公开(公告)号：EP0972056A1

公开(公告)日：2000-01-19

申请号：EP98907345.7

申请日：1998-01-30

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/47

CPC classification number: C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LU105 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to LU105-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific LU105 polypeptide, which molecules are useful for the therapeutic treatment of lung diseases, tumors or metastases.

公开(公告)号：EP1032689A1

公开(公告)日：2000-09-06

申请号：EP98958623.5

申请日：1998-11-17

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12N15/63 ,  C12N5/10 ,  C07K14/47 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  A61K38/17

CPC classification number: C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS274 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS274-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS274 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1015625A2

公开(公告)日：2000-07-05

申请号：EP98948329.2

申请日：1998-09-18

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  MERCHANT, Barbara, T. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/00

CPC classification number: C07K16/3015 ,  A61K38/00 ,  A61K2039/51 ,  C07K14/705 ,  C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS214 and transcribed from prostate, breast, or ovary tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, breast, or ovary, such as prostate, breast, or ovarian cancer. Also provided are antibodies which specifically bind to PS214-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS214 polypeptide, which molecules are useful for the therapeutic treatment of prostate, breast, or ovary diseases, tumors or metastases.

公开(公告)号：EP0954599A1

公开(公告)日：1999-11-10

申请号：EP97910048.0

申请日：1997-10-08

Applicant: Abbott Laboratories

Inventor： COHEN, Maurice ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12Q1 ,  G01N33

CPC classification number: C07K14/82 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57434

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS 112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS 112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS 112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS 112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumours or metastases.

公开(公告)号：EP0870025A1

公开(公告)日：1998-10-14

申请号：EP97938467.0

申请日：1997-08-19

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: G01N33 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  C12R1

CPC classification number: C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1038030A2

公开(公告)日：2000-09-27

申请号：EP98963112.2

申请日：1998-12-11

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  G01N33/574

CPC classification number: C07K16/18 ,  C07K14/47

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PA153 and transcribed from pancreatic tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the pancreas, such as pancreatic cancer. Also provided are antibodies which specifically bind to PA153-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PA153 polypeptide, which molecules are useful for the therapeutic treatment of pancreatic diseases, tumors or metastases.

公开(公告)号：EP1032706A1

公开(公告)日：2000-09-06

申请号：EP98958633.4

申请日：1998-11-18

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  A61K48/00

CPC classification number: C07K14/4748 ,  A61K39/00 ,  A61K2039/51 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS265 and transcribed from breast tissue, is described. Theses sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS265-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS265 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP0977893A1

公开(公告)日：2000-02-09

申请号：EP98919862.7

申请日：1998-04-23

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C07K16/00 ,  G01N33/574 ,  A61K38/17

CPC classification number: C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：EP0975772A1

公开(公告)日：2000-02-02

申请号：EP98913332.7

申请日：1998-03-31

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HAYDEN, Mark ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12N15/63

CPC classification number: C07K16/3046 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：EP0973944A1

公开(公告)日：2000-01-26

申请号：EP98913296.4

申请日：1998-03-30

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HAYDEN, Mark ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C07K16/00 ,  G01N33/574 ,  A61K38/17

CPC classification number: G01N33/6893 ,  C07K14/47 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/06 ,  Y10S435/81 ,  Y10S530/828

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.