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公开(公告)号：KR1020110100700A
公开(公告)日：2011-09-15
申请号：KR1020100019671
申请日：2010-03-05
Applicant: 가톨릭대학교 산학협력단 , 한림제약(주)
IPC: A61K31/4704 , A61K9/14 , A61K47/38 , A61P19/02
CPC classification number: A61K31/4704 , A61K9/2004
Abstract: 본 발명은 레바미피드 및 약학적으로 허용가능한 담체를 포함하는 골관절염의 예방 또는 치료용 약학 조성물을 제공한다. 상기 약학 조성물은 경구 투여용 형태일 수 있으며, 바람직하게는 정제 또는 캅셀제 형태의 고형 경구용 제형을 가질 수 있다. 또한, 상기 약학 조성물은 레바미피드가 0.5 내지 50 mg/kg, 더욱 바람직하게는 0.6 내지 6 mg/kg의 용량으로 경구투여되기에 적합한 단위 투여 형태(unit dosage form)로 제제화될 수 있다.
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12.发明公开
公开(公告)号：KR1020100067708A
公开(公告)日：2010-06-22
申请号：KR1020080126216
申请日：2008-12-12
Applicant: 가톨릭대학교 산학협력단 , 에이치 엘 지노믹스(주)
CPC classification number: A61K36/87
Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract is provided to suppress osteoclast differentiation and to prevent and treat osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The Vitis vinifera seed extract has 80-130 of procyanidolic value(PCV), 30% or less (+) catechin and (-) epicatechin, and 95-105% of proanthocyanine. A method for manufacturing the Vitis vinifera seed extract comprises: a step of adding mixture solvent of water and acetone to pulverized Vitis vinifera seed and extracting at room temperature; a step of removing acetone and suturing sodium chloride and filtering; a step of extracting the extract with acetate and concentrating; and a step of adding chloroform to the concentrate and filtering.
Abstract translation: 目的：提供含有葡萄籽提取物的药物组合物，以抑制破骨细胞分化和预防和治疗骨质疏松症。 构成：用于预防或治疗骨质疏松症的药物组合物含有葡萄种子提取物和药学上可接受的载体。 葡萄籽提取物的原花青素值（PCV）为80-130，儿茶素和（ - ）表儿茶素为30％以下，原花青素为95-105％。 葡萄种子提取物的制造方法包括：将水和丙酮的混合溶剂加入粉状葡萄种子并在室温下提取的步骤; 去除丙酮并缝合氯化钠并过滤的步骤; 用醋酸提取提取物浓缩的步骤; 以及向浓缩物中加入氯仿并过滤的步骤。
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公开(公告)号：KR101187195B1
公开(公告)日：2012-10-02
申请号：KR1020100025050
申请日：2010-03-22
Applicant: 에이치 엘 지노믹스(주) , 가톨릭대학교 산학협력단
Abstract: 본 발명은 유럽종 포도(
Vitis vinifera )의 씨 추출물 및 약학적으로 허용가능한 담체를 포함하는 위장관 궤양(gastrointestinal ulcer)의 예방 또는 치료용 약학 조성물을 제공한다.-
14.发明公开유럽종 포도의 씨 추출물 및 레바미피드를 포함하는 류마티스 관절염의 예방 또는 치료용 약학 조성물 有权用于预防或治疗包含VITIS VINIFERA PIP提取物和雷巴米地的含盐酸盐的药物组合物
公开(公告)号：KR1020120032649A
公开(公告)日：2012-04-06
申请号：KR1020100094091
申请日：2010-09-29
Applicant: 한림제약(주) , 가톨릭대학교 산학협력단
Abstract: PURPOSE: A pharmaceutical composition containing rebamipide and Vitis vinifera seed extract is provided to prevent or treat rheumatoid arthritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatoid arthritis contains rebamipide and Vitis vinifera seed extract. The pharmaceutical composition is orally administered in the form of a tablet or capsule. The dosage of rebamipide is 0.3 mg/kg a day.
Abstract translation: 目的：提供含有瑞巴派特和葡萄种子提取物的药物组合物，以预防或治疗类风湿性关节炎。 构成：用于预防或治疗类风湿性关节炎的药物组合物含有瑞巴派特和葡萄籽种子提取物。 药物组合物以片剂或胶囊的形式口服给药。 瑞巴派特的剂量为每天0.3mg / kg。
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Patent Agency Ranking
公开(公告)号：KR1020110137588A
公开(公告)日：2011-12-23
申请号：KR1020100057601
申请日：2010-06-17
Applicant: 에이치 엘 지노믹스(주) , 가톨릭대학교 산학협력단
Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract and pharmaceutically acceptable carrier is provided to prevent and treat obesity. CONSTITUTION: A pharmaceutical composition for preventing or treating obesity contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The extract has 80-130 of procyanidolic value(PCV) and contains less than 30% of (+)catechin and (-) epicatechin and 95-105% of proanthocyanidin content. A method for preparing the extract comprises: a step of mixing pulverized Vitis vinifera seed and a mixture solvent of acetone and water and isolating at room temperature; a step of filtering the extract and distilling the filtered liquid to remove acetone; a step of saturating sodium chloride and filtering; a step of extracting the liquid with ethyl acetate and concentrating; and a step of adding chloroform and filtering.
Abstract translation: 目的：提供含有葡萄籽提取物和药学上可接受的载体的药物组合物以预防和治疗肥胖症。 构成：用于预防或治疗肥胖症的药物组合物含有葡萄种子提取物和药学上可接受的载体。 提取物具有80-130原花青素值（PCV），并且含有少于30％的（+）儿茶素和（ - ）表儿茶素和95-105％的原花色素含量。 一种制备提取物的方法包括：将经粉碎的葡萄种子和丙酮和水的混合溶剂混合并在室温下分离的步骤; 过滤提取物并蒸馏过滤的液体以除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯萃取液体并浓缩的步骤; 并加入氯仿和过滤步骤。
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公开(公告)号：KR1020110021016A
公开(公告)日：2011-03-04
申请号：KR1020090078547
申请日：2009-08-25
Applicant: 가톨릭대학교 산학협력단 , 한림제약(주)
IPC: A61K31/4704 , A61P19/02 , A61K9/20 , A61K9/48
CPC classification number: A61K31/4704
Abstract: PURPOSE: A pharmaceutical composition containing rabamipide and pharmaceutically acceptable carrier is provided to prevent or treat rheumatoid arthritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatoid arthritis contains rabamipid and pharmaceutically acceptable carrier. The pharmaceutical composition is used for oral administration. The pharmaceutical composition is formed in oral solid dosage. The pharmaceutical composition has rabamipid formulated in 0.5-50 mg/kg of unit dosage form.
Abstract translation: 目的：提供含有拉巴米特和药学上可接受的载体的药物组合物，以预防或治疗类风湿性关节炎。 构成：用于预防或治疗类风湿性关节炎的药物组合物含有拉帕米特和药学上可接受的载体。 药物组合物用于口服给药。 药物组合物以口服固体剂量形成。 药物组合物具有配制在0.5-50mg / kg单位剂型中的拉巴米特。
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17.发明授权
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公开(公告)号：KR1020110049627A
公开(公告)日：2011-05-12
申请号：KR1020100025050
申请日：2010-03-22
Applicant: 에이치 엘 지노믹스(주) , 가톨릭대학교 산학협력단
Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract is provided to prevent and treat gastrointestinal ulcer. CONSTITUTION: A pharmaceutical composition for preventing or treating gastrointestinal ulcer contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The extract of Vitis vinifera seeds contains 80-130 of procyanidolic value(PCV); 30% or less of (+)catechin and (-) epicatechin; and 95-105% of proanthocyanidin. A method for preparing the Vitis vinifera seed extract comprises: a step of extracting Vitis vinifera seed seeds in a mixture solvent of acetone and water and filtering; a step of distilling liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting the liquid with ethyl acetate and concentrating; and a step of adding chloroform and filtering to obtain precipitate.
Abstract translation: 目的：提供含有葡萄籽提取物的药物组合物，用于预防和治疗胃肠溃疡。 构成：用于预防或治疗胃肠溃疡的药物组合物含有葡萄种子提取物和药学上可接受的载体。 葡萄籽提取物含有原花青素含量（PCV）80-130; 30％以下（+）儿茶素和（ - ）表儿茶素; 和95-105％的原花色素。 一种葡萄种子提取物的制备方法，其特征在于：在丙酮和水的混合溶剂中提取葡萄种子种子并过滤; 蒸馏液并除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯萃取液体并浓缩的步骤; 并加入氯仿和过滤以获得沉淀物的步骤。
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公开(公告)号：KR1020100117184A
公开(公告)日：2010-11-03
申请号：KR1020090035796
申请日：2009-04-24
Applicant: 가톨릭대학교 산학협력단 , 에이치 엘 지노믹스(주)
CPC classification number: A61K36/87
Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera for preventing or treating osteoarthritis is provided. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoarthritis contains Vitis vinifera extract and pharmaceutically acceptable carrier. Osteoarthritis is caused by aging, obesity or trauma. The Vitis vinifera extract contains 80-130 of procyanidolic value(PCV), 30% or less (+) catechin and (-) epicatechin, and 95-105% of proanthocyanidine. A method for producing Vitis vinifera extract comprises: a step of extracting Vitis vinifera and mixture of acetone and water at room temperature and filtering; a step of distilling remaining liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting with ethyl acetate and concentrating; and a step of adding chloroform and precipitating.
Abstract translation: 目的：提供一种含有葡萄酒的预防或治疗骨关节炎的药物组合物。 构成：用于预防或治疗骨关节炎的药物组合物含有葡萄葡萄提取物和药学上可接受的载体。 骨关节炎是由衰老，肥胖或创伤引起的。 葡萄籽提取物含有原花青素值（PCV）80-130，儿茶素和（ - ）表儿茶素30％以下，原花青素95-105％。 一种葡萄酒提取物的制备方法，其特征在于：在室温下提取葡萄酒和丙酮与水的混合物，过滤; 蒸馏剩余液体并除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯提取并浓缩的步骤; 并加入氯仿和沉淀的步骤。
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