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公开(公告)号：KR101336411B1
公开(公告)日：2013-12-04
申请号：KR1020110050472
申请日：2011-05-27
Applicant: 한국식품연구원
IPC: A61K36/899 , A61P25/24 , A61P25/20 , A61P25/00
CPC classification number: A61K36/899 , A61K2236/13
Abstract: 발명은 쌀 추출물의 수면 장애, 불안 또는 우울증의 개선, 예방 또는 치료를 위한 신규 용도를 제공한다. 쌀 추출물은 종래 수면유도제로 사용되는 의약인 디아제팜과 거의 동일한 수준 또는 향상된 입면시간의 감소, 수면 지속시간의 증가 및 논램 수면의 증가 효과가 있다. 쌀 추출물은 천연물로서 장기간 사용하여도 인지장애(cognitive impairment), 내성 또는 의존성이 형성되는 부작용이 없다.
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12.发明授权플로로글루시놀 또는 플로로탄닌을 포함하는 가바 Ａ형-벤조다이아제핀 수용체 활성용 조성물 및 불안 완화, 경련 개선, 진정 작용, 및 수면 유도 및 개선용 조성물 有权用于促进GABAA-苯并二氮杂受体的组合物和具有含有间苯三酚或氯光亮素的焦虑，抗惊厥，抗抑郁和睡眠改善作用的组合物
公开(公告)号：KR101260697B1
公开(公告)日：2013-05-10
申请号：KR1020110113355
申请日：2011-11-02
Applicant: 한국식품연구원
IPC: A61K36/03 , A61K31/05 , A61K31/357 , A61P25/20
Abstract: 본발명은플로로글루시놀또는플로로탄닌을유효성분으로하는 GABA-벤조다이아제핀수용체활성용조성물로서, 플로로글루시놀또는플로로탄닌은 GABA-벤조다이아제핀수용체에친화력을가지는것으로, 천연물로부터얻어진물질을이용하기때문에부작용을유발하지않고안전성을확보할수 있으며, 갈조류추출물을유효성분으로항불안, 항경련(anti-convulsant), 진정및 불면증치료용약학조성물이나불안완화, 경련개선, 진정작용, 및수면유도및 개선용식품조성물으로활용될수 있다.
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公开(公告)号：KR1020120137653A
公开(公告)日：2012-12-24
申请号：KR1020110056624
申请日：2011-06-13
Applicant: 한국식품연구원
IPC: A61K36/899 , A61P25/20 , A61P25/22 , A61P25/24
Abstract: PURPOSE: A rice bran extract for preventing or treating sleep disorder, anxiety, or depression is provided to reduce sleep latency and to increase non-REM sleep without side effects. CONSTITUTION: A pharmaceutical composition for preventing or treating sleep disorder, anxiety, or depression contains rice bran extract as an active ingredient. The extract is prepared using water, organic solvent, or a mixture thereof. The organic solvent is low carbon number alcohol, hexane, acetone, ethyl acetate, chloroform, or diethyl ether. The extract is also a fraction prepared by fractioning the organic solvent extract with a second organic solvent. A food composition for preventing or treating sleep disorder, anxiety, or depression contains the extract as an active ingredient.
Abstract translation: 目的：提供用于预防或治疗睡眠障碍，焦虑或抑郁症的米糠提取物以减少睡眠潜伏期并增加非REM睡眠而没有副作用。 构成：用于预防或治疗睡眠障碍，焦虑或抑郁症的药物组合物含有米糠提取物作为活性成分。 提取物是使用水，有机溶剂或其混合物制备的。 有机溶剂为低碳值醇，己烷，丙酮，乙酸乙酯，氯仿或二乙醚。 提取物也是通过用第二有机溶剂分馏有机溶剂提取物制备的级分。 用于预防或治疗睡眠障碍，焦虑或抑郁症的食物组合物含有提取物作为活性成分。
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公开(公告)号：KR1020120121938A
公开(公告)日：2012-11-07
申请号：KR1020110039353
申请日：2011-04-27
Applicant: 한국식품연구원
IPC: A61K36/27 , A61K36/287 , A61K36/14 , A61P25/20
Abstract: PURPOSE: A composition containing Cynanchum wilfordii, Chrysanthemum zawadskii, or Thuja orientalis extract is provided to extend sleep duration without side effect and to prevent and treat sleep disorder. CONSTITUTION: A pharmaceutical composition for preventing or treating sleep disorders contains Cynanchum wilfordii, Chrysanthemum zawadskii, or Thuja orientalis extract or a fraction thereof as an active ingredient. The composition prevents or relieves sleep disorder or induces deep sleep. The solvent fraction is a flavonoid fraction or oil fraction. A food composition for treating sleep disorder contains the extract as an active ingredient. The treatment of sleep disorder includes sedation, sleep induction, or sleep improvement.
Abstract translation: 目的：提供含有Cynanchum wilfordii，菊花（Chrysanthemum zawadskii）或东方蓟马（Thuja orientalis）提取物的组合物，以延长睡眠时间，无副作用并预防和治疗睡眠障碍。 构成：用于预防或治疗睡眠障碍的药物组合物含有西兰花（Cynanchum wilfordii），菊花（Chrysanthemum zawadskii）或东方蓟马（Thuja orientalis）提取物或其一部分作为活性成分。 该组合物可预防或缓解睡眠障碍或诱发深度睡眠。 溶剂馏分是类黄酮馏分或油馏分。 用于治疗睡眠障碍的食物组合物含有提取物作为活性成分。 睡眠障碍的治疗包括镇静，睡眠诱导或睡眠改善。
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公开(公告)号：KR101592251B1
公开(公告)日：2016-02-11
申请号：KR1020130118015
申请日：2013-10-02
Abstract: 본발명은갈조류를에탄올수용액으로추출한후, 소수성흡착수지를사용하여플로로탄닌을선택적으로흡착시킴으로써플로로탄닌의함량을증가시키면서도비소의함량을저감시킨플로로탄닌정제물의제조방법에관한것이다. 본발명에따라제조된플로로탄닌정제물은불안완화, 경련개선, 진정작용, 및수면유도및 개선에효과적으로작용할수 있는 GABA-벤조다이아제핀수용체에친화력을가지는플로로탄닌의함량을향상시켜진정작용및 수면유도효과가우수하면서도, 비소함유량을효과적으로낮추어안전성을향상시켰으며, 적은양으로도진정작용및 수면유도효과를나타낼수 있어정제, 타블렛또는주사제로사용하였을때 1회복용량을낮추어복용이용이하다.
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Patent Agency Ranking
公开(公告)号：KR1020150039643A
公开(公告)日：2015-04-13
申请号：KR1020130118015
申请日：2013-10-02
CPC classification number: A23L17/60 , A23V2002/00 , A23V2300/14
Abstract: 본발명은갈조류를에탄올수용액으로추출한후, 소수성흡착수지를사용하여플로로탄닌을선택적으로흡착시킴으로써플로로탄닌의함량을증가시키면서도비소의함량을저감시킨플로로탄닌정제물의제조방법에관한것이다. 본발명에따라제조된플로로탄닌정제물은불안완화, 경련개선, 진정작용, 및수면유도및 개선에효과적으로작용할수 있는 GABA-벤조다이아제핀수용체에친화력을가지는플로로탄닌의함량을향상시켜진정작용및 수면유도효과가우수하면서도, 비소함유량을효과적으로낮추어안전성을향상시켰으며, 적은양으로도진정작용및 수면유도효과를나타낼수 있어정제, 타블렛또는주사제로사용하였을때 1회복용량을낮추어복용이용이하다.
Abstract translation: 本发明涉及一种用乙醇溶液提取褐藻的方法，并使用疏水性吸水树脂选择性地吸收氯光亮，以增加氯光亮素的含量并降低砷的含量。 根据本发明制造的氯光亮苷精制通过增加对GABA_A-苯并二氮杂受体具有亲和力的有效功能，缓解焦虑，改善痉挛，增加镇静，诱导和改善睡眠，具有缓解焦虑和诱导睡眠的优异效果 通过有效地降低砷的含量来提高稳定性，并且能够以片剂或注射剂的形式使用一剂单位剂量容易的摄入，因为可以以较少的量产生减轻焦虑和诱导睡眠的优异效果。
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公开(公告)号：KR1020140056651A
公开(公告)日：2014-05-12
申请号：KR1020120121340
申请日：2012-10-30
Applicant: 한국식품연구원
IPC: A61K31/185 , A61K31/195 , A61P11/06 , A61P1/04
Abstract: The present invention provides new uses of fatty acid as a histamine receptor antagonist. The fatty acid is used as a natural anti-histamine agent which can be used for preventing or treating allergic rhinitis; inflammatory bowel disease; asthma; bronchitis; vomiting; stomach and duodenal ulcers; gastro-oesophageal reflux; sleep disorders; anxiety; and depression, and has an effect for reducing an increased hypnagogue time and increasing a sleep time. The fatty is a natural product derived from edible oils and fats, thereby has no side effects, which develop cognitive impairment, tolerance, or dependence, even for a long-term use.
Abstract translation: 本发明提供脂肪酸作为组胺受体拮抗剂的新用途。 脂肪酸被用作可用于预防或治疗过敏性鼻炎的天然抗组胺药物; 炎症性肠病; 哮喘; 支气管炎; 呕吐; 胃和十二指肠溃疡; 胃食管反流; 睡眠障碍 焦虑; 和抑郁症，并且具有减少增加的嗜热时间时间和增加睡眠时间的作用。 脂肪是从食用油和脂肪得到的天然产物，因此没有副作用，即使长期使用也会产生认知障碍，耐受性或依赖性。
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公开(公告)号：KR102262763B1
公开(公告)日：2021-06-10
申请号：KR1020190130751
申请日：2019-10-21
Applicant: 한국식품연구원
IPC: A61K36/9066 , A61K36/488 , A61K36/899 , A61P25/20 , A23L33/105 , A23K10/30
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公开(公告)号：KR1020210047415A
公开(公告)日：2021-04-30
申请号：KR1020190130750
申请日：2019-10-21
Applicant: 한국식품연구원
IPC: A61K36/9066 , A61P43/00 , A23L33/105
Abstract: 본발명은강황추출물을유효성분으로포함하는 GABAA 수용체효능제의부작용경감용약학조성물, 강황추출물과 GABAA 수용체효능제의복합물을유효성분으로포함하는수면장애예방또는치료용약학조성물, 및강황추출물을유효성분으로포함하는 GABAA 수용체효능제의부작용개선용건강기능식품조성물에관한것이다. 본발명의강황추출물을유효성분으로하는 GABAA 수용체효능제의부작용경감용약학조성물은종래 GABAA 수용체효능제의부작용이발생하지않는다. 또한, 본발명의강황추출물을유효성분으로하는 GABAA 수용체효능제의부작용경감용약학조성물또는 GABAA 수용체효능제의부작용개선용건강기능식품조성물은 GABAA 수용체효능제의부작용을경감시킬수 있다. 또한본 발명의강황추출물및 GABAA 수용체효능제를유효성분으로하는수면장애예방또는치료용약학조성물은, 수면의양은증가시키나수면의질을저하시켜다양한부작용의원인이될 수있는 GABAA 수용체효능제의함량을줄임으로써 GABAA 수용체효능제의부작용을경감시킬수 있다.
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20.发明公开
公开(公告)号：KR1020120078898A
公开(公告)日：2012-07-11
申请号：KR1020110000197
申请日：2011-01-03
Applicant: 한국식품연구원
IPC: A61K31/12 , A61K36/484 , A23L33/00 , A61P25/20
CPC classification number: Y02A50/415
Abstract: PURPOSE: A composition containing isoliquiritigenin for activating GABAA-benzodiazepine receptors is provided to enhance deep sleep, sedation, and anti-anxiety. CONSTITUTION: A composition for activating GABAA-benzodiazepine receptors contains a compound of chemical formula 1. A composition for deep sleep, sedation, anti-anxiety, or anti-convulsion contains the compound of chemical formula 1. A functional food for deep sleep, sedation, anti-anxiety, or anti-convulsion contains the compound of chemical formula 1. The functional food contains Glycyrrhiza uralensis Fischer extract. The extract is prepared by extracting Glycyrrhiza uralensis Fischer with 28-32% ethanol at 38-42 Deg.C for 10-14 hours.
Abstract translation: 目的：提供含有用于激活GABA A - 苯并二氮杂受体的异iqu igen素的组合物，以增强深度睡眠，镇静和抗焦虑。 组成：用于激活GABAA-苯并二氮杂受体的组合物含有化学式1的化合物。用于深度睡眠，镇静，抗焦虑或抗惊厥的组合物含有化学式1的化合物。用于深度睡眠，镇静的功能性食物 ，抗焦虑或抗惊厥含有化学式1的化合物。功能性食品含有甘草黄芪提取物。 提取物采用28-32％乙醇在38-42℃下提取甘草10-7小时。
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