公开(公告)号：KR100954561B1

公开(公告)日：2010-04-22

申请号：KR1020080039873

申请日：2008-04-29

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  김은하 ,  고민섭 ,  류지훈

IPC: C09K11/06

Abstract: 본 발명은 신규한 방사성 형광 화합물, 그 제조방법 및 그의 이용에 관한 것으로, 보다 상세하게는 1,2-디하이드로피롤로[3,4-β]인돌리진-3-온이라는 새로운 코어 스켈레톤(core skeleton)을 이용한 풀 컬러 조정가능한 방사성 형광 화합물, 그 제조방법 및 그 이용에 관한 것이다.
형광 화합물, 1,2-디히드로피롤로[3,4-β]인돌리진-3-온, 형광체, 바이오 프로브

公开(公告)号：KR1020090114092A

公开(公告)日：2009-11-03

申请号：KR1020080039873

申请日：2008-04-29

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  김은하 ,  고민섭 ,  류지훈

IPC: C09K11/06

Abstract: PURPOSE: A fluorescent compound is provided to ensure excellent photophysical and photochemical properties such as full color tunable emissive property, absolute quantum yields, resistance to photobleaching, storke shifts, and lipophilicity. CONSTITUTION: A fluorescent compound has a structure of chemical formula 1. A method for preparing the fluorescent compound comprises the steps of: (a) reacting a compound containing an aminoethyl group having R1 and R2 substitution groups with α,β-unsaturated aldehyde having R2 substitution group by reductive amination to prepare a secondary amine compound; (b) performing acylation of the secondary amine compound using acyl halide; and (c) treating the acylated compound with pyridine having R4, R5, R6 and R7 substitution groups and performing cyclization and oxidative aromatization of crude product.

Abstract translation: 目的：提供荧光化合物以确保优异的光物理和光化学性质，例如全色可调发射性质，绝对量子产率，光漂白抗性，st e位移和亲油性。 构成：荧光化合物具有化学式1的结构。制备荧光化合物的方法包括以下步骤：（a）使含有具有R 1和R 2取代基的氨基乙基的化合物与具有R 2的α，β-不饱和醛反应 取代基通过还原胺化得到仲胺化合物; （b）使用酰卤进行仲胺化合物的酰化反应; 和（c）用具有R4，R5，R6和R7取代基的吡啶处理酰化化合物，并进行粗产物的环化和氧化芳构化。