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公开(公告)号：KR100493711B1
公开(公告)日：2005-06-03
申请号：KR1020020060334
申请日：2002-10-02
Applicant: 한국화학연구원
IPC: A01K67/027
Abstract: 본 발명은 ENU를 이용한 무작위 돌연변이법에 의해 제조된 백내장 돌연변이 생쥐 및 그의 제조 방법에 관한 것으로, 보다 상세하게는 ENU를 투여해 유전자를 돌연변이 시킨 생쥐를 교배시키고, 표현형 이상체 스크리닝을 통해 확보한 백내장 돌연변이 생쥐 및 그의 제조 방법에 관한 것이다. 본 발명의 백내장 돌연변이 생쥐는 안정적으로 백내장 증상이 자손에게 유전되는 질환동물 모델로서 백내장의 진단, 예방 또는 치료에 관한 연구에 유용하게 사용될 수 있다.
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Patent Agency Ranking
公开(公告)号：KR101259153B1
公开(公告)日：2013-04-30
申请号：KR1020100112232
申请日：2010-11-11
Applicant: 한국화학연구원 , 주식회사 두배시스템
Abstract: 본 발명은 약액을 동물에게 정확하고 용이하게 투여할 수 있는 화상 점적 투여기(Video instillator)를 개시한다.
본 발명의 화상 점적 투여기는, 바디, 바디에 제공된 스위치, 바디에 설치되는 모터, 모터의 구동에 따라 회전하는 이송 스크류, 이송 스크류에 결합되어 이송 스크류의 회전에 따라 이동하는 가압부재, 약액이 수용되며 가압부재가 이동하는 거리에 연동하여 약액을 투여하는 인젝터, 스위치의 입력 신호에 의해 모터의 회전수를 제어하는 컨트롤러를 포함한다.Abstract translation: 本发明公开了一种能够准确且容易地将药物溶液给予动物的视频滴注装置。
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公开(公告)号：KR1020120050802A
公开(公告)日：2012-05-21
申请号：KR1020100112233
申请日：2010-11-11
Applicant: 한국화학연구원 , 주식회사 두배시스템
Abstract: PURPOSE: An image drop injection apparatus is provided to accurately and easily inject a drug solution to the throat of an animal, and to easily change an injector storing the drug solution. CONSTITUTION: An image drop injection apparatus comprises a body(1), a switch(3), an injector fixture(5), an injector(7), and a drug solution discharging unit. The body includes a space and a handle unit. The switch and the injector fixture are installed on the body. The injector is fitted to the injector fixture. The drug solution discharging unit is installed on the body for pressurizing the injector by the operation of the switch and discharging a drug solution from the injector.
Abstract translation: 目的：提供一种图像滴注射装置，以准确且容易地将药液注射到动物的喉部，并且容易地改变存储药物溶液的注射器。 构成：图像液滴注射装置包括主体（1），开关（3），注射器固定装置（5），注射器（7）和药液排放单元。 主体包括一个空间和一个把手单元。 开关和注射器固定装置安装在主体上。 注射器安装在注射器固定装置上。 药液排出单元安装在身体上，用于通过开关的操作对注射器加压并从注射器排出药液。
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公开(公告)号：KR1020050002286A
公开(公告)日：2005-01-07
申请号：KR1020030043657
申请日：2003-06-30
Applicant: 한국화학연구원
IPC: A01K67/027
CPC classification number: A01K67/0275 , A01K2227/105 , C12N15/09
Abstract: PURPOSE: An inherited deformity of a hindlimb mouse which has a club foot derived using a chemical material, ENU(N-ethyl-N-nitrosourea) and method for producing the same are provided. CONSTITUTION: The inherited deformity of the hindlimb mouse has the club foot derived using the ENU. The mouse is prepared by a random mutagenesis. The method for producing the same comprises the steps of: inducing a mutation by inputting ENU to a male mouse; producing 3-generation mouse by crossing the mouse having the mutation with a normal mouse, crossing an obtained 1-generation mouse with a normal mouse and backcrossing an obtained 2-generation mouse with the 1-generation mouse; and screening a mouse having the club foot symptom from the 3-generation mouse.
Abstract translation: 目的：提供使用化学物质ENU（N-乙基-N-亚硝基脲）衍生的具有球杆脚的后肢小鼠的遗传畸形及其制造方法。 构成：后肢小鼠的继承畸形具有使用ENU的球杆脚。 小鼠通过随机诱变制备。 其制造方法包括以下步骤：通过向雄性小鼠输入ENU来诱导突变; 通过与正常小鼠杂交具有突变的小鼠产生3代小鼠，将所获得的1代小鼠与正常小鼠杂交，并与所述第1代小鼠回交获得的2代小鼠; 并筛选来自3代小鼠具有足球症状的小鼠。
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公开(公告)号：KR1020040081843A
公开(公告)日：2004-09-23
申请号：KR1020030016392
申请日：2003-03-17
Applicant: 한국화학연구원
IPC: A01K67/027
CPC classification number: A01K67/0276 , A01K2227/105 , C12N15/09
Abstract: PURPOSE: Provided is a head tossing and circling mutant mouse that can be utilized in the research and the development of therapeutic agents for diseases associated with an organ of hearing and balancing, central nerves and a nerves system. CONSTITUTION: The head tossing and circling mutant mouse is produced by the process comprising the steps of: administering N-ethyl-N-nitrosourea into a male mouse; cross-breeding the above mouse with a normal mouse to obtain a 2nd generation mouse; back cross-breeding the obtained 2nd generation mouse with the above 1st generation mouse to obtain a 3rd generation mouse; and screening the mouse which exhibits head tossing and circling action from the obtained 3rd generation mouse. Particularly, the mouse is Musmusculus of BALB/c and N-ethyl-N-nitrosurea is administered in a concentration of 150 to 250 mg/kg.
Abstract translation: 目的：提供一种可以用于研究和开发与听力和平衡器官相关的疾病，中枢神经和神经系统的治疗剂的头部折叠和盘旋的突变体小鼠。 构成：通过包括以下步骤的方法产生头部折叠和盘旋的突变小鼠：向雄性小鼠施用N-乙基-N-亚硝基脲; 用正常小鼠杂交上述小鼠以获得第二代小鼠; 使用上述第1代小鼠将获得的第2代小鼠交叉繁殖，获得第3代小鼠; 并从所获得的第三代小鼠筛选显示头部抛掷和盘旋动作的小鼠。 特别地，小鼠是BALB / c的Musmusculus，并且以150-250mg / kg的浓度施用N-乙基-N-亚硝基脲。
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公开(公告)号：KR1020040029893A
公开(公告)日：2004-04-08
申请号：KR1020020060334
申请日：2002-10-02
Applicant: 한국화학연구원
IPC: A01K67/027
CPC classification number: A01K67/0275 , A01K2227/105 , A01K2267/0362 , C12N15/8509
Abstract: PURPOSE: Provided is a mutant mouse having hereditary cataract observable with naked eyes, which is useful as an excellent cataract model animal in diagnosis, prevention and treatment of cataract. CONSTITUTION: The mutant mouse having hereditary cataract is produced by random mutagenesis using N-ethyl-N-nitrosourea(ENU). Particularly, the mouse is a Mus musculus of a BALB/c line. The method for making the mutant mouse comprises the steps of: administering ENU to a male mouse to cause mutagenesis; hybridizing the mutant mouse with a normal mouse to obtain a first-generation mouse, hybridizing the first-generation mouse with a normal mouse to obtain a second-generation mouse, and counter-hybridizing the first-generation mouse with the second-generation mouse to obtain a third-generation mouse; and screening a mouse showing a cataract symptom from the third-generation mice.
Abstract translation: 目的：提供一种具有裸眼观察的遗传性白内障的突变型小鼠，可用作白内障诊断，预防和治疗中优良的白内障模型动物。 构成：具有遗传性白内障的突变小鼠通过使用N-乙基-N-亚硝基脲（ENU）的随机诱变产生。 特别地，鼠标是BALB / c线的Mus musculus。 制备突变小鼠的方法包括以下步骤：向雄性小鼠施用ENU以引起诱变; 将突变小鼠与正常小鼠杂交以获得第一代小鼠，将第一代小鼠与正常小鼠杂交以获得第二代小鼠，并将第一代小鼠与第二代小鼠逆化杂交至 获得第三代鼠标; 并筛选显示来自第三代小鼠的白内障症状的小鼠。
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