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11.发明授权
公开(公告)号：KR100467471B1
公开(公告)日：2005-01-24
申请号：KR1020010065351
申请日：2001-10-23
Applicant: 주식회사 엘컴사이언스 , 주식회사머쉬텍
Abstract: PURPOSE: A pharmaceutical composition containing, as an active ingredient, an extract of mycelium of Phellinus linteus and a fraction thereof is provided. The composition has nerve cell protecting activity and has no toxicity and is thus effectively used as a therapeutic or treating agent for neurodegenerative diseases such as cerebral apoplexy, dementia, etc. CONSTITUTION: The pharmaceutical composition contains a methanol extract of mycelium of Phellinus linteus, or an EtOAc fraction or a n-hexane fraction thereof having nerve cell protecting activity. It is formulated into a pharmaceutically acceptable formulation with a pharmaceutically acceptable excipient. For an example, 5kg of mycelium of Phellinus linteus is added with 4ml MeOH, followed by sonication, filtration and concentration under reduced pressure to produce 365g of an extract. Thereafter, the extract is suspended in distilled water, followed by fractionation with n-hexane, EtOAc, n-BuOH and concentration under reduced pressure to produce a n-hexane fraction(49g), an EtOAc fraction(34g), a n-BuOH fraction(100g) and a H2O fraction(182g).
Abstract translation: 目的：提供含有桑黄菌丝体提取物及其部分作为活性成分的药物组合物。 该组合物具有神经细胞保护活性，无毒性，因此可有效用作脑卒中，痴呆等神经退行性疾病的治疗或治疗药物。 具有神经细胞保护活性的EtOAc部分或其正己烷部分。 将其与药学上可接受的赋形剂一起配制成药学上可接受的制剂。 例如，将5kg桑黄菌丝体加入4ml甲醇，然后超声处理，过滤并在减压下浓缩以产生365g提取物。 此后，将提取物悬浮于蒸馏水中，然后用正己烷，EtOAc，n-BuOH分级并减压浓缩，得到正己烷馏分（49g），EtOAc馏分（34g），正丁醇 部分（100g）和H2O部分（182g）。
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12.发明公开밀리타리스동충하초로부터 분리된 항암활성이 있는 신물질과 그 제조방법 및 용도 失效具有由CORDYCEPS MILITARIS分离的抗体活性的新型材料（MILITARIN）及其制备方法及其用途
公开(公告)号：KR1020040080052A
公开(公告)日：2004-09-18
申请号：KR1020030014893
申请日：2003-03-10
IPC: C07C43/23
Abstract: PURPOSE: A militarin separated from Cordyceps militaris, its preparation method and a composition containing the militarin are provided, to obtain a novel material having a strong anticancer activity to B16F10, DU145 and Hela. CONSTITUTION: The militarin is represented by the formula 1. The method comprises the steps of drying Cordyceps militaris, grinding the dried one finely, extracting the ground one with methanol, and distilling the extracted ion under reduced pressure to obtain a methanol extract; dissolving the methanol extract in water, fractionating it with hexane, butanol, ethyl acetate and water in turn, and distilling the each fraction under reduced pressure to obtain a concentrate; and carrying out a first silica gel column chromatography, a second silica gel column chromatography, a Sephadex column chromatography and HPLC in turn to the butanol fraction.
Abstract translation: 目的：提供从冬虫夏草分离的军药，其制备方法和含有军药的组合物，以获得对B16F10，DU145和Hela具有很强抗癌活性的新型材料。 方法：采用以下方法：将冬虫夏草干燥，精细研磨干燥后，用甲醇萃取，并在减压下蒸馏除去提取的离子，得到甲醇提取物; 将甲醇提取物溶解在水中，依次用己烷，丁醇，乙酸乙酯和水分级，并在减压下蒸馏各级分，得到浓缩物; 并进行第一次硅胶柱层析，第二次硅胶柱层析，Sephadex柱色谱和HPLC，依次进行丁醇级分。
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公开(公告)号：KR100362902B1
公开(公告)日：2002-12-11
申请号：KR1020000035753
申请日：2000-06-27
Inventor： 성재모
IPC: A01G1/04
Abstract: 본 발명은 노랑다발동충하초(
Cordyceps bassiana ) 자실체의 대량생산에 관한 것으로, 노랑다발동충하초 균주를 탄소원, 질소원 및 물을 함유하는 배양액에서 배양하여 잡균의 혼입을 방지하며 쉽고 간편한 방법으로 활력이 우수한 액체종균을 제조하는 뛰어난 효과가 있고 상기 제조한 액체종균을 선발된 적정 배지에 생육시켜 노랑다발동충하초 자실체를 대량으로 생산하는 뛰어난 효과가 있다.-
公开(公告)号：KR1020020000674A
公开(公告)日：2002-01-05
申请号：KR1020000035751
申请日：2000-06-27
Inventor： 성재모
IPC: A01G1/04
CPC classification number: A61K36/068
Abstract: PURPOSE: A method of preparing fruit bodies of Cordyceps pruinosa by culturing a liquid spawn of Cordyceps pruinosa and culturing in a medium containing a silkworm pupa and cereals is provided, which has an effect on producing a liquid spawn having an excellent activity without contamination of various bacteria and mass-producing the titled fruit bodies. CONSTITUTION: Fruit bodies of Cordyceps pruinosa are cultured in a plate medium, the cultured mycelium is cultured in a culture solution containing 2 to 7%(w/v) carbon source, 0.1 to 1.0%(w/v) nitrogen source, 0 to 0.15%(w/v) KH2PO4, 0 to 0.15%(w/v) MgSO4.7H2O and the balance of distilled water at 22 to 30deg.C at 80 to 200rpm for 7 to 10 days to produce a liquid spawn, which is inoculated in a culturing medium containing brown rice and a silkworm pupa and cultured at 24deg.C to form fruit bodies.
Abstract translation: 目的：通过培养冬虫夏草的液体产卵并在含有蚕蛹和谷物的培养基中培养，制备冬虫夏草的果实的方法，其具有生产具有优异活性而没有各种污染的液体产物的作用 细菌和批量生产标题的水果体。 构成：将虫草的果实体在平板培养基中培养，将培养的菌丝体在含有2〜7％（w / v）碳源，0.1〜1.0％（w / v）氮源，0〜 0.15％（w / v）KH 2 PO 4，0〜0.15％（w / v）MgSO 4·7H 2 O，剩余蒸馏水在22〜30℃下以80〜200rpm搅拌7〜10天，产生液体产物， 接种在含有糙米和蚕蛹的培养基中，并在24℃下培养形成果实体。
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Patent Agency Ranking
公开(公告)号：KR1020170046920A
公开(公告)日：2017-05-04
申请号：KR1020150147123
申请日：2015-10-22
Abstract: 본발명은동충하초균사체자동접종기에관한것으로, 테이블의가장자리에형성된컨베이어(101)로이루어지는피드부(100)와; 상기피드부(100)에의해공급되는배양물이주입된배양통(P)에뚜껑을열고균사체를주입한다음두껑을닫는균사체주입실(200)과; 상기균사체주입실(200)에서균사체가주입됨배양토(P)을배출하는배출부(300)와; 상기균사체주입실(200) 내의공기를순환시키는덕터(401)를구비하는에어필터(402)가장착된에어펌프와; 동충하초균사체자동접종기전체를제어하는제어반(500) 및; 동충하초균사체자동접종기의동작이상시작동을정지하고경보하는경보수단(600)으로구성되어균사체접종실에필터링된깨끗한공기를계속해서공급하면서배출하고균사체접종시배지병의뚜껑개폐에걸리는시간을최소화하여균사체의접종과정에서균사체외 다른잡균에배지가오염되지않아배양실패, 배양불량이없으며, 뚜껑개폐수단으로배지병의뚜껑을개폐함으로써장치의구성이간단하여장치의제조에소요되는비용이적어제품의가격을저렴화할수 있으면서도장치를고장없이장기간안정되게사용할수 있는수명이긴 각별한장점이있는유용한발명이다.
Abstract translation: 本发明中，馈电单元100包括形成在所述台的边缘的传送带101涉及一种真菌菌丝自动接种; 培养物的进料部分由100注入培养管供给，打开盖子，所述（P）注入到菌丝，然后关闭盖菌丝正门（200）和; 排出单元300，用于将菌丝体注入其中的培养土壤P排出到菌丝体主流入室200中; 空气泵复合物，包括一个导体（401），以使空气循环的菌丝正门（200）和所述的空气过滤器402; 用于控制整个自动蘑菇菌根自动注射器的控制面板500; 要停止的组真菌菌丝自动接种操作的异常操作，并且包括报警装置600以提醒放电而连续供给在菌丝jeopjongsil清洁空气过滤器，并尽量减少服用菌丝体接种物sibaeji瓶菌丝体的盖打开和关闭的时间 由于介质不与在接种过程培养失败菌丝其它细菌污染，没有培养故障，通过打开和关闭培养基瓶的盖子与盖子打开和关闭装置，该装置的结构简单，少制造设备产品的成本 这是一项有用的发明，它具有可以以较低成本使用的特殊优点，但可以在很长一段时间内使用而不会失败。
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公开(公告)号：KR1020100101861A
公开(公告)日：2010-09-20
申请号：KR1020090020265
申请日：2009-03-10
CPC classification number: A01G18/00 , A01G18/60 , A01G27/001 , A01G27/02
Abstract: PURPOSE: An apparatus for injecting water into a container for culturing cordyceps militaris is provided to economically manufacture a product by automatically injecting the water into a plurality of culture containers, to inject a constant amount of the water, and to improve productivity. CONSTITUTION: An apparatus for injecting water into a container for culturing cordyceps militaris comprises: a vertical frame(10) which is vertically installed on the corners of the apparatus; a horizontal frame(20) which is fixed to the lower part of the vertical frame; supporting frames(30,30') which are fixed to the center of the horizontal frame; a control box(40) which is fixed to the supporting frames; a shelf frame(50) which is fixed to the vertical frame; a shelf(60) which is installed on the shelf frame; a water tank(70) including a water supply hose(71), a solenoid valve(V1), and a drain pipe; a water discharge pipe including the solenoid valve which is vertically installed on the lower part of the water tank; and a foot switch(90) which is connected to the control box through a lead wire.
Abstract translation: 目的：提供一种用于将水注入用于培养冬虫夏草的容器中的装置，以通过将水自动注入多个培养容器中以注入恒定量的水并提高生产率来经济地制造产品。 构成：用于将水注入到用于培养冬虫夏草的容器中的装置包括：垂直安装在设备的角上的垂直框架（10） 水平框架（20），其固定在垂直框架的下部; 支撑框架（30,30'），其固定在水平框架的中心; 控制箱（40），其固定到所述支撑框架; 固定在垂直框架上的搁架框架（50）; 搁架（60），其安装在搁架上; 包括供水软管（71），电磁阀（V1）和排水管的水箱（70） 包括垂直安装在水箱下部的电磁阀的排水管; 以及通过引线与控制箱连接的脚踏开关（90）。
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公开(公告)号：KR1020090036925A
公开(公告)日：2009-04-15
申请号：KR1020070102227
申请日：2007-10-10
Applicant: 강원대학교산학협력단 , 주식회사머쉬텍
IPC: A61K36/066 , A61P29/00
Abstract: An anti-inflammatory agent comprising cordyceps militaris extracts as an active ingredient is provided to suppress an inflammation-inducing material through the route of PI3k/AKT/IkB and the route of suppressing phosphorylation of p38 by using butanol fraction of methanol extract and cordycepin purified therefrom. A method for manufacturing butanol fraction for treating inflammation from Cordyceps militaris comprises the steps of: (a) melting methanol extract of Cordyceps militaris in water; (b) fractionating hexane, butanol, ethylacetate and water; and (c) removing solvent by decompressing the butanol fraction.
Abstract translation: 提供包含冬虫夏草提取物作为活性成分的抗炎剂，以通过使用PI3K / AKT / IkB的途径抑制炎症诱导物质，并通过使用甲醇提取物的丁醇级分和从其中纯化的冬虫夏草来抑制磷酸化p38的途径 。 制备用于治疗冬虫夏草炎症的丁醇级分的方法包括以下步骤：（a）在水中熔化冬虫夏草的甲醇提取物; （b）分馏己烷，丁醇，乙酸乙酯和水; 和（c）通过减压丁醇馏分除去溶剂。
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公开(公告)号：KR100852464B1
公开(公告)日：2008-08-18
申请号：KR1020070007103
申请日：2007-01-23
Applicant: 강원대학교산학협력단 , 주식회사머쉬텍
Abstract: 본 발명은 동충하초의 초미분을 이용한 건강보조식품 및 그 제조방법에 관한 것으로, 원적외선 건조기를 통해 건조된 동충하초를 초미분쇄하여 수용성이 증대되고, 불포화지방산이 증가되고, 항산화, 항염증 및 항암효과가 증가된 기능성 제품을 제조함으로써 종래의 티백제품보다 약리활성이 극대화된 제품을 제공하는 뛰어난 효과가 있다.
동충하초, 원적외선 건조, 초미분쇄, 생리활성-
20.发明公开
公开(公告)号：KR1020060099297A
公开(公告)日：2006-09-19
申请号：KR1020050020660
申请日：2005-03-11
IPC: C12N1/14
Abstract: 본 발명은 단포자의 액체종균배양을 이용한 자낭균문 자실체의 대량생산방법에 관한 것으로, 번데기동충하초의 균주를 액체배양하여 인공자실체의 형성을 유도하고 이로부터 단포자를 분리하여 교배형을 조사한 다음, 단포자의 교배를 통해 인공자실체 형성이 우수한 균주를 선발하고, 상기 균주의 단포자로부터 인공자실체의 최적생산조건을 확립하여 인공자실체를 대량생산하는 방법을 제공하는 뛰어난 효과가 있다.
자낭균문, 담자균문, 번데기동충하초, 자실체, 단포자, 액체배양, 대립교배형
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