公开(公告)号：WO1998007857A1

公开(公告)日：1998-02-26

申请号：PCT/US1997014665

申请日：1997-08-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/12

CPC classification number: C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了称为BU101的蛋白质的子宫肌血清蛋白家族的新成员。 BU101由一组从乳腺组织转录的连续和部分重叠的RNA序列以及由此编码的多肽来定义。 还公开了表示BU101的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：WO1998020143A1

公开(公告)日：1998-05-14

申请号：PCT/US1997020680

申请日：1997-11-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  COHEN, Maurice ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVILL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/63

CPC classification number: C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as LU103 and transcribed from lung tissue is described. A fully sequenced clone representing the longest continuous sequence of LU103 is also disclosed. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung such as lung cancer.

Abstract translation: 描述了一组由此编码的连续和部分重叠的RNA序列和多肽，命名为LU103并从肺组织转录。 还公开了表示LU103的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗，或确定个体对肺部疾病和病症的倾向，如肺癌。

公开(公告)号：WO1998018945A1

公开(公告)日：1998-05-07

申请号：PCT/US1997019836

申请日：1997-10-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/63

CPC classification number: C07K16/3015 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，称为BS106并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及预防组织特异性BS106多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：WO1998015657A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018290

申请日：1997-10-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  COHEN, Maurice ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12Q01/68

CPC classification number: C07K14/82 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57434

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS 112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS 112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS 112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS 112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumours or metastases.

Abstract translation: 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，称为PS 112并从前列腺组织转录。 还公开了表示PS 112的连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和状况（例如前列腺癌）的倾向。 还提供了特异性结合PS 112编码的多肽或蛋白质的抗体，以及预防组织特异性PS 112多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：WO1998007753A1

公开(公告)日：1998-02-26

申请号：PCT/US1997014666

申请日：1997-08-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K39/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K2319/00

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as mammaglobin and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to mammaglobin-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific mammaglobin polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，被称为乳腺球蛋白并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合乳腺球蛋白编码的多肽或蛋白质的抗体，以及预防组织特异性乳腺球蛋白多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：EP0939824B1

公开(公告)日：2007-06-06

申请号：EP97913936.7

申请日：1997-10-31

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/47 ,  C07K16/30 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577

CPC classification number: C07K16/3015 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1259542A2

公开(公告)日：2002-11-27

申请号：EP01916303.9

申请日：2001-02-28

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C07K14/47 ,  C07K16/30 ,  C07K19/00 ,  C12N5/10 ,  G01N33/574

CPC classification number: G01N33/57415 ,  C07K14/4748

Abstract: Multimeric polypeptides antigens comprising polypeptides designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring prognosticating or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein.

公开(公告)号：EP0856010A1

公开(公告)日：1998-08-05

申请号：EP97938468.0

申请日：1997-08-19

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C07K14 ,  C07K16 ,  A61K39

CPC classification number: C07K16/18 ,  A61K39/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K2319/00

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as mammaglobin and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to mammaglobin-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific mammaglobin polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1141389A2

公开(公告)日：2001-10-10

申请号：EP00908317.1

申请日：2000-01-19

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  SCHEFFEL, Christi, P. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C07K16/18

CPC classification number: C07K14/47

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP0990045A1

公开(公告)日：2000-04-05

申请号：EP98931212.9

申请日：1998-06-11

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C07K16/00 ,  G01N33/574

CPC classification number: C07K16/3023 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LS170 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to a LS170-encoded polypeptide or protein, and agonists or inhibitors which prevent action of tissue-specific LS170 polypeptides, which molecules are useful for the therapeutic treatment of lung diseases, tumors, or metastases.

Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为LS170并从肺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对肺的疾病和状况（例如肺癌）的倾向。 还提供了特异性结合LS170编码的多肽或蛋白质的抗体，以及预防组织特异性LS170多肽的作用的激动剂或抑制剂，该分子可用于治疗肺部疾病，肿瘤或转移瘤。