公开(公告)号：US20230092755A1

公开(公告)日：2023-03-23

申请号：US17948572

申请日：2022-09-20

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Bharat R. Acharya ,  Tonya D. Bonilla ,  Jessica E. DeMay ,  Stephen M. Kennedy ,  Aaron M. Marcella ,  Raj Rajagopal ,  Mark A. Roehrig ,  David A. Rosen ,  Jonah Shaver ,  Brett J. Sitter ,  Gregory W. Sitton ,  Michael L. Steiner ,  John A. Wheatley ,  Zhaohui Yang ,  Antonia E. Schaefer

IPC: G01N21/64 ,  G01N21/33 ,  G02B5/28 ,  G02B17/00

Abstract: A recycling optical cavity is defined at least by first and second optical films and is configured to receive a test material therein. The test material is configured to emit at least a second light having a second wavelength when irradiated with a first light having a first wavelength. For at least one of s- and p-polarized incident lights incident in an incident plane, and at the first and second wavelengths: at a first incident angle, the first optical film has respective optical transmittances T11(θ1) and T12(θ1), and the second optical film has respective optical transmittances T21(θ1) and T22(θ1), wherein T11(θ1)>T12(θ1), T21(θ1), T22(θ1); and at a second incident angle, the first optical film has respective optical transmittances T11(θ2) and T12(θ2), and the second optical film has respective optical transmittances T21(θ2) and T22(θ2), wherein T21(θ2)>T11(θ2), T12(θ2), T22(θ2).

公开(公告)号：US20180059108A1

公开(公告)日：2018-03-01

申请号：US15558300

申请日：2016-03-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Manjiri T. Kshirsagar ,  Raj Rajagopal

IPC: G01N33/569 ,  G01N21/76 ,  G01N33/543

CPC classification number: G01N33/569 ,  C12Q1/06 ,  G01N21/763 ,  G01N33/5436 ,  G01N33/54366 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56938 ,  G01N2469/00

Abstract: Nonwoven articles for detecting microorganisms or cellular analytes in a fluid sample are provided. The nonwoven article includes a fibrous porous matrix and concentration agent particles enmeshed in the fibrous porous matrix. The fibrous porous matrix generally consists of inorganic fibers and polymeric fibers. Methods of detecting microorganisms or cellular analytes in a fluid sample are also provided. The method includes providing the nonwoven article, providing a fluid sample suspected of containing at least one microorganism strain or target cellular analyte, contacting the fluid sample with the nonwoven article such that at least a portion of the at least one microorganism strain or target cellular analyte is bound to the nonwoven article, and detecting the presence of bound microorganism strain(s) or bound cellular analyte(s).

公开(公告)号：US20170010199A1

公开(公告)日：2017-01-12

申请号：US15271747

申请日：2016-09-21

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raj Rajagopal ,  Ramasubramani Kuduva Raman Thanumoorthy

IPC: G01N15/04 ,  B01L3/00 ,  C12Q1/02 ,  G01N1/40

CPC classification number: G01N15/042 ,  B01L3/5021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2400/0409 ,  C12Q1/02 ,  G01N1/4077 ,  G01N15/04 ,  G01N21/07 ,  G01N2001/4083 ,  G01N2015/0065 ,  G01N2015/045 ,  G01N2333/245 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Method for detecting an analyte of interest in a sample. The method can include providing a container comprising a microstructured surface, and centrifuging the container toward the microstructured surface to form a sediment and a supernatant of the sample. Following centrifugation, the container can be inverted to decant at least a portion of the supernatant of the sample from the second portion, such that a concentrate (e.g., comprising the sediment) of the sample is retained in the microstructured surface. The concentrate can then be interrogated in the microstructured surface for the analyte of interest. In some embodiments, at least a portion of the second portion can be substantially transparent, such that the concentrate can be interrogated from the outside of the container, without requiring that the container be opened prior to interrogation.

Abstract translation: 用于检测样品中感兴趣的分析物的方法。 该方法可以包括提供包含微结构化表面的容器，并将容器离心到微结构化表面以形成样品的沉淀物和上清液。 离心后，将容器倒置以从第二部分倾析样品的上清液的至少一部分，使得样品的浓缩物（例如包含沉淀物）保留在微结构化表面中。 然后可以在微结构化表面中询问浓缩物用于感兴趣的分析物。 在一些实施例中，第二部分的至少一部分可以是基本上透明的，从而可以从容器的外部询问浓缩物，而不需要在询问之前打开容器。

公开(公告)号：US20220220547A1

公开(公告)日：2022-07-14

申请号：US17612037

申请日：2020-05-15

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Wilfredo Dominguez-Nunez ,  Raj Rajagopal ,  Nicholas A. Asendorf ,  Saber Taghvaeeyan

IPC: C12Q1/6848 ,  G16B40/00 ,  C12Q1/689

Abstract: In some examples, a system for detecting inhibition of a biological assay includes a detection device configured to amplify and detect a target nucleic acid. The detection device is configured to receive a sample comprising a matrix and a quantity of the target nucleic acid and to amplify the target nucleic acid within the sample over a nucleic acid amplification cycle. The detection device is configured to capture a data set including measurements of the nucleic acid collected during the amplification cycle. The system further includes a computing device configured to receive the data set and to apply a machine-learning system to the data set to detect inhibited biological assays that tested negative for the target nucleic acid due to matrix inhibition.

公开(公告)号：US20200283660A1

公开(公告)日：2020-09-10

申请号：US16066108

申请日：2016-12-27

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Raj Rajagopal ,  Audrey A. Sherman ,  Scott M. Tapio ,  Masayuki Nakamura ,  Ann R.H. Fornof

IPC: C09J11/08 ,  C09J7/38 ,  C09J5/00 ,  B32B27/06 ,  B32B37/12 ,  B32B37/24 ,  B32B37/02

Abstract: Pressure sensitive adhesive articles include a substrate, and a layer of pressure sensitive adhesive in contact with the substrate. The pressure sensitive adhesive layer includes a pressure sensitive adhesive matrix, and at least one active enzyme dispersed within the pressure sensitive adhesive matrix. The active enzyme remains active for extended periods of time.

公开(公告)号：US10131930B2

公开(公告)日：2018-11-20

申请号：US15185792

申请日：2016-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Patrick A. Mach ,  Raj Rajagopal ,  Wensheng Xia ,  Jinsheng Zhou ,  Chunmei Guo

IPC: C12Q1/04 ,  B01J20/26 ,  B01D69/10 ,  C12Q1/24 ,  B01D63/00 ,  C12Q1/689 ,  G01N33/68 ,  B01D69/02 ,  B01J20/28

Abstract: A method of filtering a liquid sample that includes passing a sample comprising at least one biological organism through a filter membrane at a passive water volume flux of at least 10 L/m2·h·psi, wherein the filter membrane comprises a Bubble Point pore size of no more than 1.0 μm, thereby retaining at least one biological organism on the surface of the membrane; and detecting the at least one biological organism retained on the surface of the filter membrane.

公开(公告)号：US20180305544A1

公开(公告)日：2018-10-25

申请号：US15494984

申请日：2017-04-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Mario A. Perez ,  Rajdeep S. Kalgutkar ,  Raj Rajagopal ,  Samantha J. Raney

IPC: C08L77/06 ,  C08L79/02 ,  C09D177/06 ,  C09D179/02 ,  B05D3/00

CPC classification number: C08L77/06 ,  B05D3/007 ,  C08L79/02 ,  C09D177/06 ,  C09D179/02

Abstract: The present invention generally relates to curable compositions that include a benzoxazine resin and a polyamide resin, wherein the polyamide resin is a reaction product of (i) a dicarboxylic acid, wherein the dicarboxylic acid includes a non-aromatic, dicarboxylic dimer acid and the mole fraction of the non-aromatic, dicarboxylic dimer acid is between from 0.10 to 1.00, based on the total moles of dicarboxylic acid used to form the polyamide resin; and (ii) a diamine; and wherein the polyamide resin is amine terminated and includes amine end-groups. The curable compositions may be used to produce an article comprising a cured composition wherein the cured composition is the reaction product of the curable composition according to any one of the curable compositions of the present disclosure. The present invention also relates to methods of coating substrates using the curable compositions of the present disclosure.

公开(公告)号：US09909969B2

公开(公告)日：2018-03-06

申请号：US15271747

申请日：2016-09-21

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raj Rajagopal ,  Ramasubramani Kuduva Raman Thanumoorthy

IPC: G01N15/04 ,  G01N1/40 ,  B01L3/00 ,  C12Q1/02 ,  G01N21/07 ,  G01N15/00

CPC classification number: G01N15/042 ,  B01L3/5021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2400/0409 ,  C12Q1/02 ,  G01N1/4077 ,  G01N15/04 ,  G01N21/07 ,  G01N2001/4083 ,  G01N2015/0065 ,  G01N2015/045 ,  G01N2333/245 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Method for detecting an analyte of interest in a sample. The method can include providing a container including a microstructured surface, and centrifuging the container toward the microstructured surface to form a sediment and a supernatant of the sample. Following centrifugation, the container can be inverted to decant at least a portion of the supernatant of the sample from the second portion, such that a concentrate (e.g., including the sediment) of the sample is retained in the microstructured surface. The concentrate can then be interrogated in the microstructured surface for the analyte of interest. In some embodiments, at least a portion of the second portion can be substantially transparent, such that the concentrate can be interrogated from the outside of the container, without requiring that the container be opened prior to interrogation.

公开(公告)号：US20140106397A1

公开(公告)日：2014-04-17

申请号：US14122373

申请日：2012-06-26

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Raj Rajagopal ,  Kurt J. Halverson ,  Ramasubramani Kuduva Raman Thanumoorthy

IPC: C12Q1/04

CPC classification number: G01N1/4077 ,  B01L3/5021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2400/0409 ,  C12Q1/04 ,  G01N15/042 ,  G01N2001/4083 ,  G01N2001/4088

Abstract: Systems and methods for detecting an analyte of interest in a sample. The system can include a first container comprising a filter portion. The filter portion can include a filter comprising a filtrand of the sample on a first side of the filter. The system can further include a second container comprising the filter portion coupled to a detection portion comprising a microstructured surface. The method can include providing the first container, coupling the filter portion to the detection portion to form the second container where the first side of the filter faces the microstructured surface, and centrifuging the second container toward the microstructured surface. The method can further include inverting the second container after centrifuging to decant the supernatant from the detection portion, such that a concentrate comprising a sediment of the sample is retained in the microstructured surface, which can be interrogated for an analyte of interest.

Abstract translation: 用于检测样品中感兴趣的分析物的系统和方法。 该系统可以包括包括过滤器部分的第一容器。 过滤器部分可以包括在过滤器的第一侧上包括样品的过滤器的过滤器。 该系统还可以包括第二容器，其包括耦合到包括微结构化表面的检测部分的过滤器部分。 该方法可以包括提供第一容器，将过滤部分连接到检测部分，以形成第二容器，其中过滤器的第一侧面向微结构化表面，并将第二容器离心到微结构化表面。 该方法还可包括在离心后将第二容器倒置以从检测部分倾析上清液，使得包含样品沉淀物的浓缩物保留在微结构化表面中，该微结构化表面可被询问用于感兴趣的分析物。