公开(公告)号：KR1020090114092A

公开(公告)日：2009-11-03

申请号：KR1020080039873

申请日：2008-04-29

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  김은하 ,  고민섭 ,  류지훈

IPC: C09K11/06

Abstract: PURPOSE: A fluorescent compound is provided to ensure excellent photophysical and photochemical properties such as full color tunable emissive property, absolute quantum yields, resistance to photobleaching, storke shifts, and lipophilicity. CONSTITUTION: A fluorescent compound has a structure of chemical formula 1. A method for preparing the fluorescent compound comprises the steps of: (a) reacting a compound containing an aminoethyl group having R1 and R2 substitution groups with α,β-unsaturated aldehyde having R2 substitution group by reductive amination to prepare a secondary amine compound; (b) performing acylation of the secondary amine compound using acyl halide; and (c) treating the acylated compound with pyridine having R4, R5, R6 and R7 substitution groups and performing cyclization and oxidative aromatization of crude product.

Abstract translation: 目的：提供荧光化合物以确保优异的光物理和光化学性质，例如全色可调发射性质，绝对量子产率，光漂白抗性，st e位移和亲油性。 构成：荧光化合物具有化学式1的结构。制备荧光化合物的方法包括以下步骤：（a）使含有具有R 1和R 2取代基的氨基乙基的化合物与具有R 2的α，β-不饱和醛反应 取代基通过还原胺化得到仲胺化合物; （b）使用酰卤进行仲胺化合物的酰化反应; 和（c）用具有R4，R5，R6和R7取代基的吡啶处理酰化化合物，并进行粗产物的环化和氧化芳构化。

公开(公告)号：KR100874761B1

公开(公告)日：2008-12-19

申请号：KR1020070029334

申请日：2007-03-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  조명행 ,  이향연 ,  박종민

IPC: C07H3/00

CPC classification number: C07H3/00

Abstract: The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and &bgr; anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.

Abstract translation: 荧光染料标记的葡萄糖类似物及其合成方法和用途技术领域本发明涉及荧光染料标记的葡萄糖类似物及其合成方法和用途，并且更具体地涉及新型葡萄糖＆amp; 和＆amp; bgr; 其中通过O-1-糖基化标记荧光染料的端基异构体，端基异构体的不对称合成方法，端基异构体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢有关的疾病的药物的筛选方法。