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公开(公告)号：KR1020160112164A
公开(公告)日：2016-09-28
申请号：KR1020150037342
申请日：2015-03-18
Applicant: 한국교통대학교산학협력단 , 가톨릭대학교 산학협력단
IPC: A61K47/48
CPC classification number: A61K31/713 , A61K47/6939 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/351 , C12N2320/32 , A61K47/50 , A61K31/7088 , A61K47/54 , A61K47/542 , A61K47/61 , C12N15/87
Abstract: 본발명은금속나노입자기반간 표적성핵산전달체, 이의제조방법, 및상기핵산전달체을포함하는간질환치료용조성물에관한것이다. 본발명의간 표적성핵산전달체는담즙산 - 글라이콜키토산복합체로코팅됨으로써간 조직표적성이매우우수하며, 소화관을통한흡수율이매우높다. 또한, 본발명의간 표적성핵산전달체에서핵산은담즙산 - 글라이콜키토산복합체로코팅됨으로써체내효소등의분해로부터보호될수 있다. 본발명의간 표적성핵산전달체는경구투여용간질환치료제로개발될수 있다.
Abstract translation: 本发明涉及一种基于金属纳米颗粒的靶向靶向靶向核酸的载体，其制备方法和用于治疗肝病的组合物，其包含己烷载体。 本发明的肝靶向己烷载体用胆汁酸 - 乙二醇壳聚糖复合物包被，由此具有优异的肝组织靶向特性并且通过消化道具有显着高的吸收率。 此外，在肝靶向己烷载体中的己烷涂覆有胆汁酸 - 乙二醇壳聚糖复合物，从而保护身体内的酶的降解等。 可以开发肝靶向己烷载体作为用于口服给药的肝脏疾病的治疗剂。
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公开(公告)号：KR101539509B1
公开(公告)日：2015-07-29
申请号：KR1020130161764
申请日：2013-12-23
Applicant: 한국교통대학교산학협력단
Abstract: 본발명은아연알루미늄계열열 확산코팅방법및 그코팅방법으로코팅된금속에대한것이다. 보다상세하게는, 금속의열 확산코팅방법에있어서, 표면코팅의대상이되는시료금속의표면이물질을제거하는단계; 아연및 알루미늄이혼합된혼합분말재료를제조하는단계; 및상기시료금속을상기혼합분말재료에침지시켜, 가열하는단계;를포함하여, 아연-알루미늄계열열 확산코팅기술을이용하여짧은온도처리시간과경제적인공정을바탕으로친환경적이고, 다양한형상의철에코팅이가능하며부식에취약한철에우수한내식성을제공하는아연알루미늄계열열 확산코팅방법에관한것이다.
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公开(公告)号：KR1020150001692A
公开(公告)日：2015-01-06
申请号：KR1020140110846
申请日：2014-08-25
Applicant: 한국교통대학교산학협력단
IPC: A61K31/337 , A61K47/48 , A61K9/127 , A61K9/16
CPC classification number: A61K31/727 , A61K47/22 , A61K47/6925 , A61K2121/00
Abstract: The present invention relates to a water-soluble anticancer drug composed of a heparin-docetaxel conjugate and to a method for preparing the same and, more specifically, to a water-soluble anticancer drug in which a spherical nanoparticle is formed of a conjugate having aminized docetaxel self-aggregated on low-molecular weight heparin, and a hydrophilic segment of the heparin is introduced on a surface of the nanoparticle, and to a method for preparing the water-soluble anticancer drug, comprising the steps of removing a sodium salt from low-molecular heparin; introducing an amine group to docetaxel; mixing the sodium salt-removed heparin and the docetaxel with the introduced amine group to self-aggregate the mixture; and purifying the self-aggregated heparin-docetaxel conjugate. According to the present invention, provided can be a water-soluble anticancer drug capable of overcoming the low solubility of docetaxel in water, improving the administrability of heparin, and expecting a synergy effect of simultaneously applying anticancer activity of docetaxel and anticancer activity of heparin.
Abstract translation: 本发明涉及由肝素 - 多西紫杉醇缀合物组成的水溶性抗癌药物及其制备方法，更具体地说，涉及一种水溶性抗癌药物，其中球形纳米粒子由具有氨基化的共轭物形成 多西紫杉醇在低分子量肝素上自聚合，并且在纳米颗粒的表面上引入肝素的亲水性片段，以及制备水溶性抗癌药物的方法，包括以下步骤：从低 分子肝素 向多西紫杉醇引入胺基; 将引入胺基的钠盐去除肝素和多西紫杉醇混合以自组合混合物; 并纯化自聚集的肝素 - 多西紫杉醇缀合物。 根据本发明，提供能够克服多西他赛在水中的低溶解度的水溶性抗癌药物，提高肝素的给药能力，并期望同时施用多西紫杉醇的抗癌活性和肝素抗癌活性的协同作用。
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公开(公告)号：KR1020140066440A
公开(公告)日：2014-06-02
申请号：KR1020120133674
申请日：2012-11-23
Applicant: 한국교통대학교산학협력단
CPC classification number: C01B32/15 , B01J19/10 , B82Y15/00 , C01B32/182
Abstract: The present invention relates to a synthetic method of near infra-red graphene quantum dots and near infra-red graphene quantum dots synthesized thereby, which, more specifically, comprises: a process of reacting a graphene supply source in a strong acid made by mixing sulfuric acid and nitric acid, at a temperature of 50-120°C; and a process of conducting neutral reaction after adding NaOH and NaCO3 to the reaction solution. According to the present invention, stable, non-toxic and high luminant near infra-red graphene quantum dots with excellent biocompatibility and biodegradability can be synthesized under various conditions. Furthermore, the near infra-red graphene quantum dots which can be effectively applied to a biomedical field for a non-surgical visualization can be easily and conveniently synthesized.
Abstract translation: 本发明涉及近红外石墨烯量子点和由其合成的近红外石墨烯量子点的合成方法，其更具体地包括：使石墨烯供应源在通过混合硫酸制成的强酸中反应的方法 酸和硝酸，温度为50-120℃; 以及向反应溶液中加入NaOH和NaCO 3后进行中和反应的过程。 根据本发明，可以在各种条件下合成具有优异的生物相容性和生物降解性的红外线石墨烯量子点附近的稳定，无毒和高亮度。 此外，可以容易且方便地合成可以有效地应用于非手术可视化的生物医学领域的近红外石墨烯量子点。
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公开(公告)号：KR1020130083194A
公开(公告)日：2013-07-22
申请号：KR1020120003830
申请日：2012-01-12
Applicant: 한국교통대학교산학협력단
IPC: A61K36/899 , A61K36/8998 , A61P31/12
CPC classification number: A61K36/899 , A61K36/8998 , A61K2300/00
Abstract: PURPOSE: A pharmaceutical composition containing an Oryza sativa L. hull extract and a Hordeum vulgare var. hexastichon hull extract as active ingredients is provided to protect humans from an infection by pathogens such as virus, bacteria, and parasite and to maintain a healthy condition. CONSTITUTION: A pharmaceutical composition contains an Oryza sativa L. hull extract and a Hordeum vulgare var. hexastichon hull extract as active ingredients, which are mixed in a weight ratio of 1:0.5-1:5. The pharmaceutical composition contains 0.1-99.9 wt% of the extracts. The composition further contains one or more ingredients selected among Oryza sativa L., Avena sativa L., and bean shells. A functional food composition contains the extracts as active ingredients.
Abstract translation: 目的：一种含有水稻壳提取物和大麦大麦变种的药物组合物。 提供六味子壳提取物作为活性成分，以保护人免受诸如病毒，细菌和寄生虫等病原体的感染并保持健康状况。 构成：一种药物组合物含有水稻壳提取物和大麦草。 hexastichon壳提取物作为活性成分，以1:0.5-1:5的重量比混合。 药物组合物含有0.1-99.9重量％的提取物。 所述组合物还包含选自水稻（Oryza sativa L.），燕麦（Avena sativa L.）和豆壳中的一种或多种成分。 功能食品组合物含有提取物作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020120120712A
公开(公告)日：2012-11-02
申请号：KR1020110038449
申请日：2011-04-25
Applicant: 한국교통대학교산학협력단
IPC: A61K31/337 , A61K31/727 , A61K47/48 , A61P35/00
CPC classification number: A61K31/727 , A61K47/22 , A61K47/28 , A61K47/6925 , A61K2121/00
Abstract: PURPOSE: A water soluble anticancer agent containing heparin-docetaxel-taurocholic acid conjugate and a method for preparing the same are provided to create hydrophilic environment on the surface of a micelle structure and to ensure bioavailability. CONSTITUTION: A targeting water soluble anticancer agent has a spherical nanoparticles comprising docetaxel in a core and taurocholic acid on the surface. The molecular weight of the heparin is 3000-5000 da. A method for manufacturing the anticancer agent comprises: a step of removing sodium salt of low molecular heparin; a step of introducing amine groups to the docetaxel; a step of introducing amine groups to taurocholic acid; a step of mixing the heparin, docetaxel, and taurocholic acid for self-aggregation; and a step of purifying the self-aggregated heparin-docetaxel-taurocholic acid assembly.
Abstract translation: 目的：提供含有肝素 - 多西紫杉醇 - 牛磺胆酸结合物的水溶性抗癌剂及其制备方法，以在胶束结构的表面产生亲水性环境并确保生物利用度。 构成：靶向水溶性抗癌剂具有包含核心中的多西紫杉醇和表面上的牛磺胆酸的球形纳米颗粒。 肝素的分子量为3000-5000 da。 抗癌剂的制造方法包括：除去低分子肝素钠盐的工序; 将胺基引入多西紫杉醇的步骤; 将胺基引入牛磺胆酸的步骤; 将肝素，多西紫杉醇和牛磺胆酸混合以进行自聚集的步骤; 以及纯化自聚集的肝素 - 多西紫杉醇 - 牛磺胆酸组件的步骤。
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公开(公告)号：KR1020110057796A
公开(公告)日：2011-06-01
申请号：KR1020090114352
申请日：2009-11-25
Applicant: 한국교통대학교산학협력단 , 충남대학교산학협력단 , 이니스트에스티 주식회사
IPC: A61K47/36 , A61K47/12 , A61P35/00 , A61K31/203
CPC classification number: A61K47/61 , A61K31/203 , A61K47/545
Abstract: PURPOSE: A drug delivery system for anticancer and antitumor with ternary biomolecules conjugated with heparin is provided to support and release anticancer or antitumor drugs without side effects. CONSTITUTION: A drug delivery system for anticancer and antitumor contains ternary biomolecules containing heparin, aminized folic acid, and compounds with anticancer or antitumor activities. The heparin is a structure having hydroxy group(-OH), carboxy group(-COOH), and amino group(-NH_2). The compound with anticancer or antitumor activities contains carboxy group(-COOH) or amino group(-NH_2). The compouns is retinoic acid, paclitaxel, doxetaxel, vincristine, or vinorelbine.
Abstract translation: 目的：提供与肝素结合的三元生物分子的抗癌和抗肿瘤药物递送系统，以支持和释放抗癌药或抗肿瘤药物，无副作用。 构成：用于抗癌和抗肿瘤的药物递送系统包含含有肝素，氨基化叶酸和具有抗癌或抗肿瘤活性的化合物的三元生物分子。 肝素是具有羟基（-OH），羧基（-COOH）和氨基（-NH 2）的结构。 具有抗癌或抗肿瘤活性的化合物含有羧基（-COOH）或氨基（-NH 2）。 组合物是视黄酸，紫杉醇，多西他赛，长春新碱或长春瑞滨。
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公开(公告)号：KR101015106B1
公开(公告)日：2011-02-16
申请号：KR1020080060968
申请日：2008-06-26
Applicant: 한국교통대학교산학협력단 , 동양나노테크 주식회사
Abstract: 본 발명은 은나노입자의 제조방법과 이에 의해 제조된 은나노입자가 도입된 세제용 첨가제에 관한 것으로써, 소듐보로하이드라이드 용액에 질산은을 적가하여 반응시키고 여기에 폴리비닐피롤리돈과 폴리비닐알콜을 혼합하여 제조함으로써 입자 크기의 균일성이 부여된 은나노입자를 얻고, 이를 주요성분으로 사용한 세제용 첨가제를 제공한다.
본 발명에 의하여 제조된 은나노입자가 도입된 세제용 첨가제는 생활 속에서 유래된 유해균에 대한 항균력이 우수할 뿐 아니라 내성 유해균에 대한 항균력이 탁월하여 유해균 제거율 및 항균 지속력이 좋고, 인체에 무해하며, 세제용 조성물에 도입시 세정력을 감소시키지 않으면서도 사용 후 피부가 건조해지거나 당기는 감이 적어 피부 마일드성이 월등히 좋아지며, 제품으로서의 안정성이 우수한 효과를 기대할 수 있다.
세제, 은나노입자, 항균력, 세정력, 안정성-
公开(公告)号：KR1020100001165A
公开(公告)日：2010-01-06
申请号：KR1020080060974
申请日：2008-06-26
Applicant: 한국교통대학교산학협력단 , 동양나노테크 주식회사
CPC classification number: C11D3/48 , B22F9/24 , B82B3/00 , B82Y40/00 , C11D3/1206
Abstract: PURPOSE: A detergent composition containing nano-silver particles is provided to ensure excellent antibacterial activity to harmful bacteria, and good harmful bacteria removal ratio and antibiotic durability, and to improve skin mildness after use without reducing the detergency. CONSTITUTION: A method for manufacturing nano-silver particles comprises the steps of: (i) adding silver nitrate(AgNO3) to surfactant solution, stirring and reducing the mixture; (ii) adding sodium hydroxide aqueous solution to the mixed solution to control ph to 7; (iii) adding the surfactant used in (i) step and ascorbic acid to the mixed solution obtained from step (ii); (iv) adding the sodium hydroxide aqueous solution to the mixed solution obtained from step (iii) to control ph to 7; and (v) evaporating and drying the mixed solution in which pH is controlled.
Abstract translation: 目的：提供含有纳米银颗粒的洗涤剂组合物，以确保对有害细菌的优良抗菌活性，良好的有害细菌去除率和抗生素耐久性，并在使用后改善皮肤温和度，而不降低洗涤力。 构成：制造纳米银粒子的方法包括以下步骤：（i）向表面活性剂溶液中加入硝酸银（AgNO 3），搅拌并还原混合物; （ii）向混合溶液中加入氢氧化钠水溶液以控制ph至7; （iii）将（i）步骤中所用的表面活性剂和抗坏血酸加入到由步骤（ii）获得的混合溶液中; （iv）将氢氧化钠水溶液加入到由步骤（iii）获得的混合溶液中以将ph控制为7; 和（v）蒸发并干燥其中控制pH的混合溶液。
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公开(公告)号：KR1020100001160A
公开(公告)日：2010-01-06
申请号：KR1020080060968
申请日：2008-06-26
Applicant: 한국교통대학교산학협력단 , 동양나노테크 주식회사
CPC classification number: B22F9/24 , B22F2301/255 , B22F2304/054 , B82Y30/00 , B82Y40/00 , C11D3/3902
Abstract: PURPOSE: A method for producing a silver nano silver and an additive for cleansing containing the same are provided to maintain anti-bacterial efficiency. CONSTITUTION: A method for producing silver nano particle comprises: a step of dropping silver nitrate(AgNO3) into sodium borohydride(NaBH4) solution; a step of adding polyvinyl pyrrolidone(PVP) and polyvinyl alcohol(PVA) into mixture solution, heating and stirring to disperse the ingredients; and a step of evaporating and drying the dispersed material.
Abstract translation: 目的：提供一种银纳米银的制造方法和含有该银纳米银的清洗添加剂，以保持抗菌效率。 构成：银纳米颗粒的制造方法包括：将硝酸银（AgNO 3）滴加到硼氢化钠（NaBH 4）溶液中的工序; 将聚乙烯吡咯烷酮（PVP）和聚乙烯醇（PVA）加入到混合溶液中，加热搅拌分散成分的步骤; 以及蒸发和干燥分散材料的步骤。
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