135647

申请日：2008-12-29

Applicant: 연세대학교 산학협력단

Inventor： 한광협 ,  백용한 ,  정만길 ,  윤영준 ,  이현철

IPC: A61K31/343 ,  A61P1/16

Abstract: PURPOSE: A pharmaceutical composition containing lithospermate B or salt thereof for preventing or treating hepatic disorder is provided to suppress activation of hepatic stellate cells. CONSTITUTION: A pharmaceutical composition for preventing or treating hepatic disorder contains lithospermate B or salt thereof as an active ingredient. The salt of lithospermate B is magnesium lithospermate B. The hepatic disorder is hepatitis, hepatic fibrosis, or hepatic cirrhosis. A food composition for preventing or treating hepatic fibrosis or hepatic cirrhosis contains lithospermate B or salt thereof as an active ingredient.

Abstract translation: 目的：提供含有紫草素B或其盐的药物组合物，用于预防或治疗肝脏疾病，以抑制肝星状细胞的活化。 构成：用于预防或治疗肝脏疾病的药物组合物含有作为活性成分的白菊酯B或其盐。 紫花苜蓿B的盐是硼酸镁B.肝病是肝炎，肝纤维化或肝硬化。 用于预防或治疗肝纤维化或肝硬化的食物组合物含有作为活性成分的白菊酯B或其盐。

公开(公告)号：KR101656306B1

公开(公告)日：2016-09-12

申请号：KR1020140039550

申请日：2014-04-02

Applicant: 연세대학교 산학협력단

Inventor： 정원윤 ,  박광균 ,  마광택 ,  정만길

IPC: A61K36/282 ,  A61P19/10 ,  A61P19/00

Abstract: 본발명에따른개똥쑥추출물, 아테미시닌, 또는이의유도체를유효성분으로함유하는골 질환예방및 치료용약학조성물은세포독성이낮아안정적이며, 파골세포의형성을효과적으로억제할수 있을뿐만아니라, 형성된파골세포의골 흡수기작도효과적으로억제할수 있다.

公开(公告)号：KR1020150019736A

公开(公告)日：2015-02-25

申请号：KR1020130096918

申请日：2013-08-14

Applicant: 연세대학교 산학협력단

Inventor： 정만길 ,  정원윤 ,  박광균

IPC: C07H15/24 ,  A61K31/704 ,  A61P35/00

CPC classification number: C07H15/24 ,  A61K31/704 ,  C07H1/00 ,  C07H15/23

Abstract: 본 발명은 신규 항암제 풀사틸라 사포닌D 유도체와 이의 제조방법 및 이의 중간체에 관한 것이다. 본 발명은 저렴한 원료로부터 효율적 전합성을 통해 천연물 기원의 글로벌 신규 폐암치료제로 개발될 수 있는 풀사틸라 사포닌D(PSD) 유도체를 대량생산할 수 있고, PSD 유도체는 폐암에 매우 뛰어난 효과가 있다.

Abstract translation: 本发明涉及作为新型抗癌剂的脉illa皂苷D衍生物，其制造方法及其中间体。 根据本发明，可以大量生产可以发展成由天然物质衍生的全球新型肺癌治疗剂的脉动皂苷D衍生物。 脉络皂苷D衍生物（PSD）对肺癌具有非常优异的作用。

公开(公告)号：KR101210553B1

公开(公告)日：2012-12-10

申请号：KR1020100054435

申请日：2010-06-09

Applicant: 충북대학교 산학협력단 ,  연세대학교 산학협력단

Inventor： 윤여표 ,  임용 ,  정만길

IPC: C07H15/00 ,  A61K31/70 ,  A61K31/7056 ,  A61P9/00

CPC classification number: C07H15/26

Abstract: 본발명은신규당지질(glycolipid) 유도체화합물, 이화합물을유효성분으로포함하는혈관평활근세포증식억제용조성물및 이화합물을유효성분으로포함하는혈관평활근세포이상증식성질환의예방또는치료용약제학적조성물을제공한다. 본발명의신규당지질유도체화합물은뛰어난혈관평활근세포증식억제활성을가지므로, 혈관평활근세포이상증식성질환, 예를들어, 동맥경화증, 아테롬성동맥경화증, 혈관재협착증, 혈관협착증뿐만아니라이로인해이차적으로발생되는다양한심혈관계질환의예방또는치료에유용하게사용될수 있다.

公开(公告)号：KR1020110134709A

公开(公告)日：2011-12-15

申请号：KR1020100054435

申请日：2010-06-09

Applicant: 충북대학교 산학협력단 ,  연세대학교 산학협력단

Inventor： 윤여표 ,  임용 ,  정만길

IPC: C07H15/00 ,  A61K31/70 ,  A61K31/7056 ,  A61P9/00

CPC classification number: C07H15/26

Abstract: PURPOSE: A novel glycolipid derivative compound and a composition containing the same are provided to prevent or treat vascular smooth muscle cell hyperproliferation. CONSTITUTION: A glycolipid derivative compound is denoted by chemical formula 1. In chemical formula 1, R is E-cinnamoyl, C1-C10 linear alkanal of or C1-C4 linear alkyl substituted with phenyltriazolyl. A composition for suppressing vascular smooth muscle cell contains the compound of chemical formula 1. A pharmaceutical composition for preventing or treating vascular smooth muscle cell hyperproliferation contains therapeutically effective amount of the compound of chemical formula 1 and pharmaceutically acceptable carrier.

Abstract translation: 目的：提供一种新型糖脂衍生物化合物及含有此类化合物的组合物，以预防或治疗血管平滑肌细胞过度增殖。 构成：化学式1表示糖脂衍生物化合物。在化学式1中，R为E-肉桂酰基，或被苯基三唑基取代的C 1 -C 10直链烷基或C 1 -C 4直链烷基。 用于抑制血管平滑肌细胞的组合物含有化学式1的化合物。用于预防或治疗血管平滑肌细胞过度增殖的药物组合物含有治疗有效量的化学式1化合物和药学上可接受的载体。

公开(公告)号：KR1020090088496A

公开(公告)日：2009-08-20

申请号：KR1020080013796

申请日：2008-02-15

Applicant: 연세대학교 산학협력단 ,  (주)케이디알

Inventor： 정만길 ,  백융기

IPC: C07D309/10 ,  C07D407/12

Abstract: A pheromone compound, 6-(3,6-dideoxy-alpha-L-arabino-hexopyranosyloxy)heptanoic acid derivative which is isolated from C. elegans is provided to massively produce pheromone and use metabolic pathway and signal transduction system development. A 6-(3,6-dideoxy-alpha-L-arabino-hexopyranosyloxy)heptanoic acid derivative is denoted by the chemical formula (I), (II) or (III). A method for producing the 6-(3,6-dideoxy-alpha-L-arabino-hexopyranosyloxy)heptanoic acid derivative comprises: a step of reacting the chemical formula (IV) and (V) to produce the chemical formula (I); a step of performing oxidation/reduction of the compound of the chemical formula (I); and a step of removing a protection residue of the compound of the chemical formula (I).

Abstract translation: 提供信号素化合物，从秀丽隐杆线虫中分离得到的6-（3,6-二脱氧-α-L-阿拉伯 - 六吡喃糖基氧基）庚酸衍生物，以大量产生信息素，并使用代谢途径和信号转导系统发育。 6-（3,6-二脱氧-α-L-阿拉伯 - 六吡喃糖基氧基）庚酸衍生物由化学式（I），（II）或（III）表示。 制备6-（3,6-二脱氧-α-L-阿拉伯 - 六吡喃糖基氧基）庚酸衍生物的方法包括：使化学式（IV）和（V）反应以产生化学式（I）的步骤; 进行化学式（I）的化合物的氧化/还原的步骤; 以及除去化学式（I）的化合物的保护残基的步骤。

公开(公告)号：KR101277710B1

公开(公告)日：2013-06-24

申请号：KR1020100087565

申请日：2010-09-07

Applicant: 연세대학교 산학협력단

Inventor： 정만길 ,  제르미리치 ,  박광균 ,  정원윤

IPC: C07D493/18 ,  C07H13/06 ,  A61K31/335 ,  A61P35/00

CPC classification number: C07H13/04 ,  C07H15/10 ,  C07H15/18

Abstract: 본 발명은 신규한 디옥소아테미시닌-당지질 복합유도체 및 그의 혈관신생억제 용도에 관한 것이다. 본 발명의 디옥소아테미시닌-당지질 복합유도체는 그 자체로서 신규한 물질일 뿐만 아니라, 기존 약물 보다 2배이상 강한 항혈관신생 활성을 가지며 세포 독성이 없기 때문에 인체에 안전하다.

公开(公告)号：KR1020120016926A

公开(公告)日：2012-02-27

申请号：KR1020100079463

申请日：2010-08-17

Applicant: 이화여자대학교 산학협력단 ,  연세대학교 산학협력단

Inventor： 오세관 ,  정만길 ,  정재철

IPC: C07C259/06 ,  C07D317/14 ,  A61K31/165 ,  A61P25/36

Abstract: PURPOSE: A cinnamic acid derivative is provided to have high reduction activity to the toxic component of nerve cells, and to have biological stability. CONSTITUTION: A cinnamic acid derivative is in chemical formula 1. In chemical formula 1, R1 is C1-3 alkyl, phenyl, 5-6-membered heterocycloalkyl substituted by NR2R3 or substituted by benzyl or one or two alkoxy, or OR4. R2 is hydrogen or C1-3 alkyl. R3 is C1-3 alkoxy, C1-3 alkyl substituted by tetrahydrofuran, or phenyl substituted by C1-3 alkyl. R4 is C1-3 alkyl, phenyl, or benzyl.

Abstract translation: 目的：提供肉桂酸衍生物以对神经细胞的毒性成分具有高的还原活性，并具有生物稳定性。 构成：肉桂酸衍生物在化学式1中。在化学式1中，R 1为C 1-3烷基，苯基，被NR 2 R 3取代或被苄基或一个或两个烷氧基取代的5-6元杂环烷基或OR 4。 R2是氢或C1-3烷基。 R3是C1-3烷氧基，被四氢呋喃取代的C1-3烷基或被C1-3烷基取代的苯基。 R4是C1-3烷基，苯基或苄基。

公开(公告)号：KR1020110092988A

公开(公告)日：2011-08-18

申请号：KR1020100012742

申请日：2010-02-11

Applicant: 연세대학교 산학협력단

Inventor： 김용록 ,  왕강균 ,  김환규 ,  정만길 ,  이명준

IPC: C07D487/22 ,  C07D257/00

Abstract: PURPOSE: A novel porphyrine derivative is provided to enable nano/bulk structure covalent bond and to ensure high singlet oxygen production efficiency. CONSTITUTION: A compound is denoted by chemical formula 1. In chemical formula 1, M is 7-12 family transition metal; R1-R3 are independently hydrogen, C1-6 alkyl, C1-6 alkoxy, amine, or, stituted or non-substituted C5-12 aryl.

Abstract translation: 目的：提供新的卟啉衍生物，以实现纳米/体积结构共价键并确保高的单线态氧生产效率。 构成：化学式为化学式1表示。化学式1中，M为7-12族过渡金属; R 1 -R 3独立地是氢，C 1-6烷基，C 1-6烷氧基，胺，或取代或未取代的C 5-12芳基。