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公开(公告)号：KR1020080060092A
公开(公告)日：2008-07-01
申请号：KR1020060134190
申请日：2006-12-26
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K9/16 , A61K31/375 , B82Y5/00
CPC classification number: A61K9/16 , A61K31/375 , B82Y5/00
Abstract: A process for preparing ascorbic acid nanoparticles is provided to increase skin absorption rate of ascorbic acid by increasing the sectional area of ascorbic acid particles and improve skin striae-treating effects of ascorbic acid by using rapid expansion of supercritical system. A process for preparing ascorbic acid nanoparticles comprises the steps of: dissolving 0.0001-0.50 wt.% based on the weight of ethanol of ascorbic acid in ethanol; spraying the ascorbic acid dissolved solvent to the supercritical carbon dioxide through a nozzle to prepare ascorbic acid nanoparticles; flowing the supercritical carbon dioxide to the ascorbic acid nanoparticles in several times to extract and remove ethanol; and recovering the ascorbic acid nanoparticles.
Abstract translation: 提供制备抗坏血酸纳米颗粒的方法，通过增加抗坏血酸颗粒的截面面积，通过使用超临界系统的快速膨胀，改善抗坏血酸的皮肤条纹治疗效果，增加抗坏血酸的皮肤吸收率。 制备抗坏血酸纳米颗粒的方法包括以下步骤：将基于抗坏血酸乙醇重量的0.0001-0.50重量％溶于乙醇中; 通过喷嘴将抗坏血酸溶解溶剂喷涂到超临界二氧化碳中，制备抗坏血酸纳米粒子; 将超临界二氧化碳数次流过抗坏血酸纳米颗粒提取和除去乙醇; 并回收抗坏血酸纳米颗粒。
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公开(公告)号：KR1020080060082A
公开(公告)日：2008-07-01
申请号：KR1020060134179
申请日：2006-12-26
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K9/16 , A61K31/566 , B82Y5/00
CPC classification number: A61K9/14 , A61K31/566 , B82Y5/00 , Y10S514/859
Abstract: A process for preparing phytoestrogen nanoparticles is provided to improve acne-treating effects of phytoestrogen by increasing skin absorption rate and sectional area of phytoestrogen particles through the supercritical fluid process. The phytoestrogen nanoparticles are prepared by dissolving phytoestrogen in organic solvent selected from methanol and ethanol to prepare a mixture solution, contacting the mixture solution with the supercritical fluid selected from supercritical carbon dioxide, supercritical nitrogen monoxide, supercritical methane trichloride, supercritical propane, supercritical ethylene and supercritical xenon through spraying to form phytoestrogen nanoparticles, washing the phytoestrogen nanoparticles by introducing the additional supercritical fluid into the phytoestrogen nanoparticles, and recovering the phytoestrogen nanoparticles having the particle size of 100-300 nm.
Abstract translation: 提供了一种制备植物雌激素纳米颗粒的方法，通过增加植物雌激素颗粒通过超临界流体过程的皮肤吸收率和截面积来改善植物雌激素的痤疮治疗效果。 通过将植物雌激素溶解在选自甲醇和乙醇的有机溶剂中制备植物雌激素纳米颗粒，以制备混合溶液，使混合溶液与超临界二氧化碳，超临界一氧化氮，超临界三氯化甲烷，超临界甲烷，超临界乙烯和 超临界氙通过喷雾形成植物雌激素纳米颗粒，通过将额外的超临界流体引入植物雌激素纳米颗粒来洗涤植物雌激素纳米颗粒，并回收粒径为100-300nm的植物雌激素纳米颗粒。
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公开(公告)号：KR1020080044541A
公开(公告)日：2008-05-21
申请号：KR1020060113510
申请日：2006-11-16
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K47/6925 , B01J2/02 , B01J3/008
Abstract: A method for preparing nano-triclocarban is provided to obtain ultra-fine particles of triclocarban with predicted skin efficacy due to increased effective cross-section, thereby the nano-triclocarban being applied to quasi-drugs. A method for preparing nano-triclocarban comprises the steps of: (a) dissolving triclocarban into an organic solvent; (b) spraying the mixture solution obtained from the step(a) into a supercritical fluid to generate triclocarban particles; (c) introducing a supercritical fluid into the particles to remove the organic solvent therefrom; and (d) recovering the generated particles, wherein the organic solvent used regarding the organic solvent is 0.0001-0.50 wt.%, preferably 0.001-0.20 wt.%.
Abstract translation: 提供了一种制备纳米三氯班的方法，以获得具有预期的皮肤功效的三氯卡班超细颗粒，由于有效的横截面增加，纳米三氯班素被应用于准药物。 一种制备纳米三氯丹的方法包括以下步骤：（a）将三氯巴酚溶于有机溶剂中; （b）将从步骤（a）获得的混合溶液喷射到超临界流体中以产生三氯苯胺颗粒; （c）将超临界流体引入颗粒中以从其中除去有机溶剂; 和（d）回收生成的颗粒，其中关于有机溶剂使用的有机溶剂为0.0001-0.50重量％，优选0.001-0.20重量％。
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公开(公告)号：KR100994217B1
公开(公告)日：2010-11-12
申请号：KR1020080094515
申请日：2008-09-26
Applicant: 재단법인서울대학교산학협력재단
IPC: C08F6/06 , C08F6/10 , C08F220/00 , C08F220/06
CPC classification number: Y02P20/544
Abstract: 가압 액체, 초임계유체 및 그들의 혼합물을 사용하여 아크릴산과 수분이 제거된 초 흡수성 중합체의 제조방법이 개시되어 있다. 이를 수행하기 위해서는 중합 반응으로 형성된 초 흡수성 중합체에 가압 액체, 초임계 유체 또는 이들의 혼합물을 제공한다. 이후, 가압 액체, 초임계 유체 또는 이들의 혼합물을 이용한 추출 공정을 수행하여 중합반응으로 형성된 초 흡수 중합체 내에 잔류하는 아크릴산과 수분을 추출한다. 이로 인해, 상기 추출공정으로 형성된 초 흡수성 중합체는 아크릴산 잔류량이 20 내지 500ppm인 초 흡수성 중합체로 형성된다.
초 흡수성 중합체, 잔류 용매, 초임계, 이산화탄소-
公开(公告)号：KR1020090070755A
公开(公告)日：2009-07-01
申请号：KR1020070138879
申请日：2007-12-27
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: B82B3/0038 , A61K9/5123 , A61K9/513 , B82Y5/00
Abstract: Provided is a method for manufacturing supercritical nanostructure containing triclosan using a density fluctuation theory, which controls a drug delivery rate. A method for manufacturing supercritical nanostructure containing triclosan using a density fluctuation theory comprises the following steps of: spraying a mixed solution prepared by dissolving triclosan and biodegradable polymer in an organic solvent to a supercritical fluid in order to generate a triclosan and biodegradable polymer structure particle; and removing the organic solvent used by introducing the supercritical fluid to the particles. The biodegradable polymer of poly-isopropyl-butyl methacrylate-acrylic acid copolymer is used to control a drug delivery rate. The supercritical nanostructure has a particle size of 100nm or less.
Abstract translation: 提供一种使用密度波动理论制造含有三氯生的超临界纳米结构的方法，其控制药物递送率。 一种使用密度波动理论制造含有三氯生的超临界纳米结构的方法，包括以下步骤：将三氯生和可生物降解的聚合物溶于有机溶剂中制备的混合溶液喷涂到超临界流体中，以产生三氯生和可生物降解的聚合物结构颗粒; 并通过将超临界流体引入颗粒中去除所用的有机溶剂。 聚异丙基 - 甲基丙烯酸丁酯 - 丙烯酸共聚物的生物可降解聚合物用于控制药物递送率。 超临界纳米结构的粒径为100nm以下。
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Patent Agency Ranking
公开(公告)号：KR1020080060074A
公开(公告)日：2008-07-01
申请号：KR1020060134163
申请日：2006-12-26
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K31/4164 , C07D233/54 , A61P17/00
CPC classification number: Y02P20/544 , A61K31/4164 , C07D233/54
Abstract: A process for producing nanoparticles of imidazole is provided to increase the effective sectional area of imidazole particles and skin absorption rate of imidazole through the supercritical fluid process using supercritical carbon dioxide, so that the therapeutic effects of imidazole on dandruff are improved. A process for producing nanoparticles of imidazole comprises the steps of: (1) dissolving 0.0001-0.50 wt.% of imidazole in ethanol as an organic solvent to prepare a mixture solution; (2) contacting the mixture solution with supercritical carbon dioxide as supercritical fluid through spraying to form imidazole nanoparticles; (3) removing the organic solvent from the imidazole nanoparticles by using the additional supercritical fluid; and (4) recovering the formed imidazole nanoparticles.
Abstract translation: 提供一种制备咪唑纳米颗粒的方法，通过超临界二氧化碳超临界流体加工咪唑颗粒的有效截面面积和咪唑皮肤吸收率，从而提高咪唑对头皮屑的治疗效果。 制备咪唑纳米颗粒的方法包括以下步骤：（1）将0.0001-0.50重量％的咪唑溶于乙醇作为有机溶剂以制备混合溶液; （2）通过喷雾将混合溶液与超临界二氧化碳作为超临界流体接触，形成咪唑纳米颗粒; （3）通过使用附加的超临界流体从咪唑纳米颗粒中除去有机溶剂; 和（4）回收形成的咪唑纳米颗粒。
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公开(公告)号：KR1020080060059A
公开(公告)日：2008-07-01
申请号：KR1020060134136
申请日：2006-12-26
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K9/14 , A61K31/16 , B82Y5/00 , Y10S514/859
Abstract: A process for producing nanoparticles of panthenol is provided to increase skin absorption rate of panthenol by increasing effective cross section through supercritical fluid process, so that the nanoparticles of panthenol are useful for treating acnes without side effects. A process for producing nanoparticles of panthenol comprises the steps of: solubilizing 0.0001-0.50 wt.% of panthenol in organic solvent such as ethanol to prepare the panthenol solution; spraying the panthenol solution to supercritical fluid to form panthenol nanoparticles; and removing the organic solvent from the panthenol nanoparticles by introducing the additional supercritical fluid to the panthenol nanoparticles; and collecting the formed panthenol nanoparticles.
Abstract translation: 提供了一种生产泛醇纳米颗粒的方法，以通过超临界流体工艺增加有效截面来提高泛醇的皮肤吸收率，使泛醇的纳米颗粒可用于治疗痤疮而无副作用。 一种生产泛醇纳米颗粒的方法，包括以下步骤：将0.0001-0.50重量％的泛醇溶于有机溶剂如乙醇中以制备泛醇溶液; 将泛醇溶液喷洒到超临界流体中以形成泛醇纳米颗粒; 并通过将额外的超临界流体引入到泛醇纳米颗粒中从泛醇纳米颗粒中除去有机溶剂; 并收集形成的泛醇纳米颗粒。
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公开(公告)号：KR1020080044527A
公开(公告)日：2008-05-21
申请号：KR1020060113487
申请日：2006-11-16
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K31/4412 , A61J3/00 , B82Y5/00 , Y10S514/859
Abstract: A method for preparing nano-particles of piroctone olamine is provided to micronize the piroctone olamine through a supercritical fluid process using a supercritical CO2, thereby obtaining the piroctone olamine with increased skin absorption rate due to increased effective cross section. A method for preparing nano-particles of piroctone olamine comprises the steps of: (a) contacting a mixture solvent obtained by dissolving piroctone olamine into an organic solvent with a supercritical fluid by spraying the mixture solvent to generate piroctone olamine particles; and (b) removing the organic solvent from the particles by introducing a supercritical fluid thereinto, wherein 0.0001-0.50 wt.%, preferably 0.001-0.20 wt.% of the organic solvent is used regarding the weight of the piroctone olamine.
Abstract translation: 提供了一种制备吡罗酮醇胺的纳米颗粒的方法，以通过使用超临界CO 2的超临界流体方法使焦pi酮醇胺微粉化，从而由于增加的有效截面获得具有增加的皮肤吸收速率的吡罗昔康醇。 一种制备吡罗酮醇胺的纳米颗粒的方法包括以下步骤：（a）通过喷雾混合溶剂以将焦虑酮醇胺溶解于有机溶剂中而获得的混合溶剂与超临界流体接触以产生吡罗昔酮醇胺颗粒; 并且（b）通过向其中引入超临界流体从颗粒中除去有机溶剂，其中使用0.0001-0.50重量％，优选0.001-0.20重量％的有机溶剂关于吡罗酮醇的重量。
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公开(公告)号：KR100811447B1
公开(公告)日：2008-03-11
申请号：KR1020060122039
申请日：2006-12-05
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K31/164 , A61K8/68 , B82B3/0038 , B82Y40/00
Abstract: A method for preparing a ceramide nano-particle is provided to obtain the ceramide with increased skin absorption rate due to increase of an effective cross-sectional area by micronizing a particle size of the ceramide through a supercritical fluid process using a supercritical CO2. A method for preparing a ceramide nano-particle comprises the steps of: (a) mixing 0.0001-0.50 wt.% of ceramide with ethanol to prepare a mixture solution; (b) spraying the mixture solution with the speed of 0.5-1.5ml/minute into a reactor where CO2 is contained at a temperature of 313-333K under a pressure of 130-170 bar with injecting CO2 into the reactor with the speed of 2.5-3.5kg/hour to generate ceramide particles; and (c) introducing CO2 into the reactor to remove the ethanol therefrom to prepare ceramide particles having a size of 50-150 nanometers.
Abstract translation: 提供了一种制备神经酰胺纳米颗粒的方法，通过使用超临界CO 2通过超临界流体法微粉化神经酰胺的颗粒尺寸，由于增加了有效的横截面积，从而获得具有增加的皮肤吸收速率的神经酰胺。 制备神经酰胺纳米颗粒的方法包括以下步骤：（a）将0.0001-0.50重量％的神经酰胺与乙醇混合以制备混合溶液; （b）将混合物溶液以0.5-1.5ml /分钟的速度喷入反应器中，其中含有CO 2的温度为313-333K，压力为130-170巴，将CO 2以2.5的速度注入反应器 -3.5kg /小时产生神经酰胺颗粒; 和（c）将CO 2引入反应器以从其中除去乙醇以制备尺寸为50-150纳米的神经酰胺颗粒。
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公开(公告)号：KR100802278B1
公开(公告)日：2008-02-11
申请号：KR1020060134131
申请日：2006-12-26
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K9/1635 , A61K9/1694 , A61K9/5138 , A61K9/5192
Abstract: A method for preparing a nanostructure containing vitamin K is provided to solve a problem of remaining organic solvent by using a supercritical fluid extraction system and increase the skin permeation rate of the vitamin K by nano-sizing the vitamin K and control the medicinal effect delivering speed of a drug by containing a biodegradable polymer together with the drug. A method for preparing a nanostructure comprises the steps of: (a) dissolving vitamin K and a biodegradable polymer such as poly-isopropyl-butylmethacrylate-acrylic acid copolymer in an organic solvent such as ethanol to prepare a mixture solution; (b) spraying the mixture solution into a reactor containing a supercritical fluid such as CO2 to generate spherical vitamin K structure particles; (c) further introducing the supercritical fluid same as the step(b) into the reactor containing the spherical vitamin K structure particles to remove the organic solvent therefrom; and (d) recovering the organic solvent removed vitamin K structure particles.
Abstract translation: 提供一种制备含有维生素K的纳米结构的方法，通过使用超临界流体萃取系统解决残留有机溶剂的问题，并通过纳米级维生素K调节维生素K的皮肤渗透速率并控制药效递送速度 的药物通过与药物一起含有可生物降解的聚合物。 制备纳米结构的方法包括以下步骤：（a）将维生素K和可生物降解的聚合物如聚异丙基 - 甲基丙烯酸甲酯 - 丙烯酸共聚物溶解在有机溶剂如乙醇中以制备混合溶液; （b）将混合溶液喷入包含超临界流体如CO 2的反应器中以产生球形维生素K结构颗粒; （c）将与步骤（b）相同的超临界流体进一步加入到含有球形维生素K结构颗粒的反应器中以从其中除去有机溶剂; 和（d）回收除去的有机溶剂的维生素K结构颗粒。
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