公开(公告)号：EP2376462A1

公开(公告)日：2011-10-19

申请号：EP09775056.6

申请日：2009-12-16

Applicant: Abbott Laboratories

Inventor： FROST, Jennifer, M. ,  LATSHAW, Steven, P. ,  DART, Michael, J. ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  KOLASA, Teodozyj ,  PATEL, Meena ,  NELSON, Derek, W. ,  LI, Tongmei ,  PEDDI, Sridhar ,  WANG, Xueqing ,  LIU, Bo

IPC: C07D277/46 ,  C07D417/12 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D417/12 ,  C07D277/46 ,  C07D513/04

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L
1 , A
1 , R
1g , z, R
2 , R
3 , and R
4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

公开(公告)号：EP2346843A2

公开(公告)日：2011-07-27

申请号：EP09792301.5

申请日：2009-09-08

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  PEDDI, Sridhar

IPC: C07D277/46 ,  C07D417/06 ,  C07D417/14 ,  A61K31/427 ,  A61P29/00

CPC classification number: C07D417/06 ,  C07D277/46 ,  C07D417/14

Abstract: The present application relates to cannabinoid receptor ligands of formula (I), wherein X
1 , A
1 , R
x , R
2 , R
3 , R
4 , and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2219629A1

公开(公告)日：2010-08-25

申请号：EP08837396.4

申请日：2008-10-08

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  DART, Michael J. ,  NELSON, Derek W. ,  LI, Tongmei ,  LIU, Bo ,  KOLASA, Teodozyj ,  FROST, Jennifer ,  WANG, Xueqing ,  LATSHAW, Steven, P.

IPC: A61K31/015 ,  A61P43/00

CPC classification number: C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates compounds of formula (I), as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及如说明书中所定义的式（I）化合物，包含此类化合物的药物组合物，以及使用此类化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：EP2331516B1

公开(公告)日：2013-03-13

申请号：EP09791365.1

申请日：2009-08-11

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC: C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC classification number: C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

公开(公告)号：EP2411371A1

公开(公告)日：2012-02-01

申请号：EP10724168.9

申请日：2010-03-26

Applicant: Abbott Laboratories

Inventor： WANG, Xueqing ,  DART, Michael, J. ,  LIU, Bo

IPC: C07D231/40 ,  C07D285/135 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D231/40 ,  C07D285/135

Abstract: Cannabinoid receptor ligands of formula (I) wherein Ring A and R1 are as defined in the specification. Compositions including such compounds, and methods of treating conditions and disorders using such compounds and compositions are also described.

公开(公告)号：EP2411370A1

公开(公告)日：2012-02-01

申请号：EP10724167.1

申请日：2010-03-26

Applicant: Abbott Laboratories

Inventor： WANG, Xueqing ,  FROST, Jennifer, M. ,  DART, Michael, J. ,  LIU, Bo

IPC: C07D231/40 ,  C07D403/12 ,  C07D285/135 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D231/40 ,  C07D285/135 ,  C07D403/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Ring A and R1 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also described.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中环A和R 1如说明书中所定义。 还描述了包含此类化合物的组合物以及使用此类化合物和组合物治疗疾病和病症的方法。

公开(公告)号：EP2331516A1

公开(公告)日：2011-06-15

申请号：EP09791365.1

申请日：2009-08-11

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC: C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC classification number: C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X
1 , X
2 , X
3 , R
1 , and R
2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2411382A1

公开(公告)日：2012-02-01

申请号：EP10724166.3

申请日：2010-03-26

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R
1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.