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公开(公告)号：EP2432783A1
公开(公告)日：2012-03-28
申请号：EP10720502.3
申请日：2010-05-20
Applicant: Abbott Laboratories , Abbott GmbH & Co. KG
Inventor： WELCH, Dennie, S. , AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan, W. , WILSON, Noel, S. , TURNER, Sean, C. , KRUGER, Albert, W. , RELO, Ana-Lucia , SHEKHAR, Shashank , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan, F. , LI, Huanqiu , THOMPSON, Christina, M. , ZHANG, Min
IPC: C07D487/04 , C07D491/04 , C07D495/04 , A61P25/00 , A61K31/551 , A61K31/554 , A61K31/553
CPC classification number: C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
Abstract: The present application relates to processes for making aryl- and heteroaryl-fused decahydropyrroloazepine derivatives of formula (1-5), wherein the variables are as defined in the specification.
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12.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权THE VANILLOIDREZEPTORSUBTYP 1（VR1）简明氮杂双环化合物 - 受体禁止
公开(公告)号：EP1660455B1
公开(公告)日：2008-10-15
申请号：EP04780017.2
申请日：2004-08-04
Applicant: ABBOTT LABORATORIES
Inventor： BAYBURT, Erol, K. , DIDOMENICO, Stanley, Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R.; , KOENIG, John, R. , PENNER, Richard, J. , SCHMIDT, Robert, G., Jr. , TURNER, Sean, C. , WHITE, Tammie, K. , ZHENG, Guo Zhu
IPC: C07D217/24 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , C07D217/26 , C07D401/12 , C07D405/12 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
CPC classification number: C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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13.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权THE VANILLOIDREZEPTORSUBTYP 1（VR1）简明氮杂双环化合物 - 受体禁止
公开(公告)号：EP1660455A1
公开(公告)日：2006-05-31
申请号：EP04780017.2
申请日：2004-08-04
Applicant: ABBOTT LABORATORIES , Lee, Chih-Hung
Inventor： BAYBURT, Erol, K. , DIDOMENICO, Stanley, Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R.; , KOENIG, John, R. , PENNER, Richard, J. , SCHMIDT, Robert, G., Jr. , TURNER, Sean, C. , WHITE, Tammie, K. , ZHENG, Guo Zhu
IPC: C07D217/24 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , C07D217/26 , C07D401/12 , C07D405/12 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
CPC classification number: C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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